We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The management and mismanagement of Roman groves was a serious matter, and intentional and unintentional violations of these spaces could be severely punished. In spite of this, groves remained loosely defined by Romans and their boundaries were commonly misunderstood, a confusion that has continued into modern scholarship, where groves are understood as either a clearing in a wood or a dark space lit by artificial lighting. This article takes up this discussion, and explores the nature of an ancient grove as a well-attested space under forest management that influences later conversations on the nature of wooded spaces in more recent periods.
Contains 'The Shefford Beaker', by Cyril Fox. 'The Later Descent of Wingate of Harlington', by Joseph Hight Blundell. 'The Disseisins by Falk de Breaute at Luton', by G. Herbert Fowler and Michael W. Hughes. 'An Elizabethan Inquisition Concerning Bondmen', by S. Peyton. 'Roll of the Justices in Eyre, 1242', by G. Herbert Fowler. 'A list of Bedfordshire Apprentices, 1711-1720', by Mrs. Hilary Jenkinson. 'The Commune of Bedford', by Prof. F. M. Stenton. 'A Handlist of the Bedfordshire County Muniments', prepared by the County Records Committee.
Since the article which forms pp. 23-34 was printed, the writer noticed a surprising entry on the Close Roll of 1248, by which the Escheators in Hunts, and Cambs. are ordered “that, with regard to the revenue of Simon de sancto Licio in Huntindon’ from the third penny of the County, which the King caused to be taken into his own hand by reason that in these days there is no Earl of Huntindon’, they cause him again to have (rehabere) full seisin, provided that according to justice he answer for it in the King's Court to his summons.” This seems to be the only case as yet noticed of the allowance of the third penny of the County to one who had no claims on an Earldom. The nearest comparable case seems to be that of Hugh de Courtenay; he was a distant kinsman of the last of the family de Reviers, Earls of Devon, and succeeded to their estates about 1293; he claimed the third penny of Devon from the Sheriff, and it was allowed at the Exchequer till about 1325/6, when the Treasurer disallowed it on the ground that Hugh was not the Earl; Hugh protested, and finally was created Earl of Devon with full grant of the third penny, and was acquitted of the claims made by the Exchequer for what he had irregularly received in the last 8J years. A serious search of the Pipe Rolls of the period has not been possible, but no payment to Simon de St. Liz of the third penny appears in the Rolls for 1248, 1249, 1250; it might have been paid in some other way. Both in these three years and earlier is an allowance for ‘lands granted’ (terrae datae) “to the heirs of the Earl of Huntendon 40li in Brampton and Alemundebiri” (Brampton and Alconbury co. Hunts., royal lands at Domesday).
It seemed worth while to attempt to trace this highly favoured recipient, but as the eldest son of the family seems always to have been called Simon, the separation of successive generations is merely inferential.
It appears from a case reported by Bracton under 1220, that William Marshal duly received the manor of Luton with his wife, but that it was escheated in 1216 in consequence of his opposition to King John. At the conclusion of peace Falk (whether willingly or not) restored it to William, who re-granted it to him (on lease or farm) by charter. The transaction becomes thus somewhat clearer.
In another place Bracton reports an action for novel disseisin by Will, de Stanes against Falk for 2 carucates and a mill in Luton, under the year 1224. Falk does not appear, “and Robert de Lexinton and his fellows, who were Justices at Dunstaple to take that assise and before whom it was summoned, recall (recordantur) that that assise stood over for hearing because” etc. ; this seems to confirm the suggestion that the Rolls had been lost; if they had been accessible, the phrasing would probably have been different. A note to this case by Bracton's editor, Prof. Maitland, shows that he had detected the Inquisition by Martin de Pateshull which is dealt with on pp. 51-60 above, but that he regarded it (erroneously, as we think) as the record of the original Eyre of Martin de Pateshull and his fellows.—[G.H.F.].
The US government invests substantial sums to control the HIV/AIDS epidemic. To monitor progress toward epidemic control, PEPFAR, or the President’s Emergency Plan for AIDS Relief, oversees a data reporting system that includes standard indicators, reporting formats, information systems, and data warehouses. These data, reported quarterly, inform understanding of the global epidemic, resource allocation, and identification of trouble spots. PEPFAR has developed tools to assess the quality of data reported. These tools made important contributions but are limited in the methods used to identify anomalous data points. The most advanced consider univariate probability distributions, whereas correlations between indicators suggest a multivariate approach is better suited. For temporal analysis, the same tool compares values to the averages of preceding periods, though does not consider underlying trends and seasonal factors. To that end, we apply two methods to identify anomalous data points among routinely collected facility-level HIV/AIDS data. One approach is Recommender Systems, an unsupervised machine learning method that captures relationships between users and items. We apply the approach in a novel way by predicting reported values, comparing predicted to reported values, and identifying the greatest deviations. For a temporal perspective, we apply time series models that are flexible to include trend and seasonality. Results of these methods were validated against manual review (95% agreement on non-anomalies, 56% agreement on anomalies for recommender systems; 96% agreement on non-anomalies, 91% agreement on anomalies for time series). This tool will apply greater methodological sophistication to monitoring data quality in an accelerated and standardized manner.
In this poster, using the POSYDON code, we present results on binary progenitors of stripped-envelope SNe and their companions. We find that most progenitors are expected to explode, according to typical SN prescriptions (in contrast to single star progenitors). We also show the expected masses and position in the HR diagram of the companions of these SNe at the moment of explosion, allowing us to do a first statistical comparison with the compiled sample of observational detections (or upper limits) on these companions.
The proposal by Clarke and Beck offers a new explanation for the association between the approximate number system (ANS) and math. Previous explanations have largely relied on developmental arguments, an underspecified notion of the ANS as an “error detection mechanism,” or affective factors. The proposal that the ANS represents rational numbers suggests that it may directly support a broader range of math skills.
As the US faced its lowest levels of reported trust in government, the COVID-19 crisis revealed the essential service that various federal agencies provide as sources of information. This Element explores variations in trust across various levels of government and government agencies based on a nationally-representative survey conducted in March of 2020. First, it examines trust in agencies including the Department of Health and Human Services, state health departments, and local health care providers. This includes variation across key characteristics including party identification, age, and race. Second, the Element explores the evolution of trust in health-related organizations throughout 2020 as the pandemic continued. The Element concludes with a discussion of the implications for agency-specific assessments of trust and their importance as we address historically low levels of trust in government. This title is also available as Open Access on Cambridge Core.
The Variables and Slow Transients Survey (VAST) on the Australian Square Kilometre Array Pathfinder (ASKAP) is designed to detect highly variable and transient radio sources on timescales from 5 s to $\sim\!5$ yr. In this paper, we present the survey description, observation strategy and initial results from the VAST Phase I Pilot Survey. This pilot survey consists of $\sim\!162$ h of observations conducted at a central frequency of 888 MHz between 2019 August and 2020 August, with a typical rms sensitivity of $0.24\ \mathrm{mJy\ beam}^{-1}$ and angular resolution of $12-20$ arcseconds. There are 113 fields, each of which was observed for 12 min integration time, with between 5 and 13 repeats, with cadences between 1 day and 8 months. The total area of the pilot survey footprint is 5 131 square degrees, covering six distinct regions of the sky. An initial search of two of these regions, totalling 1 646 square degrees, revealed 28 highly variable and/or transient sources. Seven of these are known pulsars, including the millisecond pulsar J2039–5617. Another seven are stars, four of which have no previously reported radio detection (SCR J0533–4257, LEHPM 2-783, UCAC3 89–412162 and 2MASS J22414436–6119311). Of the remaining 14 sources, two are active galactic nuclei, six are associated with galaxies and the other six have no multi-wavelength counterparts and are yet to be identified.
The motion of a rigid sphere in ambient simple shear flow of a Newtonian fluid between infinite parallel walls is calculated via the lattice Boltzmann method for various particle Reynolds numbers, ${\textit {Re}}_p=Ga^2/\nu$, where $G$ is the velocity gradient of the shear; $a$ is the particle radius; and $\nu$ is the kinematic viscosity of the fluid. For a neutrally buoyant sphere, there exists a critical ${\textit {Re}}_p$ below which the hydrodynamic lift force has a single zero crossing, driving the particle to an equilibrium position at the centre of the channel. Above the critical ${\textit {Re}}_p$, the equilibrium position of the sphere undergoes a supercritical pitchfork bifurcation; inertial lift creates three equilibrium positions: an unstable equilibrium position at the centre and two stable equilibria equidistant from the centre. The critical ${\textit {Re}}_p$ occurs below the transition to unsteady flow, and increases with increasing particle confinement ratio, $\kappa =a/H$, where $H$ is the channel height. The equilibrium position of a non-neutrally buoyant sphere shifts toward a confining wall of the channel, in a manner that is dependent on the orientation, i.e. horizontal or vertical, of the channel. In both channel alignments, the gravitational force breaks the symmetry of the particle dynamics about the centreline of the channel, resulting in an imperfect bifurcation above a critical ${\textit {Re}}_p$. However, a sufficiently strong gravitational force will break the bifurcation and produce a single off-centre equilibrium position. We finally consider a neutrally buoyant sphere under the cessation or reversal of shear flow.
The INSYTE study provides an understanding of the management of Parkinson disease psychosis (PDP) in actual practice settings, including use of antipsychotic (APs) and their impact on clinical, economic, and humanistic outcomes. Treatment paradigms or the benefits/consequences of various “real world” PDP treatment strategies have not been evaluated. Thus, providers may be using a wide range of AP treatment strategies that contrast with consensus recommendations.
Method:
The INSYTE study is enrolling up to 750 patients from up to 100 sites in the US. Data are compiled at the baseline (BL) visit and from standard-of-care follow up visits over 3 years. PDP treatment pathways are defined from 3 BL cohorts reflecting (1) no AP medication, (2) use of pimavanserin (PIM), or (3) other AP treatment. Information about APs used is collected at each follow-up visit: history, duration, dose, adjustment, and rationale for adjustment of treatment. Outcomes assessments (clinical, quality of life, disease burden) by the physician, patient, and caregiver are also collected. AP medication and outcomes data are analyzed for patients completing a BL and 1 follow up visit (FU1).
Results:
For 404 patients with BL and FU1 visits (mean 120.7 days from BL), 56.8% used no AP medications, 26.0% used PIM, and 13.6% used other APs at BL. The No Medication group was noted to be less severe in key BL disease parameters. Considering primary PDP treatments at BL and FU1 (including no treatment), 26 distinct pathways were being employed. 12.6% of patients had AP medication adjustments between BL and FU1 visits, most frequently from the non-PIM group. Adjustments of APs occurred in many forms: introduction of a single AP (64.7%%), introduction of multiple APs (5.9%), switching to another AP (3.9%), decreasing the number of APs (5.9%), and discontinuation (19.6%).
Conclusions:
Multiple, divergent AP treatment strategies for PDP exist in actual practice. No identifiable BL characteristics correlated with the broad range of AP treatment pathways. The numerous distinct AP treatment pathways utilized (n=26) reflect discordance with the updated 2019 MDS evidence-based recommendations, which recognize only 2 APs as “efficacious” and “clinically useful”: pimavanserin and clozapine. Education of healthcare professionals remains a priority for PDP management.
UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential.
Aims
Describe the development, implementation and results of this questionnaire.
Method
An expert working group designed the questionnaire, using established measures where possible, and consulting a patient group. Operational criteria were agreed for defining likely disorder and risk states, including lifetime depression, mania/hypomania, generalised anxiety disorder, unusual experiences and self-harm, and current post-traumatic stress and hazardous/harmful alcohol use.
Results
A total of 157 366 completed online questionnaires were available by August 2017. Participants were aged 45–82 (53% were ≥65 years) and 57% women. Comparison of self-reported diagnosed mental disorder with a contemporary study shows a similar prevalence, despite respondents being of higher average socioeconomic status. Lifetime depression was a common finding, with 24% (37 434) of participants meeting criteria and current hazardous/harmful alcohol use criteria were met by 21% (32 602), whereas other criteria were met by less than 8% of the participants. There was extensive comorbidity among the syndromes. Mental disorders were associated with a high neuroticism score, adverse life events and long-term illness; addiction and bipolar affective disorder in particular were associated with measures of deprivation.
Conclusions
The UK Biobank questionnaire represents a very large mental health survey in itself, and the results presented here show high face validity, although caution is needed because of selection bias. Built into UK Biobank, these data intersect with other health data to offer unparalleled potential for crosscutting biomedical research involving mental health.