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This paper reports an expansion of the English as a second language (L2) component of the Multilingual Eye Movement Corpus (MECO L2), an international database of eye movements during text reading. While the previous Wave 1 of the MECO project (Kuperman et al., 2023) contained English as a L2 reading data from readers with 12 different first language (L1) backgrounds, the newly collected dataset adds eye-tracking data on English text reading from 13 distinct L1 backgrounds (N = 660) as well as participants’ scores on component skills of English proficiency and information about their demographics and language background and use. The paper reports reliability estimates, descriptive statistics, and correlational analyses as means to validate the expansion dataset. Consistent with prior literature and the MECO Wave 1, trends in the MECO Wave 2 data include a weak correlation between reading comprehension and oculomotor measures of reading fluency and a greater L1-L2 contrast in reading fluency than reading comprehension. Jointly with Wave 1, the MECO project includes English reading data from more than 1,200 readers representing a diversity of native writing systems (logographic, abjad, abugida, and alphabetic) and 19 distinct L1 backgrounds. We provide multiple pointers to new venues of how L2 reading researchers can mine this rich publicly available dataset.
Let x be a p-component random variable having a multivariate normal distribution with covariance matrix Σ. In this paper, we consider the problem of testing hypotheses of the form H0:Σ = b1Σ1 + … + bmΣm, where bi's are unknown scalars, and Σi's are a set of known and simultaneously diagonalizable matrices. This problem has both psychometric and statistical interest, and its basic theory is developed here. Besides, the problem of obtaining likelihood-ratio statistic for testing H0 is studied, and the statistic obtained in a special case.
In an earlier paper [Psychometrika, 31, 1966, p. 147], Srivastava obtained a test for the Hypothesis H0 : Σ =α0Σ0 + ... +αlΣl, where Σi are known matrices,αi are unknown constants and Σ is the unknown (p × p) covariance matrix of a random variablex (withp components) having ap-variate normal distribution. The test therein was obtained under (p × p) covariance matrix of a random variablex (with p components) the condition that Σ0, Σ1, ..., Σl form a commutative linear associative algebra and a certain vector θ, dependent on these, has non-negative elements. In this paper it is shown that this last condition is always satisfied in the special situation (of importance in structural analysis in psychometrics) where Σ0, Σ1, ..., Σl are the association matrices of a partially balanced association scheme.
Background: Perinatal arterial ischemic stroke (PAIS) is a focal brain injury in term neonates, identified postnatally but presumed to occur around birth. Early risk detection and targeted treatments are limited. We developed and validated a diagnostic risk prediction model from common clinical factors to predict a term neonate’s probability of PAIS. Methods: A diagnostic prediction model was developed using multivariable logistic regression. Common pregnancy, delivery, and neonatal clinical factors were collected across four registries. Variable selection was based on peer-reviewed literature. Participant inclusion criteria were term birth and no underlying predisposition to stroke. The primary outcome was discriminative accuracy of the model predicting PAIS, measured by the concordance (C-) statistic. Results: 2571 participants (527 cases, 2044 controls) were eligible for analysis. Nine variables were included in the model – maternal age, tobacco exposure, recreational drug exposure, pre-eclampsia, chorioamnionitis, maternal fever, emergency c-section, low 5-minute Apgar score, and sex – to predict the risk of PAIS in a term neonate. This model demonstrated good discrimination between cases and controls (C-statistic 0.73) and model fit (Hosmer-Lemeshow p=0.20). Conclusions: Clinical variables can be used to develop and internally validate a model of PAIS risk prediction. Identifying high-risk neonates for early screening and treatment could reduce lifelong morbidity.
Background: Perinatal arterial ischemic stroke (PAIS) is a leading cause of hemiparetic cerebral palsy. Multiple risk factors are associated with PAIS but studies are limited by small sample sizes and complex interactions. Unbiased machine learning applied to larger datasets may enable the development of robust predictive models. We aimed to use machine learning to identify risk factors predictive of PAIS and compare these to the existing literature. Methods: Common data elements of maternal, delivery, and neonatal factors were collected from three perinatal stroke registries and one control sample over a 7-year period. Inclusion criteria were MRI-confirmed PAIS, term birth, and idiopathic etiology. Random forest machine learning in combination with feature selection was used to develop a predictive model of PAIS. Results: Total of 2571 neonates were included (527 cases, 2044 controls). Risk factors uniquely identified through machine learning were infertility, miscarriage, primigravida, and meconium. When compared, factors identified through both literature-based selection and machine learning included maternal age, fetal tobacco exposure, intrapartum fever, and low 5-minute APGAR. Conclusions: Machine learning offers a novel, less biased method to identify PAIS predictors and complex pathophysiology. Our findings support known associations with concepts of placental disease and difficult fetal transition and may support early screening for PAIS.
Quantitative Miocene climate and vegetation data from the Siwalik succession of western Nepal indicate that the development of the Indian summer monsoon has had an impact, though in part, on vegetation changes. The climate and vegetation of the Lower (middle Miocene) and Middle (late Miocene–Pliocene) Siwalik successions of Darjeeling, eastern Himalaya, have been quantified. Reconstructed climate data, using the Coexistence Approach, suggest a decrease in winter temperatures and precipitation during the wettest months (MPwet) from the Lower to Middle Siwalik. The floristic assemblage suggests that Lower Siwalik forests were dominated by wet evergreen taxa, whereas deciduous ones became more dominant during the Middle Siwalik. The vegetation shift in the eastern Himalayan Siwalik was most likely due to a decrease in MPwet. The quantified climate–vegetation data from the eastern and western Himalayan Siwalik indicate that changes in the Indian summer monsoon had a profound impact on vegetation development during the period of deposition. We suggest that the decrease in winter temperature and summer monsoon rainfall during the Middle Siwalik might be linked with the Northern Hemisphere glaciation/cooling or a number of other things that were also going on at the time, including the continued rise of the Himalaya, and drying across the Tibetan region, which may have affected atmospheric circulation regionally.
Substantial progress has been made in the standardization of nomenclature for paediatric and congenital cardiac care. In 1936, Maude Abbott published her Atlas of Congenital Cardiac Disease, which was the first formal attempt to classify congenital heart disease. The International Paediatric and Congenital Cardiac Code (IPCCC) is now utilized worldwide and has most recently become the paediatric and congenital cardiac component of the Eleventh Revision of the International Classification of Diseases (ICD-11). The most recent publication of the IPCCC was in 2017. This manuscript provides an updated 2021 version of the IPCCC.
The International Society for Nomenclature of Paediatric and Congenital Heart Disease (ISNPCHD), in collaboration with the World Health Organization (WHO), developed the paediatric and congenital cardiac nomenclature that is now within the eleventh version of the International Classification of Diseases (ICD-11). This unification of IPCCC and ICD-11 is the IPCCC ICD-11 Nomenclature and is the first time that the clinical nomenclature for paediatric and congenital cardiac care and the administrative nomenclature for paediatric and congenital cardiac care are harmonized. The resultant congenital cardiac component of ICD-11 was increased from 29 congenital cardiac codes in ICD-9 and 73 congenital cardiac codes in ICD-10 to 318 codes submitted by ISNPCHD through 2018 for incorporation into ICD-11. After these 318 terms were incorporated into ICD-11 in 2018, the WHO ICD-11 team added an additional 49 terms, some of which are acceptable legacy terms from ICD-10, while others provide greater granularity than the ISNPCHD thought was originally acceptable. Thus, the total number of paediatric and congenital cardiac terms in ICD-11 is 367. In this manuscript, we describe and review the terminology, hierarchy, and definitions of the IPCCC ICD-11 Nomenclature. This article, therefore, presents a global system of nomenclature for paediatric and congenital cardiac care that unifies clinical and administrative nomenclature.
The members of ISNPCHD realize that the nomenclature published in this manuscript will continue to evolve. The version of the IPCCC that was published in 2017 has evolved and changed, and it is now replaced by this 2021 version. In the future, ISNPCHD will again publish updated versions of IPCCC, as IPCCC continues to evolve.
There are few longitudinal studies about South Asians (SAs) and little information about recruitment and retention approaches for this ethnic group.
Methods:
We followed 906 SAs enrolled in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort for 5 years. Surviving participants were invited for a second clinical exam from 2015 to 2018. A new wave of participants was recruited during 2017–2018. We assessed the yields from different methods of recruitment and retention.
Results:
A total of 759 (83%) completed the second clinical exam, and 258 new participants were enrolled. Providing a nearby community hospital location for the study exam, offering cab/shared ride reimbursement, and conducting home visits were the most effective methods for enhancing retention. New participant recruitment targeted women and individuals with lower socioeconomic status, and we found that participant referrals and active community engagement were most effective. Mailing invitational letters to those identified by electronic health records had very low yield.
Conclusion:
Recruitment and retention strategies that address transportation barriers and increase community engagement will help increase the representation of SAs in health research.
Using HINODE/XRT, GOES, SDO/AIA observations, we study a compact C-1.4 class flare outside a major sunspot of AR 12178 on 4 October 2014. This flare is associated with a peculiar coronal jet, which is erupted in two stages in the overlying corona above the compact flaring region. At the time of flare maximum, the first stage of the jet eruption occurs above the flare energy release site, and thereafter in the second stage its magneto-plasma system interacts with the overlying distinct magnetic field domain in its vicinity to build further the typical jet plasma column.
An internationally approved and globally used classification scheme for the diagnosis of CHD has long been sought. The International Paediatric and Congenital Cardiac Code (IPCCC), which was produced and has been maintained by the International Society for Nomenclature of Paediatric and Congenital Heart Disease (the International Nomenclature Society), is used widely, but has spawned many “short list” versions that differ in content depending on the user. Thus, efforts to have a uniform identification of patients with CHD using a single up-to-date and coordinated nomenclature system continue to be thwarted, even if a common nomenclature has been used as a basis for composing various “short lists”. In an attempt to solve this problem, the International Nomenclature Society has linked its efforts with those of the World Health Organization to obtain a globally accepted nomenclature tree for CHD within the 11th iteration of the International Classification of Diseases (ICD-11). The International Nomenclature Society has submitted a hierarchical nomenclature tree for CHD to the World Health Organization that is expected to serve increasingly as the “short list” for all communities interested in coding for congenital cardiology. This article reviews the history of the International Classification of Diseases and of the IPCCC, and outlines the process used in developing the ICD-11 congenital cardiac disease diagnostic list and the definitions for each term on the list. An overview of the content of the congenital heart anomaly section of the Foundation Component of ICD-11, published herein in its entirety, is also included. Future plans for the International Nomenclature Society include linking again with the World Health Organization to tackle procedural nomenclature as it relates to cardiac malformations. By doing so, the Society will continue its role in standardising nomenclature for CHD across the globe, thereby promoting research and better outcomes for fetuses, children, and adults with congenital heart anomalies.
A statistical approach is followed for prediction of tolerences of notched strength of composite laminates using the recently proposed improved inherent flaw model (IFM). In order to examine the validity of this approach, the existing fracture data on graphite/epoxy composite laminates containing central holes and cracks were used. The notched strength estimations are found to be within the range of tested values.
The present study investigates the joining of 5-mm-thick plates of superaustenitic stainless steel, AISI 904L by continuous current (CC) and pulsed current (PC) gas tungsten arc welding (GTAW) using ER2553 and ERNiCrMo-4 fillers. This research article attempts to provide a detailed structure–property relationship of these weldments. Interface microstructure revealed the absence of deleterious secondary phases at the heat affected zone in all the cases. Skeletal delta ferrite morphology at the cap of ER2553 fusion zone and multidirectional grain growth at the ERNiCrMo-4 fusion zone were observed for both the weldments. The average hardness at the fusion zone was found to be higher for PCGTA weldments using ER2553 due to the higher proportions of ferrite. Tensile studies corroborated that the failure occurred at the parent metal in all the cases. Charpy V-notch studies divulged that the CCGTA and PCGTA weldments utilizing ERNiCrMo-4 filler exhibited the greater impact toughness of 69 J and 75 J, respectively. The bend test results conveyed that both the CCGTA and PCGTA weldments using ERNiCrMo-4 exhibited soundness and ductility.
The objective of this study was to develop emission factors (EF) for methane (CH4) emissions from enteric fermentation in cattle native to Benin. Information on livestock characteristics and diet practices specific to the Benin cattle population were gathered from a variety of sources and used to estimate EF according to Tier 2 methodology of the 2006 Intergovernmental Panel on Climate Change (IPCC) Guidelines for National Greenhouse Gas Inventories. Most cattle from Benin are Bos taurus represented by Borgou, Somba and Lagune breeds. They are mainly multi-purpose, being used for production of meat, milk, hides and draft power and grazed in open pastures and crop lands comprising tropical forages and crops. Estimated enteric CH4 EFs varied among cattle breeds and subcategory owing to differences in proportions of gross energy intake expended to meet maintenance, production and activity. EFs ranged from 15.0 to 43.6, 16.9 to 46.3 and 24.7 to 64.9 kg CH4/head per year for subcategories of Lagune, Somba and Borgou cattle, respectively. Average EFs for cattle breeds were 24.8, 29.5 and 40.2 kg CH4/head per year for Lagune, Somba and Borgou cattle, respectively. The national EF for cattle from Benin was 39.5 kg CH4/head per year. This estimated EF was 27.4% higher than the default EF suggested by IPCC for African cattle with the exception of dairy cattle. The outcome of the study underscores the importance of obtaining country-specific EF to estimate global enteric CH4 emissions.
A total of 34 tomato genotypes (24 F1+10 parents) were tested for resistance to tomato leaf curl virus (ToLCV) disease by various whitefly inoculation techniques under field and insect-proof glasshouse (mass and cage) conditions. Of the ten tomato parental lines, two accessions [EC-520061 (Solanum habrochaites) and EC-521080 (Solanum pimpinellifolium)] were identified as highly resistant while four accessions (EC-520049, EC-528372, WIR-5032 and WIR-3957) of wild species were resistant to ToLCV. Out of the 24 F1 crosses, PBC×EC-520061, H-86×EC-520061, H-24×EC-520061 and DVRT-2×EC-520061 were found to be highly resistant against ToLCV disease. Biochemical (total phenol and total sugar concentration) and physiological (chlorophyll content and leaf area index) parameters were also used in healthy and disease-inoculated leaves of ten parents and six F1 hybrids to test the conformity of ToLCV-resistant and susceptible disease reactions. The results showed that among the 16 genotypes (10 parents+6 F1), EC-520061, EC-520049, PBC×EC-520061 and H-86×EC-520061 were stable for both biochemical and physiological markers while EC-521080 showed higher accumulations of total phenol and sugar concentrations and reduced leaf size between healthy and disease-inoculated leaves. The present study demonstrates the importance of the whitefly inoculation technique and biochemical and physiological markers in virus resistance screening programmes, and identifies a potential source of resistance to the ToLCV in Solanum species.
Constitute hypothesis for origin of supernumerary phantom limb (SPL) after stroke.
Method:
Single case description, review of literature and formulation of hypothesis.
Results:
A 59-year-old lady was evaluated for complaints of left-sided hemiparesis and extra limbs attached to her left shoulder for the past 7 months. Neuropsychological assessment revealed left hemineglect with SPL, and profile suggested bilateral frontal, right parietotemporal and basal ganglia involvement. Magnetic resonance imaging brain scan showed gliotic cavity secondary to the old haematoma in right putamen with white matter changes in the right frontoparietotemporal lobes.
Conclusions:
The conceptual framework of body schema can be used to classify many of the neurological disorders of body representation. Generation of SPL comes under the subtype of pathology of updating among the disorders of body schema. The continuous updating allows the body schema to modulate perceptual processing of objects according to their position in space. Brain areas classified as parts of motor system can, under pathological conditions (haemorrhage), influence body perception. So, when she used to move her arm, the representation of the estimated position was not updated by the motor commands. Sensory and motor information therefore becomes discrepant, and failure to integrate these two sources of information leads to loss of normal coherence, and the perceived shape of the body was altered by adding a SPL to accommodate the discrepancy.
We analyze a prominence-like cool plasma structure as observed by Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO). We perform the Differential Emission Measure (DEM) analysis using various filters of AIA, and also deduce the temperature and density structure in and around the observed flux-tube. In addition to deducing plasma parameters, we also find an evidence of multiple harmonics of fast magnetoacoustic kink waves in the observed prominence-like magnetic structure. Making use of estimated plasma parameters and observed wave parameters, under the baseline of MHD seismology, we deduce magnetic field in the flux-tube. The wave period ratio P1/P2 = 2.18 is also observed in the flux-tube, which carries the signature of magnetic field divergence where we estimate the tube expansion factor as 1.27. We discuss constraints in the estimation of plasma and magnetic field properties in such a structure in the current observational perspective, which may shed new light on the localized plasma dynamics and heating scenario in the solar atmosphere.
Botrytis grey mould (BGM), caused by the fungus Botrytis cinerea Pers. ex Fr., is an important disease of chickpea causing economic losses across the world in chickpea-growing regions. There are no available resistance sources in cultivated chickpea against this disease. Cicer echinospermum and C. reticulatum, the only two compatible annual wild species, have been reported to have resistance to BGM. Hence, interspecific populations were developed with susceptible cultivars as female parents and C. echinospermum accession IG 73 074 and C. reticulatum accession IG 72 937 as the pollen donors to transfer and assess the nature of genetic control for BGM. Screening the progeny indicated that resistance to BGM was controlled by a single additive gene/allele (bgmr1cr and bgmr1ce), which can be introgressed through a backcross breeding programme.
Innovation and technological change are integral to the energy system transformations described in the Global Energy Assessment (GEA) pathways. Energy technology innovations range from incremental improvements to radical breakthroughs and from technologies and infrastructure to social institutions and individual behaviors. This Executive Summary synthesizes the main policy-relevant findings of Chapter 24. Specific positive policy examples or key takehome messages are highlighted in italics.
The innovation process involves many stages – from research through to incubation, demonstration, (niche) market creation, and ultimately, widespread diffusion. Feedbacks between these stages influence progress and likely success, yet innovation outcomes are unavoidably uncertain. Innovations do not happen in isolation; interdependence and complexity are the rule under an increasingly globalized innovation system. Any emphasis on particular technologies or parts of the energy system, or technology policy that emphasizes only particular innovation stages or processes (e.g., an exclusive focus on energy supply from renewables, or an exclusive focus on Research and Development [R&D], or feed-in tariffs) is inadequate given the magnitude and multitude of challenges represented by the GEA objectives.
A first, even if incomplete, assessment of the entire global resource mobilization (investments) in both energy supply and demand-side technologies and across different innovation stages suggests current annual Research, Development & Demonstration (RD&D) investments of some US$50 billion, market formation investments (which rely on directed public policy support) of some US$150 billion, and an estimated US$1 trillion to US$5 trillion investments in mature energy supply and end-use technologies (technology diffusion).
Performance of the pea aphid, Acyrthosiphon pisum (Harris), on a holidic diet containing different metal ions was studied by individually incorporating into the diet a salt of the metal ion to be tested. The performance of the pea aphid was markedly improved when the diet contained iron; the first-generation adults reproduced, and the second-generation nymphs moulted twice or thrice, but did not reach the adult stage. Molybdenum, boron, and copper, at certain concentrations, induced the production of some live nymphs, but manganese, zinc, calcium, and cobalt did not. However, the presence of zinc, cobalt and calcium, at most of the concentrations used, slightly improved growth and reduced mortality. Furthermore, the presence of calcium appeared essential for development to the adult stage. Tolerance to all these metals was fairly high, but sodium molybdate at a concentration of 50.0 mg, and sodium borate at concentrations of 40–100 mg/100 ml of diet, appeared to reach toxic levels.Iron was found to be essential for reproduction and a range of 53–211 μg of elemental iron per 100 ml of diet appeared to be optimum. It is suggested that a synergistic effect between at least some of these metals is required for continuous reproduction of the pea aphid.