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Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) is an invasive tropical pest that is currently expanding in its geographical range into temperate regions. This study examined the temporal and spatial dynamics of B. dorsalis along an altitudinal gradient in Mpumalanga Province, South Africa, in its southernmost adventive limit, which experiences a temperate climate with dry winters. Populations were monitored from October 2020 to October 2022 at three sites with altitudes ranging from 452 to 1 741 m above sea level. At each site, clusters of attractant-based traps (methyl eugenol and three-component Biolure) were set up and serviced at least monthly. We analysed the effects of climate, time of the year, altitude, and landscape on B. dorsalis abundance. Single population peaks of B. dorsalis were recorded from mid-summer to autumn in all sites, with higher prevalence at the low-altitude site. In the low- and mid-altitude sites, catches were recorded year-round, while at the high-altitude site, there were no catches for four to six months after onset of winter. Higher B. dorsalis catches were recorded as temperatures increased and precipitation decreased. Catches were higher in commercial orchards and home gardens compared to abandoned orchards. These findings provide valuable information for improving simulation models of B. dorsalis distribution and population growth that can be used to inform the management of this pest.
Female fertility is a complex trait with age-specific changes in spontaneous dizygotic (DZ) twinning and fertility. To elucidate factors regulating female fertility and infertility, we conducted a genome-wide association study (GWAS) on mothers of spontaneous DZ twins (MoDZT) versus controls (3273 cases, 24,009 controls). This is a follow-up study to the Australia/New Zealand (ANZ) component of that previously reported (Mbarek et al., 2016), with a sample size almost twice that of the entire discovery sample meta-analysed in the previous article (and five times the ANZ contribution to that), resulting from newly available additional genotyping and representing a significant increase in power. We compare analyses with and without male controls and show unequivocally that it is better to include male controls who have been screened for recent family history, than to use only female controls. Results from the SNP based GWAS identified four genomewide significant signals, including one novel region, ZFPM1 (Zinc Finger Protein, FOG Family Member 1), on chromosome 16. Previous signals near FSHB (Follicle Stimulating Hormone beta subunit) and SMAD3 (SMAD Family Member 3) were also replicated (Mbarek et al., 2016). We also ran the GWAS with a dominance model that identified a further locus ADRB2 on chr 5. These results have been contributed to the International Twinning Genetics Consortium for inclusion in the next GWAS meta-analysis (Mbarek et al., in press).
Clozapine is the only drug licensed for treatment-resistant schizophrenia (TRS) but the real-world clinical and cost-effectiveness of community initiation of clozapine is unclear.
Aims
The aim was to assess the feasibility and cost-effectiveness of community initiation of clozapine.
Method
This was a naturalistic study of community patients recommended for clozapine treatment.
Results
Of 158 patients recommended for clozapine treatment, 88 (56%) patients agreed to clozapine initiation and, of these, 58 (66%) were successfully established on clozapine. The success rate for community initiation was 65.4%; which was not significantly different from that for in-patient initiation (58.82%, χ2(1,88) = 0.47, P = 0.49). Following clozapine initiation, there was a significant reduction in median out-patient visits over 1 year (from 24.00 (interquartile range (IQR) = 14.00–41.00) to 13.00 visits (IQR = 5.00–24.00), P < 0.001), and 2 years (from 47.50 visits (IQR = 24.75–71.00) to 22.00 (IQR = 11.00–42.00), P < 0.001), and a 74.71% decrease in psychiatric hospital bed days (z = −2.50, P = 0.01). Service-use costs decreased (1 year: –£963/patient (P < 0.001); 2 years: –£1598.10/patient (P < 0.001). Subanalyses for community-only initiation also showed significant cost reductions (1 year: –£827.40/patient (P < 0.001); 2 year: –£1668.50/patient (P < 0.001) relative to costs prior to starting clozapine. Relative to before initiation, symptom severity was improved in patients taking clozapine at discharge (median Positive and Negative Syndrome Scale total score: initial visit: 80 (IQR = 71.00–104.00); discharge visit 50.5 (IQR = 44.75–75.00), P < 0.001) and at 2 year follow-up (Health of Nation Outcome Scales total score median initial visit: 13.00 (IQR = 9.00–15.00); 2 year follow-up: 8.00 (IQR = 3.00–13.00), P = 0.023).
Conclusions
These findings indicate that community initiation of clozapine is feasible and is associated with significant reductions in costs, service use and symptom severity.
The food bank has become a charitable safety-net for those who have been failed by the social security system in times of austerity and during the Covid-19 pandemic. In this article we evidence the rise of food banking in the context of declining social security, examining the decade of austerity in the UK and the Covid-19 period. We also contextualise the process of normalisation of food banks as a new safety-net in a reduced welfare state. We argue that the welfare state has failed to address a fundamental ‘Want’ – namely, food security.
Hydrogen could help transition the global energy system to a low-carbon future by providing an energy-dense, carbon-free fuel suitable for a wide range of applications. Hydrogen is already used extensively by industry; however, the current supply chain is relatively simple and relies heavily on fossil fuels, resulting in greenhouse gas emissions. The value chain for a future hydrogen economy will be more complex and require different technologies to be further developed and scaled up, including low-emission hydrogen production, large-scale storage and transport, and new energy and industry applications. Hydrogen produced with zero carbon emissions has the potential to be a major new globally traded commodity, which could enable countries with limited renewable energy potential to decarbonise their economies, diversify the global energy supply, and increase energy security. The emergence of the hydrogen economy faces economic, social acceptance and regulatory challenges. Governments around the world have a role to play in providing policies to address potential market failures, socialising the widespread use of hydrogen and establishing international governance and regulations.
The direct dating of rock paintings is not always possible due to the lack of organic carbon compounds in pigments, or because sampling from a heritage site is often restricted. To overcome these limitations, dating laboratories have to develop new approaches. In this study, we consider sampling calcium oxalate crusts covering the painted artworks as a way to indirectly date the rock art. This stratigraphic approach includes isolating and extracting pure oxalate from the crusts. The approach was tested on natural bulk accretions collected in the open-air sites of Erongo Mountains in Namibia. The accretions were separated into two phases (pure oxalate and the remaining residues) with a special pretreatment. This process removes carbonates through acidification (HCl 6N) and dissolves the oxalate into the supernatant, leaving the minerals and windblown organic compounds in the residue. The efficiency of the separation was checked on the two phases by FTIR analyses and by 14C dating and showed that pure oxalate powders were indeed obtained. AMS radiocarbon results of various accretions on the same art panels provided ages from modern periods to 2410 ± 35 BP. From these first results, more targeted sampling campaigns can be considered to provide a terminus ante quem for the rock art.
The modern antiquities market uses radiocarbon (14C) dating to screen for forged objects. Although this fact shows the potential and power of the method, the circumstances where it is applied can be questionable and call for our attention. Here we present an outline of a call to radiocarbon laboratories for due diligence and best practice approaches to the analysis of antique objects requested by non-research clients.
From 1565 to 1570, Spain established no fewer than three networks of presidios (fortified military settlements) across portions of its frontier territories in La Florida and New Spain. Juan Pardo's network of six forts, extending from the Atlantic coast over the Appalachian Mountains, was the least successful of these presidio systems, lasting only from late 1566 to early 1568. The failure of Pardo's defensive network has long been attributed to poor planning and an insufficient investment of resources. Yet recent archaeological discoveries at the Berry site in western North Carolina—the location of both the Native American town of Joara and Pardo's first garrison, Fort San Juan—warrants a reappraisal of this interpretation. While previous archaeological research at Berry concentrated on the domestic compound where Pardo's soldiers resided, the location of the fort itself remained unknown. In 2013, the remains of Fort San Juan were finally identified south of the compound, the first of Pardo's interior forts to be discovered by archaeologists. Data from excavations and geophysical surveys suggest that it was a substantial defensive construction. We attribute the failure of Pardo's network to the social geography of the Native South rather than to an insufficient investment of resources.
The Salishan language Lushootseed shows an unusual pattern in its verbal morphology wherein its verbs are formed from intransitive, adjective-like roots via a highly productive set of suffixes, the bulk of which serve to increase the valency of their stem. These include the middle-marker, which forms intransitives, and several transitivizing affixes, which are shown here to be types of causative, their transitivizing effect being an expression of the causality inherent in the prototypical transitive event. In addition, the syntactic properties of the Lushootseed passive — formed by combining a transitivizing suffix with the middle-marker — can be analyzed as straightforward consequences of the meanings of the affixes that compose it. Treating Lushootseed causatives as subtypes of the transitive event model suggests that cross-linguistically transitive-causatives — as well as instrumentals and applicatives — may be subschematic extensions of the simple transitive clause, rather than derivations from more complex, biclausal structures.
Protohistoric Ancestral Apache Dismal River groups (A.D. 1600–1750)participated in large exchange networks linking them to other peoples on thePlains and U.S. Southwest. Ceramic vessels made from micaceous materialsappear at many Dismal River sites, and micaceous pottery recovered from theCentral High Plains is typically seen as evidence for interaction withnorthern Rio Grande pueblos. However, few mineral or chemicalcharacterization analyses have been conducted on these ceramics, and theterm “micaceous” has been applied to a broad range of vessel typesregardless of the form, size, or amount of mica in their pastes. Our recentanalyses, including macroscopic evaluation combined with petrography andneutron activation analyses (NAA), indicate that only a small subset ofDismal River sherds are derived from New Mexico clays. The rest were likelymanufactured using materials from Colorado and Wyoming. Seasonal mobilitypatterns may have given Dismal River potters the opportunity to collect micaraw materials as they traveled between the Central Plains and Front Range,and this has implications for the importance of internal Plains socialnetworks during the Protohistoric and Historic periods.
We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.
Beginning with Kathleen Deagan’s description of the St. Augustine Pattern, in which domestic relations between Spanish men and Native American women contributed to a pattern of mestizaje in Spanish colonies, gender has assumed a central role in archaeological perspectives on colonial encounters. This is especially true for those encounters that accompanied colonialism in the Americas during the sixteenth through the nineteenth centuries. Gender relations were essential to the creation of new cultural identities during this time, as indigenous communities encountered immigrant, European settler groups often comprised mostly or entirely of adult men. Yet as significant as gender is for understanding how an encounter unfolded in time and space, it can be a challenge to identify and evaluate the archaeological correlates of such relations through material culture patterns. In this article, we use the related domains of food and foodways, particularly in the social context of provisioning, to evaluate how gender relations changed during the occupation of Fort San Juan de Joara (1566–1568), located at the Berry site in western North Carolina. Our research contributes to reappraisals of the St. Augustine Pattern, which posits well-defined roles for Native American women and Spanish men, by likewise situating the agency of Native American men.
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
In this balanced and critical overview, an international team of experts examines systematically the evidence in support of the effectiveness of cognitive-behavioral approaches to treating clinical problems across the lifespan. They analyse the cognitive models of psychopathology on which these treatments are based, and identify the clinical and conceptual problems, giving specific recommendations for addressing them. The range of disorders covered includes depression, anxiety, panic disorder, schizophrenia, OCD, personality disorders, eating disorders, post-traumatic stress disorder, conduct problems and addiction.