We prove that the mapping class group is not an h-cobordism invariant of high-dimensional manifolds by exhibiting h-cobordant manifolds whose mapping class groups have different cardinalities. In order to do so, we introduce a moduli space of ‘h-block’ bundles and understand its difference with the moduli space of ordinary block bundles.

Physical inactivity is a leading cause globally of noncommunicable diseases such as diabetes, heart attacks, and strokes. Here, we present the results from a 4-week-long experimental test of a nudge designed to promote physical activity among 206 seniors in Abu Dhabi, United Arab Emirates—a population with one of the highest rates of physical inactivity in the world. We find that the “Forever Fit” nudge—a booklet containing a simple exercise program and information about the health benefits of physical activity—has a large positive effect on 93 previously inactive seniors. The nudge increases the time previously inactive participants spend being physically active from about 5 to about 15 minutes per day.

On October 21, 2022, the Spanish Competition Agency (CNMC) sanctioned the North American pharmaceutical company Merck Sharp & Dohme for abuse of a dominant position. The practice for which it was finally sanctioned consisted of the adoption of a strategy aimed at delaying and making it difficult for another company to enter the Spanish medicines market in order to protect sales for a product marketed exclusively by that company and for which had a patent. This paper analyzes this resolution in an attempt to delimit the difference between the legitimate exercise of the right to effective judicial protection and its abuse.

People with HIV (PWH) often encounter health-harming legal needs that impede their access to care, including structural issues such as racism, discrimination, unstable housing, and stigma. Medical-Legal Partnerships (MLPs) have emerged as a promising strategy to address these challenges within HIV care settings. This study aimed to identify the characteristics and strategies of MLPs that are most effective in improving HIV care continuum outcomes. A mixed-methods analysis was conducted utilizing data from a cross-sectional survey of 60 providers in MLPs. Categorical features of MLPs, such as the personnel responsible for screening for health-harming legal needs (HHLN), the organizational structure (community-based vs. institutional), and the delivery of legal services, were examined. A multiple, variable linear regression analysis was conducted to explore the association between these variables and outcomes. Community health organizations were found to be associated with a greater number of patients achieving suppressed HIV viral load. Additionally, a higher number of on-site services were positively correlated with a greater percentage of PWH achieving decreased viral load and completing follow-up appointments. Findings underscore the significance of comprehensive care approaches within MLPs for enhancing positive patient outcomes in HIV care settings.

Measurements of the ionisation state of the intergalactic medium (IGM) can probe the sources of the extragalactic ionising background. We provide new measurements of the ionising emissivity of galaxies using measurements of the ionising background and ionising photon mean free path from high-redshift quasar spectra at $2.5 \lt z \lt 6$. Unlike most prior works, we account for radiative-transfer effects and possible neutral islands from the tail of reionisation at $z \gt 5$. We combine our results with measurements of the UV luminosity function to constrain the average escaping ionising efficiency of galaxies, $\langle f_{\textrm{esc}} \xi_{\textrm{ion}}\rangle_{L_{\textrm{UV}}}$. Assuming galaxies with $M_{\textrm{UV}} \lt -11$ emit ionising photons, we find $\log (\langle f_{\textrm{esc}} \xi_{\textrm{ion}}\rangle_{L_{\textrm{UV}}}/{\textrm {erg}^{-1}Hz}) = 24.47_{-0.17}^{+0.09}$ and $24.75_{-0.28}^{+0.15}$ at $z=5$ and 6, and $1\sigma$ upper limits of $24.48$ and $24.31$ at $z = 2.5$ and 4, respectively. We also estimate the population-averaged $f_{\textrm{esc}}$ using measurements of intrinsic ionising efficiency from JWST. We find $\langle f_{\textrm{esc}} \rangle = 0.126_{-0.041}^{+0.034}$ and $0.224_{-0.108}^{+0.098}$ at $z=5$ and 6, and $1\sigma$ upper limits of $f_{\textrm{esc}}\lt 0.138$ and $0.096$ at $z=2.5$ and 4, respectively, for $M_{\textrm{UV}} \lt -11$. Our findings are consistent with prior measurements of $f_{\textrm{esc}} \lesssim 10\%$ at $z \leq 4$, but indicate a factor of several increase between $z = 4$ and 6. The steepness of this evolution is sensitive to the highly uncertain mean free path and ionising background intensity at $z\gt5$. Lastly, we find $1.10^{+0.21}_{-0.39}$ photons per H atom are emitted into the IGM between $z=6$ and $=5.3$. This is $\approx 4\times$ more than needed to complete the last 20% of reionisation absent recombinations, suggesting that reionisation’s end was likely absorption-dominated.

How did the COVID-19 outbreak affect citizens’ democratic preferences? Were the changes persistent or temporary? We track a representative sample of Spanish citizens before, during, and after the pandemic, with eight survey waves from January 2020 to January 2024. We compare democratic attitudes before and after the pandemic with individual fixed effects models. We identify a sharp increase in preferences for technical rather than ideological policy-making at the very onset of the pandemic, as well as significant changes in voters’ preferences for competent rather than honest politicians. These changes are sudden and persistent over 4 years. Using a set of repeated survey experiments, we also document a widespread willingness to sacrifice rights and freedoms to deal with the pandemic as compared to other global threats, such as international terrorism and climate change. But this effect quickly faded over time. Overall, we identify significant changes in democratic attitudes during the pandemic and a durable shift in technocratic preferences that outlived the pandemic, setting the conditions for the long-term legacies of COVID-19 on democracy.

Distinguishing between Stomylotrema bijugum and S. vicarium is challenging due to their phenotypic plasticity. In this study, adult specimens were recovered from 9 host species in the Mexican tropical lowlands. To explore the morphological differences, 32 morphological characteristics were evaluated in 54 specimens. Linear discriminant analysis provided enough evidence to differentiate the 2 species. Additionally, a principal component analysis (PCA) was performed for each species. The PCA of S. bijugum revealed 3 groups separately corresponding to specimens from the 3 hosts, suggesting host-induced phenotypic plasticity, whereas the PCA of S. vicarium revealed that the specimens from 3 host species were clustered together, indicating morphometric homogeneity. To confirm the morphological differences between the 2 species of Stomylotrema, we sequenced 2 molecular markers: the D1–D3 domains of the large subunit (LSU) from nuclear DNA and nicotinamide adenine dinucleotide dehydrogenase subunit 1 (Nad1) from mitochondrial DNA. Sequences of the LSU were aligned and compared with the LSU sequences of other congeneric species available in GenBank. Phylogenetic analyses supported the monophyly of Stomylotrema, with 2 main subclades that corresponded to S. bijugum and S. vicarium. A haplotype network was predicted with 25 Nad1 sequences, revealing the presence of 2 clusters representing the 2 species separated from each other by 98 substitutions. The current studies on S. bijugum and S. vicarium revealed new hosts and geographical regions in the Americas, suggesting that both species addressed in the current study can complete their life cycle in the Neotropical region of Mexico.

Research on the political consequences of terrorism often finds a rally around the flag effect: terrorist attacks, as other types of threats, tend to produce spikes in popularity and support for the incumbent, as citizens turn to those in power seeking protection. Most research, however, is based on single case studies that analyze very salient attacks from international terrorist organizations. Even if these studies are well identified, the question of generalizability remains, as the studied attacks are often very idiosyncratic. In this paper, we explore the rally around the flag effect in an arguably difficult context: a sustained terrorist campaign held by domestic terrorist groups in a parliamentary democracy (Spain). To overcome the limitations of the single-attack studies, we use a multiple unexpected event approach: we developed a systematic process of matching the occurrence of terror attacks during the fieldwork of official public opinion surveys in Spain, through which we identified 142 valid attack-survey pairs. We find that in the attacked region support for the incumbent increases, on average, around 4 percentage points right after an attack, while support for the opposition decreases in a similar amount. These effects seem to occur mostly for the conservative incumbent and are especially relevant for the attacks that target civilians. We use a survey experiment to provide additional evidence in support for our interpretation of the findings.