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Emerging evidence suggests a potential association between “leaky gut syndrome” and low-grade systemic inflammation in individuals with psychiatric disorders, such as schizophrenia. Gut dysbiosis could increase intestinal permeability, allowing the passage of toxins and bacteria into the systemic circulation, subsequently triggering immune-reactive responses. This study delves into understanding the relationship between plasma markers of intestinal permeability and symptom severity in schizophrenia. Furthermore, the influence of lifestyle habits on these intestinal permeability markers was determined.
Methods
Biomarkers of intestinal permeability, namely lipopolysaccharide-binding protein (LBP), lipopolysaccharides (LPS), and intestinal fatty acid binding protein (I-FABP), were analyzed in 242 adult schizophrenia patients enrolled in an observational, cross-sectional, multicenter study from four centers in Spain (PI17/00246). Sociodemographic and clinical data were collected, including psychoactive drug use, lifestyle habits, the Positive and Negative Syndrome Scale to evaluate schizophrenia symptom severity, and the Screen for Cognitive Impairment in Psychiatry to assess cognitive performance.
Results
Results revealed elevated levels of LBP and LPS in a significant proportion of patients with schizophrenia (62% and 25.6%, respectively). However, no statistically significant correlation was observed between these biomarkers and the overall clinical severity of psychotic symptoms or cognitive performance, once confounding variables were controlled for. Interestingly, adherence to a Mediterranean diet was negatively correlated with I-FABP levels (beta = −0.186, t = −2.325, p = 0.021), suggesting a potential positive influence on intestinal barrier function.
Conclusions
These findings underscore the importance of addressing dietary habits and promoting a healthy lifestyle in individuals with schizophrenia, with potential implications for both physical and psychopathological aspects of the disorder.
Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied.
Methods
One-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) and 98 healthy controls (HCs) (mean age = 24.4 ± 6.2 years, 43% females) reported the presence/absence of CA <17 years using an adapted version of the Childhood Experience of Care and Abuse (CECA.Q) and the Retrospective Bullying Questionnaire (RBQ) and underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used to assess associations between brain maps of CA and FEP effects. General linear models (GLMs) were performed to assess the interaction effects of CA and FEP on CT.
Results
Eighty-three individuals with FEP and 83 HCs reported exposure to at least one CA. CT alterations in FEP were similar to those found in participants exposed to separation from parents, bullying, parental discord, household poverty, and sexual abuse (r = 0.50 to 0.25). Exposure to neglect (β = −0.24, 95% CI [−0.37 to −0.12], p = 0.016) and overall maltreatment (β = −0.13, 95% CI [−0.20 to −0.06], p = 0.043) were associated with cortical thinning in the right medial orbitofrontal region.
Conclusions
Cortical alterations in individuals with FEP are similar to those observed in the context of socio-environmental adversity. Neglect and maltreatment may contribute to CT reductions in FEP. Our findings provide new insights into the specific neurobiological effects of CA in early psychosis.
The developmental origins of health and disease hypothesis have highlighted the link between early life environment and long-term health outcomes in offspring. For example, maternal protein restriction during pregnancy and lactation can result in adverse metabolic and cognitive outcomes in offspring postnatal. Hence, in the present study, we assess whether an isocaloric low-protein diet (ILPD) affects the fatty acid profile in breast milk, the hippocampal synaptophysin (Syn) ratio, and the oxidative stress markers in the neonatal stage of male and female offspring. The aim of this work was to assess the effect of an ILPD on the fatty acid profile in breast milk, quantified the hippocampal synaptophysin (Syn) ratio and oxidative stress markers in neonatal stage of male and female offspring. Female Wistar rats were fed with either a control diet or an ILPD during gestation to day 10 of lactation. Oxidative stress markers were assessed in serum and liver. All quantifications were done at postnatal day 10. The results showed: ILPD led to decreases of 38.5% and 17.4% in breast milk volume and polyunsaturated fatty acids content. Significant decreases of hippocampal Syn ratio in male offspring (decreases of 98% in hippocampal CA1 pyramidal and CA1 oriens, 83%, stratum pyramidal in CA3, 80%, stratum lucidum in CA3, and 81% stratum oriens in CA3). Male offspring showed an increase in pro-oxidant status in serum and liver. Thus, the data suggest that male offspring are more vulnerable than females to an ILPD during gestation and lactation.
El estudio de la Misión Salesiana (siglos diecinueve y veinte) contribuye al conocimiento del impacto que las misiones religiosas tuvieron en América. Los registros históricos sugieren un cambio en la dieta, hacinamiento y alta frecuencia de enfermedades pulmonares infecciosas, como la tuberculosis. Muchos problemas de salud surgen de desequilibrios dietarios. La insuficiencia nutricional crónica hace que los individuos sean más susceptibles a las enfermedades infecciosas, y esto a su vez reduce la disponibilidad de nutrientes para la persona, creando una retroalimentación positiva. El objetivo de este trabajo es explorar el impacto que tuvo el contacto continuo en Patagonia Austral —específicamente en el caso de la Misión Salesiana— sobre la población originaria, a partir del análisis de marcadores metabólico-nutricionales e infecciosos y teniendo en cuenta el estado nutricional y estilo de vida de los individuos que allí habitaron. Para evaluar el cambio se compararon los resultados de los individuos de la misión con información previamente publicada y nuevas revelaciones de individuos del norte de la Isla Grande de Tierra del Fuego. Por un lado, se observó una elevada prevalencia de signos patológicos tales como hiperostosis porótica, cribra orbitalia, hipoplasia del esmalte y caries; por otro, fuentes documentales y estudios de isótopos estables indican un cambio en la dieta que conlleva una reducción en la variedad de alimentos. Los cambios producidos en el estilo de vida y la alta frecuencia de enfermedades infecciosas pudieron actuar sinérgicamente, influyendo en la drástica reducción del número de personas que habitaba dentro de la misión.
Despite the considerable advances in the last years, the health information systems for health surveillance still need to overcome some critical issues so that epidemic detection can be performed in real time. For instance, despite the efforts of the Brazilian Ministry of Health (MoH) to make COVID-19 data available during the pandemic, delays due to data entry and data availability posed an additional threat to disease monitoring. Here, we propose a complementary approach by using electronic medical records (EMRs) data collected in real time to generate a system to enable insights from the local health surveillance system personnel. As a proof of concept, we assessed data from São Caetano do Sul City (SCS), São Paulo, Brazil. We used the “fever” term as a sentinel event. Regular expression techniques were applied to detect febrile diseases. Other specific terms such as “malaria,” “dengue,” “Zika,” or any infectious disease were included in the dictionary and mapped to “fever.” Additionally, after “tokenizing,” we assessed the frequencies of most mentioned terms when fever was also mentioned in the patient complaint. The findings allowed us to detect the overlapping outbreaks of both COVID-19 Omicron BA.1 subvariant and Influenza A virus, which were confirmed by our team by analyzing data from private laboratories and another COVID-19 public monitoring system. Timely information generated from EMRs will be a very important tool to the decision-making process as well as research in epidemiology. Quality and security on the data produced is of paramount importance to allow the use by health surveillance systems.
To explore the relationship between age, education, sex, and ApoE4 (+) status to brain volume among a cohort with amnestic mild cognitive impairment (aMCI).
Method:
One hundred and twenty-three participants were stratified into Hispanic (n = 75) and White non-Hispanic (WNH, N = 48). Multiple linear regression analyses were conducted with age, education, sex, and ApoE4 status as predictor variables and left and right combined MRI volumes of the hippocampus, parahippocampus, and entorhinal cortex as dependent variables. Variations in head sizes were corrected by normalization with a total intracranial volume measurement.
Results:
Bonferroni-corrected results indicated that when controlling for ApoE4 status, education, and age, sex was a significant predictor of hippocampal volume among the Hispanic group (β = .000464, R2 = .196, p < .01) and the WNH group (β = .000455, R2 = .195, p < .05). Education (β = .000028, R2 = .168, p < .01) and sex (β = .000261, R2 = .168, p < .01) were significant predictors of parahippocampal volume among the Hispanic MCI group when controlling for the effects of ApoE4 status and age. One-way ANCOVAs comparing hippocampal and parahippocampal volume between males and females within groups revealed that females had significantly larger hippocampal volumes (p < .05). Hispanic females had significantly larger hippocampal (p < .001) and parahippocampal (p < .05) volume compared to males. No sex differences in parahippocampal volume were noted among WNHs.
Conclusions:
Biological sex, rather than ApoE4 status, was a greater predictor of hippocampal volume among Hispanic and WNH females. These findings add to the mixed literature on sex differences in dementia research and highlight continued emphasis on ethnic populations to elucidate on neurodegenerative disparities.
Earlier and contemporary authors had observed the systematic aspects involved in the use of money for the nation’s trade. Locke’s novelty lies in the fact that he observed those systemic connections solely from the perspective of economic phenomena; and ‘necessities’ and the necessity of money constituted the main tool through which he described the phenomena associated with the emerging monetary economy. Instead of making the classic theological reference to usury, Locke built the theoretical foundation and normativity of money on the system of trade and its necessities, and hence on the survival of the nation. In this way he was able to gloss over the earlier theological discourse.
Chapter 7 examines Benjamin Worsley’s manifesto of natural sciences that contained utopian ideas about human capacity to overcome death, if only the right scientific approach and the right moral attitude could be achieved. Revelation substituted what Boyle believed was the impossibility of grasping moral natural law rationally. Therefore, the study of moral natural laws is practically irrelevant in his work. Boyle moved constantly between a self-sufficient and mechanistic idea of the physical world and recourse to an infinitely wise God as a guide to human knowledge. He wrote several ambitious works on these issues, which are nowadays considered foundational to the Scientific Revolution but remain practically unknown beyond specialist circles nowadays. The chapter looks in particular at The Origine of Formes and Qualities and A Free Enquiry into the Vulgarly Receiv’d Notion of Nature. These works articulate Boyle’s ambition to transmute everything in nature and his momentous critique of nature, a metaphysical and sacred concept that had been part of Western culture since at least the era of the great Greek philosophers.
The natural philosopher Robert Boyle, mentor of John Locke, took the view that the aim of science was ‘the Empire over the Creatures’. The task of Chapter 6 is to show how Robert Boyle’s new political system for an economics of natural science, primarily involving the utilitarian exploitation of nature and of trade, connected with his contribution to the development of a form of natural law and natural philosophy shorn of moral natural law. That idea drew on classical theological teachings on dominion over creatures (as set out in Genesis 1:26) together with the economic goal of making natural sciences productive – also considering the significant expansion that the British Empire was undergoing at that point in time. Theological principles about an omnipotent and bountiful God were crucial to Boyle’s plans for the achievement of broader management of nature, but as a rule he avoided consideration of anthropological theology and moral natural law in his scientific writings. A close reading of Of the Usefulness of Experimentall Natural Philosophy and of the Aretology helps in articulating these ideas.
Chapter 5 considers the theology and moral philosophy of the respected theologian and moral casuist, Robert Sanderson. The divine Sanderson despaired of the unfortunate consequences for practical morality of denying the responsibility and freedom of individuals. In its historical context his doubt amounted to finally rejecting the Calvinist doctrine of predestination. Scholars consider Sanderson’s Several Cases of Conscience Discussed in Ten Lectures in the Divinity School at Oxford a main reference for Locke in the writing of the unpublished Two Tracts of Government and his foundational Essays on the Law of Nature. Sanderson’s work sets out a moral philosophy of free will reinforced by mechanical overtones of necessary causality in reasoning. The chapter briefly analyses this type of ‘mechanical conscience’ and shows how Sanderson was committed to a de facto theory of government.
The goal of the final chapter is to examine the central role of necessities in the epistemological, moral and political theory of An Essay of Human Understanding and of the Two Treatises of Government. A study of the former shows Locke’s preoccupation with classical moral questions such as happiness and the ‘good objects of desires’ and how necessities helped him to strike a balance between tradition and the new science. As a rule of thumb of proper conduct, knowledge of necessities leads to the preservation of life, a human being’s most important duty to God. His doctrine of necessities is what made it possible for Locke to develop the theory of the public good with which, it is argued, he attempted to defeat the egoist theory of self-interest. Examination of his conception of property and money through the lens of human necessities shows a certain ambiguity in Locke’s normative ideals. Nevertheless, my conclusion is that above other considerations underlying the capital-oriented ideals of the period, the last word of Locke’s political theory is the public good represented by preservation and convenience for the commonwealth and, when possible, for the whole of humanity.
The implications for morality and natural law of Hobbes’s skilful employment of Neoplatonist metaphysics such as Avicenna’s, entailing a sharp division between the human soul and the human body, are spelled out in Chapter 3. This shows that the concept of need, rather than right is central to Hobbes’s natural law and political theory. Judgements concerning needs, including the needs of others, represent a constant source of legitimacy for acting in the state of nature and in the commonwealth. A thorough analysis of the doctrine of necessity in Leviathan, Hobbes’s masterpiece, follows. The superior and absolute sovereignty that Leviathan evaluates and proposes is the true and scientific concept of sovereignty in a commonwealth, by reference to the needs of human nature and also in accordance with divine command. Hobbes exploits his doctrine of metaphysics of necessity to explain that that type of absolute sovereignty is compatible with freedom; after all, each free act of every human being is necessary in the sense of a metaphysics of necessity.
To understand our current world crises, it is essential to study the origins of the systems and institutions we now take for granted. This book takes a novel approach to charting intellectual, scientific and philosophical histories alongside the development of the international legal order by studying the philosophy and theology of the Scientific Revolution and its impact on European natural law, political liberalism and political economy. Starting from analysis of the work of Thomas Hobbes, Robert Boyle and John Locke on natural law, the author incorporates a holistic approach that encompasses global legal matters beyond the foundational matters of treaties and diplomacy. The monograph promotes a sustainable transformation of international law in the context of related philosophy, history and theology. Tackling issues such as nature, money, necessities, human nature, secularism and epistemology, which underlie natural lawyers’ thinking, Associate Professor García-Salmones explains their enduring relevance for international legal studies today.
Chapter 10 analyses Locke’s early writings on money within the wider context of his corpuscularism and explores what I have termed his ‘doctrine of necessities’. The chapter argues that his theory concerning the ‘necessaries’ and ‘necessities’, rather than ‘rights’, gives systematic coherence not only to his political and economics writings but to his entire philosophical theory. In Locke’s early writings on money, the key issue concerns economic phenomena that belong to an interdependent scientific system. The chapter discusses in detail the literature dealing with moneylending that existed before Locke and demonstrates in this manner his originality.