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This paper reports an expansion of the English as a second language (L2) component of the Multilingual Eye Movement Corpus (MECO L2), an international database of eye movements during text reading. While the previous Wave 1 of the MECO project (Kuperman et al., 2023) contained English as a L2 reading data from readers with 12 different first language (L1) backgrounds, the newly collected dataset adds eye-tracking data on English text reading from 13 distinct L1 backgrounds (N = 660) as well as participants’ scores on component skills of English proficiency and information about their demographics and language background and use. The paper reports reliability estimates, descriptive statistics, and correlational analyses as means to validate the expansion dataset. Consistent with prior literature and the MECO Wave 1, trends in the MECO Wave 2 data include a weak correlation between reading comprehension and oculomotor measures of reading fluency and a greater L1-L2 contrast in reading fluency than reading comprehension. Jointly with Wave 1, the MECO project includes English reading data from more than 1,200 readers representing a diversity of native writing systems (logographic, abjad, abugida, and alphabetic) and 19 distinct L1 backgrounds. We provide multiple pointers to new venues of how L2 reading researchers can mine this rich publicly available dataset.
Substantial progress has been made in the standardization of nomenclature for paediatric and congenital cardiac care. In 1936, Maude Abbott published her Atlas of Congenital Cardiac Disease, which was the first formal attempt to classify congenital heart disease. The International Paediatric and Congenital Cardiac Code (IPCCC) is now utilized worldwide and has most recently become the paediatric and congenital cardiac component of the Eleventh Revision of the International Classification of Diseases (ICD-11). The most recent publication of the IPCCC was in 2017. This manuscript provides an updated 2021 version of the IPCCC.
The International Society for Nomenclature of Paediatric and Congenital Heart Disease (ISNPCHD), in collaboration with the World Health Organization (WHO), developed the paediatric and congenital cardiac nomenclature that is now within the eleventh version of the International Classification of Diseases (ICD-11). This unification of IPCCC and ICD-11 is the IPCCC ICD-11 Nomenclature and is the first time that the clinical nomenclature for paediatric and congenital cardiac care and the administrative nomenclature for paediatric and congenital cardiac care are harmonized. The resultant congenital cardiac component of ICD-11 was increased from 29 congenital cardiac codes in ICD-9 and 73 congenital cardiac codes in ICD-10 to 318 codes submitted by ISNPCHD through 2018 for incorporation into ICD-11. After these 318 terms were incorporated into ICD-11 in 2018, the WHO ICD-11 team added an additional 49 terms, some of which are acceptable legacy terms from ICD-10, while others provide greater granularity than the ISNPCHD thought was originally acceptable. Thus, the total number of paediatric and congenital cardiac terms in ICD-11 is 367. In this manuscript, we describe and review the terminology, hierarchy, and definitions of the IPCCC ICD-11 Nomenclature. This article, therefore, presents a global system of nomenclature for paediatric and congenital cardiac care that unifies clinical and administrative nomenclature.
The members of ISNPCHD realize that the nomenclature published in this manuscript will continue to evolve. The version of the IPCCC that was published in 2017 has evolved and changed, and it is now replaced by this 2021 version. In the future, ISNPCHD will again publish updated versions of IPCCC, as IPCCC continues to evolve.
We summarize some of the past year's most important findings within climate change-related research. New research has improved our understanding of Earth's sensitivity to carbon dioxide, finds that permafrost thaw could release more carbon emissions than expected and that the uptake of carbon in tropical ecosystems is weakening. Adverse impacts on human society include increasing water shortages and impacts on mental health. Options for solutions emerge from rethinking economic models, rights-based litigation, strengthened governance systems and a new social contract. The disruption caused by COVID-19 could be seized as an opportunity for positive change, directing economic stimulus towards sustainable investments.
Technical summary
A synthesis is made of ten fields within climate science where there have been significant advances since mid-2019, through an expert elicitation process with broad disciplinary scope. Findings include: (1) a better understanding of equilibrium climate sensitivity; (2) abrupt thaw as an accelerator of carbon release from permafrost; (3) changes to global and regional land carbon sinks; (4) impacts of climate change on water crises, including equity perspectives; (5) adverse effects on mental health from climate change; (6) immediate effects on climate of the COVID-19 pandemic and requirements for recovery packages to deliver on the Paris Agreement; (7) suggested long-term changes to governance and a social contract to address climate change, learning from the current pandemic, (8) updated positive cost–benefit ratio and new perspectives on the potential for green growth in the short- and long-term perspective; (9) urban electrification as a strategy to move towards low-carbon energy systems and (10) rights-based litigation as an increasingly important method to address climate change, with recent clarifications on the legal standing and representation of future generations.
Social media summary
Stronger permafrost thaw, COVID-19 effects and growing mental health impacts among highlights of latest climate science.
Despite the strong evidence for its effectiveness for depression in adolescence, cognitive behavior therapy (CBT) remains difficult to access in India. Computerized CBT offers a substantive contribution to the delivery of effective care improving accessibility of treatment. The present study is an endeavor to assess the felt needs of adolescents vis-à -vis the difficulties and stressors experienced by them. Another objective of the study has been to develop and test a culturally relevant computer assisted CBT program called 'smartteen'. The presentation will discuss the results of the pilot test of the effectiveness of the intervention on a sample of 20 participants in reducing depressive symptoms.
Methods
In this pre and post research design, 20 depressed adolescents seeking treatment from the Department of Psychiatry at a premier institute in India, are being randomly assigned to intervention (n=10) and treatment as usual (n=10). Three assessments will be carried out at pre, mid (6 weeks of intervention) and post intervention (3 months of intervention) by a blind assessor. The primary outcome is recovery from depression and analysis will be done by intent to treat.
Results and Discussion
The study is ongoing and results will be presented at the time of presentation.
We assessed the impact of an embedded electronic medical record decision-support matrix (Cerner software system) for the reduction of hospital-onset Clostridioides difficile. A critical review of 3,124 patients highlighted excessive testing frequency in an academic medical center and demonstrated the impact of decision support following a testing fidelity algorithm.
In advanced radiotherapy techniques such as intensity-modulated radiation therapy (IMRT), the quality assurance (QA) process is essential. The aim of the study was to assure the treatment planning dose delivered during delivery of complex treatment plans. The QA standard is to perform patient-specific comparisons between planned doses and doses measured in a phantom.
Materials and method
The Delta 4 phantom (Scandidos, Uppsala, Sweden) has been used in this study. This device consists of diode matrices in two orthogonal planes inserted in a cylindrical acrylic phantom. Each diode is sampled per beam pulse so that the dose distribution can be evaluated on segment-by-segment, beam-by-beam, or as a composite plan from a single set of measurements. Ninety-five simple and complex radiotherapy treatment plans for different pathologies, planned using a treatment planning system (TPS) were delivered to the QA device. The planned and measured dose distributions were then compared and analysed. The gamma index was determined for different pathologies.
Results
The evaluation was performed in terms of dose deviation, distance to agreement and gamma index passing rate. The measurements were in excellent agreement between with the calculated dose of the TPS and the QA device. Overall, good agreement was observed between measured and calculated doses in most cases with gamma values above 1 in >95% of measured points. Plan results for each test met the recommended dose goals.
Conclusion
The delivery of IMRT and volumetric-modulated arc therapy (VMAT) plans was verified to correspond well with calculated dose distributions for different pathologies. We found the Delta 4 device is accurate and reproducible. Although Delta4 appears to be a straightforward device for measuring dose and allows measure in real-time dosimetry QA, it is a complex device and careful quality control is required before its use.
An internationally approved and globally used classification scheme for the diagnosis of CHD has long been sought. The International Paediatric and Congenital Cardiac Code (IPCCC), which was produced and has been maintained by the International Society for Nomenclature of Paediatric and Congenital Heart Disease (the International Nomenclature Society), is used widely, but has spawned many “short list” versions that differ in content depending on the user. Thus, efforts to have a uniform identification of patients with CHD using a single up-to-date and coordinated nomenclature system continue to be thwarted, even if a common nomenclature has been used as a basis for composing various “short lists”. In an attempt to solve this problem, the International Nomenclature Society has linked its efforts with those of the World Health Organization to obtain a globally accepted nomenclature tree for CHD within the 11th iteration of the International Classification of Diseases (ICD-11). The International Nomenclature Society has submitted a hierarchical nomenclature tree for CHD to the World Health Organization that is expected to serve increasingly as the “short list” for all communities interested in coding for congenital cardiology. This article reviews the history of the International Classification of Diseases and of the IPCCC, and outlines the process used in developing the ICD-11 congenital cardiac disease diagnostic list and the definitions for each term on the list. An overview of the content of the congenital heart anomaly section of the Foundation Component of ICD-11, published herein in its entirety, is also included. Future plans for the International Nomenclature Society include linking again with the World Health Organization to tackle procedural nomenclature as it relates to cardiac malformations. By doing so, the Society will continue its role in standardising nomenclature for CHD across the globe, thereby promoting research and better outcomes for fetuses, children, and adults with congenital heart anomalies.
Optical pump-probe studies of cubic crystalline Ge2Sb2Te5/GaSb(001) have previously shown that the amplitude of a coherent optical phonon (COP) with frequency of 3.4 THz observed in the anisotropic reflectance (AR) signal exhibits a four-fold dependence upon the polarization of the probe beam. The appearance of the mode in the AR signal but not the reflectance (R) signal, and the dependence upon probe polarization, both suggest a three-dimensional mode character. Confirmation that this mode indeed has three-dimensional character, similar to the Raman inactive T2 mode in the pristine rock salt structure, is highly important in understanding the structure of the crystalline phase of Ge2Sb2Te5 that has important applications within data storage technology. A phonon of the same frequency has been observed in an epitaxial Ge2Sb2Te5/InAs(111) structure, suggesting that this phonon is indeed characteristic of epitaxial cubic GST. A theory, which considers the symmetry of the Raman tensor for a particular phonon mode, is used to predict the dependence of R and AR signal amplitude upon pump and probe polarization for the T2 mode of a (111) facet of the putative rock-salt structure.
Botrytis grey mould (BGM), caused by the fungus Botrytis cinerea Pers. ex Fr., is an important disease of chickpea causing economic losses across the world in chickpea-growing regions. There are no available resistance sources in cultivated chickpea against this disease. Cicer echinospermum and C. reticulatum, the only two compatible annual wild species, have been reported to have resistance to BGM. Hence, interspecific populations were developed with susceptible cultivars as female parents and C. echinospermum accession IG 73 074 and C. reticulatum accession IG 72 937 as the pollen donors to transfer and assess the nature of genetic control for BGM. Screening the progeny indicated that resistance to BGM was controlled by a single additive gene/allele (bgmr1cr and bgmr1ce), which can be introgressed through a backcross breeding programme.
Populations of the western spruce budworm, Choristoneura occidentalis, were sampled in western Montana, central Idaho, and eastern Oregon. In 22 of 24 populations, the proportion of females among pupae did not differ from 0.5. Similarly, in 21 of 24 populations, the proportion of females among adults was not different from 0.5. In all populations, differences between survival rates of male and female pupae were attributed to chance. The proportion of females among pupae (a) did not differ between insects on Douglas-fir and those on grand fir, (b) was slightly but significantly higher among insects in the mid-crown than among those in the lower crown, and (c) was significantly higher among the insects in the one site studied where average defoliation of current-year shoots was greater than 50%. Variation in the proportion of females among adults should have a negligible effect on the dynamics of these populations.
Dengue is an emerging arboviral disease and currently poses the greatest arboviral threat to human health. In recent decades, there has been a substantial increase in dengue outbreaks in many parts of the world including India. We performed an in-depth investigation of a major dengue outbreak in Andhra Pradesh, southern India in 2007 by serology, virus isolation, RT–PCR and genotyping. The results revealed an unusual emergence of dengue virus type 4 (DENV-4) along with the prevailing DENV-3. Phylogenetic analysis based on complete envelope gene of 182 globally diverse DENV-4 isolates demonstrated the involvement of a unique clade of genotype I of DENV-4 in the outbreak. This study also demonstrated a clear shift in the dominant serotype from DENV-3 to DENV-4 in India. This is the first report regarding the molecular characterization of Indian isolates of DENV-4, which has the potential to be involved in future outbreaks.
Othreis materna (L.) is an important fruit-sucking moth in Rajasthan (India). The immature stages are described in detail and illustrated by means of photographs and setal maps, points distinguishing this species from O. fullonia (Cl.) being noted. Females laid 200–400 eggs; the durations of the egg, larval and pupal stages on Tinospora cordifolia were 3–4, 16–23 and 10–13 days, respectively.
Mierofilariae of Litomosoides carinii and Dipetalonema viteae absorbed about ten times as much diethylcarbamazine (DEC) as did their adults, but bound much less. The higher uptake of DEC by the microfilariae might be related to the fact that DEC is microfilariae Binding of DEC: with the parasites supports the view that the microfilarcidal action begins with the fixation of the drug to the microfilariae.
The filarial parasites Litomosoides carinii and Dipetalonema viteae both show transcuticular uptake of adenosine 3′, 5′-cyclic monophosphate but isoproterenol is taken up by D. viteae only. The importance of this difference is discussed from the point of view of metabolic regulation. Inhibition of uptake by lectins indicates the involvement of surface sugar moieties in the transport processes.
Nine normal lactating Murrah buffaloes from the Punjab Agricultural University Dairy herd were used to assess the effect of showers and evaporative cooling on plasma oxytocin concentration, let-down time, milking time and milk yield in buffaloes. The animals were showered four times daily between 10.30 and 16.30 h or provided with evaporative cooling from 07.00 to 21.00 h. In the hot and dry period the oxytocin concentration in buffaloes given a shower was significantly greater than that of the buffaloes of the control group. In the hot and humid period there was a similar trend.
It is concluded from these studies, that cooling may increase the effective milk ejection reflex because the milk-ejection response to a given blood oxytocin concentration is different when the animal is heat stressed from when it is cooled.
It has been reported recently (Stott, 1974) that in cattle, reproductive efficiency is increased by keeping the animals under cool climatic conditions. However, in buffaloes very limited information is available. Roy, Sengupta & Misra (1962) have reported that all buffaloes exhibited oestrus and were inseminated in a group protected from direct sun radiation whereas in a non-protected group only one showed oestrus. There is no systematic information available on the effect of wallowing and showers on the oestrual behaviour of buffaloes. Therefore, the present investigation was undertaken to study the effect of cooling on oestrual behaviour in buffaloes.
Forty-five normal lactating buffaloes from Punjab Agricultural University, Dairy Farm herd, were used for this study and were divided into three groups as group I (control), group II (showers) and group III (wallowing). The study was conducted from May to September in two periods, May–June as period I (hot and dry) and July–September as period II (hot and humid). Potassium concentration was estimated on a flame photometer. The overall average values (m-equiv/l) were found to be lowest in the control group (21·5 ± 1·27) and highest in wallowing (24·3 ± 1·20). Lower values were obtained in period I than in period II. Different correlations of potassium concentration in red blood corpuscles with climatic variables are discussed. Erythrocyte potassium concentration may act as an index of heat tolerance in buffaloes.
This paper reports structural, morphological, optical and humidity sensing characteristics of pulsed laser deposited ZnO film. The XRD pattern reveals amorphous structure of the film. Scanning electron micrograph indicates formation of ZnO rods in micron size. Transmission increases gradually in the UV-VIS region. For studying the humidity sensing characteristics of the film, base of a right angled isosceles glass prism has been coated. Chopped light from a polarized He-Ne laser incident on the entry face of the prism gets reflected from the base – film – humid air interfaces and then emergent light is collected by the detector placed in front of the exit face of the prism. The least change in relative humidity which could be measured using the present configuration is 1.06RH%. Further the film is annealed at 400°C for four hours and its humidity sensing behavior is investigated in the similar manner which now shows a reversed trend. The sensitivity to humidity has decreased and the least change which could be detected now is 1.16RH%.
The present report compares the macrophage function in rodent hosts susceptible and resistant to the human lymphatic filariid Brugia malayi. Macrophages from both mastomys (resistant) and gerbil (susceptible) infected intraperitoneally (i.p.) with the infective larvae (L3) of B. malayi were isolated from peritoneal lavage at different time-intervals and formation rate of NO, H2O2, O2−, TNF-α, glutathione peroxidase and reductase was assayed. NO release was found to be significantly increased in resistant mastomys as compared to gerbils and the release was markedly suppressed by i.p. administration of the NOS inhibitor aminoguanidine (AG). The AG-treated mastomys also demonstrated significantly greater establishment of larvae which correlated well with suppressed formation of NO. Nitric oxide synergizes with superoxide to form peroxynitrite radical (potent oxidant), which is known to be more toxic per se than NO. Results indicate the possible involvement of peroxynitrite in the rapid killing of larvae in the peritoneal cavity of mastomys. In contrast, the production of H2O2 was found to be enhanced in both species indicating that B. malayi L3 could withstand the toxic effects of H2O2. The higher level of glutathione peroxidase and reductase, as observed in mastomys compared with the gerbil after larval introduction, possibly protects the cell against the injurious effect of H2O2. The TNF-α level remained virtually unchanged in both the hosts, suggesting an insignificant role for this cytokine in parasite establishment.
India is the world's dominant producer of crude Mentha arvensis oil, and exporter of its processed derivative, natural menthol. This status has been achieved through superior product price competitiveness resulting from progressive agronomic improvements that include a transition from cultivation of this mint as a semi-perennial to an annual crop. This paper describes and analyses recent developments in Indian M. arvensis cultivation.
Observations were made during 1998/99 and 1999/2000 in the fields of 295 farmers in the central Indo-Gangetic plains area. The criteria recorded included: mint cultivars used; the planting, weeding, irrigation, pesticide application and harvesting schedules; crop health in relation to diseases and pests; yields of the harvested herb and the distilled essential oil; the oil menthol content; and the net income.
Most of the farmers used the cultivar, Kosi. The performance and returns of Kosi transplanted in April had proved superior to Kosi and Shivalik suckers and to transplanted Shivalik. The returns from late-transplanted Kosi were in the range of Rupees (Rs) 25 000 to Rs 40 000 ha−1 (Rs 50≈US$1), similar to those from Kosi suckers and much higher than for both transplanted and suckers of Shivalik. This survey revealed that rotations of rice (Oryza sativa) with chickpea (Cicer arietinum) and mint, and pigeonpea (Cajanus cajan) with wheat (Triticum aestivum) and mint could be profitable in the central Indo-Gangetic plains. They also conserved inputs and were preferable to the conventional rice-wheat rotation. A re-survey in the summer of 2002 confirmed that recommendations made to farmers have led to the adoption of the Kosi and Himalaya cultivars in 80% of the survey region and that 70% of mint cultivation in the area occurs in the summer season.