Holocene environmental changes on the Paraty coastal plain in southeastern Brazil unfolded under dynamic sea-level fluctuations and shifting sedimentary regimes. Continental and marine palynomorph analyses, combined with calibrated radiocarbon dating from two sediment cores (JBS1 and JBS2), reveal a continuous depositional record spanning approximately 7800 to 1000 cal yr BP. Sandy mud and muddy sand sequences reflect variable coastal energy conditions through out the mid to late Holocene. Dinoflagellate cyst assemblages indicate a transition from open marine to marginal marine environments, with maximum marine influence between 7000 and 5000 cal yr BP. Terrestrial palynomorphs show a concurrent shift from grassland-dominated landscapes to mixed vegetation including ombrophilous forest taxa. A marked increase in pollen concentration in the upper stratigraphic layer suggests coastal progradation, enhanced continental input, and reduced marine influence during the late Holocene regression. Bayesian age-depth models demonstrate uninterrupted but variable sedimentation rates, with no evidence for erosional surfaces or depositional hiatuses. The results align with regional sea-level reconstructions and under score the role of transgressive-regressive processes and delta infilling in shaping vegetation dynamics. This integrated micropalaeontological and chronostratigraphic approach offers a robust framework for interpreting Holocene palaeoenvironmental evolution in tropical coastal settings.

Pseudoaneurysm after valve-sparing aortic root replacement is uncommon but potentially life-threatening. We report an unusual case of spontaneous resolution of an aortic root pseudoaneurysm that developed in a 14-year-old boy with Marfan syndrome following valve-sparing aortic root replacement. This case suggests that, in carefully selected situations, non-surgical management with intensive follow-up may be beneficial.

Un oficial del ejército chileno relata que en 1879 los atacameños (o Lickanantay; actuales comunidades indígenas del interior de la región de Antofagasta, norte de Chile) realizaban procesiones al volcán Licancabur todos los años. Contrastando este relato, nos propusimos investigar el camino de peregrinación que utilizaban desde el pueblo de San Pedro de Atacama hasta dicho centro ceremonial. Entregamos aquí los resultados iniciales de esta investigación y evaluamos la profundidad cronológica de las peregrinaciones a las altas montañas, las que hasta ahora se han considerado una práctica originada con el estado Inka (ca. 500 aP), como el caso del rito de la Capacocha. Si bien nuestros datos son preliminares, son concluyentes en mostrar que las prácticas peregrinas andinas a las montañas son milenarias y que se desarrollaron desde hace unos 3.300 años, continuando hasta fines del siglo diecinueve en el caso del Licancabur. En la actualidad, sin embargo, no hemos logrado dar con ningún registro ni memoria oral que dé cuenta de procesiones desde los oasis sanpedrinos al volcán, develando una notable amnesia histórica colectiva, provocada en gran parte por la reciente delimitación de las fronteras estados-nacionales después de la Guerra del Pacífico.

Native forests in Aotearoa/New Zealand are at significant risk from the plant diseases myrtle rust and kauri dieback. Mobilising for Action (MFA) was a four-year transdisciplinary research project exploring the social dimensions of these pathogens and forest health through social science, humanities, creative arts and mātauranga Māori (Māori knowledge), with experts, artists, iwi/hapū (tribes/sub-tribes) and communities, empowering and supporting them in their efforts to address forest disease and promote forest health. A waka houora (double-hulled canoe) framework guided MFA to enable Western knowledge systems to operate alongside mātaurangā Māori, allowing for collaboration, cross-cultural learning and Indigenous empowerment through artistic research and related approaches. We propose that through various creative arts approaches, MFA built relationships and partnerships between Māori and other cultures, people and forests and disciplines, in addition to developing novel research methods in forest health through storytelling and narratives, offering new possibilities in critical forest studies and care.

Aelian and Porphyry claim that only the horns of a specific species of Scythian ass can contain the corrosive water of the Styx. They also state that Alexander the Great received one of these horns from a certain Sopater as a gift, on which he had an epigram engraved before dedicating it at Delphi. This article explores the connection between this story and the reports of Alexander’s alleged assassination by the Antipatrids. In these reports, the poison used is often said to be the water of the Styx, held in an equine hoof. The tale reported by Aelian and Porphyry can be interpreted as part of the propaganda war during the time of the Diadochi, specifically as a piece of counter-propaganda responding to the accusation of treason against Antipater and his family and aiming to exonerate them.

Individuals with mental health difficulties (MHD) have a substantial reduction in life expectancy compared to the general population. It is increasingly recognised that mental health services need to improve physical healthcare as a priority. Sexual health, including consideration of high-risk sexual behaviours, medication side effects, and challenges in romantic relationships, is a further important but under-recognised aspect of overall health. We discuss some of the current issues relating to physical and sexual health, with a particular focus on youth with MHD and how we might implement holistic care in Ireland. Prioritising the resourcing of these issues could facilitate the implementation of a Shared Model of Care as recommended in Ireland’s National Mental Health Policy, Sharing the Vision.

The importance of additional language learning (ALL) is on the rise, but we do not yet have a full understanding of how learners with different characteristics approach this task. Here, we discuss the potential impact of attention-deficit/hyperactivity disorder (ADHD), a prevalent learning disability, on classroom ALL. Learners with ADHD show difficulties in the attention networks of sustained attention and executive control. It is critical, therefore, to ask how these difficulties of learners with ADHD might manifest in the demanding task of ALL, but to date there is very limited research examining this issue. The current paper sets out a theoretical framework for examining ALL in learners with ADHD, reviews the extant literature, and most importantly calls for future research to examine the way in which learners with ADHD manage the process of ALL, in an effort to highlight the involvement of sustained attention and executive control in ALL more generally.

This article considers the history of Emergency Health Kits established by United Nations agencies and the larger medical non-governmental organizations of the 1980s to analyse the significance of standardized responses in humanitarian emergencies. We argue that, far from being a rigid and immutable response, the kits reflected a (not universally realized) desire to standardize and control both supplies and medical care from international organizations. As such, humanitarian medical practice remained a disputed field in which each object or drug was negotiated at the risk of creating innovation traps. Coming at a time of increasingly global logistics capacities, the Emergency Health Kits became a central feature of a more coordinated global marketplace of humanitarian aid. The kits’ promise to provide rapid transport of emergency supplies to crisis settings across the world was often experienced as a construct, with long delays and logjams in certain regions. Even so, humanitarian organizations were agents of globalization because they imagined a system of centralized production in the Global North and supply to isolated and/or insecure locations across the world.

This study aimed to evaluate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and inactivated virus vaccination on intracytoplasmic sperm injection (ICSI) outcomes in infertile couples. A retrospective case–control study was conducted at the Royan Institute from August 2020 to March 2022. The study included 90 couples in the COVID-19 infection phase and 31 in the vaccination phase. A total of 30 infected but unvaccinated couples were compared to a control group of 60 couples with no COVID-19 infection or vaccination history. Additionally, 31 couples underwent treatment before and after receiving the Sinopharm inactivated vaccine. Key variables analysed included sperm parameters (concentration, motility, progressive motility and morphology), ovarian parameters (antral follicle count, oocyte retrieval), embryological outcomes and pregnancy outcomes. SARS-CoV-2 infection significantly reduced sperm motility (P = 0.02) and progressive motility (P = 0.01) compared to controls. Sperm concentration and morphology showed non-significant declines. Post-vaccination analysis revealed similar but statistically insignificant changes in sperm parameters. Ovarian stimulation parameters and embryological outcomes remained unaffected by both infection and vaccination. Although biochemical, clinical pregnancy and live birth rates were lower among the infected group, these differences did not reach statistical significance (p = 0.16, 0.08 and 0.09). SARS-CoV-2 infection has been associated with impaired sperm progressive motility, which may negatively influence ICSI outcomes. In contrast, vaccination with an inactivated virus does not appear to impact fertility outcomes. These findings provide crucial guidance for physicians and infertile couples managing treatments during and after the pandemic, suggesting the need for extended recovery periods before ART procedures following COVID-19 infection.

Deterministic and stochastic processes are of great importance in influencing the composition of communities. Here, we tested if deterministic and stochastic processes have the same force of influence on functional traits of tiger moth communities. Specifically, we hypothesised that the functional traits of the tribe Arctiini would be more strongly influenced by stochastic processes (associated with spatial variables), given that these moths are primarily diet and habitat generalists within a highly diverse clade. They also exhibit high morphological trait dissimilarity and are capable of occupying a wide range of vegetation habitats. On the other hand, we hypothesised that the functional traits of the tribe Lithosiini would be more influenced by deterministic processes (associated with environmental variables), given that these moths are primarily diet and habitat specialist moths and tend to occur in more specific vegetation types. In agreement with our hypotheses, the functional traits of Arctiini species were better explained by variables related to stochasticity, while the functional traits of Lithosiini were explained by deterministic processes only. Thus, the processes shaping moth distributions across communities may vary according to species’ functional traits and interspecific relationships.

In a normal pregnancy, glucocorticoids (GC), such as cortisol, play an essential role in early heart development. GC concentrations surge in late gestation to facilitate the maturation of fetal systems in preparation for birth. However, pregnancy complications related to stress, lifestyle factors, disease, and commonly used antenatal care treatments (GC therapy and artificial reproductive technology) can lead to prematurely increased GC concentrations that are detrimental to the heart before it is mature enough to benefit. These findings underpin the hypothesis that GC play a double-edged role that benefits normal heart development but is potentially harmful when dysregulated. However, the mechanisms by which both physiological and pathological elevations in GC concentrations influence the fetal cardiometabolic pathways that lead to detrimental long-term cardiovascular outcomes remain unclear. This review will, firstly, describe how cortisol regulates different aspects of cardiac development and, secondly, compare findings from different animal models that have provided mechanistic insight into how excess cortisol/GC during pregnancy impacts cardiac health across the life course.

While Centers for Medicare and Medicaid Services-mandated Antimicrobial Stewardship Programs are now in place across U.S. skilled nursing facilities, reported high rates of compliance may mask persistent gaps in clinical effectiveness. This review summarizes evidence-based antimicrobial stewardship interventions, their impact, and practical tools to support implementation. Resources from Centers for Disease Control and Prevention, Agency for Healthcare Research and Quality, other frameworks, and proposed metrics are highlighted to guide effective stewardship in resource-variable nursing home settings.

Mental health symptoms pose a significant vulnerability to stressful life events among currently married women, adversely impacting their overall well-being and quality of life. This study explores the spatial patterns and factors associated with anxiety, depressive symptoms and the co-occurrence of both symptoms among currently married women of reproductive age in Bangladesh. This study utilised data from 13,372 (weighted) currently married women aged 15–49 years in the Bangladesh Demographic and Health Survey (BDHS) 2022, which used a cross-sectional design. Multivariable logistic regression models determined the associated factors. Additionally, spatial distribution and hotspot analysis were conducted using ArcGIS version 10.8. The weighted prevalence of moderate to severe anxiety, depressive symptoms and co-occurrence of anxiety and depressive (CAD) symptoms among currently married women of reproductive age was 4.1% (95% confidence interval [CI]: 3.8%, 4.5%), 4.8% (95% CI: 4.7%, 5.4%) and 2.2% (95% CI: 2.1%, 2.6%), respectively. Clustering of anxiety symptoms (Moran’s I = 0.063, p < 0.001), depressive symptoms (I = 0.091, p < 0.001) and CAD symptoms (I = 0.082, p < 0.001) were observed, with hotspots in Rangpur, Sylhet and Chittagong regions. Logistics regression analysis shows that currently married women who were living in the Barishal, Khulna, Rangpur and Sylhet regions, who belong to households with a higher wealth index, who experienced high levels of intimate partner violence (IPV), have completed high school, who are sexually inactive and whose husbands are unemployed, were more likely to experience CAD symptoms. Additionally, currently married women of reproductive age, whose age was 25–34 years, who are labourers, whose pregnancies are terminated and who have ≥5 children ever born, are at a higher risk of having anxiety symptoms. Besides, currently married women aged 25–34 years and 35–44 years, who are underweight, were more likely to have depressive symptoms. The findings highlight a significant regional disparity in the burden of anxiety, depressive and CAD symptoms among currently married women of reproductive age in Bangladesh. These findings can help design site-specific programmes and actions for women in the hot spot areas of Rangpur, Sylhet and Chittagong.