There remain important questions about how personality shapes risk perceptions, willingness to engage in protective behaviors, and policy preferences during a changing pandemic. Focusing on the Big-5 and COVID-19 attitudes, we find associations between risk perceptions and negative emotionality and agreeableness, as well as between each Big-5 trait and protective behaviors and support for government restrictions. These associations are mostly stable over time, with instability pronounced for lockdown policy support, where agreeableness and conscientiousness diminish in importance as pandemic conditions improve. Negative emotionality, conscientiousness, and agreeableness reduce differences between the political left and right and between those who do and do not trust experts. We highlight the heterogeneous interplay between personality and political ideology to understand pandemic policy support, attitudes, and behaviors.