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This article examines the use of fuck and fucking in Danish, with a focus on their interactional functions for assessing. Data consist of 76 cases found in informal Danish conversations, analyzed within the framework of Interactional Linguistics. Fuck functions as a reactive interjection that prefaces various types of clauses. However, fuck followed by a copula clause develops an assessment out of a telling. Followed by hvor ‘how’ and an adjective, fuck performs agreeing assessment. Hvad fuck ‘what the fuck’ may occur in questions. Fucking is commonly used in copula clause assessments but also within noun phrases when no response is elicited. The study concludes that the use of fuck and fucking in Danish differs from their use in English, but also from the Danish swearword fanden ‘the devil, damn’. The conclusions indicate that interactional functions and constructions are an important factor for understanding the pragmatics of borrowing and swearing.
There has been debate about the frequency and severity of antidepressant withdrawal effects.
Methods
We set out to appraise and reanalyze an influential systematic review by Henssler and colleagues that concluded that withdrawal effects are not particularly common and rarely severe. We repeated the meta-analysis, including only studies where data were derived from systematic measures of withdrawal symptoms.
Results
Most data in the Henssler review are derived from pharmaceutical industry–sponsored efficacy studies in which withdrawal was a minor consideration. Shortcomings of the review include the use of spontaneously reported adverse events to estimate withdrawal symptoms, potential misclassification of withdrawal symptoms as relapse, inclusion of data from retrospective case-note studies, short duration of prior antidepressant use, short observation periods, the overlooking of differences between placebo and drug withdrawal effects, and the use of questionable proxies for severe withdrawal. There were also discrepancies and uncertainties in some figures used. In our reanalysis, we included only the five studies that used a systematic and relevant method to assess the incidence of any withdrawal symptom. Prior treatment was short-term (12 weeks or less) in all but one of these. The pooled percentage was 55% (95% confidence interval, CI, 31% to 81%; N = 601) without subtracting nocebo effects, with high heterogeneity.
Conclusions
Henssler’s review is based on unreliable data and does not provide an adequate basis for the evaluation of antidepressant withdrawal effects. Further good-quality research on antidepressant withdrawal is required.
Excavations at Alcatrazes, the seat of Cape Verde’s short-lived second captaincy, have exposed a Portuguese colonial settlement, demonstrating continued occupation after the relocation of its official offices. The results include insights into early Luso-African practices and the presence of West African and local-made pottery, with environmental samples ‘clocking’ colonial introductions.
This study presents an innovative framework to improve the accessibility and usability of collaborative robot programming. Building on previous research that evaluated the feasibility of using a domain-specific language based on behaviour-driven development, this paper addresses the limitations of earlier work by integrating additional features like a drag-and-drop Blockly web interface. The system enables end users to define and execute robot actions with minimal technical knowledge, making it more adaptable and intuitive. Additionally, a gesture-recognition module facilitates multimodal interaction, allowing users to control robots through natural gestures. The system was evaluated through a user study involving participants with varying levels of professional experience and little to no programming background. Results indicate significant improvements in user satisfaction, with the system usability scale overall score increasing from 7.50 to 8.67 out of a maximum of 10 and integration ratings rising from 4.42 to 4.58 out of 5. Participants completed tasks using a manageable number of blocks (5 to 8) and reported low frustration levels (mean: 8.75 out of 100) alongside moderate mental demand (mean: 38.33 out of 100). These findings demonstrate the tool’s effectiveness in reducing cognitive load, enhancing user engagement and supporting intuitive, efficient programming of collaborative robots for industrial applications.
This study aims to examine the different aspects of socio-economic status (SES) patterns in mental health from adolescence into adulthood by investigating the mean, prevalence, cumulative incidence and trajectories of several mental health measures, including depressive symptoms, mental disorder diagnosis and medication use. The different aspects of SES are investigated through the measures of subjective social status (SSS) in school, SSS in society, income and parental educational level.
Methods
Individuals born in 1989 were followed from 2004 to 2021 with surveys at ages 15, 18, 21, 28 and 32 years, supplied with yearly register data. The mean level of depressive symptoms, yearly prevalence of medication use and cumulative incidence of mental disorder diagnosis were calculated for each SES group (low, middle and high) across each measure. Group-Based Trajectory Modelling (GBTM) was used to identify depressive symptom trajectories and logistic regressions were used to analyse the relative odds ratios (ROR) of membership to the different trajectory groups by characteristics.
Results
Individuals with low SES at age 15 years across all SES measures showed higher mean depressive symptoms, prevalence of medication use and cumulative incidence of mental disorder diagnosis through adolescence and adulthood (age 15–32 years). Four depressive symptom trajectories were identified: low stable, moderate stable, decreasing and increasing trajectories. Being female, receiving medication or a mental disorder diagnosis in early adulthood and during the study period, having low SSS in school, parents not living together, being bullied, lacking support from teachers or classmates, lower levels of parents’ support or higher school pressure resulted in higher RORs of membership to the other trajectory groups compared to the low stable trajectory, while having high SSS in society resulted in a lower ROR.
Conclusions
This is the first study to detect the role of social support in relation to depressive symptom trajectories. While individuals with low social status consistently experienced more negative mental health outcomes than those with middle and high social status in the study period (age 15–32 years), low SSS showed the strongest associations. This indicates that SSS may capture vulnerable individuals not identified by traditional SES. Being female, having low SES, low social support, and other mental health outcomes were associated with higher odds of being in trajectories with more depressive symptoms. Preventive initiatives should therefore target individuals with such characteristics. It is worth exploring whether adolescents with increasing depressive symptoms could benefit from increased social support.
A major question for the future of the environment of Japan – understood here both as natural environment and living environment – is whether pressures of population decline will prompt a more general adoption of quality-of-place and quality-of-environment strategies for local place making and place survival. A combination of very low birthrates (common to most developed countries), and an unwillingness to allow large-scale immigration (in which Japan is the exception among developed countries) means that Japan is the first large developed country in the world to face massive and imminent population decline. As discussed below, total population is expected to decline by about 28 million, to 100 million by 2050, and the proportion of the elderly will increase dramatically. Overall population decline and ageing will change the context of place-making greatly, as competition for both residents and inward investment intensifies. The impacts of these pressures on local environmental governance approaches will have major consequences for the future of the Japanese settlement system and the Japanese people. This article explores the possibility that population ageing and economic decline may be creating conditions in which Japanese local governments intensify efforts towards more livable cities with a high level of environmental amenity and quality of local services.
Objectives/Goals: Early identification and profiling of planned studies is a critical administrative challenge in providing timely support for clinical trials. Here we describe the collaborative design and development of a clinical trial tracking dashboard to enhance support and quality improvement for investigator-initiated clinical trials at our institution. Methods/Study Population: Trial-CARE organized a workgroup with key stakeholders from WashU business units that manage grants, information technology, bioinformatics, data repository stewardship, and clinical trial support. The workgroup strategized next steps in a “proof-of-concept” effort to determine whether NIH investigator-initiated clinical trial metrics would be accessible via the WashU Data Warehouse. The WashU Data Warehouse is a data repository that pulls in pre-award and post-award data from sources such as the WashU Research-Grant Management System (RMS) and the NIH Reporter Tool. The proof-of-concept findings lead to implementing a plan for Phase 1 of the design, development, and piloting of a visual dashboard to track and offer targeted and timely support to NIH investigator-initiated clinical trials at WashU. Results/Anticipated Results: WashU currently has 217 grants submitted and 114 grants awarded for NIH clinical trials. In the proof of concept, we confirmed and successfully matched over 100 awarded NIH investigator-initiated clinical trials at WashU across RMS and the NIH Reporter Tool. We determined Phase I of the dashboard would track clinical trial data from these two sources via the WashU Data Warehouse. The pilot of Phase I of the dashboard will begin in February 2025. We also identified mission critical data elements not accessible via the WashU Data Warehouse (e.g., enrollment diversity, IND, and IDE). The plan to procure this data will require continued stakeholder support in Phase II of the dashboard to (1) expand data capture in RMS and (2) ingest additional data into the WashU Data Warehouse from RMS or new systems (e.g., ClinicalTrials.gov). Discussion/Significance of Impact: Early access to robust data about NIH investigator-initiated clinical trials via our newly created Phase I dashboard will better position our centralized service cores to support trial success, compliance, and quality improvement across the lifecycle of these clinical trials. In Phase II, we plan to expand the data available in the dashboard.
Elevated maternal interleukin 6 (IL-6) during pregnancy has been associated with adverse fetal brain development and neurodevelopmental disorders, which often involve executive functioning (EF) impairments. However, the association between maternal IL-6 levels during pregnancy and EF remains largely unexplored.
Methods
The COPSYCH study is based on the prospective COPSAC2010 birth cohort of 700 mother-child pairs, recruited during pregnancy. The children’s executive functioning was assessed at age 10 using: (i) the Behavior Rating Inventory of Executive Function, Second Edition (BRIEF-2) parental questionnaire, and (ii) a comprehensive neuropsychological test battery. Maternal blood levels of IL-6 and hs-CRP were measured at gestational week 24. Associations between IL-6 (main analysis) and hs-CRP (secondary analysis) and EF in children at age 10 were investigated with regression models with extensive confounder adjustment.
Results
Six hundred and four children (86% of the cohort) completed the 10-year follow-up. Higher maternal IL-6 levels were significantly associated with less efficient parental-rated executive functioning in the children: BRIEF-2 Global Executive Composite score (p = 0.003), Behavior Regulation Index (p = 0.005), Emotion Regulation Index (p=0.04), and Cognitive Regulation Index (p=0.007). Interaction analysis with sex was significant (p-value=0.01) and exploratory analyses showed that IL-6 associations to BRIEF-2 were solely driven by boys. Associations between IL-6 and neuropsychological tests, as well as associations between hs-CRP and EF outcomes, were non-significant.
Conclusion
IL-6 during pregnancy was associated with less efficient everyday EF in children at age 10. If replicated, preventive strategies targeting inflammation in pregnancy may ameliorate adverse cognitive outcomes in offspring.
The fact that criminal behavior typically has negative consequences for others provides a compelling reason to think that criminals lack prosocial motivation. This paper reports the results from two dictator game experiments designed to study the prosocial motivation of criminals. In a lab experiment involving prisoners, we find a striking similarity in the prosocial behavior of criminals and non-criminals, both when they interact with criminals and when they interact with non-criminals. Similarly, in an Internet experiment on a large sample from the general population, we find no difference in the prosocial behavior of individuals with and without a criminal record. We argue that our findings provide evidence of criminals being as prosocially motivated as non-criminals in an important type of distributive situations.
This is a new edition of the fragments of 'Anonymus Iamblichi', the mysterious Greek author excerpted by Iamblichus in chapter 20 of Protrepticus. The fragments are an important but overlooked source for early Greek ethical and political thought. Among other things, they criticize traditional forms of social benefaction, and they offer a strikingly modern approach to the analysis of society and economy revolving around the concept of pistis ('trust'). The text and translation are supplemented by a lengthy introduction, which analyses the language and style of the fragments and explores them in the literary and philosophical context of early Socratic literature. The detailed commentary discusses issues pertaining to text and interpretation.