We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The coronavirus pandemic has led to sudden changes in the lives of people around the world. The health threat, earthquakes and epidemiological measures caused certain psychological reactions in everyone. Psychiatric patients are particularly vulnerable to stress, so we were interested in how the changes at the beginning of the pandemic affected their psychological functioning.
Objectives
To check changes in some areas of psychological functioning of outpatient psychiatric patients after the “lockdown” in 2020 and to examine their connection with some sociodemographic and treatment variables.
Methods
Patients of the University Psychiatric Hospital Sveti Ivan filled out a survey questionnaire designed for the purpose of research, which consisted of sociodemographic data and items examining different areas of psychological functioning, when they arrived for an outpatient check-up.
Results
Variables were formed that examine: changes in unpleasant emotions, lack of support, lack of social interaction, changes in performing daily duties, changes in self-help behaviors and health concerns. Statistical analysis showed a significant increase in all variables, with the largest occurring in lack of social interaction, health concerns, and unpleasant emotions. The predictors of changes in psychological functioning were female gender, younger age in combination with cohabitation with parents, and the number of hospitalizations.
Conclusions
After the “lockdown” in 2020, psychiatric patients report a deterioration in psychological functioning.
The Quaternary carbonatite–nephelinite Kerimasi volcano is located within the Gregory rift in northern Tanzania. It is composed of nephelinitic and carbonatitic pyroclastic rocks, tuffs, tuff breccias and pyroclastic breccias, which contain blocks of different plutonic (predominantly ijolite) and volcanic (predominantly nephelinite) rocks including carbonatites. The plutonic and volcanic carbonatites both contain calcite as the major mineral with variable amounts of magnetite or magnesioferrite, apatite and forsterite. Carbonatites also contain accessory baddeleyite, kerimasite, pyrochlore and calzirtite. Zr and Nb minerals are rarely observed in rock samples, though they are abundant in eluvial deposits of carbonatite tuff/pyroclastic breccias in the Loluni and Kisete craters. Pyrochlore, ideally (CaNa)Nb2O6F, occurs as octahedral and cubo-octahedral crystals up to 300 μm in size. Compositionally, pyrochlore from Loluni and Kisete differs. The former is enriched in U (up to 19.4 wt.% UO2), light rare earth elements (up to 8.3 wt.% LREE2O3) and Zr (up to 14.4 wt.% ZrO2), and the latter contains elevated Ti (up to 7.3 wt.% TiO2). All the crystals investigated were crystalline, including those with high U content (a = 10.4152(1) Å for Loluni and a = 10.3763(1) Å for Kisete crystals). They have little or no subsolidus alteration nor low-temperature cation exchange (A-site vacancy up to 1.5% of the site), and are suitable for single-crystal X-ray diffraction analysis (R1 = 0.0206 and 0.0290; for all independent reflections for Loluni and Kisete crystals, respectively). Observed variations in the pyrochlore composition, particularly Zr content, from the Loluni and Kisete craters suggest crystallisation from compositionally different carbonatitic melts. The majority of pyrochlore crystals studied exhibit exceptionally well-preserved oscillatory- and sometimes sector-type zoning. The preferential incorporation of smaller and higher charged elements into more geometrically constrained sites on the growing surfaces explains the formation of the sector zoning. The oscillatory zoning can be rationalised by considering convectional instabilities of carbonatite magmas during their emplacement.
Psychosis spectrum disorder has a complex pathoetiology characterised by interacting environmental and genetic vulnerabilities. The present study aims to investigate the role of gene–environment interaction using aggregate scores of genetic (polygenic risk score for schizophrenia (PRS-SCZ)) and environment liability for schizophrenia (exposome score for schizophrenia (ES-SCZ)) across the psychosis continuum.
Methods
The sample consisted of 1699 patients, 1753 unaffected siblings, and 1542 healthy comparison participants. The Structured Interview for Schizotypy-Revised (SIS-R) was administered to analyse scores of total, positive, and negative schizotypy in siblings and healthy comparison participants. The PRS-SCZ was trained using the Psychiatric Genomics Consortiums results and the ES-SCZ was calculated guided by the approach validated in a previous report in the current data set. Regression models were applied to test the independent and joint effects of PRS-SCZ and ES-SCZ (adjusted for age, sex, and ancestry using 10 principal components).
Results
Both genetic and environmental vulnerability were associated with case-control status. Furthermore, there was evidence for additive interaction between binary modes of PRS-SCZ and ES-SCZ (above 75% of the control distribution) increasing the odds for schizophrenia spectrum diagnosis (relative excess risk due to interaction = 6.79, [95% confidential interval (CI) 3.32, 10.26], p < 0.001). Sensitivity analyses using continuous PRS-SCZ and ES-SCZ confirmed gene–environment interaction (relative excess risk due to interaction = 1.80 [95% CI 1.01, 3.32], p = 0.004). In siblings and healthy comparison participants, PRS-SCZ and ES-SCZ were associated with all SIS-R dimensions and evidence was found for an interaction between PRS-SCZ and ES-SCZ on the total (B = 0.006 [95% CI 0.003, 0.009], p < 0.001), positive (B = 0.006 [95% CI, 0.002, 0.009], p = 0.002), and negative (B = 0.006, [95% CI 0.004, 0.009], p < 0.001) schizotypy dimensions.
Conclusions
The interplay between exposome load and schizophrenia genetic liability contributing to psychosis across the spectrum of expression provide further empirical support to the notion of aetiological continuity underlying an extended psychosis phenotype.
The aim of this review paper is to review the data on tea tree (Melaleuca alternifolia) as an antimicrobial, antioxidant and acaricidal in poultry production. Tea tree exhibits a wide spectrum of antimicrobial activities with minimal inhibitory concentrations between 0.12 and 4 mg/ml. Its modes of action against Gram-negative bacterium Escherichia coli (0.12 to 1.5 mg/ml), Gram-positive bacterium Staphylococcus aureus (0.12 to 1 mg/ml), Aspergillus fumigatus (1.78 mg/ml) and yeast, Candida albicans (0.05 to 0.5 mg/ml) have been investigated using a range of different methods. As an antimicrobial, tea tree has high antifungal, bacteriostatic and germicidal activity (e.g. a decrease of 73.8% in Candida sp.), because of its components such as terpinen-4-ol, α-terpineol, linalool, α-pinene, β-pinene, β-myrcene and 1,8-cineole. Its bioactive compounds such as α-terpinene, α-terpinolene and γ-terpinene show high antioxidant activity when applied in concentrations of 100 and 200 µl/ml, while its essential oils demonstrated free radical scavenging activity of 60 to 80%. Tea trees insecticidal and acaricidal properties have been tested for tick control. The mortality of ticks (Ixodes ricinus) and poultry red mites (Dermanyssus gallinae) have been recorded at levels over 60% and 80%, respectively, when used in concentrations of 0.15 to 0.30 mg/cm2 during in vitro testing, and in vivo, when sprayed in poultry houses. When tea tree was used in a form of essential oils as a dietary supplement in concentrations of 50 to 150 mg/kg in broiler chicken diets, a significant increase in daily weight (by around 7%) and decrease in morbidity and mortality were seen. Additionally, when applied in laying hen nutrition, a significant increase in daily egg production has been recorded. Tea tree essential oils when supplemented in poultry diets have high positive effects regarding productivity performance, but this requires further field experiments to clarify standardisation of the material and effective inclusion levels.
This paper presents results from comparative thermogravimetric, calorimetric and pozzolanic activity analyses of five natural zeolite samples from Bulgaria, Slovakia, Philippines, USA and North Korea. The zeolites actively participate in the hydration processes of cement. Their activity in the early stage of hydration is based mainly on the large surface area of the particles while, in the later stages of activation, chemical reactions occur between the products of the hydration of cement and the soluble SiO2 that is present in the bulk of the zeolites. It has been shown that in all cement pastes which contain zeolite additives, the quantity of portlandite is lower than that in pure cement paste or is even totally absent. The amounts of hydration products are greater when 30% zeolite is used than when 10% zeolite is added (excluding the sample with chabazite). The lowest pozzolanic activity is shown by chabazite, which possessed the lowest SiO2/Al2O2 ratio.
Fully exchanged Ag-clinoptilolite prepared at 100°C using 1 M solution of AgNO3 was studied. The initial sample (Beli Plast deposit, Bulgaria) was enriched in clinoptilolite by a sequence of treatments – crushing, sieving, sedimentation, and separation with heavy liquids to obtain a content of about 93 wt.% of clinoptilolite intergrown with opal-C. Opal-C was subsequently removed by chemical treatment. Maximum cation exchange was reached on the seventh day (4.86(4) Ag atoms per formula unit). Rietveld structural refinement was then carried out on the Ag-exchanged clinoptilolite, and three independent Ag sites were localated in the channels of the clinoptilolite structure. Seven water sites, coordinating the Ag sites, were located. Ag-clinoptilolite is, potentially, a promising low-cost antibacterial material.
Kerimasite, ideally is a new calcium zirconium silicate-ferrite member of the garnet group from the extinct nephelinitic volcano Kerimasi and surrounding explosion craters in northern Tanzania. The mineral occurs as subhedral crystals up to 100 μm in size in calcite carbonatites, and as euhedral to subhedral crystals up to 180 μm in size in carbonatite eluvium. Kerimasite is light to dark-brown in colour and transparent with a vitreous lustre. No cleavage or parting was observed and the mineral is brittle. The calculated density is 4.105(1) g/cm3. The micro-indentation, VHN25, ranges from 1168 to 1288 kg/mm2. Kerimasite is isotropic with n = 1.945(5). The average chemical formula of the mineral derived from electron microprobe analyses (sample K 94-25) and calculated for O = 12 and all Fe as Fe2O3 is (Ca3.00Mn0.01Ce0.01Nd0.01)Σ3.03(Zr1.72Nb0.14Ti0.08Mg0.02Y0.02)Σ1.98(Ti0.09)Σ3.00O12. The largest Fe content determined in kerimasite is 21.6 wt.% Fe2O3 and this value corresponds to 1.66 a.p.f.u. in the tetrahedral site. Kerimasite is cubic, space group with a = 12.549(1) Å, V = 1976.2(4) Å3 and Z = 8. The five strongest powder-diffraction lines [d in Å, (I/Io), hkl] are: 4.441 (49) (220), 3.140 (91) (400), 2.808 (70) (420), 2.564 (93) (422) and 1.677 (100) (642). Single-crystal structure refinement revealed the typical structure of the garnet-group minerals. The name is given after the locality, Kerimasi volcano, Tanzania.
Cerianite-(Ce), ideally CeO2, occurs as rounded grains up to 5 μm across in a block of highly altered calcite carbonatite lava from the Kerimasi volcano, and as euhedral crystals up to 200 μm across in carbonatite-derived eluvial deposits in the Kisete and Loluni explosion craters in the Gregory Rift, northern Tanzania. X-ray powder diffraction data (a = 5.434(5) Å) and Raman spectroscopy (minor vibration modes at 184 and 571 cm—1 in addition to a strong signal at 449 cm—1) suggest the presence of essential amounts of large cations and oxygen vacancies in the Kisete material. Microprobe analyses reveal that the mineral contains both light and heavy trivalent rare earth elements (REE) (7.9-15.5 wt.% LREE2O3 and 4.9-9.7 wt.% HREE2O3), and that it is enriched in yttrium (7.1 — 14.5 wt.% Y2O3) and fluorine (2.2—3.5 wt.%). Single-crystal structure refinement of the mineral confirms a fluorite-type structure with a cation—anion distance of 2.3471(6) Å. The cerianite-(Ce) is considered to be a late-stage secondary mineral in the carbonatitic rocks.
The present cross-sectional serosurvey constitutes the first effort to describe the varicella zoster virus (VZV) seroepidemiology in Serbia. An age-stratified serum bank of 3570 residual samples collected between 2015 and 2016 in each of the seven districts of the Vojvodina Province was tested for IgG anti-VZV antibodies with an enzyme immunoassay. Results were standardised into common units according to the European Sero-Epidemiology Network (ESEN2) methodology. Univariable and multivariable analyses were used to examine the relationships between standardised anti-VZV positivity or logarithmically transformed antibody titres and demographic features of study subjects. Seropositivity (85% overall) increased with age, in parallel with geometric mean titres. By the time of school entry, 68% of children were immune. The slower subsequent acquisition of immunity leaves epidemiologically relevant proportions of adolescents (7%), young adults (6%) and especially females of reproductive age (6%) prone to more severe forms of varicella. In the ongoing pre-vaccine era, natural infection provides a high level of collective immunity, with the highest VZV transmission in children of preschool age. The detected gaps in VZV immunity of the Serbian population support the adoption of the official recommendations for varicella immunisation of non-immune adolescents and young adults, including non-pregnant women of childbearing age.
Solar hard X-ray and gamma-ray emission was measured by BDRG instrument, the part of set of instruments operated on board the Russian satellite Lomonosov from April 2016 until now (solar-synchronous orbit with altitude 490 km, inclination of 97.6 degrees). Lomonosov measurements (11 flares with the X-ray energy more than 10 keV, and more than half of them have class in soft X-rays less than C2) were compared to the data obtained by RHESSI and Fermi space observatories as well as the Nobeyama Radioheliograph operating at the same time. The quasi-periodicity with different periods were found in some of them.
In experiments with neutral beam injection at the early stage of a Globus-M discharge, instabilities were observed that were excited by fast ions in the frequency range of 50–200 kHz, which were identified as toroidal Alfvén eigenmodes (TAE) (Petrov et al., Plasma Phys. Rep., vol. 37, 2011, pp. 1001–1005). In contradiction with the NSTX and MAST tokamaks, a regime of TAE generation was realized with strongly developed single modes. Magnetic measurements with fast Mirnov probes have shown that most of the modes have toroidal number $n=1$. The influence of the modes on the fast particle confinement was recorded by means of a tangentially directed neutral particle analyser (NPA) and neutron detector. Hydrogen and deuterium were used as target plasma and injected beam for study of the isotopic effect. At deuterium injection into the deuterium plasma, TAE led to the neutron rate dropping by 25 %, whereas NPA fluxes of high energy dropped by 75 %. At hydrogen injection, the drop in the measured NPA fluxes did not exceed 25 %.
Poultry biodiversity conservation is a great challenge for many countries. Within the last several years, the number of endangered local breeds has increased, leading to a considerable loss of genetic resources. A similar trend was observed among the poultry breeds, including chicken, local turkey and goose breeds/lines established in Bulgaria, part of which is definitely lost. Currently these breeds/lines are at risk and/or threatened with extinction. The information obtained by phenotypic characterization of these breeds is the first step for planning the management of poultry genetic resources through setting up improved selection schemes and conservation strategies. In this paper, we reviewed the current state of knowledge regarding the morphological and phenotypic diversity of local poultry breeds and some old productive poultry lines in Bulgaria.
We finish the proof of the main structure theorems for a Chevalley group G(Φ, R) of rank ≥ 2 over an arbitrary commutative ring R. Namely, we prove that for any admissible pair (A, B) in the sense of Abe, the corresponding relative elementary group E(Φ,R, A, B) and the full congruence subgroup C(Φ, R, A, B) are normal in G(Φ, R) itself, and not just normalised by the elementary group E(Φ, R) and that [E (Φ, R), C(Φ, R, A, B)] = E, (Φ, R, A, B). For the case Φ = F4 these results are new. The proof is new also for other cases, since we explicitly define C (Φ, R, A, B) by congruences in the adjoint representation of G (Φ, R) and give several equivalent characterisations of that group and use these characterisations in our proof.
The paper presents experimental investigation of flow of dusty plasma medium formed by macroparticles in argon plasma. The dependences of the coefficient of shear viscosity of such liquid on the external force causing the flow of dusty plasma liquid and on the pressure of plasma-generating gas are studied. It is found that the viscosity of the dusty plasma medium decreases with increasing shear stress and increases with increasing pressure of buffer gas. An experimental investigation of the dynamics of macroparticles in an unperturbed liquid dusty plasma medium as a function of coupling parameter is performed; in so doing, formations of particles whose motion is correlated are observed in the region of high values of coupling parameter. It is assumed that the non-Newtonian pattern of dusty plasma liquid may be due to the emergence of crystal-like dusty plasma clusters in the ‘liquid’ phase. An experimental investigation of a crystalline dusty plasma structure under the effect of laser radiation is performed; in so doing, a macroscopic flow of the crystalline dusty plasma structure is observed under the effect of shear stress. The mechanism of formation and subsequent annihilation of edge misfit dislocations is observed and the threshold pattern of such flow is established; the threshold value of power of laser radiation is determined.
Site studies have proved Dome C to be an excellent site for optical interferometry, maybe the only possible site on Earth for the deployement of a large post-VLTI interferometric facility, like KEOPS. Indeed, recent studies have shown the possiblity of interferometric observations of faint objects, high sensitivity and high precision observations, direct imaging and nulling interferometry. However the achievement of this ambitious project assumes the pavement of aroadmap, including different steps. The first one should be a demonstrator, called Mykerinos. Mykerinos is a diluted aperture interferometer composed of at least two light collecting units with a baseline between 40 to 100 m (or more) consisting of 50 cm diameter telescopes. The telescope design is directly derived from our Laboratory's experience in the ASTEP experiment. Mykerinos will be equipped with a dual field focal instrument which is a pre-requisite for its site testing, as well as for its science demonstration purposes.
A construction and exploitation of a comparatively large I photodissociation laser system (Perun) is reported. This system was constructed in cooperation between the Institute of Physics of Czechoslovak Academy of Science in Prague and the Lebedev Institute of Physics of Soviet Academy of Science in Moscow. The laser produces subnanosecond pulses of maximum 50 J and 0·5 ns in duration. Although the pumping time by Xe flashlamps is long enough for an acoustic disturbance released in the active medium to introduce an optical inhomogeneity across the whole cross section of the laser tube, the radiation can be focused in a focal spot of a power density exceeding 1014 W/cm2, enough for meaningful laser target experiments both for a laser plasma production or a modification of solid surfaces. The repetition time of the shots is about 10 min.
Let $k$ be a field of characteristic not 2, 3. Let $G$ be an exceptional simple algebraic group over $k$ of type ${{\text{F}}_{4}},$$^{1}{{\text{E}}_{6}}$ or ${{\text{E}}_{7}}$ with trivial Tits algebras. Let $X$ be a projective $G$-homogeneous variety. If $G$ is of type ${{\text{E}}_{7}},$ we assume in addition that the respective parabolic subgroup is of type ${{\text{P}}_{7}}.$ The main result of the paper says that the degree map on the group of zero cycles of $X$ is injective.
Let $G$ be an adjoint simple algebraic group of inner type. We express the Chow motive (with integral coefficients) of an anisotropic projective $G$-homogeneous variety in terms of motives of simpler $G$-homogeneous varieties, namely, those that correspond to maximal parabolic subgroups of $G$. We decompose the motive of a generalized Severi–Brauer variety $\mathrm{SB}_2(A)$ of a division algebra $A$ of degree 5 into a direct sum of twisted motives of the Severi–Brauer variety $\mathrm{SB}(B)$ of a division algebra $B$ Brauer-equivalent to the tensor square $A^{\otimes 2}$. As an application we provide another counter-example to the uniqueness of a direct sum decomposition in the category of motives with integral coefficients.
In this paper the measurements of the dynamic breakdownvoltages Ub for linearly rising pulses in nitrogen at lowpressure are presented. The measurements were carried out for therates of voltage rise k up to $300\, {\rm V\,s}^{-1}$. Dependence of thebreakdown voltages, delay times and electron yields on the rate ofrise were obtained experimentally and theoretically under different conditions. It was found thatthe overvoltage $\overline {\Delta U_b}$ and the mean effectiveelectron yield $\overline {YP}$ is proportional to $\sqrt k$ (Yis a number of generated electrons in the interelectrode space persecond and P the breakdown probability), while the statisticaltime delay $\overline t_s$ is proportional to $1/\sqrt k$. In thesecond part, the experimental breakdown voltage distributions wereobtained, fitted by theoretical distributions and some breakdownparameters relevant to experimental conditions were determined.Based on the approximate analytical and numerical models, thedependence of the effective secondary electron yield γ onthe overvoltage and on the rate of voltage rise were derived fromthese measurements. It was found that γ varies linearlywith the overvoltage for a constant k, and the slope of γis proportional to $\sqrt k$.
In this paper we report p-GaN growth by hydride vapor phase epitaxy (HVPE) on sapphire substrates. Mg or Zn impurities were used for doping. Layer thickness ranged from 2 to 5 microns. For both impurities, as-grown GaN layers had p-type conductivity. Concentration NA-ND was varied from 1016 to 1018 cm−3. An annealing procedure at 750°C in argon ambient typically increased the concentration NA-ND in 1.5–3.5 times. For Mg doped GaN layers, room temperature hole mobility of 80 cm2V−1s−1 was measured by conventional Van Der Pau Hall effect technique for material having hole concentration of about 1x1018 cm−3. Initial results on highly electrically conducting p-type AlGaN/GaN heterostructures doped with Zn are also reported.