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We present numerical and analytical predictions of mucociliary clearance based on the continuum description of a viscoelastic mucus film, where momentum transfer from the beating cilia is represented via a Navier-slip boundary condition introduced by Bottier et al. (PLoS Comput. Biol., vol. 13, issue 7, 2017a, e1005552). Mucus viscoelasticity is represented via the Oldroyd-B model, where the relaxation time and the viscosity ratio have been fitted to experimental data for the storage and loss moduli of different types of real mucus, ranging from healthy to diseased conditions. We solve numerically the fully nonlinear governing equations for inertialess flow, and develop analytical solutions via asymptotic expansion in two limits: (i) weak viscoelasticity, i.e. low Deborah number; (ii) low cilia beat amplitude (CBA). All our approaches predict a drop in the mucus flow rate in relation to the Newtonian reference value, as the cilia beat frequency is increased. This relative drop increases with decreasing CBA and slip length. In diseased conditions, e.g. mucus properties characteristic of cystic fibrosis, the drop reaches 30 % in the physiological frequency range. In the case of healthy mucus, no significant drop is observed, even at very high frequency. This contrasts with the deterioration of microorganism propulsion predicted by the low-amplitude theory of Lauga (Phys. Fluids, vol. 19, issue 8, 2007, 083104), and is due to the larger beat amplitude and slip length associated with mucociliary clearance. In the physiological range of the cilia beat frequency, the low-amplitude prediction is accurate for both healthy and diseased conditions. Finally, we find that shear-thinning, modelled via a multi-mode Giesekus model, does not significantly alter our weakly viscoelastic and low-amplitude predictions based on the Oldroyd-B model.
The linear and nonlinear stability of two concentric jets separated by a duct wall is analysed by means of global linear stability and weakly nonlinear analysis. Three governing parameters are considered, the Reynolds number based on the inner jet, the inner-to-outer jet velocity ratio ($\delta _u$) and the length of the duct wall ($L$) separating the jet streams. Global linear stability analysis demonstrates the existence of unsteady modes of inherent convective nature, and symmetry-breaking modes that lead to a new non-axisymmetric steady state with a single or double helix. Additionally, we highlight the existence of multiple steady states, as a result of a series of saddle-node bifurcations and its connection to the changes in the topology of the flow. The neutral lines of stability have been computed for inner-to-outer velocity ratios within the range $0 < \delta _u < 2$ and duct wall distances in the interval $0.5 < L < 4$. They reveal the existence of hysteresis, and mode switching between two symmetry-breaking modes with azimuthal wavenumbers $1:2$. Finally, the mode interaction is analysed, highlighting the presence of travelling waves emerging from the resonant interaction of the two steady states, and the existence of robust heteroclinic cycles that are asymptotically stable.
A thin liquid droplet spreads on a soft viscoelastic substrate with arbitrary rheology. Lubrication theory is applied to the governing field equations in the liquid and solid domains, which are coupled through the free boundary at the solid–liquid interface, to derive a set of reduced equations that describe the spreading dynamics. Fourier transform techniques and the finite difference method are used to construct a solution for the dynamic liquid–gas and solid–liquid interface shapes, as well as the macroscopic contact angle. Substrate properties affect the spreading dynamics through the contact angle and internal droplet flow fields, and these mechanisms are revealed. Increased substrate softness increases the spreading rate, whereas increased viscoelasticity decreases the spreading rate. For the case of a purely elastic substrate, the spreading power-law exponent recovers Tanner's law in the rigid limit and increases with substrate softness.
The question here is whether the biochemical processes observable on Earth would be replicated on another planet. Take photosynthesis as an example. This is the means by which plants utilise sunlight in the production of adenosine triphosphate (ATP) and glucose as sources of energy. During this process oxygen is given off and carbon dioxide is absorbed, hence the value of photosynthesis for environments on our planet. The actual process is highly complex and involves electrons going through intricate chemical reactions leading at the end to glucose formation. There is also a kind of reverse process, which involves the release of energy through the oxidation of a chemical derived from carbohydrates, fats and proteins. This is known as the citric acid cycle, an essential metabolic pathway used by aerobic organisms.
As humans we are confronted with devices which are supposed to work and often do not. Just think of all the domestic appliances you have at home. Do all of them work? I am sure that you can remember the time when the toaster gave up the ghost or the torch in the garden shed did not work. We have a notion of device and we have an expectation that it will work. But when we say a device does not work, what do we mean? Generally, we mean that it does not perform the function we expect of it. If you put sliced bread into the toaster and press down the lever at the side and nothing happens you utter a sigh of frustration because the device is not working.
We present a theoretical asymptotic solution for high-speed transient flow through microporous media in this work by addressing the inertia effect in the high-pressure-difference pulse-decay process. The capillaric model is adopted, in which a bundle of straight circular tubes with a high length–radius ratio is used to represent the internal flow paths of microporous media so that the flow is described by a simplified incompressible Navier–Stokes equation based on the mean density, capturing the major characteristics of mass flow rate. By order-of-magnitude analysis and asymptotic perturbation, the inertial solution with its dimensionless criterion for the high-pressure-difference pulse-decay process is derived. To be compared with experimental data, the theoretical solution involves all three related effects, including the inertia effect, the slippage effect and the compressibility effect. A self-built experimental platform is therefore established to measure the permeability of microporous media by both pulse-decay and steady-state methods to validate the theoretical solution. The results indicate that the relative difference between two methods is less than 30 % even for permeability at as low as $48.2$ nD $(10^{-21}\,{\rm m}^2)$, and the present theoretical solution can accurately capture the inertia effect in the high-pressure-difference pulse-decay process, which significantly accelerates the measurements for ultra-low-permeability samples.
In classical physics, a distinction is made between two different concepts: waves and particles. However, various experiments have shown that this strict distinction must be replaced by a new concept.
In mathematical terms, an operator transforms a given function into a new function. To better understand operators, we summarise the analogies with matrices below.
What might exobeings really be like? To begin answering this question consider the deep history of our own evolution. Would the evolution of exobeings show the same key turning points we find in our own evolution? Would they develop complex multicellular life forms at an early stage and then move on to become vertebrates with a central nervous system controlled by a brain, allowing them to move around freely in their surroundings?1 Indeed, to what extent would what appear to us as preconditions, vertebrae and a skeleton to stabilise an animal’s body, be necessary on an exoplanet?
The degree of variability on an exoplanet could be similar to that found on Earth, with a certain range for cognitive ability (types of intelligence), personality, aspects of physical appearance such as size, eye and hair colour or shape of skeleton (observable in body build, hands, feet, arms, legs, etc.).
A key question that is often posed is, ‘Are we alone in the universe?’ If the answer to this question were simply ‘Yes’ or ‘No’, this book would probably not have been written. But what looks like a simple question is actually a complex and multifaceted set of issues which can hopefully be elucidated by discussing the many aspects involved.
First, by ‘the universe’ we can only mean the small corner of the galaxy which we inhabit, say within about a 100-light-year or, at maximum, 1,000-light-year radius. This is a tiny fraction of our Milky Way galaxy (at least 100,000 light years in diameter) and we cannot even see half of the galaxy which is beyond the central bulge of the disk on the other side. The Milky Way is an infinitesimally small part of the entire universe.
Normally the final section of a book on language matters would simply be labelled ‘Conclusion’, where the author reviews the main arguments in the book, draws the threads together and presents the results and insights in summary form. However, with this book there can be no definitive conclusion as the subject matter is speculative. But what one can do is summarise the possibilities of exolanguage as a series of questions with tentative answers. Admittedly, the following may be regarded by some readers as unduly anthropocentric, too heavily reliant on what we humans are like. However, in keeping with the principle applied throughout this book, the speculative sections begin with what we know from our existence on our Earth and then move in careful steps to consider what might be the case for exobeings on an exoplanet.
Consider that space exploration is not yet even 100 years old nor is digital technology, which is advancing at a breath-taking pace.1 Assuming that such technology will continue unabated and that there are no negative impacts from other quarters,2 we can further assume that the ability of humans to probe the universe with increasingly powerful instruments will continue to increase and allow us to discover ever more about the planets around other stars.
The great advances in astronomy in the past century or so were initially theoretical in that they rested on predictions about what the universe is like and how certain phenomena such as light would behave on scales much larger than those on Earth.
The ability to speak a language rests on physical aspects of our brains. We can identify areas which are especially important for language, and we can examine individuals with language impairments to gain some insights into the manner in which knowledge of language is stored in the brain. This study of language in relation to the brain is called neurolinguistics. It is a special field which is becoming increasingly a focus of interest for linguists. It is true that it is not possible to pinpoint linguistic activity in the brain, to put the transmission of minute electrical currents between nerve cells in correlation with the production of language. Nor can linguistic structures be assigned to the information stored in these cells.