Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.

With the aim of producing a 3D representation of tumors, imaging and molecular annotation of xenografts and tumors (IMAXT) uses a large variety of modalities in order to acquire tumor samples and produce a map of every cell in the tumor and its host environment. With the large volume and variety of data produced in the project, we developed automatic data workflows and analysis pipelines. We introduce a research methodology where scientists connect to a cloud environment to perform analysis close to where data are located, instead of bringing data to their local computers. Here, we present the data and analysis infrastructure, discuss the unique computational challenges and describe the analysis chains developed and deployed to generate molecularly annotated tumor models. Registration is achieved by use of a novel technique involving spherical fiducial marks that are visible in all imaging modalities used within IMAXT. The automatic pipelines are highly optimized and allow to obtain processed datasets several times quicker than current solutions narrowing the gap between data acquisition and scientific exploitation.

Rock debris covers ~30% of glacier ablation areas in the Central Himalaya and modifies the impact of atmospheric conditions on mass balance. The thermal properties of supraglacial debris are diurnally variable but remain poorly constrained for monsoon-influenced glaciers over the timescale of the ablation season. We measured vertical debris profile temperatures at 12 sites on four glaciers in the Everest region with debris thickness ranging from 0.08 to 2.8 m. Typically, the length of the ice ablation season beneath supraglacial debris was 160 days (15 May to 22 October)—a month longer than the monsoon season. Debris temperature gradients were approximately linear (r2 > 0.83), measured as −40°C m–1 where debris was up to 0.1 m thick, −20°C m–1 for debris 0.1–0.5 m thick, and −4°C m–1 for debris greater than 0.5 m thick. Our results demonstrate that the influence of supraglacial debris on the temperature of the underlying ice surface, and therefore melt, is stable at a seasonal timescale and can be estimated from near-surface temperature. These results have the potential to greatly improve the representation of ablation in calculations of debris-covered glacier mass balance and projections of their response to climate change.

Let E and D be open subsets of $\mathbb {R}^{n+1}$ such that $\overline {D}$ is a compact subset of E, and let v be a supertemperature on E. A temperature u on D is called extendable by v if there is a supertemperature w on E such that $w=u$ on D and $w=v$ on $E\backslash \overline D$. From earlier work of N. A. Watson, [‘Extendable temperatures’, Bull. Aust. Math. Soc. 100 (2019), 297–303], either there is a unique temperature extendable by v, or there are infinitely many; a necessary condition for uniqueness is that the generalised solution of the Dirichlet problem on D corresponding to the restriction of v to $\partial _eD$ is equal to the greatest thermic minorant of v on D. In this paper we first give a condition for nonuniqueness and an example to show that this necessary condition is not sufficient. We then give a uniqueness theorem involving the thermal and cothermal fine topologies and deduce a corollary involving only parabolic and coparabolic tusks.

Let $E$ and $D$ be open subsets of $\mathbb{R}^{n+1}$ such that $\overline{D}$ is a compact subset of $E$, and let $v$ be a supertemperature on $E$. We call a temperature $u$ on $D$extendable by$v$ if there is a supertemperature $w$ on $E$ such that $w=u$ on $D$ and $w=v$ on $E\backslash \overline{D}$. Such a temperature need not be a thermic minorant of $v$ on $D$. We show that either there is a unique temperature extendable by $v$, or there are infinitely many. Examples of temperatures extendable by $v$ include the greatest thermic minorant $GM_{v}^{D}$ of $v$ on $D$, and the Perron–Wiener–Brelot solution of the Dirichlet problem $S\!_{v}^{D}$ on $D$ with boundary values the restriction of $v$ to $\unicode[STIX]{x2202}D$. In the case where these two examples are distinct, we give a formula for producing infinitely many more. Clearly $GM_{v}^{D}$ is the greatest extendable thermic minorant, but we also prove that there is a least one, which is not necessarily equal to $S\!_{v}^{D}$.

Zirconolite glass-ceramics are being developed as potential wasteforms for the disposition of Pu wastes in the UK. Previous studies utilised a variety of surrogates whilst this work uses both cold-press and sinter and hot isostatic press methods to validate the wasteform with PuO2. A cold press and sinter sample was fabricated as part of a validation study for plutonium incorporation in hot isostatically pressed (HIPed) wasteforms. The results confirmed the cold-press and sinter, achieved successful waste incorporation and a microstructure and phase assemblage that was in agreement with those expected of a HIPed equivalent. A HIP sample was fabricated of the same composition and characterised by SEM and XRD. Results were in agreement with the sintered sample and achieved complete waste incorporation into the glass-ceramic wasteform. These samples have demonstrated successful incorporation of PuO2 into glass-ceramic HIPed wasteforms proposed for processing Pu-based waste-streams in the UK.

Let $u$ be a supertemperature on an open set $E$, and let $v$ be a related temperature on an open subset $D$ of $E$. For example, $v$ could be the greatest thermic minorant of $u$ on $D$, if it exists. Putting $w=u$ on $E\setminus D$ and $w=v$ on $D$, we investigate whether $w$, or its lower semicontinuous smoothing, is a supertemperature on $E$. We also give a representation of the greatest thermic minorant on $E$, if it exists, in terms of PWB solutions on an expanding sequence of open subsets of $E$ with union $E$.  In addition, in the case of a nonnegative supertemperature, we prove inequalities that relate reductions to Dirichlet solutions. We also prove that the value of any reduction at a given time depends only on earlier times.

We show that the null limit hypothesis, in the definition of a barrier, can be relaxed for normal boundary points that satisfy a mild additional condition. We also give a simple necessary and sufficient condition for the regularity of semi-singular boundary points.

We give a systematic treatment of caloric measure for arbitrary open sets. The caloric measure is defined only on the essential boundary of the set. Our main result gives criteria for the resolutivity of essential boundary functions, and their integral representation in terms of caloric measure. We also characterize the caloric measure null sets in terms of the boundary singularities of nonnegative supertemperatures.

We assessed the impact of free on-site influenza vaccination on childcare staff vaccination prevalence using 2 before-and-after studies. Vaccination was offered during the 2003-2004 and 2006-2007 influenza seasons. Staff vaccination prevalence was higher in each intervention season compared to the prior, nonintervention season. No baseline characteristics were associated with receipt of vaccination.

We study singularities of solutions of the heat equation, that are not necessarily isolated but occur only in a single characteristic hyperplane. We prove a decomposition theorem for certain solutions on D+ = D ∩ (Rn × ]0. ∞[), for a suitable open set D, with singularities at compact subset K of Rn × {0}, in terms of Gauss-Weierstrass integrals. We use this to prove a representation theorem for certain solutions on D+, with singularities at K, as the sums of potentials and Dirichlet solutions. We also give conditions under which K is removable for solutions on D∖K.