Dynamics of spheroidal particle migration within the elasto-inertial square duct flow of Giesekus viscoelastic fluids were studied by using the direct forcing/fictitious domain method. The results show rich migration behaviours, a spheroidal particle gradually transitions from the corner (CO), channel centreline (CC), inertial rotational (IR), diagonal line and cross-section midline equilibrium positions with a decrease in the elastic number, depending on the initial particle position, initial particle orientation and fluid elasticity. From the effect of secondary flow, the IR equilibrium position is reported when the fluid inertia is relatively strong. Six (five) kinds of rotational behaviours are observed for the elasto-inertial migration of prolate (oblate) spheroids. Moreover, the critical elastic number is determined for the migration of spheroidal particles in Giesekus fluids. Near the critical elastic number, oblate and prolate spheroids can simultaneously maintain the CC, CO and IR equilibrium positions, and the initial orientation of particles affects their final rotational modes and equilibrium positions. Through comprehensive analysis, empirical formulas governing the ability of oblate and prolate spheroids to maintain the CC equilibrium position are proposed as
$\textit{Wi} = 0.055\,\textit{Re}{-0.1}$ and Wi = 0.045 Re−0.35 when n = 0.5, 0.01 ≤ Wi ≤ 1. Due to the different directions of the pressure forces acting on the particles and the forces from the first normal stress difference and the second normal stress difference, the equilibrium position in Giesekus fluids is rapidly increased by increasing the secondary flow at higher elastic numbers, which is contrary to the phenomenon observed in the Oldroyd-B fluid.