To investigate the symptoms of SARS-CoV-2 infection, their dynamics and their discriminatory power for the disease using longitudinally, prospectively collected information reported at the time of their occurrence. We have analysed data from a large phase 3 clinical UK COVID-19 vaccine trial. The alpha variant was the predominant strain. Participants were assessed for SARS-CoV-2 infection via nasal/throat PCR at recruitment, vaccination appointments, and when symptomatic. Statistical techniques were implemented to infer estimates representative of the UK population, accounting for multiple symptomatic episodes associated with one individual. An optimal diagnostic model for SARS-CoV-2 infection was derived. The 4-month prevalence of SARS-CoV-2 was 2.1%; increasing to 19.4% (16.0%–22.7%) in participants reporting loss of appetite and 31.9% (27.1%–36.8%) in those with anosmia/ageusia. The model identified anosmia and/or ageusia, fever, congestion, and cough to be significantly associated with SARS-CoV-2 infection. Symptoms’ dynamics were vastly different in the two groups; after a slow start peaking later and lasting longer in PCR+ participants, whilst exhibiting a consistent decline in PCR- participants, with, on average, fewer than 3 days of symptoms reported. Anosmia/ageusia peaked late in confirmed SARS-CoV-2 infection (day 12), indicating a low discrimination power for early disease diagnosis.

Ego-documents let us hear the voices of those who have been little heard in historiography. Such documents, especially when narrative in nature, provide insight into historical events and periods by illustrating how individuals—in correspondence with their own (in)actions, (in)decisions, and (mis)convictions as well as emotions, fears, aspirations, and frustrations—experienced and perceived these historical phenomena from a contemporary personal viewpoint. Since the revival of narrative historiography in the 1980s, partly in response to the Annales school, such documents have been increasingly recognized and employed as important historical sources. Nonetheless, the terminology for designating the generic nature and encompassing the diversity of such sources, as well as the methodology for historicizing them, remain under debate.

To provide comprehensive information on the epidemiology and burden of respiratory syncytial virus hospitalisation (RSVH) in preterm infants, a pooled analysis was undertaken of seven multicentre, prospective, observational studies from across the Northern Hemisphere (2000–2014). Data from all 320–356 weeks' gestational age (wGA) infants without comorbidity were analysed. RSVH occurred in 534/14 504 (3.7%) infants; equating to a rate of 5.65 per 100 patient-seasons, with the rate in individual wGA groups dependent upon exposure time (P = 0.032). Most RSVHs (60.1%) occurred in December–January. Median age at RSVH was 88 days (interquartile range (IQR): 54–159). Respiratory support was required by 82.0% of infants: oxygen in 70.4% (median 4 (IQR: 2–6) days); non-invasive ventilation in 19.3% (median 3 (IQR: 2–5) days); and mechanical ventilation in 10.2% (median 5 (IQR: 3–7) days). Intensive care unit admission was required by 17.9% of infants (median 6 days (IQR: 2–8) days). Median overall hospital length of stay (LOS) was 5 (IQR: 3–8) days. Hospital resource use was similar across wGA groups except for overall LOS, which was shortest in those born 35 wGA (median 3 vs. 4–6 days for 32–34 wGA; P < 0.001). Strategies to reduce the burden of RSVH in otherwise healthy 32–35 wGA infants are indicated.

Exposure to adverse events is prevalent among youths and robustly associated with risk for depression, particularly during adolescence. The Dimensional Model of Adversity and Psychopathology (DMAP) distinguishes between adverse events that expose youths to deprivation versus threat, positing unique mechanisms of risk (cognitive functioning deficits for deprivation, and altered fear and emotion learning for threat) that may require different approaches to intervention. We examined whether deprivation and threat were distinctly associated with behavioral measures of cognitive processes and autonomic nervous system function in relation to depression symptom severity in a community sample of early adolescents (n = 117; mean age 12.73 years; 54.7% male). Consistent with DMAP, associations between threat and depression symptoms, and between economic deprivation and depression symptoms, were distinctly moderated by physiological and cognitive functions, respectively, at baseline but not follow-up. Under conditions of greater cognitive inhibition, less exposure to deprivation was associated with lower symptom severity. Under conditions of blunted resting-state autonomic response (electrodermal activity and respiratory sinus arrhythmia), greater exposure to threat was associated with higher symptom severity. Our findings support the view that understanding risk for youth depression requires parsing adversity: examining distinct roles played by deprivation and threat, and the associated cognitive and biological processes.

A two-year (2015 and 2016) grazing study was established to compare ewe and lamb performance when grazed on a perennial ryegrass only sward compared to more diverse sward types. In that study four sward types were investigated: a perennial ryegrass (Lolium perenne) only sward receiving 163 kg nitrogen per hectare per year (N/ha/yr) (PRG); a perennial ryegrass and white clover (Trifolium repens) sward receiving 90 kg N/ha/yr (PRGWC); a six species sward (two grasses (perennial ryegrass and timothy (Phleum pratense)), two legumes (white and red clover (Trifolium pratense)) and two herbs (ribwort plantain (Plantago lanceolata) and chicory (Cichorium intybus)) receiving 90 kg N/ha/yr (6S); and a nine species sward containing cocksfoot (Dactylis glomerata), greater birdsfoot trefoil (Lotus pedunculatus) and yarrow (Achillea millefolium) in addition to the six species listed above, receiving 90 kg N/ha/yr (9S). Each sward type was managed as a separate farmlet and stocked with 30 twin-rearing ewes at a stocking rate of 12.5 ewes/ha under rotational grazing management from turnout post-lambing until housing. Lamb live weight was recorded fortnightly and lambs were drafted for slaughter at 45 kg. Ewe live weight and body condition score (BCS) were recorded on five occasions annually. Lamb faecal egg count (FEC) was recorded fortnightly and lambs were treated with anthelmintics when mean lamb FEC per sward type was above 400 eggs per gram. Ewes grazing the 6S and 9S swards had heavier (P < 0.01) live weights and BCS throughout the study than the ewes grazing the PRG sward. Lambs grazing the 6S sward were heavier than lambs grazing all other sward types of 14 weeks old (P < 0.05). Lambs grazing the PRG sward required more days to reach slaughter weight than lambs grazing all other sward types (P < 0.001). Lambs grazing the 6S and 9S swards required fewer anthelmintic treatments than lambs grazing the PRG or PRGWC swards. In conclusion, grazing multispecies swards improved ewe and lamb performance and reduced the requirement for chemical anthelmintics.

We consider two isolated, interacting dust particles confined in plasma. Measurements of normal mode frequencies are used to determine the dust charge, the Debye shielding length and the anisotropy of the confining potential well. For dust particles confined near the sheath edge, the vertical electric field and an effective electron temperature are also determined. This method is used to characterize the sheath above a short rectangular trench in the powered electrode of a radio-frequency discharge.

In this paper we discuss 80 MHz heliograph observations of the multiple source structure and polarization of a type IV solar radio outburst on 1970 November 16. At times during the event six sources were present. Three of these were highly circularly polarized in a L.H. sense and two in a R.H. sense. The sixth source was extended and had oppositely polarized edges. From the source behaviour we conclude that the radio emission came from two expanding and one stationary magnetic arch.

We present a catalogue of 668 major metre-wavelength radio events. The data was collected from dynamic spectra (taken at Dapto, N.S.W. until 1966 and at Culgoora, N.S.W. thereafter) by means of a radio spectrograph, which records the intensity of radio emission as a function of both frequency and time. A description of the major types of metre-wavelength phenomena can be found in Wild et al. (1963), Kundu (1965), Wild and Smerd (1972) and Kruger (1979), and details of the radio spectrograph in Sheridan (1963, 1967) and Labrum (1972).

Travelling disturbances in the solar corona with velocities ~103 km/s manifest themselves at radio frequencies by two distinctive phenomena—the type II burst, the spectrum of which shows a slow frequency drift that corresponds to quasi-radial outward motion, and the moving type IV burst, for which positional observations show transverse motion directly. A close relation between the two phenomena has long been suspected, and each type has separately been ascribed to a shock wave disturbance. In this paper we summarize three events recorded by the Culgoora radioheliograph and spectograph (two in the course of publication and one unpublished) in each of which a type II and a moving type IV burst can be consistently attributed to the effects of a common shock wave.

Observations on 1970 August 11 and 12 at Mauna Loa (Hawaii) of the white-light corona revealed a rare solar event in the form of a short-lived coronal brightening off the eastern limb of the Sun. The intensity of this region, as measured at a distance ρ = 1.5 (where ρ = R/R⊙), more than doubled over a period of five hours and then fell very abruptly (~10 min) to below its initial brightness. A complex radio event in the same region was observed simultaneously with the 80 MHz radioheliograph at Culgoora (Australia). Associations between the optical and radio events will be described and the physical implications briefly discussed.

Aspects of the turbulent wind environment Micro Air Vehicles (MAVs) experience when flying outdoors were replicated in a large wind tunnel. An overview of the facility, instrumentation and initial flight tests is given. Piloting inputs and aircraft accelerations were recorded on fixed and rotary wing MAVs and for some tests, measurements of the approach flow (u,v,w sampled at 1,250Hz at four laterally disposed upstream locations) were made. The piloting aim was to hold straight and level flight in the 12m wide × 4m high × ~50m long test section, while flying in a range of turbulent conditions. The Cooper-Harper rating system showed that a rotary craft was less sensitive to the effects of turbulence compared to the fixed wing craft and that while the fixed wing aircraft was relatively easy to fly in smooth air, it became extremely difficult to fly under high turbulence conditions. The rotary craft, while more difficult to fly per. se., did not become significantly harder to fly in relatively high turbulence levels. However the rotary craft had a higher mass and MOI than the fixed wing craft and further work is planned to understand the effects of these differences.

The effects of advance ratio and the wing’s aspect ratio on the structure of the leading-edge vortex (LEV) that forms on flapping and rotating wings under insect-like flight conditions are not well understood. However, recent studies have indicated that they could play a role in determining the stable attachment of the LEV. In this study, a numerical model of a flapping wing at insect Reynolds numbers is used to explore the effects of these parameters on the characteristics and stability of the LEV. The word ‘stability’ is used here to describe whether the LEV was attached throughout the stroke or if it was shed. It is demonstrated that increasing the advance ratio enhances vorticity production at the leading edge during the downstroke, and this results in more rapid growth of the LEV for non-zero advance ratios. Increasing the wing aspect ratio was found to have the effect of shortening the wing’s chord length relative to the LEV’s size. These two effects combined determine the stability of the LEV. For high advance ratios and large aspect ratios, the LEV was observed to quickly grow to envelop the entire wing during the early stages of the downstroke. Continued rotation of the wing resulted in the LEV being eventually shed as part of a vortex loop that peels away from the wing’s tip. The shedding of the LEV for high-aspect-ratio wings at non-zero advance ratios leads to reduced aerodynamic performance of these wings, which helps to explain why a number of insect species have evolved to have low-aspect-ratio wings.

Wing deformation is observed during the flight of some insect species; however, the effect of these distorted wing shapes on the leading edge vortex (LEV) is not well understood. In this study, we investigate the effect of one of these deformation parameters, (rigid) wing camber, on the flow structures and aerodynamic forces for insect-like wings, using a numerical model of an altered fruit fly wing revolving at a constant angular velocity. Both positive and negative camber was investigated at Reynolds numbers of 120 and 1500, along with the chordwise location of maximum camber. It was found that negatively cambered wings produce very similar LEV structures to non-cambered wings at both Reynolds numbers, but high positive camber resulted in the formation of multiple streamwise vortices at the higher Reynolds number, which disrupt the development of the main LEV. Despite this, positively cambered wings were found to produce higher lift to drag ratios than flat or negatively cambered wings. It was determined that a region of low pressure near the wing’s leading edge, combined with the curvature of the wing’s upper surface in this region, resulted in a vertical tilting of the net force vector for positively cambered wings, which explains how insects can benefit from wing camber.

A foodborne outbreak with 49 cases (22 culture positive for Campylobacter sp.) following a wedding party in the East of England was investigated. A retrospective cohort study identified an association between consumption of chicken liver pâté and infection with Campylobacter jejuni/coli. There was a statistically significant association between dose (amount of chicken liver pâté eaten) and the risk of disease [‘tasted’: odds ratio (OR) 1·5, 95% confidence interval (CI) 0·04–∞; ‘partly eaten’: OR 8·4, 95% CI 1·4–87·5; ‘most or all eaten’: OR 36·1, 95% CI 3·3–2119). The local authority found evidence that the preparation of chicken livers breached Food Standards Agency's guidelines. This epidemiological investigation established a clear dose–response relationship between consumption of chicken liver pâté and the risk of infection with Campylobacter. The continuing need to raise public awareness of the risk to human health posed by undercooked chicken liver is evident.

Previous studies investigating the effect of aspect ratio ( $\mathit{AR}$ ) for insect-like regimes have reported seemingly different trends in aerodynamic forces, however no detailed flow observations have been made. In this study, the effect of $\mathit{AR}$ and Reynolds number on the flow structures over insect-like wings is explored using a numerical model of an altered fruit fly wing revolving at a constant angular velocity. Increasing the Reynolds number for an $\mathit{AR}$ of 2.91 resulted in the development of a dual leading-edge vortex (LEV) structure, however increasing $\mathit{AR}$ at a fixed Reynolds number generated the same flow structures. This result shows that the effects of Reynolds number and $\mathit{AR}$ are linked. We present an alternative scaling using wing span as the characteristic length to decouple the effects of Reynolds number from those of $\mathit{AR}$ . This results in a span-based Reynolds number, which can be used to independently describe the development of the LEV. Indeed, universal behaviour was found for various parameters using this scaling. The effect of $\mathit{AR}$ on the vortex structures and aerodynamic forces was then assessed at different span-based Reynolds numbers. Scaling the flow using the wing span was found to apply when a strong spanwise velocity is present on the leeward side of the wing and therefore may prove to be useful for similar studies involving flapping or rotating wings at high angles of attack.

To better determine the optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection, we evaluated the utility of a novel combination antibiogram. Although the combination antibiogram allowed modest fine-tuning of choices for dual antibiotic therapy, selections based on the 2 antibiograms did not differ substantively. Drug combinations with the broadest coverage were consistently composed of an aminoglycoside and a β-lactam.