This work aims to provide a systematic experimental study on the wake of two tandem cylinders of unequal diameters. The fluid dynamics around a circular cylinder of diameter
$D$ placed in the wake of another circular cylinder with a smaller diameter of
$d$ is investigated, including the time-mean drag coefficient (
$C_{D}$ ), the fluctuating drag and lift coefficients (
$C_{D}^{\prime }$ and
$C_{L}^{\prime }$ ), the Strouhal number (
$St$ ) and the flow structures. The Reynolds number based on
$D$ is kept constant at
$4.27\times 10^{4}$ . The ratios
$d/D$ and
$L/d$ vary from 0.2 to 1.0 and 1.0 to 8.0 respectively, where
$L$ is the distance from the upstream cylinder centre to the forward stagnation point of the downstream cylinder. The ratios
$d/D$ and
$L/d$ are found, based on extensive hotwire, particle imaging velocimetry, pressure and flow visualization measurements, to have a marked influence on the wake dynamics behind the cylinders. As such, the flow is classified into the reattachment and co-shedding flow regimes, the latter being further subdivided into the lock-in, subharmonic lock-in and no lock-in regions. It is found that the critical spacing that divides the two regimes is dictated by the upstream-cylinder vortex formation length and becomes larger for smaller
$d/D$ . The characteristic flow properties are documented in each regime and subdivided region, including the flow structure,
$St$ , wake width, vortex formation length and the lateral width between the two gap shear layers. The variations in
$C_{D}$ ,
$C_{D}^{\prime }$ ,
$C_{L}^{\prime }$ and the pressure distribution around the downstream cylinder are connected to the flow physics.