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Attentional impairments are common in dementia with Lewy bodies and its prodromal stage of mild cognitive impairment (MCI) with Lewy bodies (MCI-LB). People with MCI may be capable of compensating for subtle attentional deficits in most circumstances, and so these may present as occasional lapses of attention. We aimed to assess the utility of a continuous performance task (CPT), which requires sustained attention for several minutes, for measuring attentional performance in MCI-LB in comparison to Alzheimer’s disease (MCI-AD), and any performance deficits which emerged with sustained effort.
Method:
We included longitudinal data on a CPT sustained attention task for 89 participants with MCI-LB or MCI-AD and 31 healthy controls, estimating ex-Gaussian response time parameters, omission and commission errors. Performance trajectories were estimated both cross-sectionally (intra-task progress from start to end) and longitudinally (change in performance over years).
Results:
While response times in successful trials were broadly similar, with slight slowing associated with clinical parkinsonism, those with MCI-LB made considerably more errors. Omission errors were more common throughout the task in MCI-LB than MCI-AD (OR 2.3, 95% CI: 1.1–4.7), while commission errors became more common after several minutes of sustained attention. Within MCI-LB, omission errors were more common in those with clinical parkinsonism (OR 1.9, 95% CI: 1.3–2.9) or cognitive fluctuations (OR 4.3, 95% CI: 2.2–8.8).
Conclusions:
Sustained attention deficits in MCI-LB may emerge in the form of attentional lapses leading to omissions, and a breakdown in inhibitory control leading to commission errors.
This paper investigates the aspectual potential of posture verb pseudo-coordination in spoken German. In a corpus study of sitzen ‘sit’ and stehen ‘stand’, it is shown that despite a preference for activity verbs, verbs of all aspectual classes occur in the second conjunct. The posture verb imposes its durative meaning component on the second verb, thus making a progressive interpretation of the construction possible. Apart from this emergent aspectual function, German posture verb pseudo-coordination has a subjective function (conveying the speaker’s beliefs about the subject referent’s stance), and a discourse pragmatic function (information packaging).*
Reducing meat consumption is essential to curb further climate change and limit the catastrophic environmental degradation resulting from the current global food system. However, consumers in industrialised countries are hesitant to reduce their meat intake, often because they find plant-based foods less appealing. Despite the climate emergency, eating meat is still perceived as the norm, and recommended in most national dietary guidelines. To support the transition to more sustainable diets by providing insights for increasing the appeal of plant-based foods to mainstream consumers, this review presents recent research findings on how people think and communicate about meat-based and plant-based foods. The key findings we review include: (1) while vegans think about plant-based foods in terms of enjoyable eating experiences, omnivores think about plant-based foods in terms of health, vegan identity and other abstract information that does not motivate consumption in the moment. (2) Packages of ready-meals and social media posts on Instagram present plant-based foods with fewer references to enjoyable eating experiences than meat-based foods. (3) Presenting plant-based foods with language that references enjoyable eating experiences increases their appeal, especially for habitual meat eaters. This language includes words about sensory features of the food (e.g., crunchy, creamy), eating context (e.g. pub; with family) and immediate positive consequences of eating (e.g. comforting, delicious). In contrast, the term ‘vegan’ is strongly associated with negative stereotypes. Hence, rather than referring to being vegan, meat-free or healthy, the language used for plant-based foods should refer to sensory appeal, attractive eating situations and enjoyment.
A 65-day-old girl presented to the emergency room with lethargy, requiring emergency venoarterial extracorporeal membrane oxygenation for refractory cardiogenic shock. Initially, hypoplastic left heart syndrome was suspected. However, cor triatriatum with a pinpoint opening on the membrane was diagnosed based on a detailed echocardiographic examination. After membrane resection, the left heart size was restored. However, follow-up echocardiography performed 4 months later showed occlusion of both upper pulmonary veins and stenosis in both lower pulmonary veins. Hybrid balloon angioplasty was performed in all pulmonary veins, and stents were inserted into the right upper and lower pulmonary veins. Despite repeated balloon angioplasty, all pulmonary vein stenosis progressed over 6 months and the patient expired while waiting for a heart-lung transplant. Even after successful repair of cor triatriatum, short-term close follow-up is required for detecting the development of pulmonary vein stenosis.
The North-Eastern region (NER) of India falls under the Eastern Himalayan region and it is a bio-diversity hub. Diverse maize landraces with wide adaptability to extreme climatic and soil scenario like heavy rainfall, drought and acidic soil conditions have been grown in NER since time immemorial. However, maize diversity in NER region has drastically reduced due to introduction of high yielding varieties and hybrids. Modern maize breeding programmes are focused on high yield but other unique traits like stay green trait, prolificacy (more than one fertile ear per plant), self-fertilizing ability are also important and the local germplasm of the NER region can contribute with these unique traits. Prior to the selection of any lines in several breeding programmes, assessment of genetic diversity and population structure are basic requirements. Hence, in the present study assessment of genetic diversity and population structure study in 30 maize inbreds developed from different germplasm of NER was undertaken using SSR markers, selected for their broad distribution throughout the genome, in order to assess the extent of allelic diversity among the lines and whether any population structure could be established. In addition to assessing molecular diversity, the study aims to evaluate the potential for yield and other beneficial and unique alleles that have high potential to contribute in the genetic enhancement programme of maize.
Brain ageing, the primary risk factor for cognitive impairment, occurs because of the accumulation of age-related neuropathologies. Identifying effective nutrients that increase cognitive function may help maintain brain health. Tomatoes and lemons have various bioactive functions and exert protective effects against oxidative stress, ageing and cancer. Moreover, they have been shown to enhance cognitive function. In the present study, we aimed to investigate the effects of tomato and lemon ethanolic extracts (TEE and LEE, respectively) and their possible synergistic effects on the enhancement of cognitive function and neurogenesis in aged mice. The molecular mechanisms underlying the synergistic effect of TEE and LEE were investigated. For the in vivo experiment, TEE, LEE or their mixture was orally administered to 12-month-old mice for 9 weeks. A single administration of either TEE or LEE improved cognitive function and neurogenesis in aged mice to some extent, as determined using the novel object recognition test and doublecortin immunohistochemical staining, respectively. However, a significant enhancement of cognitive function and neurogenesis in aged mice was observed after the administration of the TEE + LEE mixture, which had a synergistic effect. N-methyl-d-aspartate receptor 2B, postsynaptic density protein 95, and brain-derived neurotrophic factor (BDNF) levels and tropomyosin receptor kinase B (TrkB)/extracellular signal-regulated kinase (ERK) phosphorylation also synergistically increased after the administration of the mixture compared with those in the individual treatments. In conclusion, compared with their separate treatments, treatment with the TEE + LEE mixture synergistically improved the cognitive function, neurogenesis and synaptic plasticity in aged mice via the BDNF/TrkB/ERK signalling pathway.
How do ordinary people choose survival strategies during intense, surprising political violence? Why do some flee violence, while others fight back, adapt, or hide? Individual decision-making during violence has vast political consequences, but remains poorly understood. I develop a decision-making theory focused on individual appraisals of how controllable and predictable violent environments are. I apply my theory, situational appraisal theory, to explain the choices of Indian Sikhs during the 1980s–1990s Punjab crisis and 1984 anti-Sikh pogroms. In original interviews plus qualitative and machine learning analysis of 509 oral histories, I show that control and predictability appraisals influence strategy selection. People who perceive “low” control over threats often avoid threats rather than approach them. People who perceive “low” predictability in threat evolution prefer more-disruptive strategies over moderate, risk-monitoring options. Appraisals explain behavior variation even after accounting for individual demographics and conflict characteristics, and also account for survival strategy changes over time.
The objectives of this study were to investigate the effect of level and timing of silage supplementation during early lactation on animal performance and dry matter intake (DMI). Two farm-lets were established with a high (1253 kg DM/ha) and low (862 kg DM/ha) grass availability at turnout. In spring, cows were assigned to one of two treatments as they calved over 2 years; high grass (HG) and low grass (LG). During period 1 (week 1–6), cows on the HG treatment were offered a high daily herbage allowance (DHA) with low silage and the LG treatment were offered a low DHA with high silage. In period 2 (week 7–12), half of the cows from the HG treatment in P1 switched to the LG treatment in P2 and vice versa as 20 LG cows in P1 switched to the HG treatment in P2. Cows on the HG treatment in P2 received a high DHA with no silage and the LG treatment received a low DHA with 3 kg DM/cow silage. Grass DMI was significantly higher for the HG treatment during both periods (+1.6 and +3.4 kg DM/cow/day, respectively). The HG treatment produced +0.9 kg milk/cow/day and had a higher protein concentration (+1.1 g/kg milk) compared to cows on the LG treatment during period 2. Differences in animal performance observed in period 2 were maintained throughout the 8-week carryover period.
We study a nonlinear Beltrami equation $f_\theta =\sigma \,|f_r|^m f_r$ in polar coordinates $(r,\theta ),$ which becomes the classical Cauchy–Riemann system under $m=0$ and $\sigma =ir.$ Using the isoperimetric technique, various lower estimates for $|f(z)|/|z|, f(0)=0,$ as $z\to 0,$ are derived under appropriate integral conditions on complex/directional dilatations. The sharpness of the above bounds is illustrated by several examples.
To determine the effectiveness of dry hydrogen peroxide (DHP) in reducing environmental bioburden in occupied areas.
Design:
Prospective environmental cohort study.
Setting:
The study was conducted in 2 tertiary-care hospitals and 1 free-standing emergency department.
Intervention:
Environmental air and surface sites were cultured before and after continuous deployment of DHP systems in targeted hospital areas.
Methods:
In total, 1,554 surface and 1,036 air samples were collected from 74 patient areas among the 3 facilities on 3 consecutive days before DHP deployment and on days 14, 30, 60, and 90 after deployment. At each sampling time, 2 air samples were collected at each facility from 1 room without DHP, along with 2 outdoor samples from each facility. The impact of negative-pressure usage on the efficacy of DHP was also evaluated, with 1 hospital continuously using negative pressure, another utilizing it only in patient isolation scenarios, and another without negative pressure.
Results:
In the 2 facilities without continuous negative pressure, exposure to DHP was associated with a significant reduction in surface bioburden, characterized as total colony-forming units (P = .019; P = .002). Significant associations between DHP exposure and reductions in airborne bacterial load at the 2 hospitals were observed (P ≤ .001; P = .041), and the free-standing emergency department experienced a reduction that did not achieve statistical significance (P = .073).
Conclusions:
Our findings confirm that DHP has the potential to reduce microbial air and surface bioburden in occupied patient rooms with standard ventilation parameters.
This research aims to unpack how digital technologies can facilitate the flourishing of circular business practices in small- and medium-sized enterprises by structuring a detailed going circular path that explains businesses’ evolution toward circularity. In doing so, it outlines how the observed organizations have adopted – or are adopting – circular economy principles thanks to business digitalization. Following an inductive approach based on a multiple case study methodology, we investigated 16 small- and medium-sized enterprises operating in industries that put considerable pressure on the environment (e.g., manufacturing, chemical, construction, fashion, food, and beverage). Our findings confirm how digital technologies, as well as Industry 4.0 structures, play a fundamental role in shaping, enabling, enhancing, and refining circular products and processes development. Accordingly, we outline a generalizable step-by-step process to pursue circular economy by employing digital technologies. The present study represents a practical handout for guiding companies through their going circular path.
We provide conditions under which a generalized shift-invariant (GSI) system can be approximated by a GSI system for which the generators have compact support in the Fourier domain. The approximation quality will be measured in terms of the Bessel bound (upper frame bound) for the difference between the two GSI systems. In particular, this leads to easily verifiable conditions for a perturbation of a GSI system to preserve the frame property.
The proliferation of English as an international language has had significant ramifications for the teaching and learning of languages in various educational contexts (Yu & Liu, 2022). Within the realm of higher education, the adoption of English-medium instruction (EMI) has been a particularly contentious issue, with debates raging over its potential benefits and drawbacks (Bolton et al., 2022; Bolton, Botha & Lin, 2023). One potential approach to addressing the challenges posed by EMI is the adoption of translanguaging practices, which involve the utilization of multiple languages or language varieties in communication and learning. While the concept of translanguaging has gained increasing traction in recent years, there remains a paucity of empirical research on its implementation and impact within Sino-US educational institutions where translanguaging and EMI are facing enviable pedagogical dueling.
Let $n$ be an integer congruent to $0$ or $3$ modulo $4$. Under the assumption of the ABC conjecture, we prove that, given any integer $m$ fulfilling only a certain coprimeness condition, there exist infinitely many imaginary quadratic fields having an everywhere unramified Galois extension of group $A_n \times C_m$. The same result is obtained unconditionally in special cases.
How do Asian Americans think about their ethnic origin? How do ethnic identities affect political preferences? Drawing on interviews with a diverse group of Asian Americans, I provide a nuanced understanding of how they think about their ethnic origin and pan-ethnic identities. The findings reveal that ethnicity plays a significant role in shaping electoral preferences, as Asian Americans exhibit coethnicity preferences, conditional on partisanship. Moreover, I uncover several factors that have been underexplored in the existing literature, including transnational ties, news consumption, and political preferences on foreign policies related to their home country. This article provides a more comprehensive and nuanced understanding of Asian American identities by showing that the ethnic origin roots of Asian Americans can have significant influence on their political interests and candidate preferences.
Given a fixed graph $H$ and a constant $c \in [0,1]$, we can ask what graphs $G$ with edge density $c$ asymptotically maximise the homomorphism density of $H$ in $G$. For all $H$ for which this problem has been solved, the maximum is always asymptotically attained on one of two kinds of graphs: the quasi-star or the quasi-clique. We show that for any $H$ the maximising $G$ is asymptotically a threshold graph, while the quasi-clique and the quasi-star are the simplest threshold graphs, having only two parts. This result gives us a unified framework to derive a number of results on graph homomorphism maximisation, some of which were also found quite recently and independently using several different approaches. We show that there exist graphs $H$ and densities $c$ such that the optimising graph $G$ is neither the quasi-star nor the quasi-clique (Day and Sarkar, SIAM J. Discrete Math. 35(1), 294–306, 2021). We also show that for $c$ large enough all graphs $H$ maximise on the quasi-clique (Gerbner et al., J. Graph Theory 96(1), 34–43, 2021), and for any $c \in [0,1]$ the density of $K_{1,2}$ is always maximised on either the quasi-star or the quasi-clique (Ahlswede and Katona, Acta Math. Hung. 32(1–2), 97–120, 1978). Finally, we extend our results to uniform hypergraphs.