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Antenatal corticosteroids are given to pregnant people at risk of preterm birth to reduce newborn morbidity, including respiratory distress syndrome. However, there has been concern surrounding potential adverse effects on subsequent generations. Animal studies have demonstrated endocrine and metabolic changes in those exposed to corticosteroids in utero (F1) and in the second generation (F2). We aimed to assess the effects of parental antenatal corticosteroid exposure on health of the second generation (F2) of Auckland Steroid Trial (AST) participants. In the AST, women (F0) expected to birth between 24 and 36 weeks’ gestation were randomised to betamethasone or placebo. When their children (F1) were 50 years old, they and their children (F2) were followed up with a self-report questionnaire and data linkage. The primary outcome for this analysis was body mass index (BMI) z-score in the F2 generation. Secondary outcomes included respiratory, cardiovascular, neurodevelopmental, mental and general health, and social outcomes. Of the 213 F2 participants, 144 had BMI data available. There was no difference in BMI z-score between participants whose parent was exposed to betamethasone versus placebo (mean (SD) 0.63 (1.45), N = 77 vs 0.41 (1.28), N = 67, adjusted mean difference (95% confidence interval) = 0.16 (-0.37, 0.69)). There was no evidence of a difference in rates of overweight, diabetes, respiratory disease, cardiometabolic risk factors, neurodevelopmental difficulties, mental health difficulties and social outcomes between parental betamethasone versus placebo exposure groups, but confidence intervals were wide. These findings are reassuring regarding the intergenerational safety of antenatal corticosteroids.
Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
Pulmonary artery capacitance is a relatively novel measurement associated with adverse outcomes in pulmonary arterial hypertension. We sought to determine if preoperative indexed pulmonary artery capacitance was related to outcomes in paediatric heart transplant recipients, describe the changes in indexed pulmonary artery capacitance after transplantation, and compare its discriminatory ability to predict outcomes as compared to conventional predictors.
Methods:
This was a retrospective study of paediatric patients who underwent heart transplant at our centre from July 2014 to May 2022. Variables from preoperative and postoperative clinical, catheterisation, and echo evaluations were recorded. The primary composite outcome measure included postoperative mortality, postoperative length of stay in the top quartile, and/or evidence of end organ dysfunction.
Results:
Of the 23 patients included in the analysis, 11 met the composite outcome. There was no statistical difference between indexed pulmonary artery capacitance values in patients who met the composite outcome [1.8 ml/mmHg/m2 (interquartile 0.8, 2.4)] and those who did not [1.4 (interquartile 0.9, 1.7)], p = 0.17. There were no significant signs of post-operative right heart failure in either group. There was no significant difference between pre-transplant and post-transplant indexed pulmonary artery capacitance or indexed pulmonary vascular resistance.
Conclusions:
Preoperative pulmonary artery capacitance was not associated with our composite outcome in paediatric heart transplant recipients. It did not appear to be additive to pulmonary vascular resistance in paediatric heart transplant patients. Pulmonary vascular disease did not appear to drive outcomes in this group.
Social medicine has two components: social determinants of health (SDOH) and issues that can serve as a direct cause of illness, injury, and death. Substance abuse and addiction, and interpersonal violence, are two examples. Many patients who present to the emergency department (ED) with social medicine issues often have a concurrent observable diagnosis for which they can be placed in an ED observation unit (OU), often with their social medicine protocol being secondary to their primary reason for observation. Often patients who present to EDs with complaints related to social medicine issues do not require admission, but discharging them may present a risk in terms of recidivism and repeat visits. ED OUs can provide value by allowing for the engagement of appropriate resources for patients with social medicine-related issues in a slower-paced setting that allows for a more detailed assessment as well as a warm handoff to specialty navigators.
Observation units (OUs) are an ideal location for the care coordination and proper disposition of elderly patients. The availability and intensity of resources coupled with a focus on expedited disposition allows an emergency department (ED) OU to serve as the optimal location for the geriatric patient who may require placement or other geriatric-specific interventions. As many elderly patients who require placement in sub-acute or long-term care settings fail to meet established admission criteria due to chronicity of symptoms, it becomes clear that the utility of an ED OU is vital to assist with the geriatric population. By consolidating and focusing the necessary resources in one centralized location, and by placing an emphasis on value to hospital systems and patients rather than arbitrary time-points, ED OUs stand to optimize inpatient bed utilization while at the same time allow for time sensitive dispositions for these vulnerable patients.
Neuropsychiatry training in the UK currently lacks a formal scheme or qualification, and its demand and availability have not been systematically explored. We conducted the largest UK-wide survey of psychiatry trainees to examine their experiences in neuropsychiatry training.
Results
In total, 185 trainees from all UK training regions completed the survey. Although 43.6% expressed interest in a neuropsychiatry career, only 10% felt they would gain sufficient experience by the end of training. Insufficient access to clinical rotations was the most common barrier, with significantly better access in London compared with other regions. Most respondents were in favour of additional neurology training (83%) and a formal accreditation in neuropsychiatry (90%).
Clinical implications
Strong trainee interest in neuropsychiatry contrasts with the limited training opportunities currently available nationally. Our survey highlights the need for increased neuropsychiatry training opportunities, development of a formalised training programme and a clinical accreditation pathway for neuropsychiatry in the UK.
Posttraumatic stress disorder (PTSD) has been associated with advanced epigenetic age cross-sectionally, but the association between these variables over time is unclear. This study conducted meta-analyses to test whether new-onset PTSD diagnosis and changes in PTSD symptom severity over time were associated with changes in two metrics of epigenetic aging over two time points.
Methods
We conducted meta-analyses of the association between change in PTSD diagnosis and symptom severity and change in epigenetic age acceleration/deceleration (age-adjusted DNA methylation age residuals as per the Horvath and GrimAge metrics) using data from 7 military and civilian cohorts participating in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (total N = 1,367).
Results
Meta-analysis revealed that the interaction between Time 1 (T1) Horvath age residuals and new-onset PTSD over time was significantly associated with Horvath age residuals at T2 (meta β = 0.16, meta p = 0.02, p-adj = 0.03). The interaction between T1 Horvath age residuals and changes in PTSD symptom severity over time was significantly related to Horvath age residuals at T2 (meta β = 0.24, meta p = 0.05). No associations were observed for GrimAge residuals.
Conclusions
Results indicated that individuals who developed new-onset PTSD or showed increased PTSD symptom severity over time evidenced greater epigenetic age acceleration at follow-up than would be expected based on baseline age acceleration. This suggests that PTSD may accelerate biological aging over time and highlights the need for intervention studies to determine if PTSD treatment has a beneficial effect on the aging methylome.
Chapter 5 introduces a series of more concentrated studies on specific seasons of the feste di ballo. By the secondo Settecento, the feste were an annual characteristic spectacle within Neapolitan theatrical life. The initial years of the reign of Ferdinando and Maria Carolina witnessed an unprecedented breadth of artistic patronage with the migration of theatrical performances (tragic and comic) and the feste di ballo to the Reggia di Caserta, the opulent palace rivaling even Versailles in expanse and splendor. In particular, during the period of 1769–71, multiple feste were organized annually for the newly finished court theater at Caserta. Surviving archival documents in the Casa Reale Antica (fasc. 2221–2224) provide copious details of the transformation of the space into a vast area for dancing, including the contractual agreements with artistic personnel, financial summaries of the considerable expenses, and ephemera about these events. The archival sources convey in greater detail many of the broad references found in contemporary notices appearing in the Diario Ordinario and Notizie del Mondo. Taken together, these materials illuminate the far-reaching resonance and reception of the carnevale seasons at Caserta.
The findings of the present study are detailed in the concluding Chapter 8. They underline the place and prestige of the feste di ballo within the considerable artistic landscape of early modern Naples. The chapter briefly revisits and summarizes the significant larger social, political, and artistic contexts that promoted the growth and proliferation of the feste tradition. It also considers their resonance as emblems of Neapolitan aristocratic identity prior to the rise of Napoleon and the Republican ideals that dominated the continent at the end of the century. Finally, it situates the feste di ballo as a form of historical soundscape, placing emphasis on sonic frameworks within documentary accounts of Naples and its environs.
Chapter 1 offers a précis of the feste di ballo in Naples from the ascension of Carlo di Borbone in 1734 to the long reign of his son Ferdinando IV, whose Austrian consort, Maria Carolina, remained a significant patron in local artistic life. It considers the Neapolitan milieu against the backdrop of the wider European diffusion and patronage of social dance, especially in Paris (Carlo’s great-grandfather was Louis XIV), Milan, and Rome. The contemporary letters of Alessandro and Pietro Verri provide firsthand insights into the existence of similar feste di ballo, and their influence and social resonance in these cosmopolitan cities. The deep interest of Ferdinando and Maria Carolina from the very beginning of their reign in the second half of the eighteenth century encouraged their active engagement in the programming of feste di ballo. Their well-known passion for social dancing extended from the direct planning thereof to taking center stage in the public performance of the minuet and contradance, as well as requiring the study of dance for their children. These circumstances were meticulously documented in the contemporary periodicals Gazzetta Universale and Notizie del Mondo, and in the personal correspondence and diaries discussed here.
Chapter 4 focuses on treatises by Giambattista Dufort, Il Trattato del Ballo Nobile (1728), and Gennaro Magri, Trattato teorico-prattico di ballo (1779). Given the intentionally didactic nature of Dufort’s treatise and its concentration on the minuet, the presentation of the fundamentals, mechanics of the genre, and how to execute the mandatory steps are the primary points for discussion. Magri’s later treatise is a much broader reflection on the contemporary dance environment of Naples (including ample reference to the pantomime and grottesco traditions), and it mirrors the preference for the contradance that emerged in the latter part of the century. Accordingly, Magri concentrates on this more intricate social dance, not only providing the reader with detailed explanations of its content but also devising specific graphic notation paired to original music. This approach provides unprecedented insight into contemporary social dancing and its place within the aristocratic culture of Naples. Given Magri’s career as a primo ballerino in the grottesco tradition, the narrative references ongoing polemics with Charles LePicq (student of Noverre and principal exponent of pantomime style). Finally, Magri’s role at the royal festivities in the capital city and in Caserta is considered.
The sixth chapter covers a broader expanse of time, yet provides equally detailed descriptions of the feste, as the tradition returned to the Teatro di San Carlo in 1774. Responding to criticisms of both Carlo di Borbone (now king of Spain) and the Neapolitan Secretary of State Bernardo Tanucci (who provided the Spanish sovereign with detailed complaints about the lifestyles of his son and consort), the feste di ballo returned to the capital city and the royal theater. In the period 1774–86, the feste take on greater significance, not only as an instrumentum regni projecting positive images of sovereignty, but also as a financial bulwark against the significant losses incurred in virtually every opera season (meticulously detailed in memoranda contained in the fondo Archivio Farnesiano). Surviving financial documents, personnel rosters, and ledgers provide important details about the annual feste, ranging from fundamental questions about the physical transformation of the theater into a dance space to the retention of key artistic and managerial personnel. These sources relate closely to and often confirm many of the observations found in the historical accounts of Sara Goudar and Magri’s treatise Trattato teorico-prattico di ballo (1779), among others.