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In the last decade, scholars in the Developmental Origins of Health and Disease (DOHaD) have increasingly engaged in translating the field’s insights into policy and society. Several multidisciplinary advocacy groups have been formed to promote women’s reproductive health as well as maternal and child health. They have framed DOHaD in different ways in order to attract policy attention. Framing is the practice of contextualising and interpreting the meaning of research results in various communication activities. Overall, DOHaD has often been shown to exhibit a narrow focus on individual responsibility and translation at the clinician–patient interface instead of focusing on wider socio-economic, cultural, and political factors influencing health in its framing activities. In this chapter, we examine two case studies of multidisciplinary networks (the Venice Forum and UK Preconception Partnership) and explore how they have framed DOHaD findings when communicating with and for policymakers. We analyse the social valences of these framings and make recommendations for framing DOHaD in ways that better align with social justice and health equity goals.
The electroweak unification appears mainly in the neutral current processes. The transition probabilities of all of them are predicted in terms of the weak mixing angle. Measuring the weak mixing angle.
Theory predicts the existence of three vector bosons, W+, W− and Z0. It does not predict their masses, but precisely states how they are related with two measured quantities: the Fermi constant and the weak mixing angle. The UA1 experiment and the discovery of the vector bosons.
The precision tests of the electroweak theory performed at the LEP electron–positron collider and at the Tevatron proton–antiproton collider.
The last missing element of the SM, the Higgs boson. The spontaneous symmetry breaking and the boson. The searches at LEP and at the Tevatron. The Large Hadron Collider and the ATLAS and CMS experiments. The discovery of 2012. Checking Higgs physics, measuring its mass and width, its spin and parity, its couplings to the bosons and to the fermions. All agree with the predictions of the Standard Model, so completing the experimental verification of its basic building blocks.
DOHaD and epigenetic research that investigates causal mechanisms and predictive biomarkers has often occurred in the absence of discussion of ethical, legal, and social implications or engagement with disability communities. These implications include maternal blaming, labelling, stigmatisation, and ableism. Considering the debate on different models of disability by disability activists and social scientists, this is a timely opportunity to optimise the design of epigenetic research into conditions labelled as disabilities. Research aims should address the needs of disability communities, acknowledge diversity, and move away from medical to social models of disability. Here we focus on the autistic community as an example. We argue that there is a need to work with autistic people and their supporters to co-design studies that facilitate a better understanding of autism’s challenges and assets and to use this knowledge to assist these individuals and communities. We also stress the importance of autonomy and information provision in relation to autistic individuals’ engagement with epigenetics tests. We conclude by urging researchers planning DOHaD and epigenetics research to listen to and engage with disability communities when they say, ‘nothing about us without us’.
This chapter analyzes the stepwise formation of the functional germ cell concept of sustainable mobility for elderly home care clients, following the principle of ascending from the abstract to the concrete. During a lengthy process of intervention research, a new instrument called mobility agreement was introduced to facilitate the inclusion of regular mobility exercises in home care visits and in the daily lives of the clients. In encounters between home care workers and their elderly clients, aimed at implementation of the mobility agreement, the new concept of mobility began to emerge. The simple action of standing up from the chair is the core of this concept. The formation and expansion of the germ cell took place primarily by means of bodily movements and sensations, supported by simple pictorial artifacts.
Collective concept formation in the wild may be seen as creation of new worlds, condensed or crystallized in a future-oriented concept. In some cases, collective concept formation in the wild seems to move with the name of the concept in the lead, as if in search for contents for the name. In other cases, concept formation seems to move practically in the opposite order, with the embodied and enacted novel pattern of activity in the lead, but not having a name for it. The name may be attached to this novel pattern of activity only much later. This chapter examines these opposite-looking directions of concept formation, with the aim of constructing an explanatory framework for further analyses of the dynamics of collective concept formation as creation. Although the starting points were different in the three cases discussed in this chapter, concept formation in each case moved in a spiral-like way in the same direction. This corresponds to the basic logic of ascending from the abstract to the concrete, or expansive learning. Creativity in these cases appears as practitioners’ and their clients’ collective efforts and struggles to redefine the idea of their activities – to construct and implement qualitatively new concepts to guide and organize the work practice.
This chapter analyzes the class base of support for left-wing parties in Western Europe, in light of early political socialization and patterns of intergenerational social mobility. We ask to what extent contemporary left-wing party support is a legacy of political socialization in the traditional social democratic constituency class of industrial workers – and if this is a sustainable model for future social democratic support considering postindustrial occupational transformation and upgrading. By investigating support for the Social Democrats in contrast to green and left-libertarian, radical left, and moderate and radical right parties, we identify the main competitors of the Social Democrats among classes traditionally associated with social democratic support. Analyses using the European Social Survey (2002–10) indicate three main findings. First, the composition of the electorates indicates that Social Democrats rely more than other parties on support from individuals socialized in the industrial working class, while contemporary patterns show that one-third of the social democratic electorate now stems from the middle class and workers make up the largest part of the radical right electorate. Second, as expected, contemporary middle-class social democratic support is largely a legacy from socialization in the working class, especially among older generations in Northwestern Europe. Third, new legacies are being built along postindustrially realigned patterns, as offspring of sociocultural professionals is relatively more likely to vote for the Left, but for the Green Left or Radical Left instead of the Social Democrats. However, the impact of socialization among younger generations appears to be weaker than the one identified for working-class origins in older generations. These results imply that relying on middle-class support alone is not a viable long-term strategy for the Social Democrats, given the seemingly unique impact of past industrial alignments that is unparalleled by other class–party linkages among younger generations.
DOHaD research in economics finds inequitable health and labour market outcomes but lacks insight into structural factors that contribute to disparities. In practice, social relations like racism, sexism, and ableism can translate into inequitable ‘returns to investment’ in ‘human capital’. DOHaD literature in economics could contribute more to understanding the determinants of health. It is limited by a narrow focus on molecular factors and the decontextualised use of demographic variables, which should be interpreted as proxies for hierarchical power relations. Excluding systems of oppression from analyses renders inequity-generating social structures less visible instead of clarifying their unjust consequences. Egalitarian economic approaches can address the failure to adequately integrate social structures with historically grounded, socially informed analyses. This chapter demonstrates how by tracing the devaluation of reproductive labour in economic thought to the reduction of women and girls to their reproductive roles in the DOHaD literature. The marginalisation of women’s labour and of women’s economic research contributes to the dehumanising instrumentalisation of women in orthodox economic research in DOHaD. The analysis reveals risks for women and girls, linking DOHaD literature to debates about ’foetal personhood’, women’s autonomy, and gender inequity.
Identifying children and/or adolescents who are at highest risk for developing chronic depression is of utmost importance, so that we can develop more effective and targeted interventions to attenuate the risk trajectory of depression. To address this, the objective of this study was to identify young people with persistent depressive symptoms across adolescence and young adulthood and examine the prospective associations between factors and persistent depressive symptoms in young people.
Methods
We used data from 6711 participants in the Avon Longitudinal Study of Parents and Children. Depressive symptoms were assessed at 12.5, 13.5, 16, 17.5, 21 and 22 years with the Short Mood and Feelings Questionnaire, and we further examined the influence of multiple biological, psychological and social factors in explaining chronic depressive symptoms.
Results
Using latent class growth analysis, we identified four trajectories of depressive symptoms: persistent high, persistent low, persistent moderate and increasing high. After applying several logistic regression models, we found that loneliness and feeling less connected at school were the most relevant factors for chronic course of depressive symptoms.
Conclusions
Our findings contribute with the identification of those children who are at highest risk for developing chronic depressive symptoms.
While the problem governing Stokes flow about a single particle that is subject to an external force is ill posed in two dimensions (the ‘Stokes paradox’), the related problem of two mutually repellent particles is well posed. Motivated by self-assembly phenomena in thin viscous membranes, we consider this problem in the limit of remote particles. Such limits are typically handled in the literature using reflection techniques, which provide successive approximations to the mutual hydrodynamic interactions. Since their starting point is a single particle in an unbounded fluid domain, these techniques are futile in the present two-dimensional problem. We show how this apparent contradiction is resolved via use of singular perturbations. We obtain a two-term approximation for the velocity acquired by circular disks, considering both rigid and free particle surfaces. We also illustrate our perturbation scheme for elliptic disks, deriving a renormalised single-particle velocity. The utility of our asymptotic scheme is illustrated in the general problem of hydrodynamic interaction between a cluster of remote disks.
The bubbly shock-driven partial cavitation in an axisymmetric venturi is studied with time-resolved two-dimensional X-ray densitometry. The bubbly shock waves are characterised using the vapour fraction and pressure changes across it, propagation velocity, and Mach number. The sharp changes in vapour fraction measured with X-ray densitometry, combined with high-frequency dynamic pressure measurements, reveal that the interaction of the pressure wave with the vapour cavity dictates the shedding dynamics. At the lowest cavitation number ($\sigma \sim 0.47$), the condensation shock front is the predominant shedding mechanism. However, as $\sigma$ increases ($\sigma \sim 0.78$), we observe an upstream travelling pressure discontinuity that changes into a condensation shock as it approaches the venturi throat. This coincides with the increasing strength of the bubbly shock wave as it propagates upstream, manifested by the increasing velocity of the shock front and the pressure rise across it. Consequently, the Mach number of the shock front increases and surpasses the critical value 1, favouring condensation shocks. Further, at higher $\sigma$ (${\sim }0.84\unicode{x2013}0.9$), both the re-entrant jet and pressure wave can cause cavity detachment. However, at such $\sigma$, the pressure wave likely remains subsonic. Hence cavity condensation is not favoured readily. This leads to the re-entrant jet causing the cavity detachment at higher $\sigma$. The shock front is accelerated as it propagates upstream through the variable cross-section of the venturi. This enhances its strength, favouring cavity condensation and eventual shedding. These observations explain the existence of shock fronts in an axisymmetric venturi for a large range of $\sigma$.
Previous studies have reported inconsistent findings regarding the association between post-traumatic stress (PTS) and post-traumatic growth (PTG). Three major issues could account for this inconsistency: (1) the lack of information about mental health problems before the disaster, (2) the concept of PTG is still under scrutiny for potentially being an illusionary perception of personal growth and (3) the overlooking of PTS comorbidities as time-dependent confounding factors. To address these issues, we explored the associations of PTS and PTG with trauma-related diseases and examined the association between PTS and PTG using marginal structural models to address time-dependent confounding, considering pre-disaster covariates, among older survivors of the 2011 Japan Earthquake and Tsunami.
Methods
Seven months before the disaster, the baseline survey was implemented to ask older adults about their health in a city located 80 km west of the epicentre. After the disaster, we implemented follow-up surveys approximately every 3 years to collect information about PTS and comorbidities (depressive symptoms, smoking and drinking). We asked respondents about their PTG in the 2022 survey (n = 1,489 in the five-wave panel data).
Results
PTG was protectively associated with functional disability (coefficient −0.47, 95% confidence interval (CI) −0.82, −0.12, P < 0.01) and cognitive decline assessed by trained investigators (coefficient −0.07, 95% CI −0.11, −0.03, P < 0.01) and physicians (coefficient −0.06, 95% CI −0.11, −0.02, P < 0.01), while PTS was not significantly associated with them. Severely affected PTS (binary variable) was associated with higher PTG scores, even after adjusting for depressive symptoms, smoking and drinking as time-dependent confounders (coefficient 0.35, 95% CI 0.24, 0.46, P < 0.01). We also found that an ordinal variable of the PTS score had an inverse U-shaped association with PTG.
Conclusion
PTG and PTS were differentially associated with functional and cognitive disabilities. Thus, PTG might not simply be a cognitive bias among survivors with severe PTS. The results also indicated that the number of symptoms in PTS had an inverse U-shaped association with PTG. Our findings provided robust support for the theory of PTG, suggesting that moderate levels of psychological struggles (i.e., PTS) are essential for achieving PTG, whereas intense PTS may hinder the attainment of PTG. From a clinical perspective, interventions that encourage social support could be beneficial in achieving PTG by facilitating deliberate rumination.
Chemsex occurs primarily among gay, bisexual and other men who have sex with men (GBMSM), and there is evidence of a subgroup of users who carry out chemsex-related criminal offences and experience harm. Challenges with chemsex can present to various settings; there are concerns that harm is increasing, including at interfaces between health, social care and criminal justice systems. The UK response to date has lacked a coordinated approach. An expert reference group was convened to share chemsex knowledge, articulate priorities for research and pathway development, and foster collaborative working between agencies. It made three key recommendations: develop and increase training and awareness across all services; implement a coordinated research programme with the development of a common data-set and assessment tool to fully characterise population-level needs; develop a professional network to share information, provide professional support and act as a knowledge hub. There was support for a unified multi-agency strategy incorporating the priorities identified as overarching principles.
Research in the field of Developmental Origins of Health and Disease has had a fundamental impact on our understanding of how environmental experiences and contexts influence the development of health and disease over the entire lifecourse. Covering a wide range of geographic regions, this volume includes an overview of the field, key concepts, and cutting-edge examples of interdisciplinary collaboration. The first reference text covering the interdisciplinary work of DOHaD, a broad list of contents maps the history of DOHaD, showcases examples of biosocial collaboration in action, offers a conceptual toolkit for interdisciplinary research, and maps future directions for the field. The definitive volume on biosocial collaborations in DOHaD, this will be indispensable for scholars working at the intersections of public health, lifecourse epidemiology and the social science of DOHaD. This title is also available as Open Access on Cambridge Core.
This Element addresses the following three questions: can Global English unequivocally be framed as a 'killer' language for learning LOTEs (languages other than English)? If so, under what premises? (Section 1); what are the rationales and justifications for learning LOTE in the age of Global English? (Section 2); and what are the pedagogical and policy implications for learning LOTE in the age of Global English? What can we learn from current (best and less good) practice? (Section 3). Attempts to engage learners in learning a variety of languages – rather than just English – often fail to achieve desired results, both in Anglophone and non-Anglophone contexts. Can English be blamed? What can policymakers and educators do to address the crisis? This Element proposes a new matrix of rationales for language learning, advocating an interconnected, socially embedded justification for language learning. This title is also available as Open Access on Cambridge Core.
Concept formation is predominantly analyzed in classrooms and laboratory experiments, meaning the collective formation of culturally novel concepts in practical activities 'in the wild' has largely been neglected. However, understanding and influencing the complexity and contradictions of the present world demands powerful concepts that can make a difference in practice. Going beyond the understanding of concepts as individually acquired static labels, this book develops a dialectical theory of collective formation of novel concepts in the wild, in everyday activities. Drawing on cultural-historical activity theory (CHAT), concepts are seen as contested and future-oriented means for guiding activities and their transformations. Detailed real-life examples of germ-cell concepts show how they can radically influence the course of development in different activities. Helping to identify and foster the formation of potentially powerful concepts in fields of practice, it is essential reading for researchers, advanced students and practitioners across human and social sciences. This title is also available as open access on Cambridge Core.