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Let G be a finite group and p be a prime. We prove that if G has three codegrees, then G is an M-group. We prove for some prime p that if the degree of every nonlinear irreducible Brauer character of G is a prime, then for every normal subgroup N of G, either $G/N$ or N is an $M_p$-group.
Accurate diagnosis of bipolar disorder (BPD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A depressive episode often precedes the first manic episode, making it difficult to distinguish BPD from unipolar major depressive disorder (MDD).
Aims
We use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores (PRS) that may aid early differential diagnosis.
Method
Based on individual genotypes from case–control cohorts of BPD and MDD shared through the Psychiatric Genomics Consortium, we compile case–case–control cohorts, applying a careful quality control procedure. In a resulting cohort of 51 149 individuals (15 532 BPD patients, 12 920 MDD patients and 22 697 controls), we perform a variety of GWAS and PRS analyses.
Results
Although our GWAS is not well powered to identify genome-wide significant loci, we find significant chip heritability and demonstrate the ability of the resulting PRS to distinguish BPD from MDD, including BPD cases with depressive onset (BPD-D). We replicate our PRS findings in an independent Danish cohort (iPSYCH 2015, N = 25 966). We observe strong genetic correlation between our case–case GWAS and that of case–control BPD.
Conclusions
We find that MDD and BPD, including BPD-D are genetically distinct. Our findings support that controls, MDD and BPD patients primarily lie on a continuum of genetic risk. Future studies with larger and richer samples will likely yield a better understanding of these findings and enable the development of better genetic predictors distinguishing BPD and, importantly, BPD-D from MDD.
We investigate neighbourhood sizes in the enhanced power graph (also known as the cyclic graph) associated with a finite group. In particular, we characterise finite p-groups with the smallest maximum size for neighbourhoods of a nontrivial element in its enhanced power graph.
In this paper, we investigate finite solvable tidy groups. We prove that a solvable group with order divisible by at least two primes is tidy if all of its Hall subgroups that are divisible by only two primes are tidy.
Three-dimensional (3D) food printing is a rapidly emerging technology offering unprecedented potential for customised food design and personalised nutrition. Here, we evaluate the technological advances in extrusion-based 3D food printing and its possibilities to promote healthy and sustainable eating. We consider the challenges in implementing the technology in real-world applications. We propose viable applications for 3D food printing in health care, health promotion and food waste upcycling. Finally, we outline future work on 3D food printing in food safety, acceptability and economics, ethics and regulations.
People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown.
Methods:
We collected longitudinal diagnostic information (mean = 36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND/mild cognitive impairment/other neurological disorders (ND/MCI/other) and PSY. We pre-specified NfL > 582 pg/mL as indicative of ND/MCI/other.
Results:
Diagnostic category changed from initial to final diagnosis for 23% (49/212) of patients. NfL predicted the final diagnostic category for 92% (22/24) of these and predicted final diagnostic category overall (ND/MCI/other vs. PSY) in 88% (187/212), compared to 77% (163/212) with clinical assessment alone.
Conclusions:
CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.
Let G be a p-group for some prime p. Recall that the Hughes subgroup of G is the subgroup generated by all of the elements of G with order not equal to p. In this paper, we prove that if the Hughes subgroup of G is cyclic, then G has exponent p or is cyclic or is dihedral. We also prove that if the Hughes subgroup of G is generalised quaternion, then G must be generalised quaternion. With these results in hand, we classify the tidy p-groups.
In this paper, we study the supercharacter theories of elementary abelian $p$-groups of order $p^{2}$. We show that the supercharacter theories that arise from the direct product construction and the $\ast$-product construction can be obtained from automorphisms. We also prove that any supercharacter theory of an elementary abelian $p$-group of order $p^{2}$ that has a non-identity superclass of size $1$ or a non-principal linear supercharacter must come from either a $\ast$-product or a direct product. Although we are unable to prove results for general primes, we do compute all of the supercharacter theories when $p = 2,\, 3,\, 5$, and based on these computations along with particular computations for larger primes, we make several conjectures for a general prime $p$.
Let $\eta (G)$ be the number of conjugacy classes of maximal cyclic subgroups of G. We prove that if G is a p-group of order $p^n$ and nilpotence class l, then $\eta (G)$ is bounded below by a linear function in $n/l$.
Morgan and Parker proved that if G is a group with ${\textbf{Z}(G)} = 1$, then the connected components of the commuting graph of G have diameter at most $10$. Parker proved that if, in addition, G is solvable, then the commuting graph of G is disconnected if and only if G is a Frobenius group or a $2$-Frobenius group, and if the commuting graph of G is connected, then its diameter is at most $8$. We prove that the hypothesis $Z (G) = 1$ in these results can be replaced with $G' \cap {\textbf{Z}(G)} = 1$. We also prove that if G is solvable and $G/{\textbf{Z}(G)}$ is either a Frobenius group or a $2$-Frobenius group, then the commuting graph of G is disconnected.
The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.
For a group G, we define a graph $\Delta (G)$ by letting $G^{\scriptsize\#}=G\setminus {\{\,1\,\}} $ be the set of vertices and by drawing an edge between distinct elements $x,y\in G^{\scriptsize\#}$ if and only if the subgroup $\langle x,y\rangle $ is cyclic. Recall that a Z-group is a group where every Sylow subgroup is cyclic. In this short note, we investigate $\Delta (G)$ for a Z-group G.
Let G be a finite group, and let cs(G) be the set of conjugacy class sizes of G. Recalling that an element g of G is called a vanishing element if there exists an irreducible character of G taking the value 0 on g, we consider one particular subset of cs(G), namely, the set vcs(G) whose elements are the conjugacy class sizes of the vanishing elements of G. Motivated by the results inBianchi et al. (2020, J. Group Theory, 23, 79–83), we describe the class of the finite groups G such that vcs(G) consists of a single element under the assumption that G is supersolvable or G has a normal Sylow 2-subgroup (in particular, groups of odd order are covered). As a particular case, we also get a characterization of finite groups having a single vanishing conjugacy class size which is either a prime power or square-free.
Stars form in clusters, while planets form in gaseous disks around young stars. Cluster dissolution occurs on longer time scales than disk dispersal. Planet formation thus typically takes place while the host star is still inside the cluster. We explore how the presence of other stars affects the evolution of circumstellar disks. Our numerical approach requires multi-scale and multi-physics simulations where the relevant components and their interactions are resolved. The simulations start with the collapse of a turbulent cloud, from which stars with disks form, which are able to influence each other. We focus on the effect of extinction due to residual cloud gas on the early evolution of circumstellar disks. We find that this extinction protects circumstellar disks against external photoevaporation, but these disks then become vulnerable to dynamic truncation by passing stars. We conclude that circumstellar disk evolution is heavily affected by the early evolution of the cluster.
We enumerate the number of isoclinism classes of semi-extraspecial p-groups with derived subgroup of order p2. To do this, we enumerate GL (2, p)-orbits of sets of irreducible, monic polynomials in 𝔽p[x]. Along the way, we also provide a new construction of an infinite family of semi-extraspecial groups as central quotients of Heisenberg groups over local algebras.
Let $p$ be a prime, $G$ a solvable group and $P$ a Sylow $p$-subgroup of $G$. We prove that $P$ is normal in $G$ if and only if $\unicode[STIX]{x1D711}(1)_{p}^{2}$ divides $|G:\ker (\unicode[STIX]{x1D711})|_{p}$ for all monomial monolithic irreducible $p$-Brauer characters $\unicode[STIX]{x1D711}$ of $G$.
Let $G$ be a $p$-group and let $\unicode[STIX]{x1D712}$ be an irreducible character of $G$. The codegree of $\unicode[STIX]{x1D712}$ is given by $|G:\,\text{ker}(\unicode[STIX]{x1D712})|/\unicode[STIX]{x1D712}(1)$. If $G$ is a maximal class $p$-group that is normally monomial or has at most three character degrees, then the codegrees of $G$ are consecutive powers of $p$. If $|G|=p^{n}$ and $G$ has consecutive $p$-power codegrees up to $p^{n-1}$, then the nilpotence class of $G$ is at most 2 or $G$ has maximal class.
Let $G$ be a group, $p$ be a prime and $P\in \text{Syl}_{p}(G)$. We say that a $p$-Brauer character $\unicode[STIX]{x1D711}$ is monolithic if $G/\ker \unicode[STIX]{x1D711}$ is a monolith. We prove that $P$ is normal in $G$ if and only if $p\nmid \unicode[STIX]{x1D711}(1)$ for each monolithic Brauer character $\unicode[STIX]{x1D711}\in \text{IBr}(G)$. When $G$ is $p$-solvable, we also prove that $P$ is normal in $G$ and $G/P$ is nilpotent if and only if $\unicode[STIX]{x1D711}(1)^{2}$ divides $|G:\ker \unicode[STIX]{x1D711}|$ for all monolithic irreducible $p$-Brauer characters $\unicode[STIX]{x1D711}$ of $G$.
Let $G$ be a finite group and let $p$ be a prime factor of $|G|$. Suppose that $G$ is solvable and $P$ is a Sylow $p$-subgroup of $G$. In this note, we prove that $P{\vartriangleleft}G$ and $G/P$ is nilpotent if and only if $\unicode[STIX]{x1D711}(1)^{2}$ divides $|G:\ker \unicode[STIX]{x1D711}|$ for all irreducible monomial $p$-Brauer characters $\unicode[STIX]{x1D711}$ of $G$.