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The health of people living in the USA is worse than that of inhabitants in all the other rich nations, as well as some not so rich. There is no privileged American group that can claim the best health in the world. Healthcare, although important, is surpassed by other factors. Health in a country is mostly determined by the amount of economic inequality present and the attention to early life. These issues are determined by political choices. Terms used are described. Readers are challenged to consider the most important lessons on health they have ever encountered
Both host identity and environmental factors are known to influence parasite species richness. Here, we analysed selected host traits and environmental variables associated with 3 aspects of helminth diversity in African ruminants. Based on the helminth faunas of 35 species of antelope and 1 species of giraffe, we studied drivers of species richness as well as taxonomic and functional diversity, combined for all helminths and separately for nematodes, cestodes and trematodes. A larger geographic host range and/or multiple habitats were associated with higher species richness in all helminths and each group individually as well as with functional diversity in all helminths, trematodes and cestodes. A wider host distribution range and larger relative brain size were both linked to higher taxonomic diversity in all helminths, and an increase in host longevity was linked to higher taxonomic diversity in nematodes. A higher level of climate moisture, relative humidity and primary production had a positive effect on trematode species richness and taxonomic diversity in all helminths, while trematode taxonomic diversity decreased in hosts from drier areas but increased in cestodes harboured by hosts from warmer areas. Our results highlight that patterns in parasite species richness and diversity emerge from an interplay of numerous factors, including host biology, environmental conditions and ecological traits of the parasites themselves. This points to the importance of carefully choosing the range of hosts considered for large-scale parasite diversity studies and underscores the need to avoid grouping too many types of parasites when looking for ecological patterns.
This essay coins and develops the concept of Longevity Capitalism, a biopolitical and financial regime in which both the condition of living longer and the pursuit of longevity are transformed into frontiers of accumulation. As financialisation extends into the domain of ageing, longevity – once a social and fiscal challenge – has been reframed as an investment opportunity. The essay traces a shift from collective welfare management to individualized risk-bearing, showing how uncertainty about life expectancy is converted into a new asset class. Drawing on examples such as financial instruments that profit from longevity risk, the rise of ‘age-tech’, and Silicon Valley’s ventures in life extension, it shows how biological time is increasingly treated as an economic resource. It also examines the speculative pursuit of ‘longevity escape velocity’, where technological innovation is imagined to outpace ageing and death itself becomes a technical problem. Together, these developments reveal a system in which longer life functions as a perpetually deferred investment cycle – an economy sustained by its own postponement. The essay argues that economic and biological time, wealth and health, are now fused within a single regime of managed futurity, reflecting new forms of power over who – and how – gets to live longer.
For many invasive plants, seed dormancy and persistence facilitate population expansion. These traits also complicate control efforts, as new seedlings may continue to emerge for years after the removal of existing plants. The maximum longevity of invasive plant seeds may range from years to decades. However, few seeds emerge after such a long time under field conditions. We conducted a field experiment testing the impact of seed burial depth on emergence of meadow knapweed (Centaurea × moncktonii C.E. Britton) and spotted knapweed [Centaurea stoebe L. ssp. micranthos (Gugler) Hayek] over 3 yr. For C. × moncktonii, emergence (raw data corrected for seed viability) was 57% at 0 cm, 28% at 2 cm, 3% at 4 cm, and 0% at 8 cm. For C. stoebe, emergence was 84% at 0 cm, 11% at 2 cm, 4% at 4 cm, and 0% at 8 cm. The primary flush of seedlings, averaged over Centaurea species and burial depths, occurred during the first few months of the study in fall 2018. Little emergence occurred after spring/summer 2019, although the study continued through spring/summer 2021. Our findings clarify the maximum burial depth from which these Centaurea species can emerge and demonstrate that emergence is concentrated in the first year after seed production.
Dairy cow longevity affects production economy, climate footprint, and cow welfare. Based on data from the Danish Cattle Database, this research paper evaluates the relationship between early-life risk factors associated with the period before first calving and cow longevity, including data from all Danish dairy cows culled in 2019–2023. Explanatory variables for linear mixed models included calf size, twinning, and age at first calving. Information about the length of productive life (LPL) (mean: 1,074 days) and lifetime milk yield (mean: 32,088 kg energy-corrected milk) was available for 767,305 and 716,120 cows, respectively. Milk yield per day of life increased from 7 kg in cows culled during the first lactation to more than 20 kg in cows culled in their fifth or later lactations. For cows born as singletons, LPL was one month longer for cows born as large calves than for medium-sized calves, and 2 months longer than for small calves. Cows born as twins had 2 to 3 months shorter productive lives compared to cows born as singletons. For singletons, lifetime milk yield was 1,200 kg higher for large calves than for medium-sized calves, and 2,100 kg higher than for small calves. Lifetime milk yield was 1,500 to 3,500 kg lower in cows born as twins. Cows being among the third quartile of age at first calving had an estimated productive life 2.5 months longer, and a lifetime milk yield more than 2,600 kg higher than cows calving among the first quartile of age. The results from this study clearly demonstrate the importance of ‘a good start’.
Ensuring seed viability over decades is a central challenge in ex situ conservation of plant genetic resources. Standard germination tests, while effective, are destructive and fail to detect early molecular damage that precedes viability loss. RNA integrity has emerged as a promising biomarker due to the inherent vulnerability of mRNA to oxidative degradation in the dry state. In this study, we identified and validated seed-stored mRNAs in common bean (Phaseolus vulgaris), a major crop species extensively represented in global germplasm collections, and investigated transcript degradation patterns in seeds conserved for up to 30 years. Using a comparative genomics approach, we identified 107 P. vulgaris orthologs of long-lived rice mRNAs, many encoding proteins involved in RNA stabilization, oxidoreductase activity, and primary metabolism. Thirty transcripts were validated by RT-qPCR, and the integrity of nine was assessed using paired primers targeting 5′ and 3′ regions. Degradation followed a consistent 5′→3′ pattern, particularly in longer transcripts, and correlated strongly with germination power. Predictive performance varied across transcripts: PSMA4, SMP1, and TRA2 consistently showed strong correlations with viability, whereas others were less informative. The ΔΔCq metric improved resolution by detecting degradation asymmetry. Samples included a genetically diverse panel of conserved, regenerated, and artificially aged accessions, enhancing applicability to real-world genebank conditions. Artificial aging intensified degradation signatures and mirrored patterns observed in naturally aged seeds. Altogether, our results indicate transcript integrity as a molecular biomarker for seed viability, supporting the development of robust molecular tools to inform decision-making and regeneration planning in long-term germplasm conservation.
Healthy ageing and longevity have emerged as urgent public health priorities amid global population ageing and declining birth rates. This review synthesises empirical evidence highlighting the essential role of diet and nutrition in preventing chronic diseases and supporting functional independence in later life. The review was organised using a problem-solving approach to address three core questions: ‘What’ evidence links food and nutrition with positive health outcomes; ‘Why’ do specific dietary components affect biological ageing – via mechanisms such as nutrient sensing, inflammation modulation and caloric restriction; and ‘How’ culturally tailored, person-centred dietary interventions should be developed for better adoption. Findings from centenarian populations suggest that low-energy (i.e. foods with low energy density, such as fruit and vegetables, whole grains), nutrient-rich and diverse diets may help prevent or delay age-related diseases, supporting the notion that food could be used as medicine. Moreover, addressing barriers such as food insecurity and limited access to culturally appropriate healthy food options, particularly in low-income and rural communities, is crucial for achieving equitable health outcomes. Finally, the review calls for integrating personalised nutrition strategies into clinical care and public health initiatives. These efforts can enhance healthspan, improve quality of life and reduce the broader social and economic burdens associated with ageing populations.
This chapter considers how expanded longevity should impact the law’s response to aging and the needs of older adults. Countries have long responded to old age by creating social welfare policies that use chronological age to target interventions at older adults. This chapter argues that, as life expectancy increases, the use of such age-based criteria will become more problematic: Chronological age will be an increasingly poor predictor of need, and age-based criteria will increasingly result in inequitable distribution of resources. Accordingly, it argues that polities should respond to enhanced longevity not merely by recalibrating age-based criteria to ensure efficient allocation of resources but by reducing reliance of age-based criteria. It concludes by considering whether vulnerability can serve as an alternative targeting mechanism.
There is a substantial difference between the housing that older Americans prefer and the housing that the market supplies. While market failures and seniors’ resource constraints explain part of this mismatch, zoning laws, Medicare and Medicaid reimbursement policies, and health law also loom large. Older Americans strongly prefer to age in place, in home-like environments. This chapter focuses on two types of housing that facilitate that manner of aging: Green House nursing homes and accessory dwelling units. The chapter discusses the substantial benefits for seniors who rely on others for care, and those who can live independently, in these respective kinds of housing. These benefits include substantial health and quality-of-life advantages as well as the ability to maintain connectedness within existing social networks. The chapter further examines the legal impediments to the proliferation of these housing types and the measures that some forward-looking jurisdictions are taking to facilitate their growth.
The conventional three-stage model of human life – from childhood to adulthood to old age – is being upended by social and economic changes that the 100-year life will likely amplify. If law does not adapt to new life patterns, it will worsen existing inequalities. Higher education, family and inheritance, and retirement illustrate how lives are already diverging from assumptions embedded in law about the life cycle while suggesting needed reforms.
Lynda Gratton and Andrew Scott’s prediction that the median lifespan will exceed 100 years for children born today in high-income countries is “science fiction” within the dictionary definition: a “story featuring hypothetical scientific or technological advances.” This chapter argues that for a 100-year life to become the norm within the timeframe that Gratton and Scott envision, we will need to make extraordinary progress over the next several decades in reducing old-age mortality – advances that are qualitatively different from the disease-specific innovations that attract the vast majority of biomedical investment today. To achieve those advances will require not only scientific ingenuity but also legal and political innovation. Patent law – the most familiar tool in the innovation policy toolkit – is ill-fitted for the goal of attaining century-long lives. Instead of relying on private-sector sources, we will likely need governments to commit to moonshot investments in longevity akin to the Apollo project. Yet securing support for those investments will be challenging given the political economy of public funding for biomedical research. Thus the path to a 100-year life will likely require major breakthroughs not only in the laboratory but also in the legislature.
Edited by
Richard Pinder, Imperial College of Science, Technology and Medicine, London,Christopher-James Harvey, Imperial College of Science, Technology and Medicine, London,Ellen Fallows, British Society of Lifestyle Medicine
Lifestyle Medicine is an evidence-based medical discipline that emphasises behaviour change to improve overall health, focusing on mental wellbeing, social connections, healthy eating, physical activity, sleep, and minimising harmful behaviours. The approach bridges clinical practice with public health interventions, targeting both individual and population health. It is effective in preventing, treating, and sometimes reversing chronic diseases through lifestyle modification. Clinicians practising Lifestyle Medicine support actions beyond clinical consultations, advocating for healthy environments and policies. The discipline also addresses the challenges of non-communicable diseases and enhances resilience against infectious diseases. It offers an alternative to over-medicalisation, promoting self-care and lifestyle changes alongside traditional medical treatments. The new medical paradigm recognises the modifiability of gene expression and the importance of lifestyle factors in health outcomes. Lifestyle Medicine is increasingly integrated into medical education and healthcare delivery systems. It aligns with the shift towards person-centred care that focuses on patients’ values and goals, contributing to a more holistic approach to health and wellbeing.
Edited by
Richard Pinder, Imperial College of Science, Technology and Medicine, London,Christopher-James Harvey, Imperial College of Science, Technology and Medicine, London,Ellen Fallows, British Society of Lifestyle Medicine
Physical inactivity is recognised as a global risk factor for premature mortality and morbidity. Engaging in physical activity and reducing sedentary behaviour significantly improves both mental and physical health at all ages. Lifestyle Medicine emphasises the importance of a person-centred approach to encourage physical activity during consultations. Physical activity guidelines in the UK recommend adults to engage in at least 150 minutes of moderate intensity or 75 minutes of vigorous intensity activity weekly for health benefits. Sedentary behaviour is defined as low-energy expenditure activities while awake and is an independent risk factor for ill health. Clinical and community-based interventions, including brief advice and referral to physical activity programmes, are cost-effective and improve physical activity levels. Various tools exist to assess physical activity levels and fitness in clinical settings, aiding personalised healthcare. Personalised support and health coaching techniques, such as motivational interviewing, effectively promote physical activity. Physical activity reduces the risk of long-term conditions, improves weight management, and has positive effects on metabolism and immune pathways. Supporting increased physical activity as part of Lifestyle Medicine can prevent, treat, and potentially reverse chronic health conditions.
Law and the 100-Year Life addresses the growing trend of Americans living longer and healthier lives, with many reaching the age of 100. An aging nation presents new challenges for society, which must be reimagined to accommodate longer and more varied careers, multiple marriages, and defining moments of education. This volume explores the possibility of a 'third demographic dividend', a new period of productivity following middle age, and the potential for law and policy to support or divide aging citizens. Leading scholars across various fields come together to explore topics related to aging, such as health law and trusts and estates, as well as less obvious but equally important areas like housing, criminal justice, and education. This title is also available as Open Access on Cambridge Core.
Nozick’s ‘utility monster’ is often regarded as impossible, because one life cannot be better than a large number of other lives. Against that view, I propose a purely marginalist account of utility monster defining the monster by a higher sensitivity of well-being to resources (instead of a larger total well-being), and I introduce the concept of collective utility monster to account for resource predation by a group. Since longevity strengthens the sensitivity of well-being to resources, large groups of long-lived persons may, if their longevity advantage is sufficiently strong, fall under the concept of collective utility monster, against moral intuition.
Increase in life expectancy will affect future welfare through changes in the stock of human capital and financial wealth. In projecting these changes it is important to differentiate between the direct demographic effect (a change in the population age structure) and the indirect behavioural change (a change in age-specific economic characteristics). Using a multi-country dynamic (general equilibrium) economic model, this chapter assesses the effects of increasing life expectancy on economic growth and inequality in European countries. The economic model accounts for both the direct effect of changes in the age structure of the population, given the economic characteristics, and the indirect effect of population changes on age-specific economic behaviour in a globalized economy. Projections for the period 2020-2100 show that future life expectancy improvements: (1) will have a negative impact on consumption and output per capita; (2) will negatively affect the accumulation of assets (more so in high-income compared to middle-income European countries due to the more generous pension systems in high-income countries); and (3) will lead to an increase in the intergenerational income inequality due to the fall in asset income at old age. However, it also finds that more generous old-age public transfer systems mitigate the negative impact of life expectancy gains on inequality.
The demography of contemporary hunter-gatherers, farmers and other subsistence populations provides an important lens for studying age patterns of survival and morbidity under non-industrial conditions and lifeways. Although high-quality evidence is sparse, a review suggests robust patterns of human longevity that contradict prior notions of ‘nasty, brutish and short’ lifespans suggested from the palaeodemographic literature. Life expectancy at birth averages about 30 years for hunter-gatherers, and 35 years across all human subsistence groups, a pattern similar to mid-eighteenth-century Europe. Despite short life expectancy, subsistence populations show a modal adult lifespan of about seven decades across a wide range of environments, diets and livelihoods. Over a third of adult life is spent post-reproductive. Infection, violence and accidents are primary causes of death. Post-contact acculturation has mostly improved survivorship, especially in early life, due to access to health care and modern amenities. Loss of land and livelihood, new infections and exploitation, however, have increased mortality and morbidity in some populations. Although the past two centuries have witnessed large gains in lifespan equality and survivorship, the potential for human longevity appears to be a species-typical universal.
This opening chapter provides an overview of the future societal and subsequenl scientific challenges associated with population ageing. More specifically, it emphasizes how the field of biodemography constitutes a relevant framework for future research programmes aiming to address questions of paramount importance regarding both the causes (e.g. evolutionary, mechanistics) and consequences (demographic, medical) of the ageing process. Finally, this chapter details the book contents.
Population aging is a widening demographic phenomenon in many developed countries, with the numbers of survivors above age 90 growing at steady rates. It is the source of many challenges to society. Among key factors to understand population aging, the trajectory of mortality at the highest ages figures at the centre of heated debates across disciplines, from biological to social sciences. This chapter offers a brief overview of mortality modelling above age 90, tracing the history of the most widely used mortality models at these ages, before outlining these models’ mathematical functions as well as their underlying assumptions in the most accessible way possible. Main empirical results obtained from applications of these models throughout decades of research will also be presented, following by a summary of efforts that were made to address the question of possible limits of longevity. This chapter concludes with recommendations for future research. The hope is this material will be useful for anyone who wishes to seize the broad perspective of research on mortality trajectory at highest ages.
This chapter plays an important role in the argument of the book. It shows that there is room in Aristotle’s life for a study of what is common to animals and plants in addition to separate studies of animals and plants. At the same time, it shows that what Aristotle is able, or willing, to say in common for animals and plants is truly limited. By the end of the chapter the reader will see that the Peripatetic study of life is a complex scientific endeavor consisting of at least three components: a study of what is common to animals and plants followed by separate yet coordinated studies of animals and plants. What Aristotle is able, or willing, to say in common for animals and plants is to be found within the boundaries of project of the Parva naturalia.