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Chapter 2 - Introduction to Pathologic Techniques

Published online by Cambridge University Press:  01 July 2017

Murat Gokden
Affiliation:
University of Arkansas for Medical Sciences, Little Rock
Manoj Kumar
Affiliation:
University of Arkansas for Medical Sciences, Little Rock
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Neuropathologic and Neuroradiologic Correlations
A Differential Diagnostic Text and Atlas
, pp. 23 - 39
Publisher: Cambridge University Press
Print publication year: 2000

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References

Pizzoni, C, Sarandria, C, Pierangeli, E. Clear-cell meningioma of the anterior cranial fossa. Case report and review of the literature. J. Neurosurg. Sci., 2009, 53, 3:113–17.Google ScholarPubMed
Hassoun, J, Gambarelli, D, Pellissier, JF, Henin, D, Toga, M. Germinomas of the brain. Light and electron microscopic study. A report of seven cases. Acta Neuropathol. Suppl., 1981, 7:105–8.CrossRefGoogle ScholarPubMed
Siami-Namini, K, Shuey-Drake, R, Wilson, D, et al. A 15-year-old female with progressive myelopathy. Brain Pathol., 2005, 15:265–7.Google Scholar
Keel, BR, Brit, M. McArdle's disease: A clinical review and case report. Tenn. Med., 2013, 106:33, 37.Google ScholarPubMed
Higuchi, T, Kawagoe, S, Otsu, M, et al. The generation of induced pluripotent stem cells (iPSCs) from patients with infantile and late-onset types of Pompe disease and the effects of treatment with acid-alpha-glucosidase in Pompe's iPSCs. Mol. Genet. Metab., 2014, 112:44–8.Google Scholar
Robert, F, Hardy, J. Human corticotroph cell adenomas. Semin. Diagn. Pathol., 1986, 3:3441.Google ScholarPubMed
Wierzba-Bobrowicz, T, Lewandowska, E, Matyja, E, et al. Granular cell astrocytoma. A case report with immunohistochemical and ultrastructural characterization. Folia Neuropathol., 2008, 46:286–93.Google ScholarPubMed
McCluggage, WG, Connolly, LE, McGregor, G, Hyland, PL, Hall, PA. A strategy for defining biologically relevant levels of p53 protein expression in clinical samples with reference to endometrial neoplasia. Int. J. Gynecol. Pathol., 2005, 24:307–12.CrossRefGoogle ScholarPubMed
Torlakovic, E, Nielsen, S, Vyberg, M. Antibody selection in immunohistochemical detection of cyclin D1 in mantle cell lymphoma. Am. J. Clin. Pathol., 2005, 124:782–9.Google Scholar
Goldstein, NS, Hewitt, SM, Taylor, CR, Yaziji, H, Hicks, DG, Members of Ad-Hoc Committee on Immunohistochemistry Standardization. Recommendations for improved standardization of immunohistochemistry. Appl. Immunohistochem. Mol. Morphol., 2007, 15:124–33.Google Scholar
Bordeaux, J, Welsh, A, Agarwal, S, et al. Antibody validation. BioTechniques, 2010, 48:197209.CrossRefGoogle ScholarPubMed
Eng, LF. Glial fibrillary acidic protein (GFAP): The major protein of glial intermediate filaments in differentiated astrocytes. J. Neuroimmunol., 1985, 8:203–14.CrossRefGoogle ScholarPubMed
Buccoliero, AM, Franchi, A, Castiglione, F, et al. Subependymal giant cell astrocytoma (SEGA): Is it an astrocytoma? Morphological, immunohistochemical and ultrastructural study. Neuropathology, 2009, 29:2530.Google Scholar
Viale, G, Gambacorta, M, Coggi, G, et al. Glial fibrillary acidic protein immunoreactivity in normal and diseased human breast. Virchows Arch. A Pathol. Anat. Histopathol., 1991, 418:339–48.Google Scholar
Ellison, DW, Eberhart, CG, Pietsch, T, Pfister, S. Medulloblastoma. In Louis, DN, Ohgaki, H, Wiestler, OD, et al., eds., WHO Classification of Tumours of the Central Nervous System, IARC Press, 2016, pp. 184–8.Google Scholar
Doglioni, C, Dell'Orto, P, Coggi, G, et al. Choroid plexus tumors. An immunocytochemical study with particular reference to the coexpression of intermediate filament proteins. Am. J. Pathol., 1987, 127:519–29.Google Scholar
Brat, DJ, Scheithauer, BW, Eberhart, CG, Burger, PC. Extraventricular neurocytomas: Pathologic features and clinical outcome. Am. J. Surg. Pathol., 2001, 25:1252–60.Google Scholar
Ligon, KL, Alberta, JA, Kho, AT, et al. The oligodendroglial lineage marker Olig2 is universally expressed in diffuse gliomas. J. Neuropathol. Exp. Neurol., 2004, 63:499509.Google Scholar
Nakajima, T, Watanabe, S, Sato, Y, et al. An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues. Am. J. Surg. Pathol., 1982, 6:715–27.Google Scholar
Han, CW, Min, BW, Kim, Y, et al. Immunohistochemical analysis of developmental neural antigen expression in the balloon cells of focal cortical dysplasia. J. Clin. Neurosci., 2011, 18:114–18.CrossRefGoogle ScholarPubMed
Wick, MR. Immunohistology of neuroendocrine and neuroectodermal tumors. Semin. Diagn. Pathol., 2000, 17:194203.Google Scholar
Artlieb, U, Krepler, R, Wiche, G. Expression of microtubule-associated proteins, MAP-1 and MAP-2, in human neuroblastomas and differential diagnosis of immature neuroblasts. Lab. Invest., 1985, 53:684–91.Google ScholarPubMed
Tohyama, T, Lee, VM, Rorke, LB, et al.Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab. Invest., 1992, 66:303–13.Google ScholarPubMed
Yan, H, Parsons, DW, Jin, G, et al. IDH1 and IDH2 mutations in gliomas. New Engl. J. Med., 2009, 360:765–73.CrossRefGoogle ScholarPubMed
Schaap, FG, French, PJ, Bovee, JV. Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 in tumors. Adv. Anat. Pathol., 2013, 20:32–8.Google Scholar
Appin, CL, Brat, DJ. Molecular genetics of gliomas. Cancer J., 2014, 20:6672.Google Scholar
Chen, L, Voronovich, Z, Clark, K, et al. Predicting the likelihood of an isocitrate dehydrogenase 1 or 2 mutation in diagnoses of infiltrative glioma. Neuro-oncology, 2014, 16:1478–83.Google Scholar
Camelo-Piragua, S, Jansen, M, Ganguly, A, et al. A sensitive and specific diagnostic panel to distinguish diffuse astrocytoma from astrocytosis: Chromosome 7 gain with mutant isocitrate dehydrogenase 1 and p53. J. Neuropathol. Exp. Neurol., 2011, 70:110–15.CrossRefGoogle ScholarPubMed
Burger, PC, Minn, AY, Smith, JS, et al. Losses of chromosomal arms 1p and 19q in the diagnosis of oligodendroglioma. A study of paraffin-embedded sections. Modern Pathol., 2001, 14:842–53.CrossRefGoogle ScholarPubMed
Jiao, Y, Killela, PJ, Reitman, ZJ, et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget, 2012, 3:709–22.Google Scholar
Wiestler, B, Capper, D, Holland-Letz, T, et al. ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis. Acta Neuropathol., 2013, 126:443–51.Google Scholar
Liu, XY, Gerges, N, Korshunov, A, Sabha, N, et al. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol., 2012, 124:615–25.Google Scholar
Wesseling, P, Bent, MVD, Perry, A. Oligodendroglioma: Pathology, molecular mechanisms and markers. Acta Neuropathol., 2015, 129:809–27.Google Scholar
Hendzel, MJ, Wei, Y, Mancini, MA, et al. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma, 1997, 106:348–60.Google Scholar
Fukushima, S, Terasaki, M, Sakata, K, et al. Sensitivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases. Brain Tumor Pathol., 2009, 26:51–7.CrossRefGoogle ScholarPubMed
Colman, H, Giannini, C, Huang, L, et al. Assessment and prognostic significance of mitotic index using the mitosis marker phosphohistone H3 in low- and intermediate-grade infiltrating astrocytomas. Am. J. Surg. Pathol. 2006, 30:657–64.Google Scholar
Ribalta, T, McCutcheon, IE, Aldape, KD, Bruner, JM, Fuller, GN. The mitosis-specific antibody anti-phosphohistone-H3 (PHH3) facilitates rapid reliable grading of meningiomas according to WHO 2000 criteria. Am. J. Surg. Pathol., 2004, 28:1532–6.CrossRefGoogle ScholarPubMed
Kunisch, E, Fuhrmann, R, Roth, A, et al. Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry. Ann. Rheum. Dis., 2004, 63:774–84.CrossRefGoogle ScholarPubMed
Gottfried, E, Kunz-Schughart, LA, Weber, A, et al. Expression of CD68 in non-myeloid cell types. Scand. J. Immunol., 2008, 67:453–63.Google Scholar
Pernick, NL, DaSilva, M, Gangi, MD, Crissman, J, Adsay, V. “Histiocytic markers” in melanoma. Modern Pathol., 1999, 12:1072–7.Google Scholar
Conley, A, Manjila, S, Guan, H, et al. Non-Langerhans cell histiocytosis with isolated CNS involvement: An unusual variant of Erdheim–Chester disease. Neuropathology, 2010, 30:634–47.Google Scholar
Shi, Y, Morgenstern, N. Granular cell astrocytoma. Arch. Pathol. Lab. Med., 2008, 132(12):194650.Google Scholar
Brat, DJ, Scheithauer, BW, Medina-Flores, R, Rosenblum, MK, Burger, PC. Infiltrative astrocytomas with granular cell features (granular cell astrocytomas): A study of histopathologic features, grading, and outcome. Am. J. Surg. Pathol., 2002, 26:750–7.Google Scholar
Schmid, C, Pan, L, Diss, T, Isaacson, PG. Expression of B-cell antigens by Hodgkin's and Reed–Sternberg cells. Am. J. Pathol., 1991, 139:701–7.Google Scholar
Mandybur, TI, Nazek, M. Cerebral arteriovenous malformations. A detailed morphological and immunohistochemical study using actin. Arch. Pathol. Lab. Med., 1990, 114:970–3.Google Scholar
Roy, S, Chu, A, Trojanowski, JQ, Zhang, PJ. D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas. Acta Neuropathol., 2005, 109:497502.CrossRefGoogle ScholarPubMed
Sangoi, AR, Dulai, MS, Beck, AH, Brat, DJ, Vogel, H. Distinguishing chordoid meningiomas from their histologic mimics: An immunohistochemical evaluation. Am J. Surg. Pathol., 2009, 33:669.CrossRefGoogle ScholarPubMed
Carney, EM, Banerjee, P, Ellis, CL,et al. PAX2(-)/PAX8(-)/inhibin A(+) immunoprofile in hemangioblastoma: A helpful combination in the differential diagnosis with metastatic clear cell renal cell carcinoma to the central nervous system. Am. J. Surg. Pathol., 2011, 35:262–7.Google Scholar
Hoang, MP, Amirkhan, RH. Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. Am. J. Surg. Pathol., 2003, 27:1152–6.CrossRefGoogle ScholarPubMed
Huang, HY, Park, N, Erlandson, RA, Antonescu, CR. Immunohistochemical and ultrastructural comparative study of external lamina structure in 31 cases of cellular, classical, and melanotic schwannomas. Appl. Immunohistochem. Mol. Morphol., 2004, 12:50–8.Google Scholar
Ziadi, A, Saliba, I. Malignant peripheral nerve sheath tumor of intracranial nerve: A case series review. Auris Nasus Larynx, 2010, 37:53945.CrossRefGoogle ScholarPubMed
Chen, KB, Chen, L. Glomus tumor in the stomach: A case report and review of the literature. Oncol. Lett., 2014, 7:1790–2.Google ScholarPubMed
Urabe, N, Naito, I, Saito, K, et al. Basement membrane type IV collagen molecules in the choroid plexus, pia mater and capillaries in the mouse brain. Arch. Histol. Cytol. 2002, 65:133–43.Google Scholar
Al-Hussaini, M, Dissi, N, Al-Jumaily, U, Swaidan, M. Atypical teratoid rhabdoid tumor in childhood, 15 cases of a single institute experience. Turk. Patoloji. Derg., 2014, 30:4354.Google ScholarPubMed
Kleinschmidt-DeMasters, BK, Alassiri, AH, Birks, DK, et al. Epithelioid versus rhabdoid glioblastomas are distinguished by monosomy 22 and immunohistochemical expression of INI-1 but not claudin 6. Am. J. Surg. Pathol., 2010, 34:341–54.CrossRefGoogle Scholar
Brenca, M, Rossi, S, Lorenzetto, E, et al. SMARCB1/INI1 genetic inactivation is responsible for tumorigenic properties of epithelioid sarcoma cell line VAESBJ. Mol. Cancer Ther., 2013, 12:1060–72.Google Scholar
Rickert, CH, Paulus, W. Tumors of the choroid plexus. Microsc. Res. Techn., 2001, 52:104–11.Google Scholar
Lee, MC, Park, SK, Lim, JS, et al. Atypical teratoid/rhabdoid tumor of the central nervous system: Clinico-pathologic study. Neuropathology, 2002, 22:252–60.Google Scholar
Oh, D, Prayson, RA. Evaluation of epithelial and keratin markers in glioblastoma multiforme: An immunohistochemical study. Arch. Pathol. Lab. Med., 1999, 123:917–20.Google Scholar
Cruz-Sanchez, FF, Rossi, ML, Hughes, JT, et al. Choroid plexus papillomas: An immunohistological study of 16 cases. Histopathology, 1989, 15:61–9.Google Scholar
Liu, Y, Sturgis, CD, Bunker, M, et al. Expression of cytokeratin by malignant meningiomas: Diagnostic pitfall of cytokeratin to separate malignant meningiomas from metastatic carcinoma. Modern Pathol., 2004, 17:1129–33.Google Scholar
Davis, FG, Dolecek, TA, McCarthy, BJ, Villano, JL. Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data. Neuro-Oncology, 2012, 14:1171–7.Google Scholar
Preusser, M, Capper, D, Ilhan-Mutlu, A, et al. Brain metastases: Pathobiology and emerging targeted therapies. Acta Neuropathol., 2012, 123:205–22.Google Scholar
Soffietti, R, Corunu, P, Delattre, JY, et al. Brain Metastases. In Gilhus, NE, Barnes, MR, Brainin, M, eds., European Handbook of Neurological Management, Volume 1., 2nd edn. Chichester: Wiley-Blackwell, 2010, pp. 437–45.Google Scholar
Turner, BM, Cagle, PT, Sainz, IM, et al. Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: Evaluation of 1674 cases by tissue microarray. Arch. Pathol. Lab. Med., 2012, 136:163–71.Google Scholar
Hicks, DG, Short, SM, Prescott, NL, et al. Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR. Am. J. Surg. Pathol., 2006, 30:1097–104.Google Scholar
Yamashita, Y, Nagasaka, T, Naiki-Ito, A, et al.. Napsin A is a specific marker for ovarian clear cell adenocarcinoma. Modern Pathol., 2015, 28:111–17.Google Scholar
Chu, P, Wu, E, Weiss, LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: A survey of 435 cases. Modern Pathol., 2000, 13:962–72.CrossRefGoogle ScholarPubMed
Wang, NP, Zee, S, Zarbo, RJ, et al. Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas. Appl. Immunohistochem., 1995, 3:99107.Google Scholar
Bahrami, A, Truong, LD, Ro, JY. Undifferentiated tumor: True identity by immunohistochemistry. Arch. Pathol. Lab. Med., 2008, 132:326–48.Google Scholar
Rodriguez, FJ, Tihan, T, Lin, D, et al. Clinicopathologic features of pediatric oligodendrogliomas: A series of 50 patients. Am. J. Surg. Pathol., 2014, 38: 1058–70.Google Scholar
Gan, HK, Cvrljevic, AN, Johns, TG. The epidermal growth factor receptor variant III (EGFRvIII): Where wild things are altered. FEBS J., 2013, 280:5350–70.Google Scholar
Liu, L, Backlund, LM, Nilsson, BR, et al. Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas. J. Mol. Med., 2005, 83:917–26.CrossRefGoogle ScholarPubMed
Shinojima, N, Tada, K, Shiraishi, S, et al. Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res., 2003, 63:6962–70.Google Scholar
Feldkamp, MM, Lala, P, Lau, N, Roncari, L, Guha, A. Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens. Neurosurgery, 1999, 45:1442–53.Google Scholar
Horbinski, C. To BRAF or not to BRAF: Is that even a question anymore? J. Neuropathol. Exp. Neurol., 2013, 72:27.Google Scholar
Schindler, G, Capper, D, Meyer, J,et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol., 2011, 121:397405.Google Scholar
Mrak, RE. The Big Eye in the 21st century: The role of electron microscopy in modern diagnostic neuropathology. J. Neuropathol. Exp. Neurol., 2002, 61:1027–39.Google Scholar
Ellison, D, Love, S, Chimelli, L, et al. Neuropathology, 3rd edn. Oxford: Mosby, 2013.Google Scholar
Baschong, W, Suetterlin, R, Laeng, RH. Control of autofluorescence of archival formaldehyde-fixed, paraffin-embedded tissue in confocal laser scanning microscopy (CLSM). J. Histochem. Cytochem., 2001, 49:1565–72.Google Scholar
Sun, Y, Yu, H, Zheng, D, et al. Sudan black B reduces autofluorescence in murine renal tissue. Arch. Pathol. Lab. Med., 2011, 135:1335–42.CrossRefGoogle ScholarPubMed

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