Background: We evaluated vorasidenib (VOR), a dual inhibitor of mIDH1/2, in patients with mIDH1/2 glioma (Phase 3; NCT04164901). Methods: Patients with residual/recurrent grade 2 mIDH1/2 oligodendroglioma or astrocytoma were enrolled (age ≥12; Karnofsky Performance Score ≥80; measurable non-enhancing disease; surgery as only prior treatment; not in immediate need of chemoradiotherapy). Patients were stratified by 1p19q status and baseline tumor size and randomized 1:1 to VOR 40 mg or placebo (PBO) daily in 28-day cycles. Endpoints included imaging-based progression-free survival (PFS), time to next intervention (TTNI), tumor growth rate (TGR), health-related quality of life (HRQoL), neurocognition and seizure activity. Results: 331 patients were randomized (VOR, 168; PBO, 163). The median age was 40.0 years. 172 and 159 patients had histologically confirmed oligodendroglioma and astrocytoma, respectively. Treatment with VOR significantly improved PFS and TTNI. Median PFS: VOR, 27.7 mos; PBO, 11.1 mos (P=0.000000067). Median TTNI: VOR, not reached; PBO, 17.8 mos (P=0.000000019). Treatment with VOR resulted in shrinkage of tumor volume. Post-treatment TGR: VOR, -2.5% (95% CI: -4.7, -0.2); PBO, 13.9% (95% CI: 11.1, 16.8). HRQoL and neurocognition were preserved and seizure control was maintained. VOR had a manageable safety profile. Conclusions: VOR was effective in mIDH1/2 diffuse glioma not in immediate need of chemoradiotherapy.

Demonstratives are cross-linguistically widespread deictic expressions. Demonstrative systems exhibit variation in number of terms, and parameters affecting their usage. The present paper assesses the relationship between spatial deixis and bilingualism: how language dominance affects speakers of two languages with different demonstrative systems. Here, we compare the use of demonstratives by 72 European Spanish-Catalan simultaneous bilinguals in Mallorca to 30 European Spanish monolinguals. Our results confirmed a significant effect of physical distance between speaker and referent on demonstrative choice in both languages, and differences between languages in the use of the middle term. We did not find the expected effect of language dominance in simultaneous bilinguals. Moreover, we found no influence of the hearer's position on demonstrative choice in monolinguals or bilinguals in European Spanish or Majorcan Catalan. In view of our results, the present study contributes to the debate on how bilingual speakers employ different deictic expressions.

We investigated parasitic zoonoses caused by protozoans and helminths in urban and peri-urban rat populations (Rattus norvegicus and R. rattus) in Spanish cities. Rats were trapped and then dissected to remove adult helminths, and the contents of the large intestine were retrieved for the study of parasitic forms. The Midi Parasep® solvent free (SF) technique was used to concentrate the parasites in the intestinal contents. Some of the rats studied (n = 8) were infected by the rat lungworm, Angiostongylus cantonensis, whose first stage larvae (L1) are shed in rat faeces. After the concentration technique, L1 larvae were found in the sediment of 6 of the 8 positive rats. The two negative sediment samples were due to the presence of either only adult females or, in addition to males, only young females in the lungs of the rats. In view of our results, Midi Parasep® SF turned out to be a simple, rapid, inexpensive, and sensitive method to detect nematode larvae, such as the L1 larvae of A. cantonensis (or A. costaricensis), in natural and experimentally infected rats.

Sea anemones have developed various strategies for interspecific interaction with other organisms and their own ability to obtain food, due to their coevolutionary history, ranging from mutualistic (e.g. clownfish, crustaceans, etc.) and symbiotic associations (zooxanthellae or zoochlorellae) to depredation (e.g. sea slug). This study aims to record some observations on feeding habits and interspecific interactions of Actinostella flosculifera (Le Sueur, 1817) in the locality of Pedra da Sereia in Vila Velha, Espírito Santo, Brazil, and to describe the hunting strategy of the sea slug Spurilla braziliana MacFarland, 1909 and the escape strategy of A. flosculifera. We found that the habitat of A. flosculifera is characterized by shallow pools ~10 cm deep at low tides, and this functions as a trap for many organisms and some biowaste (e.g. bones or fish drifting in from nearby populations) that fall into the oral disc. This is the first report of S. braziliana predating on A. flosculifera. We also report interspecific relationships between A. flosculifera with four species of crustaceans: Omalacantha bicornuta (Latreille, 1825), Menippe cf. nodifrons Stimpson, 1859, Alpheus cf. angulosus McClure, 2002, and Alpheus cf. carlae Anker, 2012.

Fasting is commonly used in aquaculture to empty the gut before slaughter, but little is known about how feeding frequency before fasting affects the stress response of trout. To find out more, 240 rainbow trout (Oncorhynchus mykiss) were separated into three groups with different feeding schedules during the final month of fattening, from 26 September to 28 October 2013 (daily, every two days or every four days) and two durations of pre-slaughter fasting (two days of fasting; 24.3 degree days, to nine days of fasting; 102 degree days). After slaughter, a number of stress-related parameters were measured, such as liver glycogen, skin/gill colour and haematological parameters (cortisol, glucose, lactate, triglycerides, lactate dehydrogenase and creatine phosphokinase). Trout given food every two days on the farm had lower levels of cortisol and higher levels of triglycerides and liver glycogen than the other treatments after two days of fasting; indicating that habituating trout to feed once every two days in the final month of fattening lowered their stress response to two days of fasting before slaughter.

Demonstrative words are one of the most important ways of establishing reference in conversation. This work describes Spanish-speaking children’s demonstrative production between ages 2 to 10 using data from the CHILDES corpora. Results indicate that children feature all demonstratives in their lexicon – however, the distal term is scarce throughout development. Moreover, patterns of demonstrative use are not adult-like at age 10. We compare adult and child data to conclude that children’s development of demonstrative production is largely protracted. Adult use of the distal demonstrative is higher than in young children, although both older children and adults use the medial term ese more than any other demonstratives. In contrast, younger children use proximals relatively more frequently than older children and adults. Suggestions for future research and theoretical implications for the Spanish demonstrative system are discussed.

Ageing is interrelated with the development of immunosenescence. This article focuses on one of the cell sets of the adaptive immune system, T cells, and provides a review of the known changes in T cells associated with ageing. Such fundamental changes affect both cell molecular content and internal ordering. However, acquiring a complete description of the changes at these levels would require extensive measurements of parameters and, furthermore, important fine details of the internal ordering that may be difficult to detect. Therefore, an alternative approach for the characterisation of cells consists of the performance of physical measurements of the whole cell, such as deformability measurements or migration measurements: the physical parameters, complementing the commonly used chemical biomarkers, may contribute to a better understanding of the evolution of T-cell states during ageing. Mechanical measurements, among other biophysical measurements, have the advantage of their relative simplicity: one single parameter agglutinates the complex effects of the variety of changes that gradually appear in cells during ageing.

Livestock welfare assessment helps monitor animal health status to maintain productivity, identify injuries and stress, and avoid deterioration. It has also become an important marketing strategy since it increases consumer pressure for a more humane transformation in animal treatment. Common visual welfare practices by professionals and veterinarians may be subjective and cost-prohibitive, requiring trained personnel. Recent advances in remote sensing, computer vision, and artificial intelligence (AI) have helped developing new and emerging technologies for livestock biometrics to extract key physiological parameters associated with animal welfare. This review discusses the livestock farming digital transformation by describing (i) biometric techniques for health and welfare assessment, (ii) livestock identification for traceability and (iii) machine and deep learning application in livestock to address complex problems. This review also includes a critical assessment of these topics and research done so far, proposing future steps for the deployment of AI models in commercial farms. Most studies focused on model development without applications or deployment for the industry. Furthermore, reported biometric methods, accuracy, and machine learning approaches presented some inconsistencies that hinder validation. Therefore, it is required to develop more efficient, non-contact and reliable methods based on AI to assess livestock health, welfare, and productivity.

The Alicante Survey of MAssive Stars in Hii Regions (A-SMASHeR) is aimed at finding the ratio of massive stars that are born in isolation. We present LIRIS/WHT images and EMIR/GTC spectra of the massive stellar content in A-SMASHeR regions. Our preliminary analysis yields ∼20% of regions hosting relatively (or truly) isolated massive stars.

The aim of this survey is the homogeneous characterization of a large sample of H ii regions with active star formation in order to detect observational trends supporting the two main models of massive star formation.

We present results from our ongoing infrared spectroscopic studies of the massive stellar content at the Center of the Milky Way (GC) and across the obscured Galactic disk. Together with the full characterization of these clusters, we seek to obtain a present day metallicity 2-D map of the inner Galaxy and characterize the influence on the bar in the chemical evolution. We will also constrain the clusters IMFs, infer the presence of possible top-heavy recent star formation histories and test massive star formation channels: clusters vs isolation.

Contrasting perspectives on racism and racial inequality collide in contemporary Cuba. On the one hand, government officials argue that Cuba is a racially egalitarian country; though vestiges of historical racism subsist, systematic discrimination does not. On the other hand, social movement actors and organizations denounce that racism and discrimination are systemic and affect large sectors of the Afro-Cuban population. To draw these visions into scholarly dialogue, our analytic strategy consists in the comparative examination of both narratives as well as the empirical bases that sustain them. Using data from the 1981, 2002, and 2012 Cuban Censuses for the first time, as well as various non-census evidentiary sources, both quantitative and qualitative, we examine how racial inequality has evolved in Cuba during the last decades. Our analyses of census data suggest that racial stratification has a limited impact on areas such as education, health care, occupation, and positions of leadership. We find, nonetheless, that an expanding and strikingly racialized private sector is fueling dramatic income inequality by skin color beyond the reach of official census data. Our analysis sheds light on how different data can convey profoundly different pictures of racial inequality in a given context. Moreover, we highlight that significant contradictions can coexist in the lived experiences of racism and racial inequality within a single country context.

The giant gypsum crystals of Naica cave have fascinated scientists since their discovery in 2000. Human activity has changed the microclimate inside the cave, making scientists wonder about the potential environmental impact on the crystals. Over the last 9 years, we have studied approximately 70 samples. This paper reports on the detailed chemical–structural characterization of the impurities present at the surface of these crystals and the experimental simulations of their potential deterioration patterns. Selected samples were studied by petrography, optical and electronic microscopy, and laboratory X-ray diffraction. 2D grazing incidence X-ray diffraction, X-ray μ-fluorescence, and X-ray μ-absorption near-edge structure were used to identify the impurities and their associated phases. These impurities were deposited during the latest stage of the gypsum crystal formation and have afterward evolved with the natural high humidity. The simulations of the behavior of the crystals in microclimatic chambers produced crystal dissolution by 1–4% weight fraction under high CO2 concentration and permanent fog, and gypsum phase dehydration under air and CO2 gaseous environment. Our work suggests that most surface impurities are of natural origin; the most significant anthropogenic damage on the crystals is the extraction of water from the caves.

The use of psychiatric services has been associated with a wide range of clinical variables. However, information about the impact of adolescent personality pathology related to hospital admissions is limited.