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In recent decades, the potency of cannabis resin increased globally, raising concerns, as higher potency has been associated with increased risk of psychiatric harms at the individual level. The aim here was to examine whether changes over time in the potency of seized cannabis resin samples were associated with psychiatric harms at the population level.
Methods
Data on ∆-9-tetrahydrocannabinol (THC) concentration in seized cannabis resin were obtained from forensic departments in Denmark (2000–2022), the country reporting the highest potency in Europe. Data on admissions to cannabis treatment, incidence of cannabis-induced psychosis, and dual diagnosis (schizophrenia and cannabis use disorder) were obtained from national registers. Time-dependent associations between potency and the outcomes were examined with mixed-effects linear regression models and associations across age and sex were explored. Candidate time lags were 0–10 years.
Results
THC concentration increased almost fourfold: mean 8.3–31.2% from 2000 to 2022. In fully adjusted models, THC was positively associated with first-time cannabis treatment entry at lags of 0–6, strongest at year 0 (p < 0.0001); incidence of cannabis-induced psychosis at lags of 0–4, strongest at year 0 (p < 0.0001); and incidence of dual diagnosis at lags of 0–1, strongest at year 0 (p < 0.01). No positive associations were found in unadjusted models. Subgroup analyses indicated associations in older patients and women.
Conclusions
Potency of seized cannabis resin increased almost fourfold from 2000 to 2022. Changes in cannabis potency were positively associated with psychiatric harms at the population level across all outcomes.
Poor nutrition and the rise in inequalities in diet and obesity during childhood and adolescence are of concern in Ireland and globally. Food insecurity among families is also on the rise and impacts children and youth beyond the effects of poverty alone. The social, structural and commercial determinants of health help to explain why dietary and health inequalities exist yet the solutions to such inequity have been slow, delayed and difficult to implement. This review takes a health promotion approach to the diet of children and adolescents, drawing on evidence in the Republic of Ireland and beyond to emphasize a need for supportive environments and health promoting public policy. Schools are a key setting to improve dietary habits and diet-related diseases. The impact of food environments on dietary habits both within and external to schools is clear with evidence supporting the implementation of universal school meal provision and the use of planning regulations to enable healthier environments. Evidence of how best to support children and adolescent’s diet out-of-term time is needed, especially within the Irish context. There is a clear need for upstream measures to support healthy dietary habits such as legislation to enforce restrictions of food marketing to children and extension of taxation of foods. Children and adolescents have the right and capacity to be involved in changes needed to our food system so that the marketing, availability and affordability of healthy foods becomes the norm for children and adolescents.
To examine and synthesize data on the environmental impact of diet in Latin America.
Design:
A systematic review was conducted in April 2024, using Medline, Embase, Web of Science and Scopus databases, and updated in March 2025. We synthesized the evidence on the most reported environmental impact indicators. Meta-analysis was conducted to derive pooled estimates for individual countries of the mean dietary carbon and water footprints per person/per day; crude and energy-standardised (to 8,368 kJ (2,000 kcal)) values and stratified by dietary assessment method (DAM) and sociodemographic variables.
Setting:
Latin America
Participants:
Latin American populations
Results:
Of the 4,266 studies screened, 31 were included. Data on environmental impact of diet were reported for eight Latin American countries, with most coming from Brazil. Dietary water footprint ranged from 2,078 in Chile to 3,215 L/person/day/8,368 kJ in Brazil. Dietary carbon footprint ranged from 2.1 to 7.3 kgCO2-equivalents/person/day/8,368 kJ, in Peru and Argentina, respectively. The pooled standardised carbon footprint mean was 4.1 (95% CI 2.6–5.5, I2=100%) kgCO2-equivalents/person/day/8,368 kJ with no significant differences between DAM (p=0.86). A higher carbon footprint was observed in individuals with higher education level and urban residence (p<0.05).
Conclusion:
The available evidence suggested a wide variation in dietary environmental impact between Latin American countries, but a paucity of studies conducted in countries other than Brazil. Standardised approach to estimate the environmental impact of diet across the region, and analytical perspectives in further research would support the development of country-relevant evidence-based public policies for sustainable diets in Latin America.
Healthcare organizations face ongoing challenges, including staff shortages, high rates of burnout, and a complex regulatory and financial environment. This book is among the first of its kind to introduce Polyvagal Theory (PVT), and how it explains human behavior under stress. Understanding human responses to stressful situations holds significant value in enhancing patient care and operational efficiency, leading to happier staff, increased productivity and decreased costs. PVT can be widely applied, including in human resources and workplace policies and procedures, providing significant benefit in both direct patient care and business aspects of any health care organization. Exploring the core tenets of PVT, this book equips healthcare providers and organizations with the knowledge to understand and apply this theory effectively. Featuring easy-to-understand exercises which can be applied in any setting, this is an essential guide for all healthcare providers seeking to implement PVT into their policies, procedures, and clinical interventions.
Edited by
Ashok Agarwal, Global Andrology Forum, Ohio, USA,Wael Zohdy, Cairo University, Egypt,Rupin Shah, Well Women’s Clinic, Sir H N Reliance Foundation Hospital, Mumbai
This introductory chapter emphasizes the importance of semen analysis in assessment of infertile men and its value in research. The chapter will highlight the new features in the sixth edition of the WHO laboratory manual and will explain the major differences between the manual and the clinicians’ guidelines that will be covered in this book. This chapter also provides the readers with an overview of next chapters.
This chapter provides multiple-choice questions designed to reinforce and expand your knowledge of substance use disorders and impulsive-compulsive disorders, including neurobiology of impulsivity and compulsivity, neurobiology of reward, mechanisms of drugs of abuse, treatments for substance use disorders, and treatments for impulsive-compulsive disorders such as obsessive compulsive disorder (OCD).
This chapter provides multiple-choice questions designed to reinforce and expand your knowledge of unipolar depression, including symptom presentation and assessment, neurobiology, treatment mechanisms, clinical characteristics of treatments, treatment strategies, and considerations for special populations.
Injuries to the scalp and cranium are often encountered in children who suffer abusive head trauma. Various imaging modalities, such as radiography, CT and MRI, contribute to accurately diagnosing these injuries and reliably differentiating them from normal variants. A significant challenge in both radiographic and clinical evaluations of skull fractures and extracranial soft tissue injuries is the resemblance between accidental and nonaccidental injuries. Thus, a comprehensive approach that combines imaging findings with the patient’s history, physical examination and laboratory results is essential in each case. This chapter presents vital information on the developmental anatomy of the cranium and scalp and how these relate to traumatic injuries. It also reviews the imaging features of typical abusive injuries, their association with specific mechanisms of trauma and the appropriateness of various imaging modalities.
This chapter reviews the normal anatomy, fractures and challenges of the upper extremity frequently encountered in child abuse imaging. Specifically, fracture types of the humerus, the elbow and the forearm are examined with attention to imaging techniques and protocols, particularly radiography and ultrasound.
Identify dietary patterns among U.S. older adults and examine their associations with sociodemographic and health characteristics including economic and physical-functioning-related food insecurity.
Design:
Secondary analysis of dietary intake data from the 2013–2018 What We Eat in America component of NHANES. Dietary patterns were derived using cluster analysis and compared by diet quality (HEI-2020), demographic characteristics, health indicators, and multidimensional food insecurity.
Setting:
United States.
Participants:
A nationally representative sample of 5,062 adults aged ≥60 years
Results:
Five dietary patterns were identified. The largest pattern, “Juices, smoothies, grain drinks, and soups” (53.0%), was characterized by the lowest mean energy and protein intake and a moderate HEI-2020 score (66.0 ± 0.8). In contrast, the “Cooked cereals and yogurt” pattern (10.8%) had the highest HEI-2020 score (72.3 ± 1.4) and more favorable health indicators. Patterns high in processed meats and baked goods—“Cured meats, sandwiches, and sweet bakery products” (18.1%) and “Meats, alcohol, and quick breads” (11.0%)—had the lowest diet quality scores (48.5 ± 1.0 and 58.3 ± 1.6, respectively) and were more common among younger older adults, males, current smokers, and individuals with obesity. Food insecurity due to both economic constraints and physical functioning limitations was most prevalent in the lower-quality soft-food pattern and least prevalent in the “Seafood and vegetables” pattern (0.5%).
Conclusions:
Distinct dietary patterns exist among U.S. older adults, with substantial variation in diet quality, health characteristics, and food insecurity. Interventions should address both economic and functional barriers to support nutrient-dense, texture-appropriate diets in older adults.
Numerous normal anatomical variants in the pediatric skeleton can be mistaken for fracture. It is important to be aware of variants to provide accurate diagnosis and avoid potential false interpretations of possible abuse.
Along the long bone diaphysis, in infants 1–4 months of age, smooth and thin periosteal new bone formation may be physiologic and not indicative of healing fracture. At the metaphyses in the growing skeleton, the subperiosteal bone collar is an osseous ring surrounding the metaphysis adjacent to the physis. It is responsible for variants in metaphyseal morphology, including beaking, step-offs and spurs, which can be mistaken for the classic metaphyseal lesion often associated with child abuse.
Variant ossification patterns at the acromion and pelvis, if unrecognized, can lead to concern for fracture. In addition, congenital abnormalities of the ribs and clavicles, including fusion anomalies and pseudarthroses, can simulate chronic, healing fracture.
This chapter reviews these and other developmental variants, and describes how to differentiate them from true fractures. Artifacts simulating fractures are briefly covered.