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A vermiculite (Libby, Montana) sample obtained from the Zonolite company contained mostly coarse-grained separates with only 8–7 per cent clay. The 2–50 μm fraction was used for particle-size reduction studies by wet and dry grinding, and size-fractionated into < 2, 2–5, 5–20 and 20–50 μ sizes. About 18 per cent of the sample was attrited to clay after 64 hr of wet grinding, but as much as 59 per cent of the sample was attrited to clay after only 10 min of dry grinding. There was no evidence of damage to the crystal structure of derived clays or silts except for the 20–50 μm fraction from dry grinding.
The observed CEC values of all the fractions decreased as grinding progressed, except for the 2–5 μm fraction from wet grinding where the CEC increased. The decrease in CEC was attributed to an accumulation of biotite, either as a discrete mineral and/or a mixed-layer assemblage of biotite and vermiculite attrited to the clay fraction. In contrast, the fraction showing an increase in CEC was due to an increased concentration of higher charge-density (CEC) vermiculite. Biotite-free CEC data for vermiculite suggested that, in general, the coarser vermiculite separates had a higher CEC than the finer ones.
The susceptibility of minerals in the Libby vermiculite to cleavage by grinding was: vermiculite > hydrobiotite > biotite.
The scanning electron microscope (SEM) is useful in the identification of biogenic opal. Opaline spheres, cups, and scrolled or convoluted sheets were identified in both soil and vegetative isolates. X-ray diffraction analysis indicates that both alpha quartz and cristobalite were co-associated with the amorphous opaline phase synthesized during life metabolism of deciduous tree leaves. Such crystalline phases were most abundant in the 2–5 μm fraction and many consist of anitsotropic rods with parallel extinction or equidimensional bodies with aggregate extinction. Between 2/3 and 3/4 of the total opal isolate from deciduous tree leaves was solubilized when digested for 2–5-min in boiling 0.5 N NaOH. Rate of dissolution was a function of particle-size and tree species. Biogenic opal of forest origin was about 10–15 times more soluble than grass opal, which probably reflects the higher specific surface of the former.
A mineralogical investigation by X-ray powder diffraction and optical, scanning, and transmission electron microscopy of partially weathered petrified wood in the Yegua Formation (Eocene) of east-central Texas revealed that microcrystalline quartz present in the unaltered petrified wood has been gradually dissolved and replaced by disordered silica polymorphs (mainly opal-CT) as a result of weathering. This replacement suggests that the reaction sequence: opal-A → opal-CT → quartz, which has been described elsewhere to occur during diagenetic alteration of petrified wood, is apparently reversed when the petrified wood is exposed to low-energy weathering conditions. The relatively high rate of dissolution of the quartz in the petrified wood appears to be related to its small crystallite size. The silica released by the dissolution of the quartz is subsequently reprecipitated as disordered cristobalite-tridymite (opal-CT) and poorly crystalline silica (opal-A) that, in turn, probably converts to opal-CT on aging. Opal-CT is the major silica phase in the completely altered powdery material enclosing the partially weathered petrified wood. The intermediate zone between the altered and unaltered zones contains both quartz and opal-CT.
Radiotherapy for pediatric brain tumor has been associated with late cognitive effects. Compared to conventional photon radiotherapy (XRT), proton radiotherapy (PRT) delivers less radiation to healthy brain tissue. PRT has been associated with improved long term cognitive outcomes compared to XRT. However, there is limited research comparing the effects of XRT and PRT on verbal memory outcomes.
Participants and Methods:
Survivors of pediatric brain tumor treated with either XRT (n = 29) or PRT (n = 51) completed neuropsychological testing > 1 year following radiotherapy. XRT and PRT groups were similar with respect to sex, handedness, race, age at diagnosis, age at evaluation, tumor characteristics, and treatment history (i.e., craniospinal irradiation, craniotomy, shunting, chemotherapy, radiation dose). Verbal learning and memory were assessed using the age-appropriate version of the California Verbal Learning Test (CVLT-II/CVLT-C). Measures of intellectual functioning, executive functioning, attention and adaptive behavior were also collected. Performance on neuropsychological measures was compared between treatment groups (XRT vs. PRT) using analysis of covariance (ANCOVA). On the CVLT, each participant was classified as having an encoding deficit profile (i.e., impaired learning, recall, and recognition), retrieval deficit profile (i.e., impaired recall but intact recognition), intact profile, or other profile. Chi-squared tests of independence were used to compare the probability of each memory profile between treatment groups. Pearson correlation was used to examine associations between memory performance and strategy use, intellectual functioning, adaptive behavior, attention, and executive functioning.
Results:
Overall, patients receiving PRT demonstrated superior verbal learning (CVLT Trials 1-5; t(76) = 2.61, p = .011), recall (CVLT Long Delay Free; t(76) = 3.57, p = .001) and strategy use (CVLT Semantic Clustering; t(76) = 2.29, p = .025) compared to those treated with XRT. Intact performance was more likely in the PRT group than the XRT group (71% PRT, 38% XRT; X2 = 8.14, p = .004). Encoding and retrieval deficits were both more common in the XRT group, with encoding problems being most prevalent (Encoding Deficits: 31% XRT, 12% PRT, X2 = 4.51, p = .034; Retrieval Deficits: 17% XRT, 4% PRT, X2 = 4.11, p = .043). Across all participants, semantic clustering predicted better encoding (r = .28, p = .011) and retrieval (r = .26, p = .022). Better encoding predicted higher intellectual (r = .56, p < .001) and adaptive functioning (r = .30, p = .011), and fewer parent-reported concerns about day-today attention (r = -.36, p = .002), and cognitive regulation (r = -.35, p = .002).
Conclusions:
Results suggest that PRT is associated with superior verbal memory outcomes compared to XRT, which may be driven by encoding skills and use of learning strategies. Moreover, encoding ability predicted general intellectual ability and day-to-day functioning. Future work may help to clarify underlying neural mechanisms associated with verbal memory decline following radiotherapy, which will better inform treatment approaches for survivors of pediatric brain tumor.
Radiotherapy for pediatric brain tumor is associated with reduced white matter structural integrity and neurocognitive decline. Superior cognitive outcomes have been reported following proton radiotherapy (PRT) compared to conventional photon radiotherapy (XRT), presumably due to sparing of healthy brain tissue. This study examined long-term white matter change and neuropsychological performance in pediatric brain tumor survivors treated with XRT vs. PRT.
Participants and Methods:
Pediatric brain tumor survivors treated with either XRT (n = 10) or PRT (n = 12) underwent neuropsychological testing and diffusion weighted imaging > 7 years following radiotherapy. A healthy control group (n = 23) was also recruited. Groups had similar demographic characteristics, except for handedness (p = .01), mean years of age at testing (XRT = 21.7, PRT = 16.9, Control = 15.5; p = .01), and mean years since radiation (XRT =14.7, PRT = 8.9, p < .001). Age and handedness were selected as covariates; analyses were not adjusted for time since radiation due to redundancy with treatment group (i.e., standard of care transitioned from XRT to PRT in 2007). Participants completed age-appropriate versions of the Weschler Intelligence Scales (WAISIV/WISC-IV/WISC-V) and the Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI and Motor Coordination subtests). Tractography was conducted using automated fiber quantification (AFQ), and fractional anisotropy (FA) was extracted from 12 tracts of interest. Linear mixed models were used to summarize group differences in FA, with tracts nested within subjects. Neuropsychological performance and tract-level FA were compared between groups using analysis of covariance (ANCOVA). Pearson correlation was used to examine associations between cognitive functioning and tract-level FA.
Results:
Across all tracts, FA was significantly lower in the XRT group than the PRT group (t(514) = -2.58, p = .01), but did not differ between PRT and Control groups (t(514) = .65, p = .51). For individual tracts, FA differed significantly between treatment groups (XRT < PRT) in the left inferior fronto-occipital fasciculus (IFOF), right IFOF, left inferior longitudinal fasciculus (ILF) and right uncinate (all t < -2.05, all p < .05). No significant differences in FA were found between PRT and Control participants for any tract. All neuropsychological scores were significantly lower for XRT than PRT patients (all p < .03), while PRT and Control groups performed similarly on these measures (all p >.19). Cognitive functioning was most consistently associated with FA of the corpus callosum major forceps (4/7 domains; all r > .33, all p < .04) and the left ILF (4/7 domains; all r > .37, all p <.02).
Conclusions:
Both white matter integrity and neuropsychological performance were generally reduced in patients with a history of XRT, but not in those who received PRT. The PRT group was similar to healthy control participants with respect to both FA and cognitive scores, suggesting improved long-term outcomes compared to patients receiving XRT. This exploratory study is the first to provide direct support for white matter integrity as a mechanism of cognitive sparing in PRT. Future work with larger samples is necessary to replicate these findings.
Gender- and sexuality-minoritised (GSM) adolescents are at increased risk of self-harm and suicidal behaviours compared with their cisgender and heterosexual peers. This increased risk is thought to be explained in part by exposure to stigma and societal oppression. Dialectical behaviour therapy (DBT) is an evidence-based intervention for self-harm and suicidal behaviour that may have advantages for supporting GSM young people in distress. No study has yet sought to understand what GSM-associated difficulties may be important to consider in DBT for adolescents, or the experiences of GSM young people in a standard DBT programme. Therefore, this study aimed to understand the experiences of GSM young people in DBT and what difficulties and dilemmas associated with their gender and sexuality diversity were thought by them to be important to target in DBT. Qualitative interviews were conducted with 14 GSM young people in a comprehensive DBT programme and were analysed using reflexive thematic analysis. The analysis was supported by two further GSM young people who had finished DBT. The findings were split into three over-arching themes (Identity, Impact of Others, and Space for Sexual and Gender Identity in DBT), each with themes within. The identity-based theme included ‘identity confusion and acceptance’; the relationship-based themes included ‘cis-Heterosexism’ and ‘community connectedness’; and the space within DBT themes included ‘negotiating focus and targeting in DBT’ and ‘creating safety in DBT’. Findings are discussed in relation to implications and recommendations for therapists working with GSM young people within and outside of DBT.
Key learning aims
(1) To learn about what gender- and sexuality-minoritised (GSM) young people consider to be important GSM-associated contributors to distress and thus potential treatment targets in DBT.
(2) To learn about what GSM young people felt were barriers to negotiating GSM-associated difficulties as a focus in DBT and how safety was created in the therapeutic relationship.
(3) To consider potential implications and recommendations for improvements to practice when supporting GSM young people in therapy.
An international consortium of radiocarbon (14C) laboratories was established to date the origin of the St. George’s Rotunda in Nitrianska Blatnica (Slovakia), because its age was not well established in previous investigations. Altogether, 20 samples of wood, charcoal, mortar and plaster were analyzed. The 14C results obtained from the different laboratories as well as between the different sample types were in good agreement, resulting in a 14C calibrated age of 783–880 AD (94.2% probability) for the Rotunda. Although the 14C results have very good precision, the specific plateau-shape of the calibration curve in this period caused the wide range of the calibrated age. The probability distribution from OxCal calibration shows, however, that about 86% of the probability distribution lies in the period before 863 AD, implying that the Rotunda could have been constructed before the arrival of Constantine (St. Cyril) and St. Methodius to Great Moravia. The Rotunda thus probably represents the oldest standing purpose-built Christian church in the eastern part of Central Europe.
Objectives: The Tower of London (TOL) test has probably become the most often used task to assess planning ability in clinical and experimental settings. Since its implementation, efforts were made to provide a task version with adequate psychometric properties, but extensive normative data are not publicly available until now. The computerized TOL-Freiburg Version (TOL-F) was developed based on theory-grounded task analyses, and its psychometric adequacy has been repeatedly demonstrated in several studies but often with small and selective samples. Method: In the present study, we now report reliability estimates and normative data for the TOL-F stratified for age, sex, and education from a large population-representative sample collected in the Gutenberg Health Study in Mainz, Germany (n=7703; 40–80 years). Results: The present data confirm previously reported adequate indices of reliability (>.70) of the TOL-F. We also provide normative data for the TOL-F stratified for age (5-year intervals), sex, and education (low vs. high education). Conclusions: Together, its adequate reliability and the representative age-, sex-, and education-fair normative data render the computerized TOL-F a suitable diagnostic instrument to assess planning ability. (JINS, 2019, 25, 520–529)
Non-communicable diseases are projected to become the most common causes of death in Africa by 2030. The impact on health of epidemiological and nutritional transitions in sub-Saharan Africa remains unclear. To assess the trends of dietary fatty acids over time in Uganda, we examined fatty acids in serum collected from individuals in rural south-west Uganda, at three time points over two decades. Independent cross-sectional samples of 915 adults and children were selected from the general population cohort in 1990 (n 281), 2000 (n 283) and 2008 (n 351). Serum phospholipid fatty acids were measured by GC. Multivariate regression analyses were performed to compare the geometric means of fatty acids by time period. Serum fatty acid profiling showed high proportions of SFA, cis-MUFA and industrial trans-fatty acids (iTFA), likely to be biomarkers of high consumption of palm oil and hydrogenated fats. In contrast, proportions of n-6 and n-3 PUFA from vegetable oils and fish were low. From 1990 to 2008, serum phospholipids showed increases in absolute amounts of SFA (17·3 % increase in adults and 26·4 % in children), MUFA (16·7 % increase in adults and 16·8 % in children) and n-6:n-3 PUFA (40·1 % increase in adults and 39·8 % in children). The amount of elaidic acid, iTFA from hydrogenated fats, increased in children (60·1 % increase). In this rural Ugandan population, we show evidence of unfavourable trends over time of dietary fatty acids.
The procedure for deriving interatomic potentials for molecular ionic materials, using empirical fitting procedures, is described. Potentials are obtained for carbonates, phosphates and perchlorates, and used to calculate crystal and lattice properties which are compared with available experimental data.
Major depression and anxiety disorders are known to negatively influence cognitive performance. Moreover, there is evidence for greater cognitive decline in older adults with generalized anxiety disorder. Except for clinical studies, complex executive planning functions and subclinical levels of anxiety have not been examined in a population-based sample with a broad age range.
Methods
Planning performance was assessed using the Tower of London task in a population-based sample of 4240 participants aged 40–80 years from the Gutenberg Health Study (GHS) and related to self-reported anxiety and depression by means of multiple linear regression analysis.
Results
Higher anxiety ratings were associated with lower planning performance (β = −0.20; p < 0.0001) independent of age (β = 0.03; p = 0.47). When directly comparing the predictive value of depression and anxiety on cognition, only anxiety attained significance (β = −0.19; p = 0.0047), whereas depression did not (β = −0.01; p = 0.71).
Conclusions
Subclinical levels of anxiety but not of depression showed negative associations with cognitive functioning independent of age. Our results demonstrate that associations observed in clinical groups might differ from those in population-based samples, also with regard to the trajectory across the life span. Further studies are needed to uncover causal interrelations of anxiety and cognition, which have been proposed in the literature, in order to develop interventions aimed at reducing this negative affective state and to improve executive functioning.
The outburst and storm of more than four hours’ duration that accompanied the importance 2 flare beginning at 0h25m U.T. on 9 June 1968 were observed at 80 MHz with the Culgoora radioheliograph. More than 104 heliograms in both senses of circular polarization were recorded at one-second intervals both as cathode-ray-tube photographs and as digital characters on magnetic tape. It is the purpose of this preliminary account to summarize these observations and bring attention to a new phenomenon observed before the start of the flare.
The first meaningful observation with the 80 MHz Cul-goora radioheliograph was made on 2 September 1967, a few weeks before the instrument was officially commissioned. Systematic observations, normally for 4 to 6 hours per day, began late in February 1968 and the Sun has since been observed on 438 days. The remaining days and many nights have been used for investigations of radio sources and the interplanetary medium and for maintenance and instrumental extension. The standard of reliability thus achieved has been due to the sustained efforts of K. V. Sheridan, W. J. Payten, K. R. McAlister, M. Beard and their colleagues. These first two years have been a period mainly of exploration—a phase of great interest to those engaged in observing, though possibly bewildering to those not. The present review is a first attempt to collate and summarize what has so far been found and where possible to draw preliminary conclusions. The observations to be described and their discussion have been due to a joint effort on the part of a number of workers, particularly G. A. Dulk (on leave from the University of Colorado), K. Kai (on leave from the University of Tokyo), N. R. Labrum, D. J. McLean, A. C. Riddle, K. V. Sheridan, S. F. Smerd, R. T. Stewart, and the present writer. The period has also seen considerable development in the evolution of intricate computer programmes for analysing the data, particularly on the part of L. H. Heisler and D. J. McLean.
The exact formula for the intensity of synchrotron radiation emitted by a single charged particle in vacuo was given by Schott, for the case of circular orbits, and Takakura for the case of helical orbits. In the general case the radiated power is expressed in terms of four variables which appear in (among other places) the arguments or orders of a Bessel function and its first derivative; hence the general formula gives little insight into the interpretation of synchrotron radiation and allows evaluation only in particular cases. There is a particular need for approximate formulae that yield the spectrum of the radiation in explicit form. Such approximate formulae were found by Vladimirskii and Schwinger for the case of highly relativistic electrons. In the present paper we outline the derivation of approximate formulae applicable to mildly relativistic electrons, especially those with velocity βc such that 0 ≪ β ≲ O.9. These approximations are also relevant to the case of highly relativistic electrons in a plasma with refractive index appreciably less than unity.
My lecture this evening is dedicated to my late friend and fellow astronomer, Harley Wood, who died on 26 June 1984 at the age of 72. It is a fine thing that the ASA has decided to give the name of Harley Wood to an annual public lecture at the time of the society’s Annual General Meeting. For besides making a monumental contribution to the astrometry of the southern skies, Harley became a leader, a kind of organizer and father figure, among Australian astronomers. He played a leading part in the formation of this society and was its foundation President. He will also be specially remembered by a small group of us, about half a dozen, who met regularly in the charming old building of Sydney Observatory to plan the 1973 IAU General Assembly held in Sydney, the first time ever in Australia. Harley chaired not only the local organizing committee, but the ladies’ committee too. My wife still recalls the gentle, but firm way in which Harley once admonished her for addressing a remark across the table without going through the Chair. Harley was totally approachable and totally positive at all times: you could always count on his support for any sensible initiative. He had many friends and no enemies that I have heard of. And unlike so many of his profession, there was no hint of the egotist or the prima donna. I count it a privilege to have been his contemporary and colleague.
Until comparatively recently solar activity was discussed in terms of independent centres around the Sun’s surface. These centres, which form a constantly but slowly changing pattern, were thought to be linked only beneath the photosphere by tangled magnetic fields, themselves dominated by the mechanical energy of mass motions at photospheric and lower levels. Recent discoveries now indicate that active centres interact with one another above photospheric level and especially through linkages within the corona. The linkages appear to be of at least two distinctive kinds: magneto-hydrodynamic shock waves capable of travelling vast distances through the corona at ∼103 km/s and triggering eruptions at distant centres; and magnetic field lines which loop high and wide in the corona and convey energy in the form of fast particles. These two kinds of interaction will be considered in turn.
Fluidic flight controls enable forces and moments for flight vehicle trim and manoeuvre to be produced without use of conventional moving surface controls. This paper introduces a methodology for the design of Circulation Control (CC) and Fluidic Thrust Vectoring (FTV) as fluidic controls for roll and pitch. Work was undertaken as part of the multidisciplinary FLAVIIR project, with the goal of providing full authority fluidic flight controls sufficient for a fully flapless flight of an 80kg class demonstrator aircraft known as DEMON. The design methodology considers drag, mass, volume and pneumatic power requirements as part of the overall design cost function. It is shown that the fundamental flow physics of both CC and FTV are similar, and hence there are strong similarities to the design approach of each. Flight ready CC and FTV hardware has been designed, manufactured and ground tested. The CC system was successfully wind tunnel demonstrated on an 85% scale half model of the DEMON. The design condition of a control ΔCL of 0·1 was achieved with a blowing coefficient of 0·01, giving a useable control gain of 10. The FTV system was static tested using a micro gas turbine source. The control characteristic was ‘N’ shaped, consisting of an initial high gain response in a negative sense (gain = −30) followed by a low gain response in a positive sense (gain = +3) at higher blowing rate. CC and FTV control hardware directly contributes to around 6% to the overall mass of the flight vehicle, however provision of pneumatic power carries a significant mass penalty unless generated as part of an integrated engine bleed system.
Many studies have used retrospective reports to assess the long-term consequences of early life stress. However, current individual characteristics and experiences may bias the recall of these reports. In particular, depressed mood may increase the likelihood of recall of negative experiences. The aim of the study was to assess whether specific factors are associated with consistency in the reporting of childhood adverse experiences.
Method
The sample comprised 7466 adults from Canada's National Population Health Survey who had reported on seven childhood adverse experiences in 1994/1995 and 2006/2007. Logistic regression was used to explore differences between those who consistently reported adverse experiences and those whose reports were inconsistent.
Results
Among those retrospectively reporting on childhood traumatic experiences in 1994/1995 and 2006/2007, 39% were inconsistent in their reports of these experiences. The development of depression, increasing levels of psychological distress, as well as increasing work and chronic stress were associated with an increasing likelihood of reporting a childhood adverse experience in 2006/2007 that had not been previously reported. Increases in mastery were associated with reduced likelihood of new reporting of a childhood adverse experience in 2006/2007. The development of depression and increases in chronic stress and psychological distress were also associated with reduced likelihood of ‘forgetting’ a previously reported event.
Conclusions
Concurrent mental health factors may influence the reporting of traumatic childhood experiences. Studies that use retrospective reporting to estimate associations between childhood adversity and adult outcomes associated with mental health may be biased.
This paper provides an overview of interpolation of Banach and Hilbert spaces, with a focus on establishing when equivalence of norms is in fact equality of norms in the key results of the theory. (In brief, our conclusion for the Hilbert space case is that, with the right normalizations, all the key results hold with equality of norms.) In the final section we apply the Hilbert space results to the Sobolev spaces $H^{s}({\rm\Omega})$ and $\widetilde{H}^{s}({\rm\Omega})$, for $s\in \mathbb{R}$ and an open ${\rm\Omega}\subset \mathbb{R}^{n}$. We exhibit examples in one and two dimensions of sets ${\rm\Omega}$ for which these scales of Sobolev spaces are not interpolation scales. In the cases where they are interpolation scales (in particular, if ${\rm\Omega}$ is Lipschitz) we exhibit examples that show that, in general, the interpolation norm does not coincide with the intrinsic Sobolev norm and, in fact, the ratio of these two norms can be arbitrarily large.