This project surveyed Veterans’ COVID-19 vaccination beliefs and status. 1,080 (30.8%) Veterans responded. Factors associated with being unvaccinated, identified using binomial logistic regression, included negative feelings about vaccines (OR = 3.88, 95%CI = 1.52, 9.90) and logistical difficulties such as finding transportation (OR = 1.95, 95%CI = 1.01, 3.45). This highlights the need for education about and access to vaccination.

Some supporters of religious slaughter methods claim that efficiency of bleed-out is adversely affected by stunning. Our previous study carried out in sheep at an abattoir comparing the Muslim method of slaughter without stunning with pre-slaughter stunning using a captive bolt or by electrical methods concluded that bleed-out is not adversely affected by stunning, nor improved by a neck cut without stunning. In this paper, a similar study carried out in cattle is reported. In this study, captive bolt stunning followed by neck cutting was compared with the Muslim slaughter method without stunning. The total blood loss, percentage blood loss expressed as a percentage of live weight and percentage loss of estimated total blood were calculated and compared between each group. In addition, the time periods taken to reach 25, 50, 75 and 90% of total blood loss were also calculated. There was no significant difference between the two stunning groups for any of these blood loss variables. The results, subjected to statistical analyses, also showed no apparent difference in the PCV levels and meat quality parameters between treatments. These results confirm the findings with sheep and show that the bleed-out is not adversely affected by captive bolt stunning, nor improved by a neck cut without stunning in cattle. It is anticipated that these findings may help promote the use of stunning methods during Halal slaughter.

Better control of highly pathogenic avian influenza (HPAI) outbreaks requires deeper understanding of within-flock virus transmission dynamics. For such fatal diseases, daily mortality provides a proxy for disease incidence. We used the daily mortality data collected during the 2015 H5N2 HPAI outbreak in Minnesota turkey flocks to estimate the within-flock transmission rate parameter (β). The number of birds in Susceptible, Exposed, Infectious and Recovered compartments was inferred from the data and used in a generalised linear mixed model (GLMM) to estimate the parameters. Novel here was the correction of these data for normal mortality before use in the fitting process. We also used mortality threshold to determine HPAI-like mortality to improve the accuracy of estimates from the back-calculation approach. The estimated β was 3.2 (95% confidence interval (CI) 2.3–4.3) per day with a basic reproduction number of 12.8 (95% CI 9.2–17.2). Although flock-level estimates varied, the overall estimate was comparable to those from other studies. Sensitivity analyses demonstrated that the estimated β was highly sensitive to the bird-level latent period, emphasizing the need for its precise estimation. In all, for fatal poultry diseases, the back-calculation approach provides a computationally efficient means to obtain reasonable transmission parameter estimates from mortality data.

We report the discovery in the Greenland ice sheet of a discrete layer of free nanodiamonds (NDs) in very high abundances, implying most likely either an unprecedented influx of extraterrestrial (ET) material or a cosmic impact event that occurred after the last glacial episode. From that layer, we extracted n-diamonds and hexagonal diamonds (lonsdaleite), an accepted ET impact indicator, at abundances of up to about 5×106 times background levels in adjacent younger and older ice. The NDs in the concentrated layer are rounded, suggesting they most likely formed during a cosmic impact through some process similar to carbon-vapor deposition or high-explosive detonation. This morphology has not been reported previously in cosmic material, but has been observed in terrestrial impact material. This is the first highly enriched, discrete layer of NDs observed in glacial ice anywhere, and its presence indicates that ice caps are important archives of ET events of varying magnitudes. Using a preliminary ice chronology based on oxygen isotopes and dust stratigraphy, the ND-rich layer appears to be coeval with ND abundance peaks reported at numerous North American sites in a sedimentary layer, the Younger Dryas boundary layer (YDB), dating to 12.9 ± 0.1 ka. However, more investigation is needed to confirm this association.

A synthetic data set was created by incorporating results from previously published papers on antagonistic and synergistic herbicide interactions between two herbicides applied as a tank mixture or sequentially, and then analyzed on the basis of various properties of the herbicides and target plants. Generally, interactions between herbicides were antagonistic more frequently than synergistic. This trend held no matter whether the interacting herbicides were absorbed by the same or different parts of the plant, had the same or different translocating abilities, had the same or different modes of action, and regardless of whether the target plants were annual or perennial plants, or crops or weeds. Antagonistic interactions occurred much more frequently when the target plants were monocot than dicot, and in the Compositae, Gramineae, or Leguminosae than in the Chenopodiaceae or Convolvulaceae families.

The performance of a mechanistic simulation model of crop-weed competition was tested with data on the critical period of weed competition in sugarbeets and both seeded and transplanted tomatoes. In general, there was good agreement between simulated and observed yields for different periods of weed interference in each crop. The model was then used to evaluate the influence of weed density, weed height, and weather conditions on timing of the critical period. Simulations suggested that the greater the weed density, the shorter the period of time that the crop could tolerate early-season competition, and the longer the period of time that the crop must be kept weed free to prevent yield losses. Simulations also suggested that the length of time that a crop can tolerate early-season weed competition is related more to the availability of soil moisture, or possibly essential nutrients, than to light limitations.

The critical period of weed interference in transplanted tomatoes (Lycopersicon esculentum Mill. 'Springset’) was from 28 to 35 days after transplanting. A single weeding during this period was sufficient to prevent yield reductions. A growth analysis revealed that significant differences in plant dry weight and fruit number between tomatoes from weed-free and weed-infested plots were not apparent until 56 to 70 days after transplanting. The shorter the initial weed-free period, or the longer weeds were allowed to remain in the plots before removal, the earlier reductions in tomato dry weight and fruit number appeared. Weed interference was due primarily to shading rather than water stress. Tomatoes from weed-infested plots had significantly lower stomatal conductances than those from weed-free plots, but did not differ in xylem-pressure potential or in canopy temperature. If tomatoes were kept weed-free for more than 28 days, or when weeds were present for less than 28 days after transplanting, stomatal conductances were not significantly reduced.

Reductions in yields of processing tomatoes (Lycopersicon esculentum Mill. ‘H2653’ and ‘Earlirouge′) caused by interference from eastern black nightshade (Solanum ptycanthum Dun. # SOLPT) and hairy nighthsade (S. sarrachoides Sendt. # SOLSA) were estimated for transplanted and seeded tomatoes at two locations in southern Ontario. Tomato yield losses were significantly greater in seeded than in transplanted tomatoes. Stomatal conductance and transpiration rates of seeded tomatoes decreased more rapidly with increased nightshade density than did those of transplanted tomatoes. Percent yield losses also differed between sites. Seeded tomatoes grown at high density in twin rows (33 300 and 45 000 plants/ha) had higher yields and lower percent yield losses than did tomatoes grown at low density in single rows (12 500 to 22 500 plants/ha). Nightshade dry weight and seed production decreased per plant but increased per unit area with increasing nightshade density. Nightshade dry weights and seed production did not vary with site or method of tomato establishment. A hyperbolic model provided an excellent fit to data on both tomato yield losses and nightshade seed production as a function of nightshade density.

Crop rotation is thought to reduce weed density and maintain species diversity, thus preventing the domination of a few problem weeds. Because cropping sequence dictates other agricultural management practices, variations in weed populations between cropping systems may be the direct result of crop rotation, the result of different weed management practices associated with crop rotation, or both. Studies that fail to separate the effects of crop rotation from weed management may generate misleading results. A 10-yr crop rotation study was undertaken to study the dynamics of the standing weed vegetation in Zea mays L., Glycine max L., and Triticum aestivum L. The present paper compared total weed density and diversity between monocultures and rotations under three levels of weed management. Weed management accounted for 37.9% of the variation in total weed density, whereas crop rotation accounted for only 5.5%. Weed density varied between monocultures and rotations in plots where herbicides were applied. The effectiveness of rotations in reducing weed density was dependent upon the crop. Margalef's species richness index (DMG), a measure of diversity, varied among weed management strategies, with 38.4% of the variance attributed to this factor. In the 10th year, when all plots were sown with Z. mays, few cumulative effects of crop rotation were apparent, with two exceptions. In weedy and herbicide-treated plots, weed density was higher on plots cropped with Z. mays the previous year. Also, under these weed management treatments, including a cereal in the crop rotation reduced weed density. Crop rotation, when used in combination with herbicides, provides additional weed control and is therefore an effective tool in integrated weed management.

Effects of soil pH on growth, competitive ability, and leaf nutrient content of corn (Zea mays L.), Powell amaranth (Amaranthus powellii S. Wats. ♯ AMAPO), velvetleaf (Abutilon theophrasti Medic. ♯ ABUTH), and green foxtail [Setaria viridis (L.) Beauv. ♯ SETVI] were measured in the field. Corn yields were significantly reduced by weed competition at all pH levels, but leaf nutrient content, as a percentage of dry weight, was not affected. Aboveground dry weights of Powell amaranth and velvetleaf were significantly lower at pH 4.8 than at pH 6.0 or 7.3, whereas growth of green foxtail was greater at pH 4.8 than at pH 7.3. Weed competitive ability, as evidenced by reductions in dry weight, varied with soil pH and companion plant. Powell amaranth and velvetleaf had higher levels of S, Zn, and especially Mn, at pH 4.8 than at pH 7.3. N and K in the leaf tissue were greater in the weed species than in corn at all soil pH levels. The dicot species had higher percentages of Ca and Mg in leaf tissue at all soil pH levels and accumulated higher percentages of Mn at low pH than the monocot species.

The performance of a mechanistic simulation model of crop-weed competition was evaluated with data on the effects of weed density, relative time of weed emergence, and environmental conditions on crop yield for three different crop-weed combinations. Reductions in crop yields due to weed competition were simulated accurately for all experiments, except for one case in which severe water stress combined with weed competition altered crop morphological development (height and leaf area). The mechanistic model was then used to assess the potential and constraints of two empirical models of crop-weed competition, one based upon weed density and relative time of emergence, and the other on relative leaf area. The empirical model describing the relationship between relative leaf area of the weeds shortly after crop emergence and yield loss appeared to have several advantages for management applications, whereas the mechanistic model is more suited for research purposes.

A 3-yr study was conducted on nine farms across southern Ontario to evaluate the risks and benefits of different approaches to weed management in corn and soybean. Weed control decisions were based on field scouting and recommendations from the Ontario version of HADSS™, the herbicide application decision support system. Treatments were selected to maximize profit (economic threshold approach) or to maximize yield (highest treatment efficacy). Reduced rates of the high efficacy treatment for each field also were included. Weed density before and after treatment, crop yields, weed seed return, and the effect of weed control decisions on weed density 1 yr after treatment were assessed. Crop yield varied among years and farms but was not affected by weed control treatment. Weed control at 28 d after treatment (DAT) was often lower and weed density, biomass, and seed production 70 DAT were often higher with the profit maximization approach compared with the yield maximization approach. However, weed density 1 yr later, after each cooperator had applied a general weed control program, did not vary significantly among the previous year's weed control treatments. Reduced rates of the high efficacy treatments did not lead to increased weed problems the next year, despite lower weed control and increased weed seed production in some years. During the 3 yr of the study, weed control costs with the profit maximization approach were approximately Can$45/ha less than with the yield maximization approach.

Field studies were conducted over 3 yr at two locations to evaluate the effects of glyphosate rate and application timing on barnyardgrass control, seed production, seed viability, and seedbank density the year after herbicide application in glyphosate-resistant corn. Glyphosate was applied at 0, 112, 225, 450, 675, or 900 g ai/ha when barnyardgrass was at the two-, four-, or six-leaf stage of growth. Visual estimates of percent control increased whereas density, dry weight, seed production, and seedbank density the year after treatment decreased as the rate of glyphosate was increased from 0 to 450 g/ha. Increasing the rate of glyphosate from 450 to 900 g/ha (registered rate) had no further effect on any measured parameter. Seed viability was not affected by glyphosate rate nor application timing. Corn yield declined only at a glyphosate rate of 225 g/ha and below. Barnyardgrass control improved as application was delayed to the six-leaf stage because this weed had an extended period of emergence. There was no interaction between glyphosate rate and application timing on any parameter, and yield was not affected by glyphosate-application timing. The use of extremely low glyphosate rates (112 or 225 g/ha) resulted in reduced corn yields, increased barnyardgrass seed production, and seedbank density the year after application.

The objectives of this study were to determine the efficacy and risk of controlling weeds at reduced herbicide rates under various environmental and biotic conditions, through analysis of published data on the use of below-labeled rates of herbicides. A database was established by extracting information from previously published papers on weed control at below-labeled rates of herbicides in crop production systems over large geographical and temporal scales. The database was then analyzed to evaluate the efficacy and risk of using herbicides at various reduced rates under different management systems. Using below-labeled herbicide rates in conjunction with interrow cultivation is an effective way of reducing herbicide input in agricultural systems while maintaining satisfactory weed control. There are greater opportunities for herbicide reduction using preemergence (PRE) than preplant incorporated (PPI) or postemergence (POST) herbicides, in coarse-textured than in fine-textured soils, and in corn than in soybean or wheat. The success of reducing herbicide rates does not depend on whether the herbicides are applied in conventional or conservation tillage systems or whether they are used with or without adjuvants. The above conclusions are based on studies conducted in experimental fields where weed pressures may be subjectively chosen to be high. Greater potential for herbicide reduction may exist at locations or in cropping systems were weed pressure is low.

Field studies were conducted over 3 yr at two locations to evaluate the effect of glyphosate rate and time of application on common lambsquarters control, density, dry weight, seed production, and the number of seedlings emerging from soil cores taken the year after herbicide application in glyphosate-resistant corn. Glyphosate was applied at 0, 112, 225, 450, 675, or 900 g ai/ha when common lambsquarters were at the two-, four-, or six-leaf stage of growth. Nicosulfuron was applied to all experimental areas to control annual grasses. Visual estimates of percent control increased, whereas density, dry weight, seed production, and seedlings emerging the year after treatment decreased as the rate of glyphosate was increased from 0 to 450 g/ha. Increasing the glyphosate rate above 450 g/ha had little effect on these parameters. Corn yield declined only at glyphosate rates below 450 g/ha. Time of application had no effect on common lambsquarters control and corn yield because little emergence occurred after the first glyphosate application. There was no interaction between glyphosate rate and time of application for any of the parameters evaluated. In these studies, the application of glyphosate at half the manufacturer's registered rate provided control of common lambsquarters equivalent to the full-registered rate with no measured increase in weed seed production and no increase in weed seedlings emerging from soil cores the year after herbicide application. The results suggest that in some cases the use of reduced herbicide rates can provide excellent weed control and maintain crop yields, while reducing the cost of production and the environmental impact of herbicides. The use of extremely low rates (112 or 225 g/ha), however, resulted in reduced corn yields, increased common lambsquarters seed production and seedlings emerging the year after application, and possibly increased weed management costs in subsequent years.

Background: There are no disease modifying agents for the treatment of Alzheimer’s disease (AD). Pathologically, AD is associated with the misfolding of two peptides: beta-amyloid (plaques) and tau (tangles). Methods: Using large-scale computer simulations, we modelled the misfolding of both beta-amyloid and tau, identifying a common conformational motif (CCM; i.e. an abnormal peptide shape), present in both beta-amyloid and tau, that promotes their misfolding. We screened a library of 11.8 million compounds against this in silico model of protein misfolding, identifying three novel molecular classes of putative therapeutics as anti-protein misfolding agents. We synthesized approximately 400 new chemical entity drug-like molecules in each of these three classes (i.e. 1200 potential drug candidates). These were comprehensively screened in a battery of five in vitro protein oligomerization assays. Selected compounds were next evaluated in the APP/PS1 doubly transgenic mouse model of AD. Results: Two new classes of molecules were identified with the ability to block the oligomerization of both beta-amyloid and tau. These compounds are drug-like with good pharmacokinetic properties and are brain-penetrant. They exhibit excellent efficacy in transgenic mouse models. Conclusion: Computer aided drug design has enabled the discovery of novel drug-like molecules able to inhibit both tau and beta-amyloid misfolding.

Since the publication of “A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals” in 2008, prevention of healthcare-associated infections (HAIs) has become a national priority. Despite improvements, preventable HAIs continue to occur. The 2014 updates to the Compendium were created to provide acute care hospitals with up-to-date, practical, expert guidance to assist in prioritizing and implementing their HAI prevention efforts. They are the product of a highly collaborative effort led by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), the American Hospital Association (AHA), the Association for Professionals in Infection Control and Epidemiology (APIC), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise, including the Centers for Disease Control and Prevention(CDC), the Institute for Healthcare Improvement (IHI), the Pediatric Infectious Diseases Society (PIDS), the Society for Critical Care Medicine (SCCM), the Society for Hospital Medicine (SHM), and the Surgical Infection Society (SIS).

Since the publication of “A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals” in 2008, prevention of healthcare-associated infections (HAIs) has become a national priority. Despite improvements, preventable HAIs continue to occur. The 2014 updates to the Compendium were created to provide acute care hospitals with up-to-date, practical, expert guidance to assist in prioritizing and implementing their HAI prevention efforts. They are the product of a highly collaborative effort led by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), the American Hospital Association (AHA), the Association for Professionals in Infection Control and Epidemiology (APIC), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise, including the Centers for Disease Control and Prevention (CDC), the Institute for Healthcare Improvement (IHI), the Pediatric Infectious Diseases Society (PIDS), the Society for Critical Care Medicine (SCCM), the Society for Hospital Medicine (SHM), and the Surgical Infection Society (SIS).

Infect Control Hosp Epidemiol 2014;35(8):967–977

Winter barley cv. Igri, winter wheat cv. Avalon and spring wild oats (Avena fatua) were studied in monocultures in pots and in the field. The field experiments were located near Bristol and Bury St Edmunds in 1988/89. Pot sowings were monthly, whereas there was a single sowing date for each of the two field locations. Base temperatures for emergence in pots were 2·2, 1·3 and 2·3 °C for barley, wheat and A. fatua respectively. Barley was consistently the fastest to emerge. Leaf number was strongly correlated with photothermal time from emergence, with barley producing leaves at the greatest rate. Base temperatures for leaf appearance were −6, −5 and −3 °C for barley, wheat and A. fatua respectively. The field studies confirmed the ranking of the species based on the pot experiments. Both a model based on photothermal time and one based on rate of change of daylength at emergence gave good descriptions of the data. It is argued that correlations of rates of development with individual environmental variables are not sufficient to deduce the underlying mechanisms.