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NASA’s all-sky survey mission, the Transiting Exoplanet Survey Satellite (TESS), is specifically engineered to detect exoplanets that transit bright stars. Thus far, TESS has successfully identified approximately 400 transiting exoplanets, in addition to roughly 6 000 candidate exoplanets pending confirmation. In this study, we present the results of our ongoing project, the Validation of Transiting Exoplanets using Statistical Tools (VaTEST). Our dedicated effort is focused on the confirmation and characterisation of new exoplanets through the application of statistical validation tools. Through a combination of ground-based telescope data, high-resolution imaging, and the utilisation of the statistical validation tool known as TRICERATOPS, we have successfully discovered eight potential super-Earths. These planets bear the designations: TOI-238b (1.61$^{+0.09} _{-0.10}$ R$_\oplus$), TOI-771b (1.42$^{+0.11} _{-0.09}$ R$_\oplus$), TOI-871b (1.66$^{+0.11} _{-0.11}$ R$_\oplus$), TOI-1467b (1.83$^{+0.16} _{-0.15}$ R$_\oplus$), TOI-1739b (1.69$^{+0.10} _{-0.08}$ R$_\oplus$), TOI-2068b (1.82$^{+0.16} _{-0.15}$ R$_\oplus$), TOI-4559b (1.42$^{+0.13} _{-0.11}$ R$_\oplus$), and TOI-5799b (1.62$^{+0.19} _{-0.13}$ R$_\oplus$). Among all these planets, six of them fall within the region known as ‘keystone planets’, which makes them particularly interesting for study. Based on the location of TOI-771b and TOI-4559b below the radius valley we characterised them as likely super-Earths, though radial velocity mass measurements for these planets will provide more details about their characterisation. It is noteworthy that planets within the size range investigated herein are absent from our own solar system, making their study crucial for gaining insights into the evolutionary stages between Earth and Neptune.
Invasive emergent and floating macrophytes can have detrimental impacts on aquatic ecosystems. Management of these aquatic weeds frequently relies upon foliar application of aquatic herbicides. However, there is inherent variability of overspray (herbicide loss) for foliar applications into waters within and adjacent to the targeted treatment area. The spray retention (tracer dye captured) of four invasive broadleaf emergent species (water hyacinth, alligatorweed, creeping water primrose, and parrotfeather) and two emergent grass-like weeds (cattail and torpedograss) were evaluated. For all species, spray retention was simulated using foliar applications of rhodamine WT (RWT) dye as a herbicide surrogate under controlled mesocosm conditions. Spray retention of the broadleaf species was first evaluated using a CO2-pressurized spray chamber overtop dense vegetation growth or no plants (positive control) at a greenhouse (GH) scale. Broadleaf species and grass-like species were then evaluated in larger outdoor mesocosms (OM). These applications were made using a CO2-pressurized backpack sprayer. Evaluation metrics included species-wise canopy cover and height influence on in-water RWT concentration using image analysis and modeling techniques. Results indicated spray retention was greatest for water hyacinth (GH, 64.7 ± 7.4; OM, 76.1 ± 3.8). Spray retention values were similar among the three sprawling marginal species alligatorweed (GH, 37.5 ± 4.5; OM, 42 ± 5.7), creeping water primrose (GH, 54.9 ± 7.2; OM, 52.7 ± 5.7), and parrotfeather (GH, 48.2 ± 2.3; OM, 47.2 ± 3.5). Canopy cover and height were strongly correlated with spray retention for broadleaf species and less strongly correlated for grass-like species. Although torpedograss and cattail were similar in percent foliar coverage, they differed in percent spray retention (OM, 8.5± 2.3 and 28.9 ±4.1, respectively). The upright leaf architecture of the grass-like species likely influenced the lower spray retention values in comparison to the broadleaf species.
Unoccupied aerial application systems (UAAS) are gaining popularity for weed management to increase applicator safety and to deliver herbicide treatments where treatment sites limit ground-based spray equipment. Several studies have documented UAAS application strategies and procedures for weed control in terrestrial settings, yet literature describing remote spray technology for use in aquatics remains limited. Currently, applicators seek guidance for UAAS deployment for aquatic weed management to overcome site access restrictions, deal with environmental limitations, and improve ground-based applicator safety in hazardous treatment scenarios. In the present case studies, we evaluate a consumer-available UAAS to deliver the herbicide, florpyrauxifen-benzyl, as both foliar and directed in-water spray applications. The first case study showed that the invasive floating-leaved plant, yellow floating heart, was controlled 80% to 99% by 6 wk after treatment (WAT) following UAAS foliar herbicide treatments. The second case study demonstrated that UAAS directed in-water herbicide application reduced variable-leaf watermilfoil visible plant material by 94% at 5 WAT. Likewise, directed in-water applications from UAAS eliminated the need to deploy watercraft, which improved overall operational efficiency. Data from both case studies indicate that UAAS can provide an effective and efficient treatment strategy for floating-leaved and submersed plant control among common herbicide treatment scenarios. Future integration of UAAS in aquatic weed control programs is encouraged, especially among smaller treatment sites (≤4 ha) or where access limits traditional spray operations.
Expanding the current aquatic herbicide portfolio, reducing total spray volumes, or remotely delivering herbicide using novel spray technologies could improve management opportunities targeting invasive aquatic plants, where options are more limited. However, research on giant salvinia (Salvinia molesta Mitchell) response to foliar herbicide applications at carrier volumes ≤140 L ha−1 is incomplete. Likewise, no data exist documenting S. molesta control with unoccupied aerial application systems (UAAS). Following the recent >100-ha incursion of S. molesta in Gapway Swamp, NC, a case study was developed to provide guidance for ongoing management efforts. In total, three field trials evaluated registered aquatic and experimental herbicides using a 140 L ha−1 carrier volume. Select foliar applications from UAAS were also evaluated. Results at 8 wk after treatment (WAT) indicated the experimental protoporphyrinogen oxidase inhibitor, PPO-699-01 (424 g ai ha−1), in combination with endothall dipotassium salt (2,370 g ae ha−1) provided 78% visual control, whereas control when PPO-699-01 (212 g ai ha−1) was applied alone was lower at 35%. Evaluations also showed diquat (3,136 g ai ha−1) alone, glyphosate (4,539 g ae ha−1) alone, and metsulfuron-methyl (42 g ai ha−1) alone achieved 86% to 94% visual plant control at 8 WAT. Sequential foliar applications of diquat, flumioxazin (210 g ai ha−1), and carfentrazone (67 g ai ha−1) at 6 wk following exposure to in-water fluridone treatments were no longer efficacious by 6 WAT due to plant regrowth. Carfentrazone applications made from a backpack sprayer displayed greater control than applications made with UAAS deploying identical carrier volumes at 2 WAT; however, neither application method provided effective control at 8 WAT. Additional field validation is needed to further guide management direction of S. molesta control using low carrier volume foliar applications.
Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact.
Methods:
We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations.
Results:
BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI.
Conclusions:
We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.
Invasive aquatic plants constantly threaten freshwaters and associated environs globally. Water resource managers frequently seek new control tactics to combat invasive macrophytes, especially when the availability of herbicides registered for submersed plant control is limited. The synthetic auxin herbicide, florpyrauxifen-benzyl, recently registered (2018) for aquatic site applications in the United States, has shown success in controlling several invasive aquatic weeds. Studies were conducted to evaluate responses of native and invasive submersed plants to florpyrauxifen-benzyl under growth chamber conditions to provide insight on the selectivity of varying herbicide concentrations in New Zealand. Florpyrauxifen-benzyl concentrations evaluated ranged from 0.01 to 107.86 µg ai L−1, encompassing the maximum use concentration (48 µg L−1) for submersed plant applications. Dose–response metrics indicated the New Zealand native species watermilfoil [Myriophyllum triphyllum Orchard] was highly sensitive to florpyrauxifen-benzyl following a 21-d static exposure, having a dry weight 50% effective concentration (EC50) value of 1.2 µg L−1. The invasive species oxygen-weed [Lagarosiphon major (Ridley) Moss] and Canadian waterweed (Elodea canadensis Michx.) were less sensitive, with dry weight EC50 values of 35.4 and >107.86 µg L−1, respectively. Brazilian waterweed (Egeria densa Planch.) was most tolerant to the tested concentrations, as EC50 values were not achieved. Overall, results indicate florpyrauxifen-benzyl demonstrates potential for controlling L. major, with further large-scale screening required to confirm control among field site applications. As the native species (M. triphyllum) was most sensitive to florpyrauxifen-benzyl compared with the invasive plant evaluated (I/N ratio indicated >31.3 times more sensitive), any targeted concentration used for invasive plant control for field applications would likely injure the native M. triphyllum plants. Future studies should investigate additional native and invasive species for management guidance and consider how exposure times influence plant response using similar florpyrauxifen-benzyl concentrations tested in the present study.
Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2–4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a Neutron Star Extreme Matter Observatory (NEMO): a gravitational-wave interferometer optimised to study nuclear physics with merging neutron stars. The concept uses high-circulating laser power, quantum squeezing, and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above 1 kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year and potentially allow for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.
Since Sydney Shoemaker published his seminal article ‘Self-Reference and Self-Awareness’ in 1968, the notion of ‘Immunity to Error through Misidentification’ (IEM) has received much attention. It crops up in discussions of personal identity, indexical thought and introspection, and has been used to interpret remarks made by philosophers from Wittgenstein to William James. The precise significance of IEM is often unspecified in these discussions, however. It is unclear, for example, whether it constitutes an important status of judgments, whether it explains an important characteristic of judgments, or whether it merely marks an important characteristic of judgments. Nevertheless, reference to IEM abounds, making this obscure notion seem all the more significant.
‘Where am I?’ This is something we might expect to hear from hapless explorers or academics with no sense of direction. If we can, we'll explain to our inquirer that he is east of East St. Louis and hope he can find his way from there. If he persists, insisting that he is not really lost, but only cannot find himself no matter how hard he looks, we might reasonably suspect that we are dealing with that peculiarly incorrigible academic explorer, the philosopher. When we hesitantly point to his body, we hear him explain, exasperated, ‘No, don't you get it? That's my body, but I’m looking for my self! And I cannot find it!’ At this point it is tempting to slip away, convinced that our philosophical friend is throttling himself with the noose of his own cleverness and is at risk of intellectual suicide by denying that he in fact has a self. Nevertheless, we shouldn't turn away so quickly: some pretty ingenious people from radically diverse schools of thought have endorsed the claim that the self ineluctably evades detection.
Frank Jackson’s knowledge argument is naturally viewed as a more precise version of Thomas Nagel’s argument in “What Is It Like to Be a Bat.” In particular, Jackson directed our attention to the challenge phenomenal knowledge poses for physicalism. Viewed this way, the knowledge argument focuses more on the question of “what it’s like to echolocate” than what it’s like to be a bat. The worry, to put it a more Nagelian way, is that the nature of phenomenal states escapes the objective picture of the world provided by our best sciences. I think there is another strand of Nagel’s argument that often gets ignored and that could be made clearer by a corollary to Jackson’s knowledge argument. This strand sticks a little closer to Nagel’s original question, and directs us to think about what it is like to be, or to have, a self. Just as in Jackson’s original argument, there can be much debate about what the implications of this corollary argument are – whether the implications are metaphysical or not; whether the argument even gets off the ground, etc. But I think the knowledge argument about the self is worth setting forth nonetheless, if only to get a little clearer about something else that might seem to be missing from the objective point of view.
Treatment for hoarding disorder is typically performed by mental health professionals, potentially limiting access to care in underserved areas.
Aims
We aimed to conduct a non-inferiority trial of group peer-facilitated therapy (G-PFT) and group psychologist-led cognitive–behavioural therapy (G-CBT).
Method
We randomised 323 adults with hording disorder 15 weeks of G-PFT or 16 weeks of G-CBT and assessed at baseline, post-treatment and longitudinally (≥3 months post-treatment: mean 14.4 months, range 3–25). Predictors of treatment response were examined.
Results
G-PFT (effect size 1.20) was as effective as G-CBT (effect size 1.21; between-group difference 1.82 points, t = −1.71, d.f. = 245, P = 0.04). More homework completion and ongoing help from family and friends resulted in lower severity scores at longitudinal follow-up (t = 2.79, d.f. = 175, P = 0.006; t = 2.89, d.f. = 175, P = 0.004).
Conclusions
Peer-led groups were as effective as psychologist-led groups, providing a novel treatment avenue for individuals without access to mental health professionals.
Declaration of interest
C.A.M. has received grant funding from the National Institutes of Health (NIH) and travel reimbursement and speakers’ honoraria from the Tourette Association of America (TAA), as well as honoraria and travel reimbursement from the NIH for serving as an NIH Study Section reviewer. K.D. receives research support from the NIH and honoraria and travel reimbursement from the NIH for serving as an NIH Study Section reviewer. R.S.M. receives research support from the National Institute of Mental Health, National Institute of Aging, the Hillblom Foundation, Janssen Pharmaceuticals (research grant) and the Alzheimer's Association. R.S.M. has also received travel support from the National Institute of Mental Health for Workshop participation. J.Y.T. receives research support from the NIH, Patient-Centered Outcomes Research Institute and the California Tobacco Related Research Program, and honoraria and travel reimbursement from the NIH for serving as an NIH Study Section reviewer. All other authors report no conflicts of interest.
I argue, contrary to Dennis Schulting in Kant’s Radical Subjectivism, that the main reasoning of Kant’s transcendental deduction of the categories is progressive, not regressive. Schulting is right, however, to emphasize that the deduction takes the object cognized to be constituted in an idealism-entailing way. But his reasoning has gaps and bypasses Kant’s most explicit deduction argument, independent of the Transcendental Aesthetic, for idealism. Finally, Schulting’s claim that Kantian discursivity itself requires idealism overlooks the fact that Kantian general judgements can be true in a domain of objects without being specifically of or about any particular ones of those objects.
What sorts of things undergird a person's character and what does the answer tell us about the person's relationship to her body, her environment, and the people who surround her? For the purpose of ascribing virtue, vice, and character, what are the boundaries of the person? Traditionally, philosophers have accepted mentalism, the view that only mental features are relevant to character. Even philosophers inclined to say that character is partially constituted by nonmental features would be inclined to accept skindividualism: a person's virtue must involve a disposition that is wholly grounded by features inside the person's skin. Drawing from arguments in the philosophy of mind and data from social psychology, I argue that skindividualism is wrong. Virtues can be extended, in the sense that the grounds for a person's virtues might not be inside that individual's skin. If this is the case, persons are not skindividuals.
Oocyte donation has been used to treat human infertility for nearly 30 years, and remains particularly popular in helping women of advanced reproductive age, yet it also poses ethical concerns. Due to increasing demand and undersupply of available oocyte (or egg) donors, a niche business has developed in which “agencies” assist physician practices in advertising, recruiting, screening and even “matching” donors to recipients in need of such services. The advent of the Internet has increased the number and visibility of these services, creating a market in which programs bid for women perceived as having desired traits and superior pedigrees. A few questionable ethical aspects of these agencies have been examined by ourselves and others, including patterns of monetary compensation that directly conflict with the American Society for Reproductive Medicine's (ASRM) ethical guidelines, but many questions remain unexamined.
For-profit agencies that recruit and often match egg donors with intended parents exist alongside licensed, professional fertility clinics that actually perform the medical procedures.
Three new species of inadunate crinoids of Early Mississippian age from the Ramp Creek Formation along Indiana Creek, southern Montgomery County, Indiana, are described. Poteriocrinites amplus n. sp. is the first correctly identified record from North America of this long-ranging Old World genus. Poteriocrinites macropleurus and P. doris from the Burlington Limestone are here reassigned to Springericrinus. Interchange of Mississippian crinoid genera between Europe and North America is rare, many genera being endemic. Springericrinus sacculus n. sp. is the youngest reported species of this North American counterpart of Poteriocrinites. This new species exhibits two advanced features: presence of only one, rather than three, anal plate, and presence of 3 or 4, rather than 1 or 2, primibrachial plates per ray. The third species, Decadocrinus stellatus n. sp., presents an interesting blend of characters usually used as generic discriminators between Decadocrinus and Histocrinus. The specimen could possibly be considered to be an intermediate between these two genera that are currently placed, incorrectly we believe, in two separate superfamilies.
This study provides the first systematic account of word-final cluster acquisition in bilingual children. To this end, forty Welsh–English bilingual children differing in language dominance and age (2;6 to 5;0) participated in a picture-naming task in English and Welsh. The results revealed significant age and dominance effects on cluster acquisition, with greater overall accuracy on the English clusters. Interestingly, although the Welsh-dominant children outperformed the English-dominant ones on the Welsh clusters, they did not exhibit a concomitant lag on the English clusters. It is argued that this asymmetry is a direct reflection of the sociolinguistic situation in Wales with English as the majority language and Welsh the minority language. The study also revealed accelerated rates of acquisition for English clusters compared with age-matched monolinguals reported elsewhere (Templin, 1957), thereby supporting claims that bilingual contexts may have a facilitative effect on phonological acquisition (Goldstein & Bunta, 2012; Grech & Dodd, 2008).