Rapid etiological diagnosis of diarrheal disease is challenging in multi-pathogen settings. Host blood transcriptomes provide a pathogen-agnostic signal, but models must be accurate and interpretable. We analyzed peripheral blood transcriptomes from pigs experimentally challenged with Lawsonia intracellularis, enterotoxigenic Escherichia coli, transmissible gastroenteritis virus, porcine deltacoronavirus, and Clostridium perfringens type C, plus healthy controls. Six machine learning algorithms were compared. The best model, a deep neural network (DNN), underwent feature selection to build 50-, 20-, and 5-gene classifiers. Performance was evaluated by receiver operating characteristic analysis and standard metrics. Interpretability was achieved using SHapley Additive exPlanations (SHAP) and a 20-gene Kolmogorov–Arnold network (KAN) that provided explicit gene-to-node functions. The DNN outperformed other algorithms (AUC: 0.690, accuracy: 73.2%, recall: 91.3%, F1: 0.792). A 20-gene DNN preserved this performance (AUC: 0.690, 95% CI: 0.507–0.854) and was chosen as the optimal model, whereas a 5-gene model slightly increased AUC but reduced recall. Pathway enrichment of the 20 genes implicated immune and metabolic pathways, including PI3K–Akt, cytokine–cytokine receptor interaction, and AMPK signaling. SHAP consistently identified ACTG1, SLC5A1, and ATP1A1 as dominant contributors across pathogens. The 20-gene KAN achieved comparable performance (AUC: 0.71) and yielded simple linear mappings showing negative effects of ACTG1/SLC5A1 and positive effects of ATP1A1 on the internal risk signal. A compact, biologically coherent 20-gene host signature enables accurate and interpretable prediction of diverse diarrheal pathogens, with ACTG1, SLC5A1, and ATP1A1 emerging as core cross-pathogen markers and promising diagnostic candidates.

The axisymmetric nozzle mechanism is the core part for thrust vectoring of aero engine, which contains complex rigid-flexible coupled multibody system with joints clearance and significantly reduces the efficiency in modeling and calculation, therefore the kinematics and dynamics analysis of axisymmetric vectoring nozzle mechanism based on deep neural network is proposed. The deep neural network model of the axisymmetric vector nozzle is established according to the limited training data from the physical dynamic model and then used to predict the kinematics and dynamics response of the axisymmetric vector nozzle. This study analyses the effects of joint clearance on the kinematics and dynamics of the axisymmetric vector nozzle mechanism by a data-driven model. It is found that the angular acceleration of the expanding blade and the driving force are mostly affected by joint clearance followed by the angle, angular velocity and position of the expanding blade. Larger joint clearance results in more pronounced fluctuations of the dynamic response of the mechanism, which is due to the greater relative velocity and contact force between the bushing and the pin. Since axisymmetric vector nozzles are highly complex nonlinear systems, traditional numerical methods of dynamics are extremely time-consuming. Our work indicates that the data-driven approach greatly reduces the computational cost while maintaining accuracy, and can be used for rapid evaluation and iterative computation of complex multibody dynamics of engine nozzle mechanism.

Multilingual question answering (MQA) is an effective access to multilingual data to provide accurate and precise answers, irrespective of language. Although a wide range of datasets is available for monolingual QA systems in natural language processing, benchmark datasets specifically designed for MQA are considerably limited. The absence of comprehensive and benchmark datasets hinders the development and evaluation of MQA systems. To overcome this issue, the proposed work attempts to develop the EHMQuAD dataset, an MQA dataset for low-resource languages such as Hindi and Marathi accompanying the English language. The EHMQuAD dataset is developed using a synthetic corpora generation approach, and an alignment is performed after translation to make the dataset more accurate. Further, the EHMMQA model is proposed to create an abstract framework that uses a deep neural network that accepts pairs of questions and context and returns an accurate answer based on those questions. The shared question and shared context representation have been designed separately to develop this system. The experiments of the proposed model are conducted on the MMQA, Translated SQuAD, XQuAD, MLQA, and EHMQuAD datasets, and EM and F1-score are used as performance measures. The proposed model (EHMMQA) is collated with state-of-the-art MQA baseline models for all possible monolingual and multilingual settings. The results signify that EHMMQA is a considerable step toward the MQA system utilizing Hindi and Marathi languages. Hence, it becomes a new state-of-the-art model for Hindi and Marathi languages.

During lateral root (LR) development, morphological alteration of the developing single LR primordium occurs continuously. Precise observation of this continuous alteration is important for understanding the mechanism involved in single LR development. Recently, we reported that very long-chain fatty acids are important signalling molecules that regulate LR development. In the study, we developed an efficient method to quantify the transition of single LR developmental stages using time-lapse imaging followed by a deep neural network (DNN) analysis. In this ‘insight’ paper, we discuss our DNN method and the importance of time-lapse imaging in studies on plant development. Integrating DNN analysis and imaging is a powerful technique for the quantification of the timing of the transition of organ morphology; it can become an important method to elucidate spatiotemporal molecular mechanisms in plant development.

The minimum flight time of spacecraft rendezvous is one of the fundamental indexes for mission design. This paper proposes a rapid trajectory planning method based on convex optimisation and deep neural network (DNN). The time-optimal trajectory planning problem is reconstructed into a double-layer optimisation framework, with the inner being a convex optimisation problem and the outer being a root-finding problem. The thrust properties corresponding to time-optimal control are analysed theoretically. A DNN-based rapid planning method (DNN-RPM) is put forward to improve computational efficiency, in which the trained DNN provides a high-quality initial guess for Newton’s method. The DNN-RPM is extended to search for the optimal entering angle of natural-motion circumnavigation orbit injection problem and the minimum reconfiguration time of spacecraft swarm. Numerical simulations show that the proposed method can improve the computational efficiency while ensuring the calculation accuracy.

House price prediction is an important problem that could benefit home buyers and sellers. Traditional models for house price prediction use numerical attributes such as the number of rooms but disregard the house description text. The recent developments in text processing suggest these can be valuable attributes, which motivated us to use house descriptions. This paper focuses on the house asking/advertising price and studies the impact of using house description texts to predict the final house price. To achieve this, we collected a large and diverse set of attributes on house postings, including the house advertising price. Then, we compare the performance of three scenarios: using only the house description, only numeric attributes, or both. We processed the description text through three word embedding techniques: TF-IDF, Word2Vec, and BERT. Four regression algorithms are trained using only textual data, non-textual data, or both. Our results show that by using exclusively the description data with Word2Vec and a Deep Learning model, we can achieve good performance. However, the best overall performance is obtained when using both textual and non-textual features. An $R^2$ of 0.7904 is achieved by the deep learning model using only description data on the testing data. This clearly indicates that using the house description text alone is a strong predictor for the house price. However, when observing the RMSE on the test data, the best model was gradient boosting using both numeric and description data. Overall, we observe that combining the textual and non-textual features improves the learned model and provides performance benefits when compared against using only one of the feature types. We also provide a freely available application for house price prediction, which is solely based on a house text description and uses our final developed model with Word2Vec and Deep Learning to predict the house price.

An onboard three-dimensional (3D) trajectory generation approach based on the reinforcement learning (RL) algorithm and deep neural network (DNN) is proposed for hypersonic vehicles in glide phase. Multiple trajectory samples are generated offline through the convex optimisation method. The deep learning (DL) is employed to pre-train the DNN for initialising the actor network and accelerating the RL process. Based on the offline deep policy deterministic actor-critic algorithm, a flight target-oriented reward function with path constraints is designed. The actor network is optimised by the end-to-end RL and policy gradients of the critic network until the reward function converges to the maximum. The actor network is considered as the onboard trajectory generator to compute optimal control values online based on the real-time motion states. The simulation results show that the single-step online planning time meets the real-time requirements of onboard trajectory generation. The significant improvement in terminal accuracy of the online trajectory and the better generalisation under biased initial states for hypersonic vehicles in glide phase is observed.

3D object detection using point cloud is an essential task for autonomous driving. With the development of infrastructures, roadside perception can extend the view range of the autonomous vehicles through communication technology. Computation time and power consumption are two main concerns when deploying object detection tasks, and a light-weighted detection model applied in an embedded system is a convenient solution for both roadside and vehicleside. In this study, a 3D Point cLoud Object deTection (PLOT) network is proposed to reduce heavy computing and ensure real-time object detection performance in an embedded system. First, a bird’s eye view representation of the point cloud is calculated using pillar-based encoding method. Then a cross-stage partial network-based backbone and a feature pyramid network-based neck are implemented to generate the high-dimensional feature map. Finally, a multioutput head using a shared convolutional layer is attached to predict classes, bounding boxes, and the orientations of the objects at the same time. Extensive experiments using the Waymo Open Dataset and our own dataset are conducted to demonstrate the accuracy and efficiency of the proposed method.

Instrument delivery is critical part in vascular intervention surgery. Due to the soft-body structure of instruments, the relationship between manipulation commands and instrument motion is non-linear, making instrument delivery challenging and time-consuming. Reinforcement learning has the potential to learn manipulation skills and automate instrument delivery with enhanced success rates and reduced workload of physicians. However, due to the sample inefficiency when using high-dimensional images, existing reinforcement learning algorithms are limited on realistic vascular robotic systems. To alleviate this problem, this paper proposes discrete soft actor-critic with auto-encoder (DSAC-AE) that augments SAC-discrete with an auxiliary reconstruction task. The algorithm is applied with distributed sample collection and parameter update in a robot-assisted preclinical environment. Experimental results indicate that guidewire delivery can be automatically implemented after 50k sampling steps in less than 15 h, demonstrating the proposed algorithm has the great potential to learn manipulation skill for vascular robotic systems.

This work introduces robust multi-dialectal part of speech tagging trained on an annotated data set of Arabic tweets in four major dialect groups: Egyptian, Levantine, Gulf, and Maghrebi. We implement two different sequence tagging approaches. The first uses conditional random fields (CRFs), while the second combines word- and character-based representations in a deep neural network with stacked layers of convolutional and recurrent networks with a CRF output layer. We successfully exploit a variety of features that help generalize our models, such as Brown clusters and stem templates. Also, we develop robust joint models that tag multi-dialectal tweets and outperform uni-dialectal taggers. We achieve a combined accuracy of 92.4% across all dialects, with per dialect results ranging between 90.2% and 95.4%. We obtained the results using a train/dev/test split of 70/10/20 for a data set of 350 tweets per dialect.

Our aim is to develop a smartphone-based life-logging system. Human activity recognition (HAR) is one of the core techniques to realize it. Recent studies reported the effectiveness of feed-forward neural network (FF-NN) and recurrent neural network (RNN) as a classifier for HAR task. However, there are still unresolved problems in those studies: (1) a life-logging system using only a smartphone for recording device has not been developed, (2) only indoor activities have been utilized for evaluation, (3) insufficient investigations/evaluations of RNN. In this study, we address these unresolved problems as follows: (1) we build a prototype system for life-logging and conduct data recording experiment on this system to include both indoor and outdoor activities. The experimental results of HAR on this new dataset showed that RNN-based classifier was still effective. (2) From the results of a HAR experiment, it was demonstrated that a multi-layered Simple Recurrent Unit with a non-linear transform at the bottom layer and a highway-connection was the most effective. (3) We could grasp the reason for the improvement of RNN from FF-NN by observing the posterior probabilities over test data.