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There is substantial international variation in recommended vitamin C intake levels. In the United States, the recommendation is 90 mg/day for men and 75 mg/day for women, while in the United Kingdom (UK), the current recommendation – established in 1991 – is only 40 mg/day for adults. This UK level was based on the 1953 Sheffield study, which found that 10 mg/day prevents scurvy, with 40 mg/day chosen as the recommended level for yielding somewhat higher plasma levels. In this commentary, we argue that the UK recommendation overlooked key evidence available at the time. Specifically, at least six controlled trials published before 1991 reported benefits from vitamin C supplementation in participants whose baseline vitamin C intake was already 40 mg/day or higher. One randomized controlled trial, published in 1993, found benefits from vitamin C supplementation even at a baseline intake of about 500 mg/day; however, this trial involved ultramarathon runners, and the findings should not be broadly generalised. Nonetheless, such results challenge the assumption that 40 mg/day is universally adequate to maintain full health. We also highlight that the UK recommendations were narrowly focused on preventing dermatological symptoms of scurvy, despite strong evidence – even at the time – that vitamin C deficiency can also cause cardiac dysfunction and greater morbidity due to respiratory infections. We conclude that the current UK vitamin C recommendation should be re-evaluated in light of controlled trial evidence and broader clinical outcomes.
This article seeks to answer the question of how interbranch organisations (IBOs) can facilitate coordination among agents involved in transactions within agri-food chains. An IBO is a complex entity that establishes relationships among agents operating at different stages of a supply chain. The empirical analysis focuses on the Italian tomato supply chain and adopts a Process-tracing approach. The study is grounded in meso-institutions theory and demonstrates how the meso-institutional nature of the analysed IBO helps explain its role in establishing coordination among agents by performing the functions outlined by the theory. The institutional outcome of this relationship is the adoption of a contractual system that facilitates coordination itself. The contractual system identified provides an example of the articulation between the meso-institutional and micro-institutional levels.
American sloughgrass [Beckmannia syzigachne (Steud.) Fernald] is a troublesome wheat weed. We tested the germination of B. syzigachne seeds under different temperatures with growth chambers (12 h dark/12 h light, 12000 lx), simulating those during the sowing periods of early- (25/15 C), ordinary- (20/10 C), late- (15/5 C), and very late-sown winter wheat (5/0 C). We also tested the accumulated temperatures required for seedling growth to the 2- to 5-leaf stages, using 225 populations collected from wheat fields in eastern China. The average 1000-seed weight of the 225 populations was 1.2 ± 0.01 g. Overall populations tested did not show seed germination after 21 days of treatment (DAT) at 5/0 C or constant 30 C. At 14 DAT with 25/15 C, 20/10 C, and 15/5 C, the mean germination rates were 85.4%, 6.4%, and 0.1%, respectively. These rates increased to 99.9%, 58.6%, and 21.7% at 21 DAT. Populations collected from lower latitude regions germinated significantly faster (P < 0.05) under optimal conditions. Accumulated temperatures required for growing the 2nd, 3rd, 4th, and 5th leaf were 139.0 ± 1.0, 127.8 ± 1.0, 115.6 ± 1.0, and 98.9 ± 0.7 C, which showed a significant decreasing trend. The narrower optimal temperature range for B. syzigachne seed germination and higher thermal requirements for early seedling growth constrain its distributions, while the heterogeneous seed germination facilitates its infestations in wheat planting areas in eastern China.
The dating of the qameṣ shift (*/aː/ > [ɔː]) in the Tiberian tradition of Biblical Hebrew has long been a scholarly puzzle. In this article I present possible evidence for this shift in the Greek transcriptions of Origen’s Hexapla, datable to the first half of the third century ce in Palestine. While the evidence is limited both in attested tokens and in grammatical scope, it is suggested that lexical diffusion may account for the gradual spread of this shift, as recorded in different stages of the transmission of Biblical Hebrew.
This study investigates the production, online processing, and offline comprehension of non-canonical structures in Mandarin-speaking children with Developmental Language Disorder (DLD). We tested three Mandarin non-canonical structures, which differed in word order, the presence or absence of morphosyntactic cues, and the distance between the displaced element and its trace. Syntactic priming was adopted to elicit production, and a self-paced listening task with picture verification was used to examine online processing and offline comprehension accuracy, among 22 DLD children aged 5 to 9 and 37 age-, SES-, and nonverbal IQ-matched typically developing (TD) children. Results showed a quantitative difference between DLD and TD children across non-canonical structures in production and offline comprehension. In online processing, TD children immediately used different cues when they were available, whereas DLD children relied on the most informative cue within a given structure and context and integrated redundant cues only at a later stage. These findings point toward a complex interaction of representational weakness and domain-general processing constraints whereby DLD children show difficulties in allocating processing resources to integrate multiple linguistic cues.
When it was first introduced, the Youth Criminal Justice Act (YCJA) had two primary goals of reducing the reliance on custody and increasing uniformity in sentencing practices. Twenty years later, the YCJA has succeeded in dramatically lowering overall rates of youth in custody, but this gain has been selectively experienced by non-Indigenous youth and regional disparities in sentencing practices persist. In this paper, we suggest that the YCJA’s inability to meet its goals is due to overcriminalization by over depth. Using Indigenous youth sentencing as a case study, we argue the YCJA’s layered and sometimes conflicting principles have symptoms of overcriminalization by over depth, including over- and under-inclusiveness, arbitrariness, and confusion in implementation. To more effectively meet the YCJA’s initial goals, we propose legislative streamlining and systemic reforms, including specialized Indigenous youth courts and enhanced community-based resources, as pathways to greater justice.
Social cohesion suffers when people perceive that they live among others who differ from them, even if such people live in homogeneous neighborhoods. This article shows that (1) two individuals who live in equally diverse local contexts may not perceive the same amount of diversity in that context, nor think of the boundaries of their local community in the same way; and (2) when comparing two individuals who live in equally diverse local contexts, the one who thinks they live with more minorities tends, on average, to see lower social cohesion and less collective efficacy among their neighbors. These descriptive results align with a causal framework that distinguishes the objective environment from that of the subjective context. Revealing that perceptions of social reality matter above and beyond the experience of objective context adds evidence to a theory of context effects that involves perceptions as well as experience.
Higher-order uncertainty is uncertainty about what one’s evidence supports. In many cases, a rational reaction to such uncertainty is to engage in inquiring activities like double-checking or redeliberating, with the aim of securing a firmer grasp of the evidence. An attractive idea is to account for the epistemic impact of higher-order uncertainty in terms of these inquiring activities. However, I argue that zetetic accounts along these lines are, at best, incomplete, because they cannot deal satisfactorily with cases in which higher-order uncertainty persists even if further inquiry is not required (cases at the end of inquiry). In this paper, I put forward a more general account of the impact of higher-order uncertainty. On this view, higher-order uncertainty may defeat propositional justification by undermining one’s access to the relevant evidence. Losing access to some evidence often calls for further inquiry. However, when this further inquiring is ineffective, inadvisable, or merely optional, one may be justified to adopt instead revised attitudes that fit one’s limited access to the evidence. This proposal accounts for the impact of higher-order uncertainty at the end of inquiry and offers an appealing explanation of the relations between this type of uncertainty and inquiry.
This paper studies the effect of gender imbalance on assortative matching and household income inequality. Using data across prefectures in China, we show that a higher sex ratio in the marriage market is negatively associated with both assortative marriage and household income inequality. Motivated by empirical evidence, we develop a heterogeneous-agent model to study the mechanism behind the pattern. The quantitative results of the model match the empirical evidence: a higher sex ratio is associated with a lower degree of assortative matching, which leads to a decrease in household income inequality. When we allow men and women to choose their level of education endogenously before entering the marriage market, we find that a higher sex ratio leads to a higher level of education investment among both men and women, with men investing more significantly than women.
Results are presented of an experimental investigation into the levitation of spheres on thin layers of viscous fluid. In one set of experiments the layer is formed on a planar vertical wall and in a second investigation the sphere sits on a fluid layer on the inside of a rotating horizontal cylinder. The motion takes place at a set of fixed locations in the latter case whereas the sphere generally translates up or down the plane wall of the belt. Lubrication layers formed between the surfaces of the spheres and the walls induce slip. Two distinct states are identified, and excellent accord is found between experimental results and those from a recently developed theory for the single-track state which is only observed in the rotating horizontal cylinder. The two-track state exists in both sets of experiments, but theoretical progress with this remains an outstanding challenge.
Past research suggests that polygenic scores for major depressive disorder (MDD-PGS), family conflict, and parental acceptance may all predict depressive outcomes among adolescents. Few studies have examined the interplay of these factors through gene–environment interaction (GxE) and gene–environment correlation (rGE) in racially/ethnically diverse samples of adolescents. Methods: Utilizing latent curve analysis and growth mixture modeling in a diverse sample of 10,771 adolescents from the Adolescent Brain and Cognitive Development (ABCD) study, the present study examined how MDD-PGS, family conflict, and parental acceptance predicted depressive trajectory class membership through GxE and rGE in independent models for Black, Latinx, and White adolescents. Results: Among all youth, MDD-PGS and family conflict were associated with greater intercept-levels of depressive symptoms. Among Latinx and White youth, parental acceptance was associated with lower intercept levels of depressive symptoms. MDD-PGS (among all youth), lower parental acceptance (among Latinx and White youth), and greater family conflict (among White youth) increased odds of higher-risk trajectories. Evidence of rGE through family conflict was found among White youth. No evidence of GxE was found. Conclusion: Our findings highlight utility of MDD-PGS and the need to expand conceptualizations of environment to identify salient supportive and stressful experiences across racially/ethnically diverse youth.
Many archaeology graduate students pursue advanced degrees in the hope of undertaking an academic career. Job-listing websites often serve as the first port-of-call for students seeking academic positions. We examined tenure-track job advertisements over the past decade to gain insights into the academic job market for archaeologists. Using data from the community-edited Academic Jobs Wiki for Archaeology, we examined changes in the academic job market over time. We investigated the editing dynamics of the Wiki to understand its users and their biases. We then analyzed the text of 431 job ads posted from 2013 to 2023. Our analysis addresses the question of how archaeological topics, methods, and geographic regions specified in archaeological job ads have shifted over time. We also explored whether the labor burden for applicants has changed over time: do institutions request more information and documents from applicants at the initial stages of application, compared to a decade ago? Finally, we assessed the influence of sociopolitical factors on the changing focus of research topics in the field. We conclude with implications for archaeology students, graduates, and advisors seeking to understand the dynamics of the academic job market and the requirements of employers.
La reciente excavación arqueológica efectuada en el centro provincial inka de Tambo Viejo, en el valle de Acarí, Perú, resultó en el hallazgo de una pequeña construcción de forma rectangular y semisubterránea. En su interior encontramos hojas y semillas de coca en asociación con arena limpia. Esta evidencia sugiere que la pequeña construcción sirvió para el almacenamiento de las hojas de coca, las que habían sido cubiertas con arena limpia para garantizar su preservación. La arena tiene propiedades térmicas que crean condiciones relativamente frías y que son óptimas para la preservación de productos orgánicos.
Estimate bacterial pathogen contamination of healthcare workers’ (HCW) long-sleeved attire.
Design:
Prospective observational study.
Setting:
Tertiary care hospital.
Participants:
HCWs wearing long-sleeved attire providing direct inpatient care.
Intervention:
Sampling of both sleeves of HCWs wearing long-sleeved attire was performed using a swab and cultured for aerobic bacterial growth classified as potential pathogens or presumptive skin commensals. Potential predictors of sleeve contamination, including participant survey responses related to attire and infection prevention practices, were analyzed using univariate analyses. Whole genome sequencing compared isolates to a genomic surveillance database of patient clinical isolates.
Results:
Among 280 samples, 81.1% (n = 227) demonstrated any bacterial growth and 20.7% (n = 58) grew ≥1 potential pathogen. Speciated organisms included alpha-hemolytic streptococci (n = 28), Bacillus sp. (n = 20), and Pantoea/Mixta sp. (n = 8), gram-negative bacilli (n = 6), and Staphylococcus aureus (n = 2). Univariate analysis demonstrated that sleeves sampled on non-intensive care units (P = .038) were significantly associated with any bacterial growth, and attire type (P = .002) and sleeve material (P = .004) were associated with growth of ≥1 potential pathogen. Fleece attire and material were more likely to be contaminated than other attire and material types. Sequenced isolates from sleeve samples were not genetically related to any patient isolates.
Conclusions:
HCW long sleeve contamination occurs frequently, including with potential pathogens. Changing trends in attire type may have an impact on bacterial transmissibility. While this study could not infer transmission events associated with clinically diagnosed patient infections, the potential benefit of a “bare below the elbows” attire policy warrants further investigation.
Efforts to address overuse of antibiotics for RTIs are important to limit antimicrobial resistance. Leaflets used during GP consultations can empower patients to self-manage respiratory infections (RTIs) and support a reduction in unnecessary antibiotic prescribing.
Objectives:
This study aimed to assess the feasibility and acceptability of a Treat Your RTI (TY-RTI) patient leaflet for GP consultations in Ireland.
Methods:
A single-arm mixed-methods feasibility study was conducted. Six GPs in daytime practice and three GPs in out-of-hours (OOH) services were recruited to use the TY-RTI leaflet during routine RTI consultations where an immediate antibiotic was not deemed necessary. GPs and patients completed questionnaires to assess the feasibility and usefulness of the leaflet during the consultation. Ethical approval was obtained.
Results:
The TY-RTI patient leaflet was used by GPs in 201 RTI consultations (57 in OOH, 28%), and 84 (42%) patients/parents completed the questionnaire (9/84 in OOH, 11%). For over 90% (182/201) of consultations, GPs reported the leaflet was useful, supported communication, safety-netting, and did not increase consultation time. All patients/parents found the leaflet easy to read and useful. They reported the leaflet gave them confidence to self-manage RTIs without antibiotics (88%, 74/84), and it changed their views of the need for antibiotics (81%, 68/84).
Conclusions:
This study demonstrates the feasibility and acceptability of the TY-RTI leaflet for GPs and patients, supporting its wider implementation. The leaflet supports improved communication and safety netting in the consultation and empowers patients in the self-management of RTIs, with potential to reduce patients’ antibiotic-seeking behavior.
An increasing number of children and adolescents are prescribed second-generation antipsychotic medications, which may lead to cardiometabolic or other physical health impairments. It is unknown whether lifestyle interventions can prevent or manage these adverse effects.
Aims
To evaluate the effectiveness of lifestyle interventions for preventing or managing cardiometabolic risks and other adverse physical health outcomes in this population.
Method
Four bibliographic databases were searched up to February 2024. Randomised controlled trials reporting a physical health outcome of children or adolescents (aged 6–17 years) taking antipsychotics and participating in a lifestyle intervention compared with treatment as usual (TAU) were eligible for inclusion. The Cochrane Risk of Bias 2 tool was used to assess risk of bias. Data were synthesised via a random-effects meta-analysis and narrative synthesis.
Results
Four studies with a total of 370 participants were included. Most (75%) had a high risk of bias. Lifestyle interventions resulted in moderate but statistically non-significant reductions in participants’ body mass index (standard mean difference −0.70, 95% CI: −1.70 to 0.31) compared with TAU. Some studies reported improvements in other physical health outcomes favouring the intervention, although findings were inconsistent and varied across different measures. Reporting of secondary indicators of physical health, including participant or family health behaviours, was limited.
Conclusions
The effectiveness of lifestyle interventions for preventing or managing the cardiometabolic risk and other adverse physical health outcomes in this population is unclear due to the limited number of available trials, small samples and high risk of bias. Larger trials are needed.
This study investigates the effect of participation in the Global Value Chain (GVC) on Multidimensional Energy Poverty (MEPI), and the role played by the quality of institutions (QI) in the short and long run for 51 African countries over the period 1995–2018. For this purpose, the DCCE-PMG approach is employed, as well as both the GVC and QI indices. MEPI includes electricity, clean fuel, and technology for cooking. The findings show that GVC participation negatively affects MEPI in both the short and long run, meaning that the GVC reduces energy poverty in Africa. Besides, there is mixed evidence regarding the heterogeneity effect according to rural and urban locations. The evidence further shows that GVCs interact with institutions to negatively impact both energy poverty and the rural–urban MEPI gap, implying that the better the institutional quality, the larger the effect of GVC integration on energy poverty reduction. Therefore, a better quality of institution enables local firms, participating in the GVC, to easily capture technology and knowledge diffusion to promote energy development and fulfill the spatial inequality in energy poverty. Additional tests allow us to confirm the evidence and, moving forward, the implications of participation in the GVC.
We report the first detections of Otiorhynchus albidus Stierlin (Coleoptera: Curculionidae) in North America. The first specimens of O. albidus were found inside a home in Kelowna, British Columbia, Canada, in June 2022, and additional specimens from the same location were collected throughout 2023 and 2024. Otiorhynchus albidus is of European origin. It is known to attack tree fruits and ornamental plants. Otiorhynchus albidus sometimes co-occurred with O. raucus (Fabricius), an already established weevil species in British Columbia that is a pest of tree fruits, grapes, vegetables, and ornamental plants. To test different surveillance methods and understand the seasonal occurrence of O. albidus, surveys for adult weevils were conducted in 2023 and 2024 with pitfall traps (outside the home) and sticky traps (inside and outside the home) in 2023. Both O. albidus and O. raucus were recovered with pitfall and sticky traps and were found in both years. We provide a key and reference DNA barcodes (from the cytochrome c oxidase subunit 1 region) to distinguish O. albidus from similar species present in Canada. Otiorhynchus albidus has the potential to become a pest of tree fruits and ornamental plants in North America, as well as a nuisance pest for homeowners.