Danon disease is a rare X-linked disorder caused by deficiency of the lysosome-associated membrane protein-2. We report a case of hypertrophic obstructive cardiomyopathy secondary to a novel mutation in the lysosome-associated membrane protein-2 gene in a 10-year-old male adolescent. We performed a modified extended Morrow procedure to minimise the risk of death and improve the patient’s quality of life. The patient did not have exertional dyspnoea, and auscultation did not reveal a cardiac murmur at 1-year follow-up.

In the future, when we compare the welfare of a being of one substrate (say, a human) with the welfare of another (say, an artificial intelligence system), we will be making an intersubstrate welfare comparison. In this paper, we argue that intersubstrate welfare comparisons are important, difficult, and potentially tractable. The world might soon contain a vast number of sentient or otherwise significant beings of different substrates, and moral agents will need to be able to compare their welfare levels. However, this work will be difficult, because we lack the same kinds of commonalities across substrates that we have within them. Fortunately, we might be able to make at least some intersubstrate welfare comparisons responsibly in spite of these issues. We make the case for cautious optimism and call for more research.

Personality disorders are a group of psychological disorders characterised by a developmental nature, long-lasting impairment and emotional suffering. Personality disorders have an estimated prevalence rate of approximately 8% in community settings, but in in-patient settings the rate might be as high as 76%. Cognitive–behavioural therapies (CBTs) include psychotherapies that emphasise the identification and modification of maladaptive thought patterns and behaviours that contribute to the maintenance of psychological disorders. CBTs have demonstrated their effectiveness in treating various types of personality disorder. This article focuses on the nature of personality disorders and their categorial and dimensional assessment and neurobiology. We present three influential CBT models used in personality disorders: schema therapy, cognitive interpersonal therapy and dialectical behaviour therapy. For each one, we outline the rationale, intervention strategies and therapeutic techniques, with practical examples and summary tables to illustrate their application.

This article examines how individual police officers in China interpret and justify the use of excessive force on social media through their WeChat Subscription Accounts (WSAs). Existing research examines how the police department uses social media to justify deadly force, but overlooks individual officers’ online justifications. Adopting a critical discourse analysis approach, this study analyses 211 articles commenting on a prominent case of police violence in China. The findings shed light on the online voice of Chinese frontline officers, revealing an ideology that defends the use of excessive force. The articles published in WSAs displayed strong empathy towards the involved officer; contested the characterization of the incident as police brutality by police officials, the public, and the media; and employed various strategies to justify the officer’s actions. The discussion section expands on these findings by drawing comparisons to justifications in the United States, emphasizing the distinctive dynamic between individual officers’ online expression and official police discourse in China, and offering insights for scholars examining online expression and digital nationalism in the Chinese context.

This article analyzes the AFL-CIO’s international economic policy activism in the late 1960s and early 1970s within the context of the collapse of Bretton Woods monetary system. It shows that AFL-CIO economists developed a far-reaching critique of multinational corporations that encompassed not only concerns about import competition and capital flight but also charges that multinational firms contributed to the United States’ balance of payments woes. Fighting charges that union wages drove inflation, labor leaders maintained that private capital outflows and intracompany transactions exacerbated U.S. payments deficits. They therefore advocated for capital controls and import restrictions as alternatives to fiscal and monetary restraint. Their efforts to preserve the expansionary policies underpinning postwar liberalism, however, ultimately failed. By calling attention to the AFL-CIO’s failed activism in international monetary politics, the article offers a new vantage point for understanding organized labor’s declining influence in the last third of the twentieth century.

Didemnum vexillum is an aggressive, rapidly growing colonial ascidian and regarded as a global alien invasive species in temperate waters. It has recently become established in the western Mediterranean and the vectors of its introduction were assumed to be shipping or oyster trade. A dense settlement of it was encountered on nets of the bluefin tuna (Thunnus thynnus) cages placed at 60–65 m depths off the İzmir Peninsula (eastern Aegean Sea, eastern Mediterranean) in December 2022. It had considerably clogged net's eye openings, hindering water circulations inside cages. It had a vertical distributional pattern on 35 m long-nets, occurring solely on depths from surface down to 15 m, around where a summer thermocline develops. It has entirely replaced the native black mussel Mytilus galloprovincialis on nets. This colonial ascidian changed the routine cleaning procedure of nets in the farming. Three possible ways of its introduction to the eastern Mediterranean were proposed, but the most reasonable one is its secondary transfer via nets or ships from Malta. Mechanisms of its invasion biology and behaviour should be studied and monitored in the region.

This study explores how employees’ flow experience at work emerges, is sustained, and continuously grows over time. Based on the job demand-resource model, we propose the intraday upward spiral of flow: Challenging demands and job resources activate employees’ flow experience, further encouraging them to seek more challenges and resources. Furthermore, drawing on the perseverative cognition theory and spill-crossover model, we propose the inter-day upward spiral of flow: The antecedents (or consequences) of flow can overflow from work to the family domain and result in employees’ positive rumination, thus promoting the next-day flow experience. Our diary study generated 1,208 data points from 142 employees over 10 working days. We found that in the morning, challenging demands and job resources positively affected the participants’ flow, further encouraging them to pursue more challenging demands and job resources in the afternoon and thus enter this state again. Moreover, the afternoon’s challenging demands and job resources promoted the respondents’ problem-solving pondering at night, which further increased their next-morning challenging demands, job resources, and, thus, their flow. Through this study, we expand the emerging literature on positive organizational behavior and provide information for practitioners on how to build and sustain employees’ peak states.