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This paper provides an overview of the current status of ultrafast and ultra-intense lasers with peak powers exceeding 100 TW and examines the research activities in high-energy-density physics within China. Currently, 10 high-intensity lasers with powers over 100 TW are operational, and about 10 additional lasers are being constructed at various institutes and universities. These facilities operate either independently or are combined with one another, thereby offering substantial support for both Chinese and international research and development efforts in high-energy-density physics.
The emotion regulation network (ERN) in the brain provides a framework for understanding the neuropathology of affective disorders. Although previous neuroimaging studies have investigated the neurobiological correlates of the ERN in major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns in the ERN and whether the abnormal FC in the ERN can serve as a therapeutic response signature remain unclear.
Methods
A large functional magnetic resonance imaging dataset comprising 709 patients with MDD and 725 healthy controls (HCs) recruited across five sites was analyzed. Using a seed-based FC approach, we first investigated the group differences in whole-brain resting-state FC of the 14 ERN seeds between participants with and without MDD. Furthermore, an independent sample (45 MDD patients) was used to evaluate the relationship between the aforementioned abnormal FC in the ERN and symptom improvement after 8 weeks of antidepressant monotherapy.
Results
Compared to the HCs, patients with MDD exhibited aberrant FC between 7 ERN seeds and several cortical and subcortical areas, including the bilateral middle temporal gyrus, bilateral occipital gyrus, right thalamus, calcarine cortex, middle frontal gyrus, and the bilateral superior temporal gyrus. In an independent sample, these aberrant FCs in the ERN were negatively correlated with the reduction rate of the HAMD17 score among MDD patients.
Conclusions
These results might extend our understanding of the neurobiological underpinnings underlying unadaptable or inflexible emotional processing in MDD patients and help to elucidate the mechanisms of therapeutic response.
In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unified conclusion.
Methods
To address this variability, our study adopts a novel framework to parse individualized ALFF abnormalities. We hypothesize that individualized ALFF abnormalities can be portrayed as a unique linear combination of shared differential factors. Our study involved two large multi-center datasets, comprising 2424 patients with MDD and 2183 healthy controls. In patients, individualized ALFF abnormalities were derived through normative modeling and further deconstructed into differential factors using non-negative matrix factorization.
Results
Two positive and two negative factors were identified. These factors were closely linked to clinical characteristics and explained group-level ALFF abnormalities in the two datasets. Moreover, these factors exhibited distinct associations with the distribution of neurotransmitter receptors/transporters, transcriptional profiles of inflammation-related genes, and connectome-informed epicenters, underscoring their neurobiological relevance. Additionally, factor compositions facilitated the identification of four distinct depressive subtypes, each characterized by unique abnormal ALFF patterns and clinical features. Importantly, these findings were successfully replicated in another dataset with different acquisition equipment, protocols, preprocessing strategies, and medication statuses, validating their robustness and generalizability.
Conclusions
This research identifies shared differential factors underlying individual spontaneous neural activity abnormalities in MDD and contributes novel insights into the heterogeneity of spontaneous neural activity abnormalities in MDD.
Tea can improve the progression of some metabolic diseases through anti-inflammatory and antioxidant effects, but its impact on non-alcoholic fatty liver disease (NAFLD) is still controversial. The aim of this paper is to identify the relationship between tea and NAFLD by Mendelian randomisation (MR) and complete clinical validation using National Health and Nutrition Examination Survey (NHANES) database. MR used data from Genome Wide Association Study, with inverse-variance weighted (IVW) as principal analytical methods. The reliability of the results was verified by a series of sensitivity and heterogeneity tests. Subsequently, clinical validation was conducted using NHANES (2005–2018), involving 22 257 participants, grouped by the type of tea. Green tea drinkers were categorised into four groups (Q1–Q4) by quartiles of green tea intake, from lowest to highest (similar for black tea drinkers and other tea drinkers). Models were constructed by logistic regression to estimate the role of tea consumption (Q1–4) on NAFLD. Finally, using fibrosis-4 index (FIB-4) to evaluate the severity of hepatic fibrosis, the effect of tea consumption (Q1–4) on the degree of hepatic fibrosis was investigated by linear regression. IVW method (OR = 0·43, 95 % CI: 0·21, 0·85, P = 0·01) and weighted median method (OR = 0·35, 95 % CI: 0·14, 0·91, P = 0·03) revealed there was a causal relationship between tea and NAFLD. An array of sensitivity analyses validated the reliability of results. Analysis of NHANES indicated tea drinker present a slightly lower prevalence of NAFLD than non-tea drinker (green tea drinkers: 47·6 %, black tea drinkers: 46·3 %, other tea drinker: 43·2 %, non-tea drinkers: 48·1 %, P < 0·05). After adjusting for confounders, compared with the lowest black tea consumption (Q1), the population with the highest black tea consumption (Q4) was independently related to lower presence of NAFLD (Q4: OR = 0·69, 95 % CI: 0·50, 0·93, P < 0·05), such association remained stable in the overweight subgroup. As further analysed, Q4 also displayed a significant negative correlation with the level of hepatic fibrosis in patients with NAFLD (β = –0·073, 95 % CI: –0·126, −0·020, P < 0·01).Tea reduces the morbidity of NAFLD and ameliorates hepatic fibrosis degree in those already suffering from the disease.
To investigate the status quo of residents’ knowledge, attitude, belief, and practice (KABP) and social support and the correlation of KABP with social support under normalized coronavirus disease (COVID-19) pandemic prevention and control.
Methods:
A questionnaire was designed based on the KABP model, and an online survey was conducted among residents in September 2022. SPSS software (version 25.0) was used to analyze the data. Two independent sample t-tests, one-way analysis of variance (ANOVA), multivariate linear regression analysis, and Pearson’s correlation analysis were conducted.
Results:
In total, 326 valid questionnaires were obtained. The scoring rates of residents’ KABP and social support were 68.1%, 92.2%, 89.3%, 75.3%, and 62.6%, respectively. Main factors influencing residents’ knowledge included gender, nationality, education level, practice, and social support; those influencing attitude were belief and practice; those influencing belief were place of residence, attitude, and practice; those influencing practice were knowledge, attitude, belief, and social support; and those influencing social support were marital status, place of residence, knowledge, and practice. Social support was positively correlated with knowledge and practice.
Conclusions:
This study provides a scientific foundation for the current normalized prevention and control of COVID-19 and is conducive to health managers to better carry out prevention and control related health education for specific groups.
This paper explores the use of inkjet-printing technology for transparent transmitarrays, presenting a viable alternative to traditional copper microwire counterparts. The study focuses on achieving high-gain performance crucial for wireless communication systems, with a particular emphasis on the fifth-generation (5G) millimeter-wave communication. Transparent transmitarrays leverage transparent conducting films and conductive mesh structures, overcoming opacity limitations and seamlessly integrating with urban architecture. In this paper, the inkjet-printing process is detailed for fabricating transmitarray apertures, highlighting the flexibility and precision in depositing nanosilver particles onto a glass substrate. The design intricacies involve optimizing feeding characteristics, determining unit cell structures, and constructing transmitarrays of various sizes. To validate the proposed technique, three different apertures (15 × 15, 20 × 20, and 25 × 25 unit cells) are constructed. The antenna performances are evaluated in terms of reflection coefficients, radiation efficiency, realized gain, and patterns, demonstrating the effectiveness of inkjet-printed transmitarrays. Comparative analysis with copper microwire counterparts is also conducted, validating the inkjet-printing technology for similar gain performance with added advantages of flexibility, compatibility with transparent substrates, and cost-effective manufacturing.
The gibbons (family Hylobatidae) represent one of world’s most threatened group of taxa. In theory they are an attractive group for interdisciplinary research but are often unconsciously overlooked. We conducted a systematic review in Web of Science and Google Scholar between January 1900 and February 2020 using PRISMA guidelines and strict search criteria to investigate (1) the number of mixed-method biosocial studies published on gibbons; (2) focus species and countries; (3) social analytical approaches used; and (4) the success of this approach in elucidating conservation issues. Only 31 mixed-method biosocial studies have been published on gibbons, 56 per cent on Nomascus species but none on Symphalangus. China and Vietnam were the most popular study locations. Optimistically, 68 per cent of publications were led by gibbon-range country researchers, but only 48 per cent of studies represented international collaborations; 81 per cent of studies addressed a conservation-related topic, highlighting the potential efficacy of using this approach in primate conservation research. However, few studies provided details of data collection methods, methods of analysis and sample sizes, and only one study used an anthropological analytical approach. We therefore encourage further cross-disciplinary international collaborations to better our understanding of human–gibbon relations on a deeper, more contextual level.
Except for the eastern hoolock (Hoolock leuconedys), all gibbon species are regarded as critically endangered or endangered. The rediscovery of the Cao vit gibbon (Nomascus nasutus) in 2002 was exciting news for gibbon conservationists. However, its importance was hindered by disputation of its species status. Herein, we review the taxonomy, ecology and conservation of N. nasutus since its rediscovery. Morphology, vocalisations and genetic evidence suggests that N. nasutus is a distinct species from the western black-crested gibbon (N. concolor) and Hainan gibbon (N. hainanus). There is one confirmed population of approximately 120 individuals in a small karst forest along the China–Vietnam border. Although their habitat has been degraded by human activities, they have adapted behavioural strategies to life in karst forest, and reproduction has been successful. Two reserves have been established in both Vietnam and China, and no hunting has been reported. Besides goat grazing, human disturbances have largely been eliminated or controlled. Successful transboundary conservation interventions have contributed to this population’s slow increase despite it approaching its habitat carrying capacity. Habitat restoration is a priority for this species’ conservation. Future research directions include long-term population monitoring, karst forest restoration, impacts of human disturbances, and intra- and inter-species food competition.
Gibbons and siamangs (termed ‘gibbons’ hereafter) are members of the family Hylobatidae and are the smallest of the apes, distinguished by their coordinated duets, territorial songs, arm-swinging locomotion and small family group sizes. They are the most speciose of the apes with four extant genera (Hylobates, Hoolock, Symphalangus and Nomascus) distributed across East and Southeast Asia. Of the 20 species, 95 per cent are considered critically endangered or endangered according to the International Union for Conservation of Nature (IUCN) Red List of Threatened Species (Rawson et al., 2011; Fan and Bartlett, 2017; IUCN, 2021).
Hylobatids (gibbons and siamangs) are the smallest of the apes distinguished by their coordinated duets, territorial songs, arm-swinging locomotion, and small family group sizes. Although they are the most speciose of the apes boasting twenty species living in eleven countries, ninety-five percent are critically endangered or endangered according to the IUCN's Red List of Threatened Species. Despite this, gibbons are often referred to as being 'forgotten' in the shadow of their great ape cousins because comparably they receive less research, funding and conservation attention. This is only the third book since the 1980s devoted to gibbons, and presents cutting-edge research covering a wide variety of topics including hylobatid ecology, conservation, phylogenetics and taxonomy. Written by gibbon researchers and practitioners from across the world, the book discusses conservation challenges in the Anthropocene and presents practice-based approaches and strategies to save these singing, swinging apes from extinction.
In this paper, we study the asymptotic profiles of positive solutions for diffusive logistic equations. The aim is to study the sharp effect of linear growth and nonlinear function. Both the classical reaction-diffusion equation and nonlocal dispersal equation are investigated. Our main results reveal that the linear and nonlinear parts of reaction term play quite different roles in the study of positive solutions.
The uplift history of northeastern Asian continental margin has been the subject of much debate. The Sanjiang Basin is an ideal area to investigate the uplift history of this margin. We present new data from sandstone petrology, whole-rock geochemistry, U–Pb geochronology and Hf isotopy of detrital zircons to trace the provenance of the basin and to unravel the uplift history of the northeastern Asian continental margin. We investigated the chemical and plagioclase indices of alteration and index of compositional variability (CIA, PIA and ICV, respectively) in samples from two formations. The geochemical proxies indicate that source rocks were subjected to an intensified weathering process. Based on the high SiO2/Al2O3 values and low K2O, we infer that the two basinal strata experienced silicification and insignificant potassium metasomatism. Sandstone petrography is indicative of low degrees of sedimentary sorting, suggesting a proximal deposition. The provenance fingerprints of light rare earth, high-field-strength and transition metal elements indicate that parts of the provenance included recycled sediments, and that first-cycle sediments were derived mainly from felsic rocks with a minor contribution from intermediate and mafic rocks. The combined detrital zircon U–Pb ages and Hf isotopic results constrain the contributions of different source terranes over time. The provenance results, in combination with seismic profile interpretations from the Sanjiang Basin, suggest that the northeastern Asian continental margin experienced at least three stages of uplift, which were driven by subduction initiation of the Paleo-Pacific Ocean during the Jurassic Period, a plate motion change during the Early Cretaceous Epoch, and a shallowing of the slab dip angle during the Late Cretaceous Epoch.
For $n\geq 3$, let $Q_n\subset \mathbb {C}$ be an arbitrary regular n-sided polygon. We prove that the Cauchy transform $F_{Q_n}$ of the normalised two-dimensional Lebesgue measure on $Q_n$ is univalent and starlike but not convex in $\widehat {\mathbb {C}}\setminus Q_n$.
The flow structures and the acoustic feedback loops of underexpanded round jets are investigated by numerical simulations. The jets have a Mach number of 1 at the nozzle exit and a diameter-based Reynolds number of $2.5 \times {10^3}$. Three nozzle pressure ratios (NPRs) of 2.2, 2.4 and 2.6 are considered. The wavelengths of the screech tones are in good agreement with the experimental measurements on high-Reynolds-number jets in the literature. The screech tones are respectively at the A1 and B modes for the jets at NPRs of 2.2 and 2.6. Two screech tones at the A2 and B modes are identified in the jet at the NPR of 2.4 and the wavelet analyses conducted on the pressure fluctuations confirm that these two modes are contemporaneous. The amplitude and phase fields of fluctuating pressure at the screech frequencies are presented in the nozzle exit plane and azimuthal planes. The effective source locations of the screech tones are determined based on the distributions of the phase. The number of periods contained in the screech feedback loop is equal to the number of cells in the standing wave between the nozzle exit and the effective source. The screech frequencies estimated by the classical feedback model agree well with the numerical results at different modes. A modified model, in which the classical feedback model and the upstream-propagating acoustic wave mode of the jet are combined, shows that the screech feedback loops at the A1 and A2 modes are associated with the same acoustic wave mode. The modified model fails to estimate the screech frequencies at the B mode. Different feedback mechanisms lead to the coexistence of the A2 and B modes. The coherent structures corresponding to different screech modes are extracted by dynamic mode decomposition.