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Since the beginning of mass vaccination campaign for COVID-19 in Italy (December 2020) and following the rapidly increasing vaccine administration, sex differences have been emphasized. Nevertheless, incomplete and frequently incoherent sex-disaggregated data for COVID-19 vaccinations are currently available, and vaccines clinical studies generally do not include sex-specific analyses for safety and efficacy. We looked at sex variations in the COVID-19 vaccine’s effectiveness against infection and severe disease outcomes. We conducted a nationwide retrospective cohort study on Italian population, linking information on COVID-19 vaccine administrations obtained through the Italian National Vaccination Registry, with the COVID-19 integrated surveillance system, held by the Istituto Superiore di Sanità. The results showed that, in all age groups, vaccine effectiveness (VE) was higher in the time-interval ≤120 days post-vaccination. In terms of the sex difference in vaccination effectiveness, men and women were protected against serious illness by vaccination in a comparable way, while men were protected against infection to a somewhat greater extent than women. To fully understand the mechanisms underlying the sex difference in vaccine response and its consequences for vaccine effectiveness and development, further research is required. The sex-related analysis of vaccine response may contribute to adjust vaccination strategies, improving overall public health programmes.
Weeds are a fundamental component of agroecosystems and, if not appropriately managed, can cause severe crop yield losses. New perspectives on weed management are required, because current approaches, such as herbicide application or soil tillage, have significant environmental and agronomic drawbacks. We propose the concept of “neutral weed communities,” which are weed communities that coexist with crops and do not negatively affect crop yield and quality compared with weed-free conditions. Management practices that promote neutral weed communities can enable reduced use of herbicides and soil tillage while enhancing ecosystem services and biodiversity. We report scientific evidence of neutral weed communities and survey ecological explanations for why different weed communities have different effects on crop production. We also propose two weed management approaches for attaining neutral weed communities. The first approach aims to maximize weed biodiversity using traditional approaches such as cropping system diversification and integrated weed management. Higher weed biodiversity is associated with lower dominance of competitive weed species that reduce crop yield. The second approach relies on modern tools such as robots and biotechnology to manipulate the density of specific weed species. This approach can remove highly problematic species and minimize niche overlap between the weeds and crops. Given the complexity of interactions among crops, weeds, and other components of the agroecosystem, we highlight the need for multidisciplinary research to illuminate mechanisms that determine the neutrality of weed communities.
Various research has demonstrated that rapid racial demographic change may aid in triggering various forms of backlash under certain conditions. This has led scholars to speak of Whites “defending” their local environment in the face of eroding racial dominance. However, little research has addressed how perceptions of racism among minorities may be triggered under conditions of demographic change. This study attempts to fill this gap in the literature by examining the relationship between racial demographic change for Blacks, Hispanics, and Asians and perceptions of racial problems among these groups in the United States. Using standard OLS regressions, ordered logistic regressions, multinomial logistic regressions, and techniques accounting for selection into treatment, I find that Blacks and Hispanics living in counties undergoing rapid growth of Black and Hispanic populations, respectively, have higher perceptions of racial problems. Asians show no evidence of increased perceptions of racial problems in counties undergoing rapid Asian growth. For Blacks, this relationship is concentrated among those without at least a four-year degree and residents of counties with lower initial White populations (and higher initial Black populations). For Hispanics, it is similarly concentrated among those without at least a four-year degree, but also is likely stronger among residents of counties with higher initial White populations (and lower initial Hispanic populations), highlighting unique racial dynamics. This research adds to a growing body of work showing the importance of examining demographic change at the local level in order to understand some of today’s most pressing political and social issues.
Literature on childhood Functional Neurological Disorders (FNDs) is spare. Clinical presentations are vaguely characterized and often misdiagnosed in younger ages. Their main neurological features enrol: Psychogenic non-epileptic seizures (PNES), Functional movement disorders (FMDs), sensory alterations, cephalgia and feeding problems.
Objectives
The study was aimed to better characterize the childhood population of FND, because of they represent an emerging challenge for clinicians, giving its higher presentation in the younger age and the difficulties of an early and differential diagnosis as well as an effective management.
Methods
Our study retrospectively examined the characteristics of 82 FNDs children and adolescents (8 to 16 y.o.; 13 males; 29 females) referred as neurological inpatients of an urban academic neuropsychiatric department, from 2014 to 2019. Three main clinical aspects were analysed: type and pattern of symptoms manifestations (DSM-5 criteria); Life Events; family functioning.
Results
FND accounted for 2% of 5-years consultations of neurological inpatients (M: F=1:2). The clinical presentation was characterized in 70% by pattern of co-expressed neurological symptoms: FMDs (9.5%); PNES (12%); dizziness/lipothymia (12%); paraesthesia/anaesthesia (16%). Generalized pain was associated in 38% of the reported patterns while cephalgia in 44%. Sleep disorders were reported in 40%. Previous psychiatric diagnoses were uncommon (2 out 82). Antecedent stressors were identified in 97% of patients for personal illness history and in the 93% for chronic illness in the family anamnesis. Family problems were in 25% of cases.
Conclusions
Our data contributes to better characterize the childhood population of FND, describing clinical patterns of presentation, highlighting putative antecedent stressors and risk factors
Triple Network Model (TNM), which considers the dynamic interaction between Default Mode (DMN), Salience (SN), and Central Executive (CEN) networks, explains clinical features in mental disorders from a neurophysiological perspective. Some studies highlight the increased connectivity in TNM in adults with Borderline Personality Disorder (BPD), but little is known about adolescents.
Objectives
The aim of our preliminary study was to investigate TN functional connectivity (FC) in BPD adolescents with a history of traumatic experiences, and its correlation with dissociative symptoms.
Methods
15 BPD adolescents (DSM-5 criteria) with early traumatic experiences were compared to 15 healthy controls, matched for sex and age. Dissociation Questionnaire (DIS-Q) was administered. Eyes-closed resting-state (RS) EEG recordings were performed (19 electrodes; 10- 20 system) and analyzed using Exact Low-Resolution Electromagnetic Tomography software (eLORETA). FC was computed for all frequency bands and 9 Regions of Interest for TNM.
Results
BPD adolescents showed a hyper-connection between CEN and DMN [dorso-lateral prefrontal cortex (dlPFC) and posterior cingulate cortex (PCC); PCC and left posterior parietal cortex (PPC)] and within the CEN (left and right PPC). The strength of PCC-dlPFC and left-right PPC connections was correlated with dissociative symptoms severity.
Conclusions
FC alterations can already be identified in BPD adolescents, supporting the need for early diagnosis. Normally DMN and CEN show opposite functioning. In our BPD adolescents, the absence of this “anti-correlation” reflects the typical confusion between internal and external mental states, which clarify their difficulties in metacognition or mentalization. Moreover, in dissociative symptoms, two CEN nodes are also involved, not only DMN as previously described.
Morphological and genetic investigations have led to the identification of Spiophanes adriaticus sp. nov. (Polychaeta: Spionidae) from the North Adriatic Sea (Central Mediterranean). A total of 81 specimens were recorded along the sublittoral zone between 8 and 27.5 m of depth. This species differs from other congeners by having: two pairs of black eyes, a cirriform occipital antenna, dorsal ciliated organs as thin bands usually extending to chaetigers 11–12, dorsal ciliated crests from chaetiger 14–17, undulate glandular opening on chaetigers 5–7, unhooded hooks from the 15th chaetiger and Y shaped tubes. A detailed description and illustrations are provided for the new species. Through DNA barcoding results and comparison of DNA sequences of the new species with those of other congeners available in the GenBank database, the validity of the new finding was confirmed. Spiophanes adriaticus sp. nov. represents the eighth species of Spiophanes recorded for the Mediterranean Sea. A key for the identification of Mediterranean Spiophanes species is also provided.
The upside-down jellyfish Cassiopea is a benthic scyphozoan, considered a non-indigenous invasive species in the Mediterranean, forming large blooms in eutrophic areas. Taxonomy of the genus Cassiopea is extremely difficult because morphological/meristic characters used are variable within the same species, overlapping among different species, and cryptic species have been identified by molecular markers; nine Cassiopea species are recognized on the basis of molecular study. Mediterranean records of Cassiopea have been ascribed to andromeda species on the basis of a hypothesized invasion pathway from the Suez Canal. In the current study, an analysis of the main morphological characters of the sampled Cassiopea jellyfish from Palermo (Tyrrhenian Sea) was carried out and subsequently, molecular analyses were performed by using COI barcode in order to identify the species. Molecular data were compared with published information in GenBank. Morphological characters were highly variable, but molecular analyses confirmed that Mediterranean Cassiopea specimens belong to andromeda species. Moreover, high values of sequence divergence were found between Mediterranean Cassiopea and the other C. andromeda from the Red Sea, Hawaii and Florida. These results lead to a discussion of possible explanations linked to life history features of the species. Two different explanations are proposed; the first is that Mediterranean C. andromeda, finding a suitable ecological niche good for colonization and proliferation, could have been isolated in Palermo Harbour. The second considers the possibility of multiple introduction events by human transport as demonstrated for other non-indigenous jellyfish; in this case Cassiopea genetic differences increased in the invaded area.
Discussions of Virginia Woolf's contradictory nature are nothing new. In his 1972 biography of his aunt, Quentin Bell portrays Virginia as a fragile, apolitical figure “terrified of the world,” despite the fact that she wrote two major political works and participated in both the Labour Party and the Women's Co-operative Guild (126). In his 1967 autobiography, Leonard Woolf calls Virginia “the least political animal that has lived since Aristotle invented the definition.” But in the very next sentence he describes another, contradictory side of Virginia. She was, he writes, “intensely interested in things, people, and events, and, as her new books show, highly sensitive to the atmosphere which surrounded her, whether it was personal, social, or historical. She was therefore the last person who could ignore the political menaces under which we all lived” during the interwar period (27). As Leonard knew and as we have learned, Virginia Woolf was firmly planted in the real world, in both deed and word. It is her engagement with the everyday realities of the world around her—in her writing as well as in her life—that has lent her iconic status as a writer, a thinker, and an agent for change. In Virginia Woolf: Public and Private Negotiations (2000), Anna Snaith points out that Woolf's writing did not serve to lock her away “within some internal realm” but “is proof of her constant engagement with public debates” (3). This commitment, along with her complex sense of how historical and societal forces work together to influence individual behavior, heightened Woolf's awareness of the connections between the personal and the political and strengthened her own resolve to resist the norms. In “Moments of Being,” Woolf called these forces “invisible presences,” realizing their power over our thinking and our actions (80). These forces, which include groups, public opinion, and what other individuals say and think, attract us or repel us. They sometimes influence us to be what we are not and other times influence us to act in ways that do not reflect our genuine beliefs or values. Woolf, however, resisted such influences. In her work and in her life, she questioned society's expectations and refused to be compelled to act and write in accordance with its presumptions.
The chances of surviving an out-of-hospital cardiac arrest depend on early and high-quality cardiopulmonary resuscitation (CPR). Our aim is to verify whether the use of feedback devices during laypersons’ CPR training improves chest compression quality.
Methods
Laypersons totalling 450 participating in Basic Life Support and Automated External Defibrillation (BLS/AED) courses were randomly divided into three groups: group No Feedback (NF) attended a course without any feedback, group Short Feedback (SF) a course with 1-minute training with real-time visual feedback, and group Long Feedback (LF) a course with 10-minute training with real-time visual feedback. At the end of each course, we recorded 1 minute of compression-only CPR. The primary end point was the difference in the percentage of compressions performed with correct depth.
Results
There was a significant improvement in the percentage of compressions with correct depth in the groups receiving feedback compared to the other (NF v. LF, p=0.022; NF v. SF, p=0.005). This improvement was also present in the percentage of compressions with a complete chest recoil (71.7% in NF, 86.6% in SF, and 88.8% in LF; p<0.001), compressions with the correct hand position (93.2% in NF, 98.2% in SF, and 99.3% in LF; p<0.001), and in the Total CPR Score (79.4% in NF, 90.2% in SF, and 92.5% in LF; p<0.001). There were no significant differences for all of the parameters between group SF and group LF.
Conclusions
Real-time visual feedback improves laypersons’ CPR quality, and we suggest its use in every BLS/AED course for laypersons because it can help achieve the goals emphasized by the International Liaison Committee on Resuscitation recommendations.
We report two cases of Star-Planet Interaction (SPI) in two systems with hot Jupiters: HD 189733 and HD 17156. We used HST-COS to study the FUV variability of HD 189733 after the planetary eclipse. With the support of MHD simulations, we evince that material is likely evaporating from the planet and accreting onto the parent star. This produces a hot spot on the stellar surface, co-moving with the planetary motion and responsible of the X-ray and FUV variability at peculiar planetary phases. In HD 17156, which hosts a hot Jupiter in an eccentric orbit, we observed an enhancement of the X-ray activity at the passage of its planet at the periastron. The origin can be due to magnetic reconnection between the planetary and stellar magnetic fields, or due to material tidally stripped from the planet and accreting onto the star.
Words. Virginia Woolf used them. And she described them. She called them wild. She called them free. She spoke of them as irresponsible but sensitive, democratic but un-teachable, self-conscious but unwilling to be confined. Words, she said in her 1937 BBC radio broadcast, are changeable. They take on one meaning, then another. They convey truths that are many-sided. They mean one thing to you, another thing to me. Words, she knew, have power. They have the power to express our thoughts and our emotions and the power to provide meaning that transcends generations. Words also have the power to liberate our thinking from the routine and from the stale—whether we are writing of the world at home or the world abroad.
In this paper, I will discuss two words that have been applied to Woolf, two words used to stamp her with an indelible label. These two words are used to deny her charmingly contradictory nature and to disallow her the changeability she grants to words themselves. The first word is feminist. The second word is pacifist. Like others before me, I will make the case that Woolf was both. Like others before me, I will also make the case that Woolf rejected both. Woolf, like words, was unwilling to be confined to one meaning. Woolf, like words, was changeable. Woolf, like words, can't be caught and sorted into a certain kind of order.
To make the case for Woolf as feminist and pacifist, as well as her refusal to label herself as either, I will provide a brief overview of her work as it relates to her feminist war resistance at home and abroad. I will then look at specific diary entries and letters dating from 1916 through 1938 in which Woolf refers to her own feminism and pacifism. I will also review passages in A Room of One's Own (1929) and Three Guineas (1938) that mention those concepts in general terms. In conclusion, I will discuss her 1940 essay, “Thoughts on Peace in an Air Raid,” which I argue she wrote from a feminist pacifist perspective that persisted throughout her life, despite her changeability.
Virginia Woolf was a journalist, a novelist, and a publisher. If she were alive today, would she also be a blogger? In her day, Woolf used radio airwaves, the cutting edge medium of her day, to communicate with her readers. If she were writing today, I believe she would have embraced the World Wide Web, the medium that has revolutionized publishing and other forms of communication, to share her art. The fact that Woolf's online popularity has grown, rather than decreased, since the early 1990s, a time when material of all kinds began flooding the Web, supports that premise. Her message, her style, and her popular persona all combine to make her a growing online commodity. As a result, the quantity of websites presenting Woolf-related facts and commentary continues to multiply at a rapid pace. Consider the numbers. In “Who's Afraid that Feminism Is Finished? Virginia Woolf and Contemporary Commodification,” Jane Wood reported that on 9 January 2007, she conducted a Google search on Woolf's name and came up with 2.4 million hits (22). When I conducted the same search two and a half years later, on 27 June 2009, the number had increased to 2.7 million, a ten percent jump. On 10 May 2012, I did another Google search that produced nearly double that number, at 4.08 million hits. Today, a year later, the number of hits on Woolf's name has more than doubled again—to 8.24 million. It is clear that Woolf is a World Wide Web phenomenon whose popularity continues to climb at a dizzying pace.
Blogging is part of that online picture. And I maintain that Woolf would approve of publishing online via a blog for several reasons, including the fact that blogging is the modern day version of the Hogarth Press. When Virginia and Leonard Woolf created the Hogarth Press in 1917, they were able to control their own means of publication. Blogging allows us to do the same thing today. It provides the opportunity to do what Woolf advocates in Three Guineas (1938)—seize the methods of production in order to share our own truths about politics and history, art and culture, and society at large.
The growth kinetics of Cu2ZnSnS4 thin films and powders was studied using in-situ synchrotron data. Isothermal and isochronal measurements were performed at the MCX beamline of the Elettra synchrotron (Trieste, Italy). Diffraction line profile analysis was used to follow the changes in the domain size distribution during isothermal measurements, and the change in the mean volume of the domains was studied using the Johnson-Mehl-Avrami equation. The growth was found to be diffusion controlled from small dimensions while the nucleation rate is temperature dependent. An activation energy of 210 kJ/mol could be estimated. In case of the isochronal data, the evolution of inverse of the integral breadth of the diffraction peaks in dependence on temperature was studied using the Ozawa and Šatava equations. The activation energy determined for the growth process is between 112(2) and 145(5) kJ/mol.
One new dorvilleid species belonging to the genus Ophryotrocha Claparède & Mecznikow, 1869 is described. The studied material was collected in circalittoral seabeds (70–100 m depth) in the Cantabrian Sea (north-east Atlantic Ocean). The new species Ophryotrocha cantabrica is characterized by having well-developed antennae and palps, parapodia with long dorsal cirrus, sub-triangular acicular lobes and inferior chaetal lobe well-developed, as well as the presence of P-type maxillae and bifid mandibles slightly tagged. The most closely related Ophryotrocha species are O. longidentata Josefson, 1975 and O. lobifera Oug, 1978; however, both species have biarticulated palps. Other differences with O. cantabrica sp. nov. are: body size and shape, parapodia morphology and number of setae, as well as the shape of mandibles and maxillae.
We present results of the X-ray monitoring of V4046 Sgr, a close classical T Tauri star binary, with both components accreting material. The 360 ks long XMM observation allowed us to measure the plasma densities at different temperatures, and to check whether and how the density varies with time. We find that plasma at temperatures of 1–4 MK has high densities, and we observe correlated and simultaneous density variations of plasma, probed by O VII and Ne IX triplets. These results strongly indicate that all the inspected He-like triplets are produced by high-density plasma heated in accretion shocks, and located at the base of accretion flows.
We present a preliminary 3D potential field extrapolation model of the joint magnetosphere of the close accreting PMS binary V4046 Sgr. The model is derived from magnetic maps obtained as part of a coordinated optical and X-ray observing program.
A new preparation procedure to obtain tetragonal pure zirconia powders is reported together with a detailed analysis of the profile of X-ray Diffraction (XRD) peaks. The crystallization kinetic up to 800°C is described through r.m.s. microstrain and crystallite size distributions. The results of two methods of profile analysis are compared. After thermal treatments up to 100°C the samples of amorphous gel prepared crystallize in the tetragonal structure. The monoclinic phase occurs only above this temperature. Moreover the tetragonal to monoclinic transformation has a strong effect in changing the shape of the distributions. Studying the crystallite size distributions we can infer a critical size of about 300 Å for the tetragonal crystallites to transform. The shape of the mean crystallite of a fully tetragonal sample is also described.
Pet therapy had its origins in the USA in the early 1960s and is based on the hypothesis that the relationship between different species may have a therapeutic effect.
The essential polyunsaturated fatty acids (PUFAs) are divided into two classes, n-3 (ω-3) and n-6 (ω-6) and their dietary precursors are α-linolenic (ALA) and linoleic acid (LA), respectively. PUFAs are precursors of a wide range of metabolites, for example eicosanoids like prostaglandins and leukotrienes, which play critical roles in the regulation of a variety of biological processes, including bone metabolism.
A large body of evidence supports an effect of PUFA on bone metabolism which may be mediated by regulation of osteoblastogenesis and osteoclast activity, change of membrane function, decrease in inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumour necrosis factor alpha (TNF-α), modulation of peroxisome proliferators-activated receptor γ (PPARγ) and influence in NO secretion and NO synthase.
Animal studies have shown that a higher dietary omega-3/omega-6 fatty acids ratio is associated with beneficial effects on bone health. Human studies conducted in elderly subjects suggest that omega-3 instead of omega-6 has a positive effect on bone metabolism. In spite of increasing evidence, studies conducted in humans do not allow us to draw a definitive conclusion on the usefulness of PUFAs in clinical practice.