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In many countries, women participate in politics at lower rates than men. This gap is often most pronounced among young adults. Civic education programs that provide non-partisan political information are commonly used to try to close this gender gap. However, information alone rarely reduces the gap and sometimes exacerbates it. We extend the literature emphasizing the psychological resources women need to participate by evaluating whether embedding efficacy-promoting messages within civic education reduces gender disparities in participation. In collaboration with Zambian civic organizations, we implemented a field experiment before national elections that randomly assigned urban young adults to an information-only course or the same course with efficacy-promoting messages. We find that the efficacy-promoting course substantially increased young women’s political interest and participation, narrowing gender gaps across a wide range of behavioral and attitudinal outcomes. We discuss the study’s implications for theories of political participation and the design of civic education.
The leptomedusa Dichotomia cannoides is reported for the first time from the Red Sea, extending its known distribution beyond the western Atlantic and western Pacific Ocean. Five specimens were documented in the northern Gulf of Aqaba, and one was collected for molecular analysis. In situ photography was used to extract diagnostic characters and natural habitus. DNA barcoding of the mitochondrial COI gene showed 98.03% identity with D. cannoides from Florida. Phylogenetic analysis confirmed its placement within D. cannoides, distinct from related leptothecate taxa. This finding increases the number of Leptothecata species recorded in the region to 15. The delayed detection of D. cannoides in the Red Sea may be due to its small size, limited seasonality or a recent introduction via ballast water or hull fouling. The species remains known only from its medusa stage. We further discuss how environmental DNA may help uncover its life cycle and those of other hydrozoans.
This study examines the future temporal reference (FTR) system among Francophones and Anglophones speaking English in Kapuskasing, Ontario. Previous studies have shown that in Laurentian French, the go future is the preferred variant, and the strongest determinant of variant choice is polarity: negatives strongly favor the inflected future. In Canadian English, the go future has no polarity effect and there is robust variation with will, highlighting a key contrast in the underlying constraints between the French and English FTR systems. The results show that while older Anglophones pattern in tandem with known studies of English, Francophones, as well as young Anglophones, exhibit the polarity contrast of the French system, even though they are speaking English. We suggest that these results may stem from social alignment between Francophones and Anglophones driven by increasing linguistic and social symmetry in the community, as well as increasing positive affect toward French in Kapuskasing.
Radiotherapy (RT) is a highly effective breast cancer treatment. However, RT can deliver radiation dose to the healthy tissues of the shoulder, increasing the potential for long-term shoulder morbidity. This study compared the dose delivered to key shoulder muscles between common RT techniques and patient positioning.
Methods:
The treatment plans of 54 patients were analysed, including those treated in the prone and supine positions. Eight shoulder muscles were contoured on each patient’s computer tomography scan. The following breast treatment techniques were analysed: hybrid-intensity-modulated RT (hybrid IMRT), wedged field, two partial arcs volumetric-modulated arc therapy (VMAT), hybrid VMAT, and 3-field supraclavicular technique. Moreover, the effect of patient positioning was also evaluated (supine versus prone). Muscle radiation exposure was compared for the mean dose and the percent muscle volume exposed to V15 Gy and V30 Gy.
Results:
The mean dose and exposed volume for the pectoralis major and pectoralis minor were similar between hybrid IMRT, wedged field, VMAT, and hybrid VMAT. VMAT and hybrid VMAT delivered a greater mean dose to most posterior shoulder muscles compared to hybrid IMRT, though overall exposure remained generally low for these muscles. The 3-field supraclavicular technique increased radiation exposure to all shoulder muscles, particularly to the pectoralis major, the pectoralis minor and the supraspinatus. Prone positioning significantly reduced V15 Gy and V30 Gy exposure for both anterior and posterior shoulder muscles.
Conclusion:
Shoulder muscle exposure was similar between hybrid IMRT, wedged field, VMAT and hybrid VMAT. The anterior shoulder muscles were consistently exposed to radiation with all RT techniques investigated in this study. In comparison, the 3-field supraclavicular technique substantially increased the radiation exposure to the posterior shoulder muscles. Lastly, delivering radiation in the prone position spared the anterior and posterior shoulder muscles. These findings inform treatment planning decisions aimed at mitigating the risk of long-term shoulder dysfunction.
The current study examined perceptions of and experiences with Flint Families Cook, a virtual cooking and nutrition programme for youth and families.
Design:
Families were invited to participate in virtual focus groups after completing the 5-week Flint Families Cook programme. The research study was guided by Social Cognitive Theory. Researchers used thematic analysis to examine the transcribed focus groups, identify patterns across transcripts and develop emerging themes.
Setting:
Families living in Flint and surrounding Genesee County, Michigan, USA, engaged in virtual focus groups via Zoom.
Participants:
Youth (n 32; 59 % female, 53 % African American) and adult caregivers (n 31; 90 % female, 39 % African American) participated in focus groups between October 2020 and February 2022.
Results:
Five themes were generated from the focus group discussions: (i) general cooking challenges; (ii) class format; (iii) family support; (iv) provision of food; and (v) instruction and learning.
Conclusions:
In addition to perceived positive impacts on cooking skills and nutrition education, many participants shared that Flint Families Cook encouraged family cohesion and support. Most caregivers felt the programme, which included instruction by a chef and dietitian as well as ingredient box delivery, had important impacts on the emotional health of youth and family resilience. Flint Families Cook, and similar virtual scalable programmes, could broadly reach children and families to support physical and psychosocial health, especially in low-resource communities where such interventions may be most beneficial.
Using a comparative reading of Antigone and Iphigenia, the paper illuminates how differing modes of finality within a political moment can be construed along gender lines. For feminine characters whose political life never experiences a birth while ensconced in the Athenian apparatus of male political oppression, understanding how Antigone and Iphigenia both become politically born by entering a mode of finality aids in pinpointing one of the very few agentic methods available to women in ancient Athens. Through a careful understanding of Greek tragedy, the place of women in Ancient Athens, and a discussion of views of gender during the time, the paper offers a multi-disciplinary view, understanding the text for what it is within a contemporary reading of gender. What does Antigone’s suicide imply about gendered power inside a political situation and what does Iphigenia’s sacrifice take away? Antigone’s suicide effectively makes her a masculine actor in the eyes of an Ancient Athenian spectator while Iphigenia’s sacrifice is uniquely feminine. This paper also represents preliminary work into the importance and significance of persons who are politically cornered but have open to them an intentional mode of finality.
Biomphalaria straminea (Gastropoda: Planorbidae) and Physa acuta (Gastropoda: Physidae), both invasive species in southern China, are important vectors for zoonotic diseases. However, the lack of information on the infection dynamics of Angiostrongylus cantonensis in these snails leaves gaps in understanding the compatibility mechanisms between the snails and the parasite. This study aims to reveal differences in A. cantonensis infection between B. straminea and P. acuta from Guangdong, southern China, and to investigate the potential interaction mechanisms between A. cantonensis and P. acuta. We found that both phenotypic color variants of B. straminea snails were highly susceptible to A. cantonensis (100%). The load of the L3 larvae ranged from 243 to 765 per snail, and it was positively correlated with the infection dosage. Based on the comparison of third-stage larvae quantities, B. straminea is more suitable than P. acuta for establishing the life cycle of A. cantonensis in the laboratory. In contrast, geographic isolates of P. acuta exhibited variable susceptibility (13–91%) and markedly lower parasite loads, with 6–32 third-stage larvae per snail. Diverse strains of P. acuta exhibit distinct immune responses to A. cantonensis, characterized by varied expression patterns of immune-related genes such as TEP1, HSP70, FREP2, Cu-Zn_SOD1, Fe-Mn_SOD2, MIF and Galectin. Our findings establish B. straminea as both a high-risk vector and a laboratory model for studying the life cycle of A. cantonensis, while highlighting P. acuta as a model for investigating parasite-snail interactions, thereby enhancing our understanding of snail-parasite dynamics in southern China.
End-of-life dreams and visions (ELDVs) and delirium frequently occur near death but differ in core features. Clinical differentiation becomes challenging when they co-occur. This case report illustrates the interplay between ELDVs and delirium, examines the limits of current diagnostic criteria in mixed cases, and outlines a nuanced approach to distinction.
Methods
We report the case of an elderly Brazilian woman with metastatic cancer who exhibited both ELDVs and delirium. Mental status was serially assessed using the Confusion Assessment Method (CAM). ELDV accounts were prospectively triangulated across patient, family, and clinician reports to enhance reliability and contextual understanding.
Results
The patient’s experiences showed ELDV hallmarks – vivid, realistic encounters with deceased relatives, biographical relevance, and preparatory themes – yet many were affectively distressing and occurred alongside fluctuating attention and consciousness consistent with delirium. CAM effectively identified delirium but could not, on its own, distinguish ELDVs within delirious states. When co-occurring, ELDVs often emerged during “windows of lucidity” marked by preserved autobiographical context, intact recall with subsequent coherent narration, and insight, despite intense emotional valence. Distress alone was not discriminatory, probably being shaped by psychosocial and cultural factors. These observations indicate the need to supplement CAM with qualitative and phenomenological criteria, including content, vividness, biographical meaning, insight, cultural fit, and acuity/recall.
Significance
To our knowledge, this is the first case to map evolving end-of-life mental status using serial CAM while prospectively documenting ELDVs via triangulated reports. The findings highlight the complexity of differentiating co-occurring ELDVs and delirium and challenge the sufficiency of CAM alone. An integrated approach – combining CAM screening with structured ELDV assessment – may prevent misclassification and support holistic, dignified palliative care. As a single case in an underexplored domain, these insights require confirmation in larger, prospective studies to assess generalizability.
The story of the Panama Canal is often framed as a morality tale juxtaposing French tragedy and American triumph (or imperialism). What gets lost in this depiction is a pair of adventurous entrepreneurs, Anthoine de Gogorza and Louis Lacharme, whose efforts led Ferdinand de Lesseps to his doomed canal project. This article shows how the roots of the Panama Canal emerged from the forests of Colombia’s Sinú River Valley, whose settlement, in turn, was fostered by the search for canal routes in the Darien. Yet despite the spatial proximity of these two regions, their overlooked connections were woven together through the ‘lifepaths’ of de Gogorza and Lacharme as they moved from France to Colombia and around the globalizing Atlantic of the nineteenth century. Following their movements, in turn, sheds light on the overlooked figure of the foreign speculator, the business of exploration, and marketing the tropics.
We introduce a relaxation of stability, called almost sure stability, which is insensitive to perturbations by subsets of Loeb measure $0$ in a non-standard finite group. We show that almost sure stability satisfies a stationarity principle in the sense of geometric stability theory for measure-independent elements. We apply this principle to deduce the existence of squares in dense almost surely stable subsets of Cartesian products of non-standard finite groups, possibly non-abelian. Our results imply qualitative asymptotic versions for Cartesian products of finite groups. In the final section, we establish the existence of $3\times 2$-grids (and thus of L-shapes) in dense almost surely stable two-dimensional subsets of finite abelian groups of odd order.
We estimated the vaccine effectiveness (VE) of second monovalent and bivalent booster vaccines containing Omicron BA.1 or BA.4/BA.5 and the protection conferred by natural immunity against SARS-CoV-2 infection in Luxembourg. We conducted a test-negative case–control study among residents aged 60 years or older by integrating national socio-demographic, COVID-19 vaccination, and testing data, achieving full population coverage. Using conditional logistic regression, we estimated absolute and relative VE of monovalent and bivalent boosters and natural immunity from prior infection. Our analysis included 5,390 test-positive cases and 11,048 test-negative controls matched by week of testing between September 2022 and April 2023. Absolute VE for monovalent and bivalent boosters decreased from 64.8% and 66.6% in the first month to 1.5% and 16.5% after 5–6 months, respectively. The bivalent was superior to the monovalent booster only in individuals without natural immunity (relative VE 25.7%, 95% confidence interval 11.4%; 37.7%). Natural immunity lasted longer than vaccine-induced immunity with 80.7% protected at 4–8 months and 44.9% at 15–25 months post-infection. Both second booster vaccines provided temporary protection against SARS-CoV-2 infection; bivalent boosters offered a slight benefit over monovalent boosters. Natural immunity appears to confer longer-lasting protection.
The hydrodynamics of wetting involves a singularity of viscous stress, and its microscopic regularisation ultimately determines the speed at which contact lines move over a surface. In a recent paper, Luo & Gao (J. Fluid Mech., vol. 1019, 2025, A52) explore a new analytical solution, based on which they construct a model for ‘slippery wedge flow’. This lucid approach provides an accurate description of viscous wetting flows in the presence of slip, without the usual restriction to small contact angles, and offers a quantitative multiscale formalism for slippery contact lines.
The global diffusion of sewing machines required concerted efforts from manufacturers, sales agents, and, most significantly, local consumers, who rendered the machine legible and desirable across diverse social settings. As this article shows, however, in politically volatile contexts, it was manufacturers who most decisively shaped these processes. Focusing on the Singer Company—the largest and most influential of its kind—the article examines how this process unfolded in the Ottoman empire during the Armenian massacres of the 1890s. Occurring when ethnic and religious homogeneity was becoming central to the political order, the Ottoman case offers an especially important early example of global firms’ responses to the emerging pressures of exclusionary—and often violent—political and economic reordering. The article traces how Singer tested adaptive strategies that not only sustained its regional presence but also recalibrated its business model. In doing so, it contributes to global history by demonstrating how seemingly localized episodes of political violence became formative sites of adaptation, attuning global corporations to a world increasingly structured by systemic violence, warfare, and demographic homogenization.
This study has investigated the relationship between the gut microbiota composition and the growth performance in pigs from birth to the finishing stage, focusing on nutrient metabolism. Of fifty-nine crossbred pigs [(Landrace × Large Yorkshire) × Duroc] from seven sows, individuals with high and low daily gain (DG) were assigned to high DG (HDG, n 11) and low DG (LDG, n 8) groups. Faecal samples collected at weaning (21 d), growing (95–106 d) and finishing (136–152 d) stages were analysed for amino acids, SCFA and microbial composition using 16S rRNA sequencing. Although birth and weaning weights were similar in both groups, the HDG group had significantly higher weights in the growing and finishing stages (P < 0·01). The microbial composition of the LDG group revealed a higher abundance of f_Lachnospiraceae;__ at weaning (P < 0·05), whereas the HDG group contained a higher abundance of g_Streptococcus and g_Prevotella 7 at the finishing stage (P < 0·05). Functional analysis revealed increased amino acid metabolism in the HDG group at the finishing stage (P < 0·05). During the growing stage, total free faecal amino acid content was low in the HDG group (P < 0·05); at weaning, levels of isobutyric and isovaleric acids, key amino acid fermentation products (P < 0·05, P < 0·01), were higher. These findings indicate growth stage-specific differences in the gut microbiota and metabolic profiles between groups with different growth performance, suggesting that microbial and metabolic characteristics may influence growth performance.
This systematic review and meta-analysis was a study that enquired into the prevalence and epidemiology of depression in university students in Pakistan, between 2000 and 2025. Depression is a significant global mental illness with high prevalence in young adulthood. University students are the most susceptible to this risk because of the factors related to it, i.e., academic stress, financial hardships, social pressure, and cultural stigma of mental illness. Although the concerns have been on the increase, the prevalence rates of depression have been widely varied among Pakistani students, with some studies reporting as low as 2.5% to as high as 85%, primarily because of the sampling techniques, assessment instruments, and geographical settings. The present review is based on the findings of 35 studies involving over 11,000 students and suggests that the prevalence rate is approximately 51% in a pooled form, meaning that about 50% of university students in Pakistan are subjected to depressive symptoms. The high level of heterogeneity of the selected studies highlights the acute necessity of the formulation of a standard-based diagnostic criteria and culturally competent mental health assessment instruments. Moreover, systemic challenges, such as the shortage of trained mental health professionals and the general unawareness of the disorder, are continuing to affect the diagnosis and treatment of the disorder at an early stage. According to the results, the necessity of a multi-faceted approach toward mental health, including the establishment of counseling facilities in universities, the development of stress management training, and the federal stigma-reduction campaign, is pressing. The most significant elements of enhancing the well-being of students and the mental health landscape of Pakistan as a whole are early intervention and empowering mental health infrastructure.
Overweight and obesity have become a global public health concern, with prevalence rising sharply in low- and middle-income countries. This study analysed temporal trends in overweight and obesity among schoolchildren in the largest capital city of Brazil, from 2006 to 2024.
Design:
Repeated cross-sectional.
Setting:
Schoolchildren aged 6 to 19 years from Porto Velho, Rondônia, Brazil.
Participants:
A total of 12 646 participants were evaluated. To assess the BMI z-score, standardised body mass and height measurements were used, stratified by sex (male and female) and age group (6–10 and 11–19 years). Temporal trends were assessed using joinpoint regression analysis.
Results:
Overall, 17·8 % of participants were classified with overweight, and 8·6 % were classified with obesity. The study also found that obesity prevalence was consistently higher among younger age groups compared to adolescents. The results revealed a significant increase in obesity prevalence among girls (annual percentage change (APC) = 5·81 %; 95 % CI = 1·03–10·81; P-value = 0·021) and children aged 6 to 10 years (APC = 5·20 %; 95 % CI = 1·17–9·39; P-value = 0·017), while no significant trends were observed for overweight or for male adolescents or adolescents aged 11 to 19 years.
Conclusions:
Our findings indicate rising obesity among girls and children aged 6–10 years and support the need for urgency. We recommend targeted action, including implementing mandatory quality physical education and school nutrition standards, enforcing restrictions on marketing to children and prioritising municipal policies that increase access to healthy foods.
Hippoboscoidea flies exhibit highly specific ectoparasitic relationships with bats, shaped by both intrinsic factors (e.g. bat behaviour) and extrinsic factors (e.g. land use). Understanding the dynamics of these parasite–host interactions is essential for uncovering co-evolutionary patterns and informing conservation strategies. To this end, we studied bat–fly interactions across different elevations in a montane forest of Amazonas, northern Peru. The most abundant bats were Carollia brevicauda, C. perspicillata and Sturnira oporaphilum, while Paraeuctenodes similis and Trichobius joblingi were the most common flies. Most flies exhibited monoxenous host specificity. Bat–fly interaction networks revealed high modularity and specialization at both local and regional scales. Modules typically grouped bat species of the same genus or subfamily, suggesting that phylogenetic constraints and roosting behaviour may shape those interaction patterns. Nestedness within modules (compound structure) emerged in the aggregated regional network, aligning with the integrative hypothesis of specialization. Although network structures were broadly similar across sites, species turnover contributed to subtle differences in module composition and specialization. These differences were congruent with the changes in species roles of certain bats and flies. This study represents the first of its kind in Peru and addresses significant knowledge gaps in the ecology of bat–fly interactions in the Neotropics.
A better understanding of calcitonin gene-related peptide (CGRP) inhibitor use is in migraine treatment needed.
Methods:
A retrospective, observational, population-based cohort study was conducted using administrative data. Adults (≥18 years) who received ≥1 prophylactic CGRP inhibitor in Canada (six provinces) between 2018 (first approved) and 2023 were identified. CGRP inhibitor use was described; migraine-related acute medication and healthcare use were compared pre–post CGRP inhibitor initiation (independent and paired t-tests).
Results:
12,851 adults were identified. CGRP inhibitor use increased from 11.8 (incident/prevalent) to 22.4 (incident) and 57.3 (prevalent) per 100,000 adults. Erenumab use decreased over time, as use of newer agents increased. During the 1-year period after CGRP inhibitor initiation, 57.4% had concomitant use with a different prophylactic migraine medication class (onabotulinumtoxinA injection: 23.2%; oral non-CGRP inhibitor: 34.2%), and 30.4% stopped use (21.3% switched to a different prophylactic migraine medication class; 9.1% discontinued all prophylactic migraine medication). During the 1-year period after CGRP inhibitor initiation (versus before), days of supply for migraine-related acute medication was lower (mean [standard deviation]: 129 [191] versus 145 [197] days; mean difference [95% confidence interval]: −16: [−22, −11] days), as were the number of healthcare visits (7.36 [8.70] versus 9.18 [10.10]; −1.82 [−2.06, −1.58]).
Conclusion:
CGRP inhibitor use increased from 2018 to 2023. After CGRP inhibitor initiation, most patients had concomitant use with a different prophylactic migraine medication class, and some stopped use; migraine-related acute medication and healthcare use were lower (versus before). Findings provide a real-world description of the evolving landscape of CGRP inhibitor use in Canada.
Continuous morphological traits play a crucial role in phylogenetic inference, yet they are often discretized due to limited software support and challenges of handling missing data efficiently. We present a new implementation of the Brownian motion model for continuous trait evolution in the Bayesian phylogenetics software MrBayes. Our approach efficiently accommodates any proportion of missing data and supports evolutionary rate variation across characters and data partitions. It is compatible with both non-clock and relaxed clock models. We validate the implementation through simulations and apply it to empirical datasets of pterosaurs and ancient humans, demonstrating that continuous traits can improve phylogenetic resolution. This development expands the methodological tool kit for morphological and total-evidence phylogenetics and is applicable across diverse taxonomic groups.
Beliefs in evil spirits and the practice of deliverance from supernatural forces have been widespread throughout history. Many psychological and physical afflictions have been attributed to involuntary demonic possession. Traditional remedies, for those reporting inhabitation by evil spirits, can involve exorcism believed to expel such forces. Similar beliefs may be symptomatic of major mental illness and treatments namely medication and psychotherapy, are frequently recommended. An increasingly secular western world is also seeing growth in non-denominational Christian churches and other faiths, who accept spirit possession and exorcism. Culturally competent mental health professionals, seeking to understand their patients’ world view, may struggle with exorcism, seeing it as an interference to conventional treatment. They may be being unwilling thus to attempt differentiation between possession and mental illness. This paper explores the diversity of views on this topic and points of contention and overlap. The risks and cautions necessary in approaching this issue are stressed.