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Predation is a strong driver of prey behaviour and sympatric species are likely exposed to similar selective predatory pressures. We test the hypothesis that this leads to similar anti-predator behaviours using the widespread Neotropical snake tribe Pseudoboini as our model. We reviewed and compiled documented defensive behaviours for all species, adding new unreported behaviours for three species. We used a cluster analysis to generate a matrix of defensive behaviour dissimilarity between species. We then used a phylogenetic generalized linear mixed model to test how behaviour dissimilarity changed with geographical overlap, similarity in ecological traits, and phylogenetic relatedness. Only 41 species had available data on defensive behaviour, with only 22 of those represented in the phylogeny. We found that similarity in defensive behaviour is significantly (albeit not strongly) correlated with geographical overlap, but only for species with similar body sizes. Phylogenetic relatedness by itself was a poor predictor of behaviour dissimilarity. This corroborates our hypothesis that defensive behaviours are spatially structured at larger scales but that this can be modulated by morphological differences. Testing inter-species ecogeographical differences of defensive behaviour and its implications can be broadly applied to other taxa.
Between 2014 and 2019, millions of people witnessed and participated in a mass of commemorative activities for the First World War. Millions of pounds were spent for projects that brought together academic historians, community groups, artists, schools and the general public. These projects have been reviewed in government evaluations, by arts organisations and universities. However, commemoration is highly context-specific, affected by the contemporary actors as much as the events commemorated. Since 2019, the pandemic and the ongoing financial crisis in Higher Education have undermined the strength of the research community and the arts and heritage sectors. The world is becoming increasingly polarised and new technologies such as Artificial Intelligence pose new challenges for our discipline. By 2039, we can expect that there will be increased public interest in commemorating the Second World War. This contribution reviews the learning from the commemoration activities between 2014 and 2019 to identify what we can apply to 2039 and how we can begin to prepare in our current environment.
This before–after study aimed to evaluate whether an order-set intervention would improve CABP-guideline concordance among outpatients.
Setting:
This study included adult patients presenting to outpatient clinics (n = 92) and urgent care centers (n = 39) within a community-based health system without a formal outpatient antibiotic stewardship program (ASP).
Intervention:
The intervention consisted of an antibiotic order-set and awareness campaign. Patient encounters were identified via CABP ICD-10 codes and IDSA-relevant patient comorbidities (chronic heart, lung, liver, or renal disease; diabetes mellitus; alcoholism; malignancy; asplenia) were extracted from the electronic health record. Primary outcome was to describe the proportion of patients receiving concordant therapy per IDSA guideline and local antibiogram in a pre- (May 2023 – April 2024) and post-intervention period (May 2024 – December 2024).
Results:
Baseline and intervention antibiotic concordance rate was 33.3% (1,467/4,401 encounters) and 28.0% (1,388/4,954 encounters), respectively. Among patients with no comorbidity, monotherapy prescriptions (concordant and discordant) decreased post-intervention and were replaced by higher levels of combination therapy (15% increase), albeit all discordant due to lack of comorbidities. Among patients with comorbidities, combination antibiotics increased by 12% post-intervention, driven by concordant prescriptions including amoxicillin/clavulanate plus azithromycin while the most frequently prescribed discordant combination was amoxicillin plus azithromycin. Trends were similar in primary care and urgent care centers.
Conclusions:
A stewardship intervention, including an order-set and awareness campaign improved the selection of combination therapy for appropriate patients but did not improve overall guideline concordance. For health systems without a dedicated outpatient ASP, these data will help bolster stewardship efforts towards more effective strategies.
Poor socket fit is the leading cause of prosthetic limb discomfort. However, currently clinicians have limited objective data to support and improve socket design. Finite element analysis predictions might help improve the fit, but this requires internal and external anatomy models. While external 3D surface scans are often collected in routine clinical computer-aided design practice, detailed internal anatomy imaging (e.g., MRI or CT) is not. We present a prototype statistical shape model (SSM) describing the transtibial amputated residual limb, generated using a sparse dataset of 33 MRI and CT scans. To describe the maximal shape variance, training scans are size-normalized to their estimated intact tibia length. A mean limb is calculated and principal component analysis used to extract the principal modes of shape variation. In an illustrative use case, the model is interrogated to predict internal bone shapes given a skin surface shape. The model attributes ~52% of shape variance to amputation height and ~17% to slender-bulbous soft tissue profile. In cross-validation, left-out shapes influenced the mean by 0.14–0.88 mm root mean square error (RMSE) surface deviation (median 0.42 mm), and left-out shapes were recreated with 1.82–5.75 mm RMSE (median 3.40 mm). Linear regression between mode scores from skin-only- and full-model SSMs allowed prediction of bone shapes from the skin with 3.56–10.9 mm RMSE (median 6.66 mm). The model showed the feasibility of predicting bone shapes from surface scans, which addresses a key barrier to implementing simulation within clinical practice, and enables more representative prosthetic biomechanics research.
Long-acting injectable antipsychotic medications (LAIs) are more beneficial than oral medications for people with schizophrenia. However, some individuals are unable to visit out-patient clinics due to their symptoms, resulting in missed monthly LAI injections and subsequent relapse. Home visits for administration of LAIs could potentially reduce treatment failure, but there are no comparative studies on their effectiveness.
Aims
This study aims to evaluate whether home visit administration of LAIs, compared with the out-patient clinic, reduces treatment failure for those with schizophrenia.
Method
We conducted a retrospective cohort study using electronic medical records from Seijin Hospital. Patients diagnosed with schizophrenia and treated with LAIs during hospitalisation between 1 April 2020 and 31 March 2023 were included. Following discharge, patients were followed for 1 year, either under home visits or out-patient clinic visits. The primary outcome was defined as treatment failure, including psychiatric rehospitalisation, discontinuation of treatment or death. Multivariate Cox proportional hazards regression analysis was performed to evaluate treatment failure risks.
Results
A total of 125 patients in the home visit group and 117 in the out-patient group were included. During the follow-up period, home visits significantly reduced the risk of treatment failure (hazard ratio 0.62, 95% CI 0.40–0.97). However, having two or more psychiatric hospitalisations (hazard ratio 2.32, 95% CI 1.28–4.37) and living alone following discharge (hazard ratio 1.77, 95% CI 1.07–2.86) were associated with significantly increased risk of treatment failure.
Conclusions
Home visits, compared with out-patient clinic care, significantly reduce treatment failure in individuals with schizophrenia undergoing LAI treatment.
The arrival of COVID-19 in the US during the spring of 2020 cast a spotlight on the issue of vaccinations and their efficacy. School closures and school vaccination policies were among the most contentious arenas of debate as parents, teachers, and policymakers wrestled with how best to respond to the pandemic. Disease in school is not a new topic—our nation has previously faced outbreaks of influenza, polio, measles, and more. A look at the past can teach us much about how to understand the passionate, and sometimes partisan, views about school vaccination. Outside of schools, the anti-vax movement has enjoyed greater visibility and support even as public health officials emphasize the importance of herd immunity and broad vaccinations. The confirmation of Robert F. Kennedy Jr. as Health and Human Services secretary in February of this year makes it likely that the issues of school vaccination and immunization policy will continue to be vigorously debated.
Microplastic release in Antarctica is an issue of increasing concern, despite the limited human presence in the region. This study estimates the annual release of microplastics from the wastewaters of scientific facilities through the use of personal care products and laundering. Furthermore, it analyses the most cost-efficient policy interventions to target this pollution. The study has estimated a potential release of 238 kg per year, which is negligible on a continental scale but could have substantial local environmental impacts. A comprehensive cost-efficiency analysis demonstrates that microplastic release can be effectively mitigated through low-cost preventative measures, such as installing washing machine filters and banning hygiene products containing microbeads. Furthermore, the implementation of wastewater treatment systems is suggested as a crucial and long-term cost-effective solution for treating wastewater effluent and removing other pollutants from the Antarctic region. These results provide a framework to inform policy decisions on microplastic release in Antarctica and lay the foundation for improved environmental protection strategies in this sensitive region.
This article offers a fresh examination of the different kinds of labour and labourers in the pseudo-Virgilian Moretum, and argues that the poem lends expression to the difficulty of distinguishing between exploitation and collaboration in any form of production, but particularly in literary production. At its core, this article considers the ways in which the Moretum repeatedly denies readerly attempts to pin down the exact status of, and relationship between, the poem’s two principal characters, Simulus and Scybale. This lack of clarity is important for the poem’s interpretation: if, as many have argued, the Moretum is about poetic labour, then the ambiguous socio-economic status of its central characters should lead critics to ask what the poem is trying to say about the nature of literary production. This article shows that, throughout the Moretum, exploitative labour is presented as collaborative, and vice versa; and this, in turn, allows the poem to raise the question of whether there can ever be collaboration without exploitation in the Roman literary world. By thus reading the Moretum as an exploration of willed and coerced co-production in literature, new light can be shed on the poem’s authorship.
Marbled Teal Marmaronetta angustirostris is a globally threatened species that has been undergoing population declines across much of its range in recent years. This is particularly true in the Middle East and the Caucasus, where the species once commonly bred across much of the region. However, there is a dearth of recent literature and population-level assessments of the species in the countries in this region. For example, the last update of conservation status for Marbled Teal in Armenia was undertaken in 2009 and in Türkiye in 2008. Therefore, this study addresses the urgent need for an updated evaluation of the species’ status in both Armenia and Türkiye. For Armenia, the current population estimate is 8–11 breeding pairs, with a steep decline of 87% between 2003 and 2019. In Türkiye, the species appears to be functionally extirpated from the country due to an absence of breeding in almost a decade and multiple years without any records, with only a handful of wandering individuals detected in recent years. This study highlights the threats facing the species, particularly changes to wetland habitat and quality as well as hunting pressures and illegal poaching. Based on our findings, we propose that the conservation status of Marbled Teal in both countries be updated from “Endangered” to “Critically Endangered”. Finally, we note the conservation requirements for the species in the region and provide a set of recommendations for its protection, including a species recovery plan. Without urgent conservation measures such as the creation of new protected areas and establishment of new populations from released birds, the long-term viability of Marbled Teal populations in the region is in jeopardy.
Polybius claims that equality to speak in public (ἰσηγορία) and freedom of speech (παρρησία) are the fulcrum of a democracy (2.38.6) and hence the most beautiful of political values (6.57.9). But his reasons for valuing them so dearly have remained obscure. This article argues that ἰσηγορία and παρρησία in Polybius maximize the role of persuasion—instead of sheer force—in the polity; that they favour rational decision-making; and that they keep excessive ambition at bay. Those important political goods disappear when the citizens who enjoy ἰσηγορία and παρρησία become tepid in their commitment to the equal right to speak freely. The article argues that, for Polybius, that commitment fades when the citizens take ἰσηγορία and παρρησία for granted, mostly on account of habit (τὸ σύνηθϵς, 6.9.5). Polybius sets himself the task of dishabituating his readers from ἰσηγορία and παρρησία, by showing that they are always fragile.
This article describes how and why propaganda affected recipients differently in two distinct situations, namely forced exposure and selective exposure, when they received propaganda during a series of six original survey experiments conducted in China. The prevailing view is that people are more likely to resist information they receive if their exposure to it is forced. But the study addressed in this article found that citizens who prefer not to view propaganda news, when given a choice, actually demonstrate higher average treatment effects on pro-regime attitudes compared to those who willingly read propaganda news (i.e. where participants in the control group were assigned a reading of non-propaganda news). Moreover, this study shows that participants who prefer not to read propaganda news exhibit higher average treatment effects when rating the issue presented in the news as more understandable and important—compared to those who willingly engage with the propaganda. That suggests a possible rationalization pathway in this phenomenon.1
We present a novel approach to synthesizing recursive functional programs from input–output examples. Synthesizing a recursive function is challenging because recursive subexpressions should be constructed while the target function has not been fully defined yet. We address this challenge by using a new technique we call block-based pruning. A block refers to a recursion- and conditional-free expression (i.e., straight-line code) that yields an output from a particular input. We first synthesize as many blocks as possible for each input–output example, and then we explore the space of recursive programs, pruning candidates that are inconsistent with the blocks. Our method is based on an efficient version space learning, thereby effectively dealing with a possibly enormous number of blocks. In addition, we present a method that uses sampled input–output behaviors of library functions to enable a goal-directed search for a recursive program using the library. We have implemented our approach in a system called Trio and evaluated it on synthesis tasks from prior work and on new tasks. Our experiments show that Trio significantly outperforms prior work.
A newly discovered grave in Wadi Nafūn, Oman, features a unique burial structure, combining monumental architecture and the collective deposition of human remains from multiple Neolithic groups. Detailed analysis of the burial community reveals new insights into Neolithic rituals and subsistence strategies during the Holocene Humid Period in southern Arabia.