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The impact of hepatitis B virus (HBV) infection on clinical outcomes of coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study is to explore this impact. For this systematic review and meta-analysis, we searched PubMed, Web of Science, Embase, Cochrane library, China National Knowledge Infrastructure (CKNI), China Science and Technology Journal Database (VIP), and Wan Fang database for articles between 1 January 2020 and 1 February 2023. We used the Newcastle–Ottawa Quality Assessment to evaluate the study’s quality. A random-effects meta-analysis was performed utilising the rates of severe/critical illness and death in COVID-19 patients with and without HBV infection. Eighteen studies with a total of 40,502 participants met the inclusion criteria. The meta-analysis showed that compared to those without HBV infection, COVID-19 patients with HBV were at increased risk of mortality (OR = 1.65, I2 = 58%, and 95% CI 1.08–2.53) and severity (OR = 1.90, I2 = 44%, and 95% CI 1.62–2.24). The region and gender may influence the outcomes of COVID-19 patients with HBV infection, but it requires more global data to confirm. In conclusion, HBV infection is significantly linked to an increased risk of severity and mortality in COVID-19.
We show that the size-Ramsey number of the $\sqrt{n} \times \sqrt{n}$ grid graph is $O(n^{5/4})$, improving a previous bound of $n^{3/2 + o(1)}$ by Clemens, Miralaei, Reding, Schacht, and Taraz.
Developed sequential order statistics (DSOS) are very useful in modeling the lifetimes of systems with dependent components, where the failure of one component affects the performance of remaining surviving components. We study some stochastic comparison results for DSOS in both one-sample and two-sample scenarios. Furthermore, we study various ageing properties of DSOS. We state many useful results for generalized order statistics as well as ordinary order statistics with dependent random variables. At the end, some numerical examples are given to illustrate the proposed results.
The aim of this study is to evaluate the infection risk of aircraft passengers seated within and beyond two rows of the index case(s) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A(H1N1)pdm09 virus, and SARS-CoV-1. PubMed databases were searched for articles containing information on air travel–related transmission of SARS-CoV-2, influenza A(H1N1)pdm09 virus, and SARS-CoV-1 infections. We performed a meta-analysis of inflight infection data. In the eight flights where the attack rate could be calculated, the inflight SARS-CoV-2 attack rates ranged from 2.6% to 16.1%. The risk ratios of infection for passengers seated within and outside the two rows of the index cases were 5.64 (95% confidence interval (CI):1.94–16.40) in SARS-CoV-2 outbreaks, 4.26 (95% CI:1.08–16.81) in the influenza A(H1N1)pdm09 virus outbreaks, and 1.91 (95% CI:0.80–4.55) in SARS-CoV-1 outbreaks. Furthermore, we found no significant difference between the attack rates of SARS-CoV-2 in flights where the passengers were wearing masks and those where they were not (p = 0.22). The spatial distribution of inflight SARS-CoV-2 outbreaks was more similar to that of the influenza A(H1N1)pdm09 virus outbreaks than to that of SARS-CoV-1. Given the high proportion of asymptomatic or pre-symptomatic infection in SARS-CoV-2 transmission, we hypothesised that the proximity transmission, especially short-range airborne route, might play an important role in the inflight SARS-CoV-2 transmission.
A testing rate for measles above 80% is required by the WHO European Region Measles Elimination strategy to verify elimination. To comply with this rate, we explored factors associated with the return of oral fluid kits (OFK) by suspected measles cases. We described the cases and conducted a mixed-effects analysis to assess the relationship between socio-demographic and public health management characteristics and the likelihood of returning an OFK to the reference laboratory. Of 3,929 cases who were sent a postal OFK, 2,513 (67%) returned the kit. Adjusting for confounding, registration with a general practitioner (GP) (aOR:1.48, 95%CI:1.23–1.76) and living in a less deprived area (aOR:1.35, 95%CI:1.04–1.74) were associated with an increased likelihood of returning the OFK. The odds of returning the OFK also increased if the HPT contacted the parents/guardians of all cases prior to sending the kit and confirmed their address (aOR:2.01, 95%CI:1.17–3.42). Cases notified by a hospital (aOR:1.94, 95%CI:1.31–2.87) or GP (aOR:1.52; 95%CI:1.06–2.16) also had higher odds of returning the OFK. HPTs may want to consider these factors when managing suspected cases of measles since this may help in increasing the testing rates to the WHO-recommended level.
While finite element (FE) modeling is widely used for ultimate strength assessments of structural systems, incorporating complex distortions and imperfections into FE models remains a challenge. Conventional methods typically rely on assumptions about the periodicity of distortions through spectral or modal methods. However, these approaches are not viable under the many realistic scenarios where these assumptions are invalid. Research efforts have consistently demonstrated the ability of point cloud data, generated through laser scanning or photogrammetry-based methods, to accurately capture structural deformations at the millimeter scale. This enables the updating of numerical models to capture the exact structural configuration and initial imperfections without the need for unrealistic assumptions. This research article investigates the use of point cloud data for updating the initial distortions in a FE model of a stiffened ship deck panel, for the purposes of ultimate strength estimation. The presented approach has the additional benefit of being able to explicitly account for measurement uncertainty in the analysis. Calculations using the updated FE models are compared against ground truth test data as well as FE models updated using standard spectral methods. The results demonstrate strength estimation that is comparable to existing approaches, with the additional advantages of uncertainty quantification and applicability to a wider range of application scenarios.
We consider the simple random walk on the d-dimensional lattice $\mathbb{Z}^d$ ($d \geq 1$), traveling in potentials which are Bernoulli-distributed. The so-called Lyapunov exponent describes the cost of traveling for the simple random walk in the potential, and it is known that the Lyapunov exponent is strictly monotone in the parameter of the Bernoulli distribution. Hence the aim of this paper is to investigate the effect of the potential on the Lyapunov exponent more precisely, and we derive some Lipschitz-type estimates for the difference between the Lyapunov exponents.
The purpose of and benefits from conducting program evaluations are described in this section. Accreditation of healthcare services is instrumental to terminate unpopular programs and to open up new and innovative ones. Healthcare policy makers use program evaluations to improve healthcare and social services. The evaluating team focuses on the following issues.
This epilogue recaps the major approaches to healthcare decision-making covered in this book, whether those decisions are reached by patients, insurance agents, government agents including policy makers, or healthcare professionals including hospital administrators.
Any adverse event is detrimental to patient welfare and to the reputations of the hospital/clinic, physicians’ or nurses’ licensing agency, and health insurance providers. All healthcare professionals desire to avoid adverse events. The chance for a recurrence of an adverse event could be lessened if health administrators learn from its first occurrence. For this purpose, health administrators perform what is termed root cause analysis (RCA). More often, RCA is done by interdisciplinary professionals and members of the patient community as an interactive team. There are three types of RCA – divergent, serial, or convergent. Which one among the three is medically or intuitively nontrivial? This chapter provides concepts, tools, and remedial plans to address non-repeatability. This knowledge springs from the collection of pertinent data for the selected adversity, an analytic approach to trace the causes, and setting up plans to ensure its nonoccurrence in the future.
What is a decision? A decision is the process of selecting one option over others for the sake of some advantages. The advantages might be a minimal use of time or human resources, or constrained and/or gained profits. When no alternative appears that is better than the chosen decision in any sense, that decision is called the optimal decision. Attaining the optimum decision is not quite trivial at times due to the complexity of reality. The decision maker is often in need of technical experts called analysts who can simplify, organize, and make the decision easier for the decision maker. Decision-making is a cooperative effort to reach the optimal decision. When these joint efforts succeed, the decision maker and the analyst are appreciated and applauded. When the decision results in failure with a measurable loss, the decision maker is blamed. The decision maker therefore undertakes full responsibility for directing the decision-making process.
First, let us examine the role of uncertainty in scientific inquiries in general and in healthcare decision-making in particular. Weurlander (2020) warns physicians to be careful to deal with uncertainty before making decisions to treat patients. Koffman et al. (2020) discuss reasons for involving uncertainty in healthcare, especially with respect to the COVID-19 pandemic. Uncertainty is not easily defined because of inadequate, incomplete, and ambiguous information.
Many occurrences in personal and professional life exhibit patterns of complete unpredictability – climate, disease outbreaks, financial volatility, natural disasters. Especially in healthcare, a specified outcome might be seen or missing. This vagueness is framed as uncertainty and raises fundamental challenges. Understanding how uncertainties appear is perhaps the beginning of solving this issue. Like an atom can be decomposed to its constituent parts of electrons, neutrons, and protons, the probability of uncertainty can be decomposed to its axioms. Refer to Camio et al. (2019) and Scoones (2019) for more discussion of how uncertainty is identified and illustrated.
First, let us examine why decisions become more authentic and accurate when they are based on evidence. Not all healthcare professionals are convinced data-based decision-making is prudent. To make such decision-making feasible, knowledge of data collection and its analysis is a necessity. Analysts help decision makers handle these complex technicalities. Rarely does a decision maker encounter only one technicality. Consequently, the decision maker may need more than one analyst.
How do we define an analyst? An analyst has the expertise and the knowledge base to study the available information and to understand the choices in front of the decision maker along with the consequences of each.
How do we define the healthcare administrator as a decision maker? The healthcare decision maker has the responsibility to make the best decision in his or her healthcare practices.
In this chapter, methods to collect data from several reliable sources are articulated first. Then the importance of checking the authenticity of the data source is stated. Storing the collected data in Excel spreadsheets is vital. Refer to Hardin and Kotz (2020) for suggestions on improving data collection and amenability. Surging in popularity, mobile health (mHealth) apps foster research, clinical regimens, and individual well-being.
These procedures encourage proactivity and ongoing accountability for healthcare. For the purpose of addressing pertinent healthcare inquiries and quantifying health outcomes, information gathering and assessment on selected variables within a structure coalesce into a process called data collection, which is an essential step in research in all fields, including healthcare. While methods vary across disciplines, the emphasis of all data collection should be accuracy.
Healthcare administrators working in hospitals, clinics, government agencies, and financial and insurance institutions must probe whether the healthcare services they provide are effective, efficient, and optimal. Health economists and data analysts invest time and effort to project the future performance of the healthcare services their institutions provide. These and related concerns could be answered by time series data analysis and forecasting. Hospital/clinic administrators, healthcare professionals, insurance agents, and patients all desire high-quality healthcare services utilizing a minimal amount of resources.
Developed and developing nations alike notice a percentage of their populations has inadequate health insurance coverage. Resources providers encounter restrictions that forbid financial support to underserved populations, including those with no health insurance coverage. Attempts have frequently been made to raise efficiency and cost-effectiveness in healthcare services. However, to achieve these goals, background knowledge and skill are essential and good understanding of forecasting methods can help healthcare administrators learn, apply, and utilize data to attain their goals. Every constituency involved in healthcare is aware of the necessity to improve the quality of healthcare services on a daily or a periodical basis.