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Chapter 7 begins with Kornblith’s attempt to resurrect a teleology of the mind or intellect. I countenance his semantic, desire and pragmatic arguments, maintaining that none of them shows truth or true belief to be an objective good. By contrast, Aristotle’s idea that the intellect is constitutively directed at truth does show this (in virtue of the Aristotelian functionalist schema: i.e. all functions are correlated with perfections or goods). And Aristotle’s idea is corroborated not only by ‘folk’ and theoretical psychology, but also by cognitive science. For the latter is wedded to the notion that the brain is a cognitive system, functionally directed at cognition (viz. true belief). I go on to address three critiques of this intellectual teleology – those put forward by William James, evolutionary biology and global scepticism respectively – and argue that none of them is cogent. Next, I unpack two alternative accounts of the relation between truth and goodness – those of Ayer and Davidson – and maintain that they, too, fall short. Last, I tackle intellectual goods beyond true belief – such as knowledge and understanding – asking whether they or their objects form discernible hierarchies.
We need to identify novel, tractable therapeutic targets for anxiety disorders. Converging evidence suggests the endogenous opioid system plays a role in modulating affective processing, but its contribution to regulation of threat processing in humans remains unclear.
Aims
We investigated the neural correlates of non-specific opioid antagonism on explicit and implicit regulation of threatening stimuli in healthy volunteers, using functional magnetic resonance imaging (fMRI).
Method
In a randomised, double-blind, placebo-controlled, crossover design, 38 healthy participants received the opioid antagonist naltrexone (50 mg) or placebo before completing two tasks during fMRI: (a) a cognitive emotional reappraisal task probing explicit regulation and (b) a face-viewing task probing implicit processing.
Results
Contrary to our hypothesis, we found naltrexone reduced distress ratings during the reappraisal task (p = 0.044) without impairing regulation success. Explicit regulation in the reappraisal task engaged lateral prefrontal regions similarly across drug conditions. However, naltrexone attenuated ventromedial prefrontal cortex, thalamus and caudate activation when viewing negative images. Naltrexone additionally altered ventromedial prefrontal cortex activity and in task-positive regions including right premotor area and frontal pole compared with placebo when viewing emotional faces. In particular, naltrexone increased left middle frontal gyrus activity when viewing fearful faces.
Conclusions
Our results support a role for opioid signalling in automatic emotional regulation, but not in explicit regulation. Furthermore, naltrexone appeared to diminish activity in task-positive regions in response to emotional faces. These findings are consistent with a model where endogenous opioids ‘fine-tune’ affective responses to both negative and positive stimuli. Future research should explore dose–response effects, kappa-opioid contributions and whether similar results are seen in clinical populations.
Panic disorder is among the most common mental disorders, characterised by recurrent, unexpected panic attacks that are highly distressing and further lead to pervasive anxiety about future attacks and maladaptive behavioural changes. Existing pharmacological and psychological treatments often fail to produce lasting improvement, and relapse is common. Neither antidepressants, the current first-line drug treatments, nor benzodiazepines exert their actions sufficiently rapidly to head off panic attacks between the initial indications of panic symptoms and the fully developed panic attack. Therefore, there is a clear need for new pharmacological compounds, particularly those that could be administered at the first warning signs of an impending panic attack, to disrupt its genesis. Here we discuss the acid-sensing ion channel (ASIC) as a therapeutic target and the potential of amiloride, an ASIC antagonist administered via nasal spray, for rapid access to the brain, as a compound with potential to fill this need. We summarise relevant preclinical studies, including a demonstration of nebulised amiloride’s ability to normalise responses to carbon dioxide, a panicogenic, brain-acidifying agent. Following existing safety, stability and pharmacokinetic studies, clinical trials are needed to test the efficacy of this compound in individuals with panic disorder and/or recurrent panic attacks.
This clinical reflection explores the evolving landscape of teaching and training in old age psychiatry, highlighting recent reforms such as the 2022 UK curriculum revision, which emphasises person-centred, interdisciplinary and digitally enhanced care. It examines national and international initiatives addressing health inequalities, integration of artificial intelligence, and co-produced education. The article underscores the need for adaptable, inclusive and forward-thinking training to meet the complex mental health needs of an ageing global population.
Takes up another aspect of free will, the challenge of scientific determinism. I argue that Jewish tradition contains surprisingly many thinkers who either deny free will or (more commonly) greatly limit its scope, question its value, or embrace compatibilism (the thesis that free will and determinism are compatible). Some of what these thinkers say can be transferred to the challenge of determinism as it exists today.
This undergraduate biological psychology textbook offers a critical introduction to brain and behavior. Psychology lectures open with 'the brain is the most complex and mysterious object in the universe', only to quickly reduce that complexity by teaching simplified models. This textbook challenges these narratives by focusing on the latest neurotechnological advances, to clarify the limits of current models, and to inspire the development of safe and accessible technologies for human use. Its central aim is to promote critical thinking and inspire students to pose novel research questions that build from current advances. It is an ideal textbook for instructors who are eager to push beyond a conventional introductory curriculum. Beautifully illustrated and full of practical applications, it is accompanied by teaching slides and a test bank.
Most psychiatric disorders in adulthood originate in childhood or adolescence. Hence, managing mental health in children and adolescents is crucial. This clinical reflection aims to capture some of the contemporary and emerging trends in teaching and training in child and adolescent psychiatry worldwide. Future directions for child and adolescent psychiatry training programmes are also highlighted.
While most programmes in neuroscience are understandably built around imparting foundational knowledge of cell biology, neurons, networks and physiology, there is less attention paid to critical perspectives on methods. This book addresses this gap by covering a broad array of topics including the philosophy of science, challenges of terminology and language, reductionism, and social aspects of science to challenge claims to explanation and understanding in neuroscience. Using examples from dominant areas of neuroscience research alongside novel material from systems that are less often presented, it promotes the general need of scientists (and non-scientists) to think critically. Chapters also explore translations between neuroscience and technology, artificial intelligence, education, and criminology. Featuring accessible material alongside further resources for deeper study, this work serves as an essential resource for undergraduate and graduate courses in psychology, neuroscience, and biological sciences, while also supporting researchers in exploring philosophical and methodological challenges in contemporary research.
Bessel van der Kolk’s book The Body Keeps the Score has maintained exceptional cultural and clinical influence since its publication in 2014, remaining a best-seller and shaping public discourse on trauma. Its central claims – that trauma causes lasting neurobiological damage and that body-based treatments are uniquely effective – have been widely embraced but seldom subjected to systematic critical evaluation in peer-reviewed literature. This commentary synthesises the evidentiary basis for these claims as a counterweight to an influential narrative. It situates these findings within broader discussions of neuroscience framing, cultural appeal and evidence-based communication, underscoring the need for rigorous, balanced engagement with widely disseminated mental health narratives.
This textbook introduces the fundamentals of MATLAB for behavioral sciences in a concise and accessible way. Written for those with or without computer programming experience, it works progressively from fundamentals to applied topics, culminating in in-depth projects. Part I covers programming basics, ensuring a firm foundation of knowledge moving forward. Difficult topics, such as data structures and program flow, are then explained with examples from the behavioral sciences. Part II introduces projects for students to apply their learning directly to real-world problems in computational modelling, data analysis, and experiment design, with an exploration of Psychtoolbox. Accompanied by online code and datasets, extension materials, and additional projects, with test banks, lecture slides, and a manual for instructors, this textbook represents a complete toolbox for both students and instructors.
Cutting-edge computational tools like artificial intelligence, data scraping, and online experiments are leading to new discoveries about the human mind. However, these new methods can be intimidating. This textbook demonstrates how Big Data is transforming the field of psychology, in an approachable and engaging way that is geared toward undergraduate students without any computational training. Each chapter covers a hot topic, such as social networks, smart devices, mobile apps, and computational linguistics. Students are introduced to the types of Big Data one can collect, the methods for analyzing such data, and the psychological theories we can address. Each chapter also includes discussion of real-world applications and ethical issues. Supplementary resources include an instructor manual with assignment questions and sample answers, figures and tables, and varied resources for students such as interactive class exercises, experiment demos, articles, and tools.
As we think and act, the brain is constantly producing Big Data in the firing of its neurons and in the connections that are strengthened and weakened. This chapter discusses how we can study the brain and the Big Data that it creates. First, we discuss how clever behavioral tasks, looking at development and other species, and natural variation across people are our first tools for understanding the brain. Next, we delve into describing several popular brain imaging methods – direct recording, electroencephalography, magnetoencephalography, magnetic resonance imaging, and a few others. We discuss how to interpret the Big Data shown by brain maps, and some Big Data methods like multiple comparisons correction to consider when viewing this data. Finally, we end the chapter discussing the ethical question of whether such neuroimaging allows mindreading.
Music & spoken language share many features by combining smaller units (e.g., words, notes) into larger structures (e.g., sentences, musical phrases). This hierarchical organization of sound is culturally contingent & communicates meaning to listeners. Comparisons of music & language from a cognitive neuroscience perspective provide several insights into commonalities & differences between these systems, how they are represented in the brain. The cognitive neuroscience research of music & language, emphasizes the pitfalls & promises identified, including (1) the apparent acoustic & structural similarities between these systems, (2) how both systems convey meaning to listeners, (3) how these systems are learned over the course of development, & (4) the ways in which experience in one domain influences processing in the other domain. We conclude that searching for similarities in how these complex systems are structured (e.g., comparing musical syntax to linguistic syntax) represents a pitfall that researchers should approach with caution. A promising approach in this area of research is to examine how general cognitive mechanisms underlie the learning & maintenance of both systems
Inspired by interesting research in the field of neuroscience, Dorothea Haspelmath-Finatti argues that singing in a liturgical context is not only an essential part of the act of praising and praying, but it is also healthy.
Manufacturing Dissent reveals how the early twentieth century's 'lost generation' of writers, artists, and intellectuals combatted disinformation and 'fake news.' Cultural historians, literary scholars, and those interested in the power of literature to encourage critical thought and promote democracy will find this book of particular value. The book is interdisciplinary, focusing on the rich literary and artistic period of American modernism as a new site for examining the psychology of public opinion and the role of cognition in the formation of beliefs. The emerging twentieth-century neuroscience of 'plasticity,' habit, and attention that Harvard psychologist William James helped pioneer becomes fertile ground for an experimental variety of literature that Stephanie L. Hawkins argues is 'mind science' in its own right. Writers as diverse as F. Scott Fitzgerald, Zora Neale Hurston, Ernest Hemingway, and Gertrude Stein sought a public-spirited critique of propaganda and disinformation that expresses their civic engagement in promoting democratic dissent.
What makes music an enduring art that has withstood the test of time across so many cultural contexts? Here we review the literature on emotion and reward as it relates to music, grounding our review on multiple methodological traditions in neuroscience, as well as newer work that combines these tools with music technology and sound design. Key to these disparate lines of research is the idea that the reward system is functionally and structurally connected to the auditory system, giving rise to individual differences in the sensitivity and felt emotion for music. We conclude with implications of this research for the design and implementation of music-based interventions for improving cognitive and brain health, especially for those with neurodegenerative diseases.
This chapter presents a comprehensive workflow for applying network machine learning to functional MRI connectomes. We demonstrate data preprocessing, edge weight transformations, and spectral embedding techniques to analyze multiple brain networks simultaneously. Using multiple adjacency spectral embedding (MASE) and unsupervised clustering, we identify functionally similar brain regions across subjects. Results are visualized through abstract representations and brain-space projections, and compared with established brain parcellations. Our findings reveal that MASE-derived communities often align with known functional and spatial organization of the brain, particularly in occipital and parietal areas, while also identifying regions where functional similarity doesn’t imply spatial proximity. We illustrate how network machine learning can uncover meaningful patterns in complex neuroimaging data, emphasizing the importance of combining algorithmic approaches with domain expertise to motivate the remainder of the book.
James’s modernism is based directly on the psychology he founded, and specifically on his recognition that the self is malleable (or “plastic”), aggregate, distributed, and capable of mental reform. Yet James’s outspoken critique of US imperialism and the lynching of African Americans reflected his understanding of the dangerous potential of conversion – namely, that revolutions in belief carry a measure of uncertainty and risk, not just to individual believers but to the very fabric of democratic thought. Jamesean conversion therefore dramatizes the processes by which consent is staged from within and from without. The self enacts the drama in the form of an internal dialogue in which one imagines one’s “self” inhabiting a particular temporo-spatial location, as if fulfilling the role of a protagonist in a work of fiction. Against that background, Henry James’s What Maisie Knew and Harold Frederic’s The Damnation of Theron Ware dramatize the processes through which individuals become plastically transformed under the manipulations of powerful “pattern-setters” of public opinion. By fracturing and fragmenting imperial forms of selfhood, these psychological Bildungsromane inaugurate a reform modernism that registers dissent from the imperial sway of groups, demonstrating the strenuous effort required by individuals to transform oppressive systems from within.
This chapter invites readers to consider how an engagement with hip-hop music and culture can contribute to a better understanding of mental health, psychiatry, psychology, public health, and neuroscience. It provides an introduction to hip-hop therapy, highlighting the use of rap by psychologists and counsellors to promote mental well-being. The chapter goes on to examine the work that the Hip-Hop Psych initiative has undertaken in advancing the role of hip-hop in primary care. With hip-hop’s pre-eminence as a global musical force, greater attention to how mental health is represented in hip-hop can provide healthcare professionals with tools to aid discussions with patients about potential trends related to hip-hop icons, such as contagion effects of suicide, self-harm, and self-medication. Hip-hop offers a platform for artists and those who embrace the culture to address their emotional experiences through rap. By exploring lyrical content, the chapter uncovers how performers express their mental health challenges and fashion resilience within challenging circumstances. It argues that attention to this material could also help identify language disturbances associated with mental health conditions, and indicates the potential gains from the use of technology and neuroscientific research to support hip-hop music interventions.