Hostname: page-component-848d4c4894-hfldf Total loading time: 0 Render date: 2024-05-18T02:30:38.265Z Has data issue: false hasContentIssue false

“Social physiology” for psychiatric semiology: How TTOM can initiate an interactive turn for computational psychiatry?

Published online by Cambridge University Press:  28 May 2020

Guillaume Dumas
Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris, Paris, France. Human Brain and Behavior Laboratory, Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL
Tudi Gozé
Department of Psychiatry, Psychotherapies, Art Therapy, Toulouse University Hospital, Toulouse, France. Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs – EA3051, Université de Toulouse, Jean Jaurès, France.
Jean-Arthur Micoulaud-Franchi
Services d'explorations fonctionnelles du système nerveux, Clinique du sommeil, CHU de Bordeaux, 33076Bordeaux, France. jean-arthur.micoulaud-franchi@chu-bordeaux.fr USR CNRS 3413 SANPSY, CHU Pellegrin, Université´ de Bordeaux, Bordeaux, France.


Thinking through other minds (TTOM) encompasses new dimensions in computational psychiatry: social interaction and mutual sense-making. It questions the nature of psychiatric manifestations (semiology) in light of recent data on social interaction in neuroscience. We propose the concept of “social physiology” in response to the call by the conceivers of TTOM for the renewal of computational psychiatry.

Open Peer Commentary
Copyright © The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)


Berrios, G. E. (1996) The history of mental symptoms: Descriptive psychopathology since the nineteenth century. Cambridge University Press.CrossRefGoogle Scholar
Bolis, D., Balsters, J., Wenderoth, N., Becchio, C. & Schilbach, L. (2017) Beyond autism: Introducing the dialectical misattunement hypothesis and a Bayesian account of intersubjectivity. Psychopathology 50(6):355–72. Scholar
Bolis, D. & Schilbach, L. (2018b) “I Interact Therefore I Am”: The self as a historical product of dialectical attunement. Topoi 114. Scholar
Borsboom, D., Cramer, A. & Kalis, A. (2018) Brain disorders? Not really… Why network structures block reductionism in psychopathology research. Behavioral and Brain Sciences 42:154. Scholar
Cermolacce, M., Sass, L. & Parnas, J. (2010) What is bizarre in bizarre delusions? A critical review. Schizophrenia Bulletin 36(4):667–79. ScholarPubMed
Dumas, G. (2011) Towards a two-body neuroscience. Communicative & Integrative Biology 4(3):349–52. ScholarPubMed
Dumas, G., Chavez, M., Nadel, J. & Martinerie, J. (2012) Anatomical connectivity influences both intra-and inter-brain synchronizations. PloS one 7(5).CrossRefGoogle ScholarPubMed
Dumas, G., Kelso, J. A. & Nadel, J. (2014) Tackling the social cognition paradox through multi-scale approaches. Frontiers in Psychology 5:882. ScholarPubMed
Dumas, G., Nadel, J., Soussignan, R., Martinerie, J. & Garnero, L. (2010) Inter-brain synchronization during social interaction. PLoS ONE 5(8):e12166. ScholarPubMed
Friston, K. J. & Frith, C. D. (2015a) A duet for one. Consciousness and Cognition 36:390405. Scholar
Friston, K. J., Redish, A. D. & Gordon, J. A. (2017) Computational nosology and precision psychiatry. Computational Psychiatry 1:223. ScholarPubMed
Fuchs, T. (2015) Pathologies of intersubjectivity in autism and schizophrenia. Journal of Consciousness Studies 22(1–2):191214.Google Scholar
Gozé, T., Moskalewicz, M., Schwartz, M. A., Naudin, J., Micoulaud-Franchi, J.-A. & Cermolacce, M. (2019) Reassessing “praecox feeling” in diagnostic decision making in schizophrenia: A critical review. Schizophrenia Bulletin 45(5):966–70. ScholarPubMed
Hari, R. & Kujala, M. V. (2009) Brain basis of human social interaction: From concepts to brain imaging. Physiological Reviews 89(2):453–79. ScholarPubMed
Kirmayer, L. J. & Crafa, D. (2014) What kind of science for psychiatry? Frontiers in Human Neuroscience 8:435. ScholarPubMed
Kirmayer, L. J. & Ramstead, M. J. D. (2017) Embodiment and enactment in cultural psychiatry. In: Embodiment, enaction, and culture: Investigating the constitution of the shared world, eds. Durt, C., Fuchs, T., & Tewes, C., pp. 397422. MIT Press.Google Scholar
Kirmayer, L. J. & Sartorius, N. (2007) Cultural models and somatic syndromes. Psychosomatic Medicine 69(9):832–40. ScholarPubMed
Lavelle, M., Healey, P. G. T. & McCabe, R. (2014) Nonverbal behavior during face-to-face social interaction in schizophrenia: A review. The Journal of Nervous and Mental Disease 202(1):4754. ScholarPubMed
Marr, D. (1982) Vision: A computational investigation into the human representation and processing of visual information. W. H. Freeman.Google Scholar
Micoulaud-Franchi, J.-A., Dumas, G., Quiles, C. & Vion-Dury, J. (2016) From clinic to the “foul and exciting field of life”: A psychiatric point of view on clinical physiology. Annales Médico-Psychologiques, Revue Psychiatrique 175(1):21. Scholar
Micoulaud-Franchi, J.-A., Quiles, C., Batail, J.-M., Lancon, C., Masson, M., Dumas, G. & Cermolacce, M. (2018) Making psychiatric semiology great again: A semiologic, not nosologic challenge. L'Encephale 44(4):343–53. Scholar
Montague, P. R., Berns, G. S., Cohen, J. D., McClure, S. M., Pagnoni, G., Dhamala, M., Wiest, M. C., Karpov, I., King, R. D., Apple, N. & Fisher, R. E. (2002) Hyperscanning: Simultaneous fMRI during linked social interactions. NeuroImage 16(4):1159–64. ScholarPubMed
Montague, P. R., Dolan, R. J., Friston, K. J. & Dayan, P. (2011) Computational psychiatry. Trends in Cognitive Sciences 1–9. ScholarPubMed
Nordgaard, J., Sass, L. A. & Parnas, J. (2013) The psychiatric interview: Validity, structure, and subjectivity. European Archives of Psychiatry and Clinical Neuroscience 263(4):353–64. ScholarPubMed
Parnas, J. (2011) A disappearing heritage: The clinical core of schizophrenia. Schizophrenia Bulletin 37(6):1121–30.CrossRefGoogle ScholarPubMed
Parnas, J. & Zandersen, M. (2018) Self and schizophrenia: Current status and diagnostic implications. World Psychiatry 17(2):220–21. ScholarPubMed
Redcay, E. & Schilbach, L. (2019) Using second-person neuroscience to elucidate the mechanisms of social interaction. Nature Reviews Neuroscience 20(8):495505. ScholarPubMed
Sass, L., Borda, J. P., Madeira, L., Pienkos, E. & Nelson, B. (2018) Varieties of self disorder: A bio-pheno-social model of schizophrenia. Schizophrenia Bulletin 44(4):720–27.CrossRefGoogle ScholarPubMed
Schilbach, L. (2016) Towards a second-person neuropsychiatry. Philosophical Transactions of the Royal Society B: Biological Sciences 371(1686):20150081. ScholarPubMed
Schilbach, L., Timmermans, B., Reddy, V., Costall, A., Bente, G., Schlicht, T. & Vogeley, K. (2013) Toward a second-person neuroscience. Behavioral and Brain Sciences 36(04):393414. Scholar
Shea, N., Boldt, A., Bang, D., Yeung, N., Heyes, C. & Frith, C. D. (2014) Supra-personal cognitive control and metacognition. Trends in Cognitive Sciences 18(4):186–93. ScholarPubMed
Stanghellini, G., Bolton, D. & Fulford, W. K. M. (2013) Person-centered psychopathology of schizophrenia: Building on Karl Jaspers’ understanding of patient's attitude toward his illness. Schizophrenia Bulletin 39(2):287–94. ScholarPubMed
Thompson, E. & Varela, F. J. (2001) Radical embodiment: Neural dynamics and consciousness. Trends in Cognitive Sciences 5(10):418–25.CrossRefGoogle ScholarPubMed
Wang, X.-J. & Krystal, J. H. (2014) Computational psychiatry. Neuron 84(3):638–54. ScholarPubMed