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For independent exponentially distributed random variables $X_i$, $i\in {\mathcal{N}}$, with distinct rates ${\lambda}_i$ we consider sums $\sum_{i\in\mathcal{A}} X_i$ for $\mathcal{A}\subseteq {\mathcal{N}}$ which follow generalized exponential mixture distributions. We provide novel explicit results on the conditional distribution of the total sum $\sum_{i\in {\mathcal{N}}}X_i$ given that a subset sum $\sum_{j\in \mathcal{A}}X_j$ exceeds a certain threshold value $t>0$, and vice versa. Moreover, we investigate the characteristic tail behavior of these conditional distributions for $t\to\infty$. Finally, we illustrate how our probabilistic results can be applied in practice by providing examples from both reliability theory and risk management.
In this article we prove new central limit theorems (CLTs) for several coupled particle filters (CPFs). CPFs are used for the sequential estimation of the difference of expectations with respect to filters which are in some sense close. Examples include the estimation of the filtering distribution associated to different parameters (finite difference estimation) and filters associated to partially observed discretized diffusion processes (PODDP) and the implementation of the multilevel Monte Carlo (MLMC) identity. We develop new theory for CPFs, and based upon several results, we propose a new CPF which approximates the maximal coupling (MCPF) of a pair of predictor distributions. In the context of ML estimation associated to PODDP with time-discretization $\Delta_l=2^{-l}$, $l\in\{0,1,\dots\}$, we show that the MCPF and the approach of Jasra, Ballesio, et al. (2018) have, under certain assumptions, an asymptotic variance that is bounded above by an expression that is of (almost) the order of $\Delta_l$ ($\mathcal{O}(\Delta_l)$), uniformly in time. The $\mathcal{O}(\Delta_l)$ bound preserves the so-called forward rate of the diffusion in some scenarios, which is not the case for the CPF in Jasra et al. (2017).
In this paper, we consider functional limit theorems for Poisson cluster processes. We first present a maximal inequality for Poisson cluster processes. Then we establish a functional central limit theorem under the second moment and a functional moderate deviation principle under the Cramér condition for Poisson cluster processes. We apply these results to obtain a functional moderate deviation principle for linear Hawkes processes.
Suppose k balls are dropped into n boxes independently with uniform probability, where n, k are large with ratio approximately equal to some positive real $\lambda$. The maximum box count has a counterintuitive behavior: first of all, with high probability it takes at most two values $m_n$ or $m_n+1$, where $m_n$ is roughly $\frac{\ln n}{\ln \ln n}$. Moreover, it oscillates between these two values with an unusual periodicity. In order to prove this statement and various generalizations, it is first shown that for $X_1,\ldots,X_n$ independent and identically distributed discrete random variables with common distribution F, under mild conditions, the limiting distribution of their maximum oscillates in three possible families, depending on the tail of the distribution. The result stated at the beginning follows from the ensemble equivalence for the order statistics in various allocations problems, obtained via conditioning limit theory. Results about the number of ties for the maximum, as well as applications, are also provided.
In this paper we first use the distribution of the number of records to demonstrate that the right tail probabilities of counts of rare events are generally better approximated by the right tail probabilities of a Poisson distribution than those of the normal distribution. We then show that the moderate deviations in Poisson approximation generally require an adjustment and, with suitable adjustment, we establish better error estimates of the moderate deviations in Poisson approximation than those in [18]. Our estimates contain no unspecified constants and are easy to apply. We illustrate the use of the theorems via six applications: Poisson-binomial distribution, the matching problem, the occupancy problem, the birthday problem, random graphs, and 2-runs. The paper complements the works [16], [8], and [18].
We investigate stochastic comparisons of parallel systems (corresponding to the largest-order statistics) with respect to the reversed hazard rate and likelihood ratio orders for the proportional reversed hazard rate (PRHR) model. As applications of the main results, we obtain the equivalent characterizations of stochastic comparisons with respect to the reversed hazard rate and likelihood rate orders for the exponentiated generalized gamma and exponentiated Pareto distributions. Our results recover and strengthen some recent results in the literature.
We investigate the Hawkes processes on the positive real line exhibiting both self-excitation and inhibition. Each point of such a point process impacts its future intensity by the addition of a signed reproduction function. The case of a nonnegative reproduction function corresponds to self-excitation, and has been widely investigated in the literature. In particular, there exists a cluster representation of the Hawkes process which allows one to apply known results for Galton–Watson trees. We use renewal techniques to establish limit theorems for Hawkes processes that have reproduction functions which are signed and have bounded support. Notably, we prove exponential concentration inequalities, extending results of Reynaud-Bouret and Roy (2006) previously proven for nonnegative reproduction functions using a cluster representation no longer valid in our case. Importantly, we establish the existence of exponential moments for renewal times of M/G/$\infty$ queues which appear naturally in our problem. These results possess interest independent of the original problem.
We consider the threshold-one contact process, the threshold-one voter model and the threshold-one voter model with positive spontaneous death on homogeneous trees $\mathbb{T}_d$, $d\ge 2$. Mainly inspired by the corresponding arguments for the contact process, we prove that the complete convergence theorem holds for these three systems under strong survival. When the system survives weakly, complete convergence may also hold under certain transition and/or initial conditions.
This paper studies the scaling of the expected total queue size in an $n\times n$ input-queued switch, as a function of both the load $\rho$ and the system scale n. We provide a new class of scheduling policies under which the expected total queue size scales as $O\big( n(1-\rho)^{-4/3} \log \big(\!\max\big\{\frac{1}{1-\rho}, n\big\}\big)\big)$, over all n and $\rho<1$, when the arrival rates are uniform. This improves on the best previously known scalings in two regimes: $O\big(n^{1.5}(1-\rho)^{-1} \log \frac{1}{1-\rho}\big)$ when $\Omega\big(n^{-1.5}\big) \le 1-\rho \le O\big(n^{-1}\big)$ and $O\big(\frac{n\log n}{(1-\rho)^2}\big)$ when $1-\rho \geq \Omega(n^{-1})$. A key ingredient in our method is a tight characterization of the largest k-factor of a random bipartite multigraph, which may be of independent interest.
Perron–Frobenius theory developed for irreducible non-negative kernels deals with so-called R-positive recurrent kernels. If the kernel M is R-positive recurrent, then the main result determines the limit of the scaled kernel iterations $R^nM^n$ as $n\to\infty$. In Nummelin (1984) this important result is proven using a regeneration method whose major focus is on M having an atom. In the special case when $M=P$ is a stochastic kernel with an atom, the regeneration method has an elegant explanation in terms of an associated split chain. In this paper we give a new probabilistic interpretation of the general regeneration method in terms of multi-type Galton–Watson processes producing clusters of particles. Treating clusters as macro-individuals, we arrive at a single-type Crump–Mode–Jagers process with a naturally embedded renewal structure.
Enterotoxigenic Escherichia coli (ETEC) is a well-established cause of traveller's diarrhoea and occasional domestic foodborne illness outbreaks in the USA. Although ETEC are not detected by conventional stool culture methods used in clinical laboratories, syndromic culture-independent diagnostic tests (CIDTs) capable of detecting ETEC have become increasingly prevalent in the last decade. This study describes the epidemiology of ETEC infections reported to the Minnesota Department of Health (MDH) during 2016–2017. ETEC-positive stool specimens were submitted to MDH to confirm the presence of ETEC DNA by polymerase chain reaction (PCR). Cases were interviewed to ascertain illness and exposures. Contemporaneous Salmonella cases were used as a comparison group in a case-case comparison analysis of risk factors. Of 222 ETEC-positive specimens received by MDH, 108 (49%) were concordant by PCR. ETEC was the sixth most frequently reported bacterial enteric pathogen among a subset of CIDT-positive specimens. Sixty-nine (64%) laboratory-confirmed cases had an additional pathogen codetected with ETEC, including enteroaggregative E. coli (n = 40) and enteropathogenic E. coli (n = 39). Although travel is a risk factor for ETEC infection, only 43% of cases travelled internationally, providing evidence for ETEC as an underestimated source of domestically acquired enteric illness in the USA.
Non-invasive prenatal testing (NIPT) is increasingly being adopted as a screening test in the UK and is currently accessed through certain National Health Service healthcare systems or by private provision. This audit aims to describe reasons for and results of cytogenomic investigations carried out within UK genetic laboratories following an NIPT result indicating increased chance of cytogenomic abnormality (‘high-chance NIPT result’).
Method
A questionnaire was sent out to 24 genetics laboratories in the UK and completed by 18/24 (75%).
Results
Data were returned representing 1831 singleton pregnancies. A total of 1329 (73%) invasive samples were taken following NIPT results showing a high chance of trisomy 21; this was confirmed in 1305 (98%) of these by invasive sampling. Trisomy 21 was confirmed in >99% of patients who also had high-screen risk results or abnormal scan findings. Amongst invasive samples taken due to NIPT results indicating a high chance of trisomy 18, 84% yielded a compatible result, and this number dropped to 49% for trisomy 13 and 51% for sex chromosomes.
Conclusion
In the UK, the majority of patients having invasive sampling for high-chance NIPT results are doing so following an NIPT result indicating an increased chance of common trisomies (92%). In this population, NIPT performs particularly well for trisomy 21, but less well for other indications.
Bonus-malus systems (BMSs) are widely used in actuarial sciences. These systems are applied by insurance companies to distinguish the policyholders by their risks. The most known application of BMS is in automobile third-party liability insurance. In BMS, there are several classes, and the premium of a policyholder depends on the class he/she is assigned to. The classification of policyholders over the periods of the insurance depends on the transition rules. In general, optimization of these systems involves the calculation of an appropriate premium scale considering the number of classes and transition rules as external parameters. Usually, the stationary distribution is used in the optimization process. In this article, we present a mixed integer linear programming (MILP) formulation for determining the premium scale and the transition rules. We present two versions of the model, one with the calculation of stationary probabilities and another with the consideration of multiple periods of the insurance. Furthermore, numerical examples will also be given to demonstrate that the MILP technique is suitable for handling existing BMSs.
Let (Y, Z) denote the solution to a forward-backward stochastic differential equation (FBSDE). If one constructs a random walk $B^n$ from the underlying Brownian motion B by Skorokhod embedding, one can show $L_2$-convergence of the corresponding solutions $(Y^n,Z^n)$ to $(Y, Z).$ We estimate the rate of convergence based on smoothness properties, especially for a terminal condition function in $C^{2,\alpha}$. The proof relies on an approximative representation of $Z^n$ and uses the concept of discretized Malliavin calculus. Moreover, we use growth and smoothness properties of the partial differential equation associated to the FBSDE, as well as of the finite difference equations associated to the approximating stochastic equations. We derive these properties by probabilistic methods.
In this paper we study first passage percolation on a random graph model, the configuration model. We first introduce the notions of weighted diameter, which is the maximum of the weighted lengths of all optimal paths between any two vertices in the graph, and the flooding time, which represents the time (weighted length) needed to reach all the vertices in the graph starting from a uniformly chosen vertex. Our result consists in describing the asymptotic behavior of the diameter and the flooding time, as the number of vertices n tends to infinity, in the case where the weight distribution G has an exponential tail behavior, and proving that this category of distributions is the largest possible for which the asymptotic behavior holds.
In a classical, continuous-time, optimal stopping problem, the agent chooses the best time to stop a stochastic process in order to maximise the expected discounted return. The agent can choose when to stop, and if at any moment they decide to stop, stopping occurs immediately with probability one. However, in many settings this is an idealistic oversimplification. Following Strack and Viefers we consider a modification of the problem in which stopping occurs at a rate which depends on the relative values of stopping and continuing: there are several different solutions depending on how the value of continuing is calculated. Initially we consider the case where stopping opportunities are constrained to be event times of an independent Poisson process. Motivated by the limiting case as the rate of the Poisson process increases to infinity, we also propose a continuous-time formulation of the problem where stopping can occur at any instant.
Now in its fourth edition, Essential Epidemiology is an engaging and accessible introduction to the foundations of epidemiology. It addresses the study of infectious and chronic diseases, public health and clinical epidemiology, and the role of epidemiology in a range of health monitoring and research activities. Contemporary, historical and hypothetical examples enable students to engage with content, while mathematics is kept understandable with complex mathematics housed in optional material so the book remains accessible. With over ninety questions and answers to work through, this book is an essential resource for students, practitioners and anyone else who needs to interpret health data in their studies or work. Epidemiology's most important goal is to bring rigour to the collection, analysis and interpretation of health data to improve health on a global scale; Essential Epidemiology provides readers the tools to achieve that goal.
We prove a ‘resilience’ version of Dirac’s theorem in the setting of random regular graphs. More precisely, we show that whenever d is sufficiently large compared to $\epsilon > 0$, a.a.s. the following holds. Let $G'$ be any subgraph of the random n-vertex d-regular graph $G_{n,d}$ with minimum degree at least $$(1/2 + \epsilon )d$$. Then $G'$ is Hamiltonian.
This proves a conjecture of Ben-Shimon, Krivelevich and Sudakov. Our result is best possible: firstly the condition that d is large cannot be omitted, and secondly the minimum degree bound cannot be improved.
We report key learning from the public health management of the first two confirmed cases of COVID-19 identified in the UK. The first case imported, and the second associated with probable person-to-person transmission within the UK. Contact tracing was complex and fast-moving. Potential exposures for both cases were reviewed, and 52 contacts were identified. No further confirmed COVID-19 cases have been linked epidemiologically to these two cases. As steps are made to enhance contact tracing across the UK, the lessons learned from earlier contact tracing during the country's containment phase are particularly important and timely.