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Facial and orbital trauma are frequently seen in cases of child abuse, with certain patterns, such as specific types of retinal haemorrhage, being highly indicative of abusive head trauma. These injuries can be subtle on imaging and often lack a clear history. While some abusive injuries may resemble accidental ones, particular injury patterns or combinations of injuries, alongside additional clinical findings, raise concerns for abuse. Radiologists play a critical role in diagnosing these injuries by obtaining a thorough history and utilizing advanced imaging techniques like MRI and CT with three-dimensional reconstructions, which provide detailed views of soft tissue and bone. Recognizing subtle signs of trauma and correlating them with the clinical context is essential for accurate diagnosis and the child’s protection. Early detection and precise diagnosis by the radiologist enable the multidisciplinary team to intervene appropriately, ensuring the safety and well-being of vulnerable children.
This chapter provides a summary of longstanding and updated research for the accurate diagnosis of fractures of the clavicle, sternum and scapula in the setting of suspected physical abuse of infants and young children. Findings key to diagnosing fractures by radiographic skeletal survey, computed tomography, ultrasound and magnetic resonance imaging are demonstrated with numerous representative examples. A section for each of these anatomical regions includes a detailed review of anatomy and injury mechanisms in addition to characteristic imaging features. Considerations for differential diagnosis and pitfalls in interpretation are presented specific to each anatomic area. Attention to imaging technique and careful evaluation of findings are emphasized to promote proper diagnosis.
Restrictive interventions are used in the treatment of some people with severe mental disorders such as psychosis – including psychiatric intensive care unit (PICU) admission, seclusion and restraint. Early Intervention in Psychosis (EIP) service input may improve outcomes in psychosis, but it is unclear whether specific components of EIP care reduce the need for restrictive practice.
Aims
To examine associations between EIP care components, demographic characteristics and restrictive interventions.
Method
We conducted a retrospective cohort study of 14 874 people who used EIP services in England, using linked data from the National Clinical Audit of Psychosis and the Mental Health Services Data Set. We examined associations between EIP components and time to PICU admission (primary outcome) alongside seclusion/physical restraint/injected chemical restraint/requests for police assistance (secondary outcomes), using multilevel Cox regression, adjusting for demographic factors and clustering by service.
Results
Higher hazards of restrictive interventions were observed among men, younger people and several minority ethnic groups. Individuals eligible for clozapine who were not offered it (hazard ratio 1.51, 95% CI 1.20–1.91) or refused it (hazard ratio 1.46, 95% CI 1.02–2.10) had higher hazards of PICU admission than those not eligible, whereas those who were eligible for clozapine and received it did not. There was weaker evidence of similar effects on hazards of physical restraint and seclusion. Receipt of CBT for psychosis was associated with reduced hazards of PICU admission (hazard ratio 0.80, 95% CI 0.67–0.95) and physical restraint (hazard ratio 0.68, 95% CI 0.47–0.98). Substance use was associated with increased hazards of PICU admission and requests for police assistance, although substance use interventions appeared to partially mitigate this.
Conclusions
Marked demographic disparities exist in the use of restrictive practice. Specific EIP care components may be associated with reductions. Strengthening evidence-based EIP provision and addressing structural inequalities may support progress towards less coercive and more equitable care.
Edited by
Ashok Agarwal, Global Andrology Forum, Ohio, USA,Wael Zohdy, Cairo University, Egypt,Rupin Shah, Well Women’s Clinic, Sir H N Reliance Foundation Hospital, Mumbai
The WHO laboratory manual sixth edition covers sperm cryopreservation in a dedicated chapter, focused on the risk assessment of cryopreservation, storage of human semen, and the cryopreservation protocols. However, it does not cover the clinical perspectives on sperm freezing. This chapter covers clinical indications of sperm cryopreservation, sperm preparation for cryostorage, the critical elements related to testicular sperm freezing and use in intracytoplasmic sperm injection, and also the special concerns and dimensions in testicular sperm freezing for oncofertility, together with a discussion on the variations in cryopreservation practices in the context of medico-legal and psychological implications.
The present study aimed to investigate the association between adherence to the DASH diet and the risk of depression and anxiety severity in a large group of Iranian adults.
Design:
In this cross-sectional study, dietary intakes were assessed using a validated 65-item food frequency questionnaire. The Beck Anxiety Inventory and the Beck Depression Inventory II were used to assess anxiety and depression, respectively. Ordinal logistic regression was applied to evaluate the association between DASH diet and depression and anxiety severity.
Setting:
Mashhad stroke and heart atherosclerosis disorder (MASHAD) study.
Participants:
6537 and 6539 adults aged 35-65 years for depression and anxiety, respectively.
Results:
We found no significant association between adherence to the DASH diet and depression severity, in the total participants as well as both gender in either crude (total: OR: 0.98; 95% CI: 0.87-1.09, men: OR: 0.88; 95% CI: 0.73-1.07, and women: OR: 1.01; 95% CI: 0.88-1.17) or fully adjusted models (total: OR: 1.03; 95% CI: 0.91-1.16, men: OR: 0.95; 95% CI: 0.78-1.17, and women: OR: 1.04; 95% CI: 0.90-1.21). Regarding anxiety, we found that men in the third tertile of DASH diet score had lower risk of experiencing more severe anxiety compared to those in the first tertile (OR: 0.80; 95% CI: 0.67-0.96). However, after controlling for potential confounders, this relationship became non-significant (OR: 0.89; 95% CI: 0.74-1.07). In the total participants as well as women, we failed to find any significant association between adherence to the DASH diet and anxiety severity either before (total: OR: 0.97; 95% CI: 0.87-1.09, women: OR: 1.05; 95% CI: 0.92-1.21) or after controlling for possible confounders (total: OR: 1.01; 95% CI: 0.90-1.12, women: OR: 1.06; 95% CI: 0.92-1.22).
Conclusions:
We found no significant association between adherence to DASH diet and depression and anxiety severity among adults.
Health technology assessment (HTA) has long been the cornerstone of evidence-informed policy for healthcare decision-making. While randomized controlled trials (RCTs) remain fundamental, they do not always reflect the realities of everyday clinical practice. Real-world evidence (RWE) is increasingly recognized as an important complement, capable of capturing variations in population, setting, and practice that influence health outcomes. In Malaysia and across ASEAN, the growing focus on RWE reflects both global momentum and regional aspirations to strengthen data-driven policymaking. This perspective reflects on Malaysia’s experience in integrating RWE into HTA and considers how this evolution can inform regional efforts. It argues that the adoption of RWE signifies not only a methodological advance but a transformation in how evidence is conceptualized, governed, and applied. Developing robust data systems, analytical expertise, and cross-country collaboration will be essential to ensure that real-world data are translated into meaningful evidence for equitable and sustainable healthcare decisions.
Abusive spinal injury is important to understand and recognize as it may be the only manifestation of child physical abuse and may result in significant morbidity and mortality if undetected. In this chapter, we review historical literature about spinal trauma in the era of radiography and skeletal surveys as well as the expanding literature, epidemiology and understanding of this manifestation of inflicted injury in the era of increased CT and MRI utilization. We highlight key anatomic considerations of developing infants and young children, which make them susceptible to specific types of inflicted spine trauma with emphasis placed on the craniocervical junction, which is particularly susceptible to injury. We provide many imaging case examples to help the reader understand and recognize the myriad and specific types of injuries that occur. Considering our increased understanding of abusive spinal trauma, we discuss implications to imaging evaluation, technique and screening if inflicted spinal injury is detected or suspected.
This chapter provides multiple-choice questions designed to reinforce and expand your knowledge of bipolar disorder, including symptom presentation and assessment, neurobiology, treatment mechanisms, clinical characteristics of treatments, treatment strategies, and considerations for special populations.
The Nutrition Society of Australia’s 2025 Annual Scientific Meeting was held at the Gold Coast Convention Centre, Queensland, Australia, from 3 to 5 December. Centred on the theme ‘Nourishing Generations: 50 Years of the Nutrition Society of Australia’, the meeting marked a milestone in the Society’s history and celebrated its enduring contribution to nutrition science. The conference featured a public symposium, pre-conference workshops, plenary lectures, thematic oral and poster sessions, and dedicated sessions for early career researchers. A highlight of the meeting was the recognition of four outstanding researchers who received Awards of Excellence for their significant contributions to the field. Together, these elements created a vibrant and forward-looking scientific meeting that honoured the past while showcasing cutting-edge research and innovation across diverse fields of nutrition, reflecting a shared commitment to advancing health equity through evidence-based practice.
Fractures from accidental trauma to the extremities or ribs in young infants are rare. Towards the end of the first year, when infants begin to gain mobility, accident fractures become more common and are quite prevalent in toddlers. All patterns of accidental fractures may also occur due to abuse; however, presentation and clinical and associated physical examination and imaging findings may suggest abuse. Fractures similar to high specificity abusive fractures may rarely occur from accidental mechanisms.
Iatrogenic fractures are rare in infants and young children. Careful review of the purported mechanism and for underlying bone disease is necessary. Radiographic findings may overlap with abusive fractures, suggesting mechanistic similarities.
The implementation of the World Health Organization’s multimodal strategy is crucial for strengthening infection prevention and control (IPC) programs. This study aimed to evaluate and compare the perceptions of infection prevention and control professionals (IPCPs) and healthcare workers (HCWs) regarding the effectiveness of the multimodal strategy.
Methods:
In this study, an online survey was designed that included five MM components: system change, education and training, monitoring and feedback, reminders and communication, and cultural change. The survey was completed by IPCPs and HCWs within the institutions.
Results:
A total of 102 IPCPs and 166 HCWs from 96 institutions participated in the survey. The mean career duration was 19.8 ± 9.5 years. An Infection Control Committee (ICC) was present in 98% of participants’ institutions, and 88% held meetings every three months. Only 10 (10.4%) institutions met the ratio of 1IPC nurse per 150 beds. Effective communication techniques training was provided annually to 55.9% of IPCPs and 59.6% of HCWs.
Eighty-one (79.4%) IPCPs reported using effective communication when explaining the five indications of hand hygiene, but only 77 (46.4%) HCWs agreed (P < .001). Ninety-one (89.2%) IPCPs confirmed that effective communication techniques were used in bundle training. But, only 25 (15.0%) HCWs agreed, while 112 (67.5%) HCWs reported being undecided (P < .001). Sixty-one (64.7%) IPCPs and 130 (78.3%) HCWs believed that their institutions effectively motivated HCWs towards IPC measures compliance. However, 44 (43.1%) IPCPs and 29 (17.5%) HCWs were undecided (P = .002).
Conclusion:
The survey reveals significant inconsistencies among IPCPs and HCWs regarding communication effectiveness, and perceptions of compliance with infection-control measures. These findings highlight the need for more inclusive and transparent communication strategies, regular interdisciplinary training, and stronger organizational support to improve IPC practices.
This study evaluated the consumption of rice and beans in Brazil, two staples of the Brazilian diet, by describing their consumption according to sociodemographic characteristics and assessing its association with nutritional quality, environmental impact, and affordability of the diet.
Design:
Cross-sectional study.
Setting:
Brazil.
Participants:
We analysed food consumption data from 46,164 individuals aged 10 years and older, based on the most recent Household Budget Survey (2017–2018) in Brazil. The survey used a two-stage cluster sampling design and provides nationally representative data, covering all regions, states, metropolitan areas, capitals, and urban and rural zones in Brazil.
Results:
In Brazil, rice and beans accounted for 10.75% and 6.33% of total daily energy intake, respectively. Their consumption was important across all sociodemographic groups analysed. Rice and beans intake was associated with nutritional quality, reduced environmental impact, and lower diet costs. Higher combined consumption of rice and beans was associated with a 44.49% reduction in nutritional inadequacies in the diet, a 17.64% decrease in carbon footprint, a 21.05% decrease in water footprint, and a 38.03% reduction in total diet cost, compared to lower consumption.
Conclusions:
Promoting increased consumption of rice and beans in Brazil offers a culturally appropriate solution in response to the global call for healthier and more sustainable diets, and is the most effective approach to improve human health and environmental sustainability in an affordable way in Brazil.
In Africa, bewitchment is described as a moral framework that helps individuals and societies make sense out of disease and misfortune. Numerous African belief systems attribute difficult-to-treat health problems to bewitchment, rather than a conventional medical diagnosis, especially if biomedical doctors are unable to resolve the condition. This study examines one such illness, known as xifula, in rural Limpopo Province, South Africa.
Methods:
Using convenience sampling, 95 participants (≥18 years old) were interviewed to gauge their knowledge of the condition known as xifula. Data was analysed using NVivo software.
Findings:
Xifula is a cultural concept of distress related to bewitchment. The most common symptom of xifula is swelling of the legs or hands, followed by chronic headaches. Participants noted that xifula can start as a minor ailment, but then grows into a larger problem. After a long period without healing, however, xifula can begin to represent a significant threat to the individual’s health. Nearly all participants noted that xifula cannot be treated by Western biomedical professionals and instead requires a traditional healer to treat the condition.
Interpretation:
This research highlights the importance of context-specific education about the diagnosis and treatment of common ailments, as beliefs about afflictions, their causes, and appropriate treatments suggest a need for tailored information. As biomedical and traditional healthcare currently exist as parallel, siloed structures of diagnosis and treatment in Africa, there should also be efforts to bridge the divide between the two.
Funding:
This study was funded by a grant from the John Templeton Foundation.
The clinical approach to the diagnosis of abusive head trauma involves many medical specialties. Careful history, which includes an understanding of pediatric development, differential diagnosis of medical conditions and the types of injuries that can result in head trauma is necessary. The collaboration with radiologists, neuroradiologists, ophthalmologists, neurosurgeons and many other specialists provides informative insight into a child’s presentation of head trauma, whether accidental or inflicted through an abusive act. This chapter informs the clinical and biomechanical evidence associated with injuries often seen in cases of abusive head trauma, and highlights how collaboration between researchers in both fields can enhance the safety and protection of children.
Edited by
Ashok Agarwal, Global Andrology Forum, Ohio, USA,Wael Zohdy, Cairo University, Egypt,Rupin Shah, Well Women’s Clinic, Sir H N Reliance Foundation Hospital, Mumbai
The interpretation of semen analysis results has undergone significant changes with the release of the WHO sixth edition manual, which abandons traditional reference ranges based on the 5th percentile of fertile populations. Historically, clinicians relied heavily on fixed reference limits to classify semen parameters as normal or abnormal, directly influencing fertility assessments. However, this approach has been criticized for its lack of global representativeness, biological variability, and limited predictive power for fertility potential. This chapter discusses the rationale behind abandoning rigid reference limits, explores the current role and limitations of semen analysis, and proposes new frameworks for interpreting semen reports. These include the use of percentile-based sliding scales to reflect fertility gradients and correlations with time to pregnancy, which better capture male fertility potential. The chapter also examines geographic, ethnic, and biological variability in semen parameters and outlines potential decision limits to improve clinical utility. Finally, practical recommendations are offered for clinicians to apply these concepts in patient management, emphasizing the importance of a nuanced, evidence-based approach.
This chapter reviews the imaging approach in suspected child physical abuse, including differing presentations of child physical abuse as well as recommendations for screening children at risk. Imaging strategy of the skeleton, including radiography, chest CT, ultrasound, whole-body MR and radionuclide bone imaging is reviewed.
Edited by
Ashok Agarwal, Global Andrology Forum, Ohio, USA,Wael Zohdy, Cairo University, Egypt,Rupin Shah, Well Women’s Clinic, Sir H N Reliance Foundation Hospital, Mumbai
This chapter provides multiple-choice questions designed to reinforce and expand your knowledge of sleep/wake disorders, including symptom presentation and assessment, neurobiology, treatment mechanisms, clinical characteristics of treatments, treatment strategies, and considerations for special populations.