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Environmental exposures are known to be associated with pathogen transmission and immune impairment, but the association of exposures with aetiology and severity of community-acquired pneumonia (CAP) are unclear. A retrospective observational study was conducted at nine hospitals in eight provinces in China from 2014 to 2019. CAP patients were recruited according to inclusion criteria, and respiratory samples were screened for 33 respiratory pathogens using molecular test methods. Sociodemographic, environmental and clinical factors were used to analyze the association with pathogen detection and disease severity by logistic regression models combined with distributed lag nonlinear models. A total of 3323 CAP patients were included, with 709 (21.3%) having severe illness. 2064 (62.1%) patients were positive for at least one pathogen. More severe patients were found in positive group. After adjusting for confounders, particulate matter (PM) 2.5 and 8-h ozone (O3-8h) were significant association at specific lag periods with detection of influenza viruses and Klebsiella pneumoniae respectively. PM10 and carbon monoxide (CO) showed cumulative effect with severe CAP. Pollutants exposures, especially PM, O3-8h, and CO should be considered in pathogen detection and severity of CAP to improve the clinical aetiological and disease severity diagnosis.
Traditionally, electricity distribution networks were designed for unidirectional power flow without the need to accommodate generation installed at the point of use. However, with the increase in Distributed Energy Resources and other Low Carbon Technologies, the role of distribution networks is changing. This shift brings challenges, including the need for intensive metering and more frequent reconfiguration to identify threats from voltage and thermal violations. Mitigating action through reconfiguration is informed by State Estimation, which is especially challenging for low voltage distribution networks where the constraints of low observability, non-linear load relationships, and highly unbalanced systems all contribute to the difficulty of producing accurate state estimates. To counter low observability, this paper proposes the application of a novel transfer learning methodology, based upon the concept of conditional online Bayesian transfer, to make forward predictions of bus pseudo-measurements. Day ahead load forecasts at a fully observed point on the network are adjusted using the intraday residuals at other points in the network to provide them with load forecasts without the need for a complete set of forecast models at all substations. These form pseudo-measurements that then inform the state estimates at future time points. This methodology is demonstrated on both a representative IEEE Test network and on an actual GB 11 kV feeder network.
The atomic bomb uses fission of heavy elements to produce a large amount of energy. It was designed and deployed during World War II by the United States military. The first test of an atomic bomb occurred in July 1945 in New Mexico and was given the name Trinity; this test was not declassified until 1949. In that year, Geoffrey Ingram Taylor released two papers detailing his process in calculating the energy yield of the atomic bomb from pictures of the Trinity explosion alone. Many scientists made similar calculations concurrently, although Taylor is often accredited with them. Since then, many scientists have also attempted to calculate a yield through various methods. This paper walks through these methods with a focus on Taylor’s method—based on first principles—as well as redoing the calculations that he performed with modern tools. In this paper, we make use of state-of-the-art computer vision tools to find a more precise measurement of the blast radius, as well as using curve fitting and numerical integration methods. With more precise measurements we are able to follow in Taylor’s footstep toward a more accurate approximation.
In this work, we consider two sets of dependent variables $\{X_{1},\ldots,X_{n}\}$ and $\{Y_{1},\ldots,Y_{n}\}$, where $X_{i}\sim EW(\alpha_{i},\lambda_{i},k_{i})$ and $Y_{i}\sim EW(\beta_{i},\mu_{i},l_{i})$, for $i=1,\ldots, n$, which are coupled by Archimedean copulas having different generators. We then establish different inequalities between two extremes, namely, $X_{1:n}$ and $Y_{1:n}$ and $X_{n:n}$ and $Y_{n:n}$, in terms of the usual stochastic, star, Lorenz, hazard rate, reversed hazard rate and dispersive orders. Several examples and counterexamples are presented for illustrating all the results established here. Some of the results here extend the existing results of [5] (Barmalzan, G., Ayat, S.M., Balakrishnan, N., & Roozegar, R. (2020). Stochastic comparisons of series and parallel systems with dependent heterogeneous extended exponential components under Archimedean copula. Journal of Computational and Applied Mathematics380: Article No. 112965).
The mycosis histoplasmosis is also considered a zoonosis that affects humans and other mammalian species worldwide. Among the wild mammals predisposed to be infected with the etiologic agent of histoplasmosis, bats are relevant because they are reservoir of Histoplasma species, and they play a fundamental role in maintaining and spreading fungal propagules in the environments since the infective mycelial phase of Histoplasma grows in their accumulated guano. In this study, we detected the fungal presence in organ samples of bats randomly captured in urban areas of Araraquara City, São Paulo, Brazil. Fungal detection was performed using a nested polymerase chain reaction to amplify a molecular marker (Hcp100) unique to H. capsulatum, which revealed the pathogen presence in organ samples from 15 out of 37 captured bats, indicating 40.5% of infection. Out of 22 Hcp100-amplicons generated, 41% corresponded to lung and trachea samples and 59% to spleen, liver, and kidney samples. Data from these last three organs suggest that bats develop disseminated infections. Considering that infected bats create environments with a high risk of infection, it is important to register the percentage of infected bats living in urban areas to avoid risks of infection to humans, domestic animals, and wildlife.
Nontuberculous mycobacteria (NTM) is a large group of mycobacteria other than the Mycobacterium tuberculosis complex and Mycobacterium leprae. Epidemiological investigations have found that the incidence of NTM infections is increasing in China, and it is naturally resistant to many antibiotics. Therefore, studies of NTM species in clinical isolates are useful for understanding the epidemiology of NTM infections. The present study aimed to investigate the incidence of NTM infections and types of NTM species. Of the 420 samples collected, 285 were positive for M. tuberculosis, 62 samples were negative, and the remaining 73 samples contained NTM, including 35 (8.3%) only NTM and 38 (9%) mixed (M. tuberculosis and NTM). The most prevalent NTM species were Mycobacterium intracellulare (30.1%), followed by Mycobacterium abscessus (15%) and M. triviale (12%). M. gordonae infection was detected in 9.5% of total NTM-positive cases. Moreover, this study reports the presence of Mycobacterium nonchromogenicum infection and a high prevalence of M. triviale for the first time in Henan. M. intracellulare is the most prevalent, accompanied by some emerging NTM species, including M. nonchromogenicum and a high prevalence of M. triviale in Henan Province. Monitoring NTM transmission and epidemiology could enhance mycobacteriosis management in future.
In September 2023, the UK Health Security Agency identified cases of Salmonella Saintpaul distributed across England, Scotland, and Wales, all with very low genetic diversity. Additional cases were identified in Portugal following an alert raised by the United Kingdom. Ninety-eight cases with a similar genetic sequence were identified, 93 in the United Kingdom and 5 in Portugal, of which 46% were aged under 10 years. Cases formed a phylogenetic cluster with a maximum distance of six single nucleotide polymorphisms (SNPs) and average of less than one SNP between isolates. An outbreak investigation was undertaken, including a case–control study. Among the 25 UK cases included in this study, 13 reported blood in stool and 5 were hospitalized. One hundred controls were recruited via a market research panel using frequency matching for age. Multivariable logistic regression analysis of food exposures in cases and controls identified a strong association with cantaloupe consumption (adjusted odds ratio: 14.22; 95% confidence interval: 2.83–71.43; p-value: 0.001). This outbreak, together with other recent national and international incidents, points to an increase in identifications of large outbreaks of Salmonella linked to melon consumption. We recommend detailed questioning and triangulation of information sources to delineate consumption of specific fruit varieties during Salmonella outbreaks.
Qu, Dassios, and Zhao (2021) suggested an exact simulation method for tempered stable Ornstein–Uhlenbeck processes, but their algorithms contain some errors. This short note aims to correct their algorithms and conduct some numerical experiments.
In a Model Predictive Control (MPC) setting, the precise simulation of the behavior of the system over a finite time window is essential. This application-oriented benchmark study focuses on a robot arm that exhibits various nonlinear behaviors. For this arm, we have a physics-based model with approximate parameter values and an open benchmark dataset for system identification. However, the long-term simulation of this model quickly diverges from the actual arm’s measurements, indicating its inaccuracy. We compare the accuracy of black-box and purely physics-based approaches with several physics-informed approaches. These involve different combinations of a neural network’s output with information from the physics-based model or feeding the physics-based model’s information into the neural network. One of the physics-informed model structures can improve accuracy over a fully black-box model.
This paper considers testing for unit roots in Gaussian panels with cross-sectional dependence generated by common factors. Within our setup, we can analyze restricted versions of the two prevalent approaches in the literature, that of Moon and Perron (2004, Journal of Econometrics 122, 81–126), who specify a factor model for the innovations, and the PANIC setup proposed in Bai and Ng (2004, Econometrica 72, 1127–1177), who test common factors and idiosyncratic deviations separately for unit roots. We show that both frameworks lead to locally asymptotically normal experiments with the same central sequence and Fisher information. Using Le Cam’s theory of statistical experiments, we obtain the local asymptotic power envelope for unit-root tests. We show that the popular Moon and Perron (2004, Journal of Econometrics 122, 81–126) and Bai and Ng (2010, Econometric Theory 26, 1088–1114) tests only attain the power envelope in case there is no heterogeneity in the long-run variance of the idiosyncratic components. We develop a new test which is asymptotically uniformly most powerful irrespective of possible heterogeneity in the long-run variance of the idiosyncratic components. Monte Carlo simulations corroborate our asymptotic results and document significant gains in finite-sample power if the variances of the idiosyncratic shocks differ substantially among the cross-sectional units.
Burden of bacteraemia is rising due to increased average life expectancy in developed countries. This study aimed to compare the epidemiology and outcomes of bacteraemia in two similarly ageing populations with different ethnicities in Singapore and Denmark. Historical cohorts from the second largest acute-care hospital in Singapore and in the hospitals of two Danish regions included patients aged 15 and above who were admitted from 1 January 2006 to 31 December 2016 with at least 1 day of hospital stay and a pathogenic organism identified. Among 13 144 and 39 073 bacteraemia patients from Singapore and Denmark, similar 30-day mortality rates (16.5%; 20.3%), length of hospital stay (median 14 (IQR: 9–28) days; 11 (6–21)), and admission rate to ICU (15.5%; 15.6%) were observed, respectively. Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus ranked among the top four in both countries. However, Singaporeans had a higher proportion of patients with diabetes (46.8%) and renal disease (29.5%) than the Danes (28.0% and 13.7%, respectively), whilst the Danes had a higher proportion of patients with chronic pulmonary disease (18.0%) and malignancy (35.3%) than Singaporeans (9.7% and 16.2%, respectively). Our study showed that top four causative organisms and clinical outcomes were similar between the two cohorts despite pre-existing comorbidities differed.
Given a graph $F$, we consider the problem of determining the densest possible pseudorandom graph that contains no copy of $F$. We provide an embedding procedure that improves a general result of Conlon, Fox, and Zhao which gives an upper bound on the density. In particular, our result implies that optimally pseudorandom graphs with density greater than $n^{-1/3}$ must contain a copy of the Peterson graph, while the previous best result gives the bound $n^{-1/4}$. Moreover, we conjecture that the exponent $1/3$ in our bound is tight. We also construct the densest known pseudorandom $K_{2,3}$-free graphs that are also triangle-free. Finally, we give a different proof for the densest known construction of clique-free pseudorandom graphs due to Bishnoi, Ihringer, and Pepe that they have no large clique.