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Stress leads to neurobiological changes, and failure to regulate these can contribute to chronic psychiatric issues. Despite considerable research, the relationship between neural alterations in acute stress and coping with chronic stress is unclear. This longitudinal study examined whole-brain network dynamics following induced acute stress and their role in predicting chronic stress vulnerability.
Methods
Sixty military pre-deployment soldiers underwent a lab-induced stress task where subjective stress and resting-state functional magnetic resonance imaging were acquired repeatedly (before stress, after stress, and at recovery, 90 min later). Baseline depression and post-traumatic stress symptoms were assessed, and again a year later during military deployment. We used the Leading Eigenvector Dynamic Analysis framework to characterize changes in whole-brain dynamics over time. Time spent in each state was compared across acute stress conditions and correlated with psychological outcomes.
Results
Findings reveal significant changes at the network level from acute stress to recovery, where the frontoparietal and subcortical states decreased in dominance in favor of the default mode network, sensorimotor, and visual states. A significant normalization of the frontoparietal state activity was related to successful psychological recovery. Immediately after induced stress, a significant increase in the lifetimes of the frontoparietal state was associated with higher depression symptoms (r = 0.49, p < .02) and this association was also observed a year later following combat exposure (r = 0.49, p < .009).
Conclusions
This study revealed how acute stress-related neural alterations predict chronic stress vulnerability. Successful recovery from acute stress involves reducing cognitive–emotional states and enhancing self-awareness and sensory–perceptual states. Elevated frontoparietal activity is suggested as a neural marker of vulnerability to chronic stress.
A structurally transforming multi-mode product can realize a changing set of functions across its modes, replacing multiple related products while offering increased cost, space, and time efficiency. However, there is a lack of connected methods that address the additional design complexities due to the product’s physical transformations and the resulting structural component-sharing between modes. A framework, grounded in standard design practice and built upon existing methods, is proposed to help navigate the two most impacted design stages: 1. Problem Definition and 2. Conceptual Design. The Problem Definition stage in this new framework involves identifying the external factor that determines the product’s modes and defining the functional requirements for the modes and transformation methods. The Conceptual Design stage involves iteratively linking conceptualized forms of each mode to adjacent modes through conceptualized transformation methods. The framework is demonstrated in a case study involving the design of a structurally transforming multi-mode piece of children’s furniture that transforms between a cradle, floor seat and a multipurpose toddler step stool. The proposed framework is a promising step toward systematically, cohesively, and comprehensively addressing design challenges during the development of a wide variety of structurally transforming multi-mode products, therefore facilitating better, more effective product design.
In R. v Jogee; Ruddock v The Queen, the Supreme Court abolished “joint enterprise liability”, thus removing the need for a doctrine that used to temper the harshness of joint enterprise: the “fundamental difference” rule. The Supreme Court nevertheless allowed this rule to linger on in the form of an “overwhelming supervening act” doctrine. That doctrine has led to the creation of yet another: an “escalation” doctrine. We argue that there is no place in the post-Jogee law of complicity for doctrines based on fundamental difference, overwhelming supervening acts or escalation. This is no mere semantic quibble. It has significant implications for the way in which complicity law should be applied, especially in homicide cases.
International humanitarian law is a subject of universal importance and relevance. Since 1974, the problems of restatement and development have engaged the attention of the Geneva Diplomatic Conference on the Reaffirmation and Development of International Humanitarian Law Applicable in Armed Conflicts.
In this article, Professor J. G. Starke, Q.C. surveys developments in international humanitarian law over the last quarter century and examines in detail Australia's contribution to those developments. The process by which the idea of “laws of war” has come to be superseded by the concept of international humanitarian law is outlined, while reference is also made to the principal sources of international humanitarian law. Australia's interest in international humanitarian law since World War II is discussed, as is the background to the present continuing Geneva Conference and proceedings at its first three sessions in 1974, 1975 and 1976. The contribution of Australia to the work of the Geneva Conference is thoroughly examined. In particular, the stance of the Australian government on various issues before the Conference is set forth in detail. The article also assesses Australia's contribution to the development of international humanitarian law.
An estimated 129000 cases of Lyme borreliosis (LB) are reported annually in Europe. In 2022, we conducted a representative web-based survey of 28034 persons aged 18–65 years old in 20 European countries to describe tick and LB risk exposures and perceptions. Nearly all respondents (95.0%) were aware of ticks (range, 90.4% in the UK to 98.8% in Estonia). Among those aware of ticks, most (85.1%) were also aware of LB (range, 70.3% in Switzerland to 97.0% in Lithuania). Overall, 8.3% of respondents reported a past LB diagnosis (range, 3.0% in Romania to 13.8% in Sweden). Respondents spent a weekly median of 7 (interquartile range [IQR] 3–14) hours in green spaces at home and 9 (IQR 4–16) hours away from home during April–November. The most common tick prevention measures always or often used were checking for ticks (44.8%) and wearing protective clothing (40.2%). This large multicountry survey provided needed data that can be used to design targeted LB prevention programmes in Europe.
To begin a tour of research on implicit bias, the construct must be defined conceptually and operationally, and Section 1 does just that. As we shall see, the accumulated literature has been characterized by definitional divergences that merit investigation and resolution.
In this section, we reassess the value of explicit prejudice measures. P.J. Henry starts this discussion by reviewing critiques of implicit prejudice measures and points to the overwhelming evidence of the power of explicit measures to predict important outcomes. To date, implicit measures have not yet been shown to be similarly capable. Henry explains how the “implicit revolution” was founded on the claim that explicit measures are useless, yet this is clearly not so.
Despite twenty years of research, we have not yet reached a point of consensus about what might be considered the most important issue in the study of implicit bias: when and how strongly does it shape cognition and behavior? This section of this handbook reviews some of the relevant literature.
Recent decades have seen a series of attempts to further develop measures of implicit bias. Some observers have suggested drawing on lessons learned in the literature on optimal measurement of explicit bias to enhance implicit bias measures. Suggestions have also been made about how to improve meta-analyses of studies quantifying the strength of the link between implicit attitudes and behavior. For example, outdated statistical methods used in many meta-analyses of implicit bias may have led to incorrect inferences about the average effect sizes and can be avoided using newer techniques. Further improvement has been suggested to more effectively take into account omitted variables that may create spurious associations of implicit attitudes and behavior.