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Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.
The H3N2 canine influenza virus (CIV) emerged from an avian reservoir in Asia to circulate entirely among dogs for the last 20 years. The virus was first seen circulating outside Asian dog populations in 2015, in North America. Utilizing viral genomic data in addition to clinical reports and diagnostic testing data, we provide an updated analysis of the evolution and epidemiology of the virus in its canine host. CIV in dogs in North America is marked by a complex life history – including local outbreaks, regional lineage die-outs, and repeated reintroductions of the virus (with diverse genotypes) from different regions of Asia. Phylogenetic and Bayesian analysis reveal multiple CIV clades, and viruses from China have seeded recent North American outbreaks, with 2 or 3 introductions in the past 3 years. Genomic epidemiology confirms that within North America the virus spreads very rapidly among dogs in kennels and shelters in different regions – but then dies out locally. The overall epidemic therefore requires longer-distance dispersal of virus to maintain outbreaks over the long term. With a constant evolutionary rate over 20 years, CIV still appears best adapted to transmission in dense populations and has not gained properties for prolonged circulation among dogs.
With the rise of online references, podcasts, webinars, self-test tools, and social media, it is worthwhile to understand whether textbooks continue to provide value in medical education, and to assess the capacity they serve during fellowship training.
Methods:
A prospective mixed-methods study based on surveys that were disseminated to seven paediatric cardiology fellowship programmes around the world. Participants were asked to read an assigned chapter of Anderson’s Pediatric Cardiology 4th Edition textbook, followed by the completion of the survey. Open-ended questions included theming and grouping responses as appropriate.
Results:
The survey was completed by 36 participants. When asked about the content, organisation, and utility of the chapter, responses were generally positive, at greater than 89%. The chapters, overall, were rated relatively easy to read, scoring at 6.91, with standard deviations plus or minus 1.72, on a scale from 1 to 10, with higher values meaning better results. When asked to rank their preferences in where they obtain educational content, textbooks were ranked the second highest, with in-person teaching ranking first. Several themes were identified including the limitations of the use of textbook use, their value, and ways to enhance learning from their reading. There was also a near-unanimous desire for more time to self-learn and read during fellowship.
Conclusions:
Textbooks are still highly valued by trainees. Many opportunities exist, nonetheless, to improve how they can be organised to deliver information optimally. Future efforts should look towards making them more accessible, and to include more resources for asynchronous learning.
The Maungaparerua halloysite deposit is located on the North Island of New Zealand some 210 km north of Auckland. The halloysite deposit was formed by hydrothermal alteration of rhyolite flow rocks. Superimposed on the hydrothermally altered halloysite is deep intensive surficial weathering resulting from the humid climate on the extreme tip of the North Island. The deposit has been drilled and the cores have been analyzed mineralogically and chemically. Drilling has shown that the deposit is circular or ovate and covers about 350 acres. The altered rocks contain about 50% quartz and fine amorphous silica and 50% of a mix of halloysite, kaolinite, and allophane with a small amount of plagioclase feldspar in the coarse fraction. The upper 8–30m, with an average of 15m, of the halloysite alteration deposit consists of relatively soft clay. Below this soft clay, which is the result of intense surficial weathering, the clay becomes hard and dense. The halloysite and kaolin from this deposit are mined and beneficiated using wet process techniques of dispersion, centrifugation, leaching, dewatering, and drying. The products are used as filler in paper, paint, and plastics and as a ceramic raw material for producing whiteware and fine china. This deposit is unique in that it contains a very high proportion of halloysite in the clay fraction. The detailed geology, mineralogy, geochemistry, and the physical properties of the clay will be discussed.
Aqueous Al passes from octahedral to tetrahedral coordination over a narrow pH interval, or threshold. This interval is 5.5–6.5 at 25°C and shifts to lower pH as temperature increases. The concentration of aqueous tetrahedrally coordinated Al is a quasi-step function of the solution pH, and, by the mass-action law, so should be the amount of tetrahedral Al incorporated by a silicate that crystallizes from the aqueous solution. Qualitative support for this prediction (which applies to quartz, opal-CT, kaolin-group minerals, pyrophyllite, micas, chlorites, and other low-temperature silicates) comes from the very topology of equilibrium activity diagrams and from several pairs of associated waters and authigenic silicates from weathering, hydrothermal, and diagenetic environments. The uptake of tetrahedral Al also depends on the aqueous concentrations of monovalent cations and silica, and on the mineral's structural constraints.
Solid solution of tetrahedral Al in halloysite in turn produces the characteristic bent or tubular crystals of this mineral. This genetic link between aqueous chemistry (mainly pH), tetrahedral-Al uptake by a low-temperature silicate, and the mineral's crystal morphology may operate also in other silicates.
The first stage of lateritic weathering of pyroxenes in the Niquelandia area, Brazil, leads either to Fe-rich products or to a phyllosilicate clay. In relatively unfractured parent rock the phyllosilicate clay contains Ni-rich smectites, the atomic ratio of Ni: octahedral cations ranging from 0.3 to 0.5. These smectites were studied by polarized light microscopy, X-ray powder diffraction (XRD), transmission electron microscopy, and electron microprobe, and infrared, optical absorption, Mössbauer, and extended X-ray absorption fine-structure (EXAFS) spectroscopy. The chemical composition of the smectite is constant on the optical microscope scale even to the smallest analyzed particles (3000 A in diameter and about 75 Å thick). From XRD data the mineral is principally a swelling, trioctahedral smectite; however, some kerolite-pimelite-like layers are present, and a weak 06,33 reflection indicates the presence of a small amount of a dioctahedral phase. Mössbauer results show that all Fe cations are Fe3+ in octahedral sites. The structural formula of the smectite is: (Ca0.01K0.05)(Al0.17Fe0.5Mg0.48Ni1.47Cr0.02)(Si3.92Al0.08)O10(OH)2
The results obtained from all the above methods suggest that in the smectites Ni, and, perhaps, a small amount of Mg are clustered in pimelite-like domains (or layers), whereas Fe and some Al are clustered in nontronite-like domains (or layers). Most selected-area electron diffraction patterns exhibit continuous or punctuated (hk) rings, indicating that particles contain several stacked layers. The patterns of some thin particles, however, suggest dioctahedral layers having trans-octahedral vacancies, such as in the Garfield, Washington, nontronite. Thus, the Ni-Fe-Mg-smectite, which seemingly is homogeneous, actually consists of mixed trioctahedral and dioctahedral layers or domains.
Gadfly petrels Pterodroma spp. are among the most threatened bird taxa. Conservation interventions have been successfully developed and applied for some gadfly petrel species, but a substantial gap remains in conservation science for this group in the tropical Pacific Ocean. The Vanuatu Petrel Pterodroma [cervicalis] occulta is an ideal exemplar to develop a pipeline for conservation science in tropical Pacific gadfly petrels as it is subject to many of the challenges facing other gadfly petrel taxa in the region. We review over 40 pelagic Vanuatu Petrel records and five research expeditions to the only known colony on the island of Vanua Lava, Vanuatu. These records provide a baseline from which to recommend conservation research actions for the taxon. The population status, taxonomy, distribution, and threat profile of the taxon are all poorly known, and these areas are high priorities for future research.
Surgical repair of channels between the ventricles is enhanced when the surgeon knows precisely where to place a patch, or baffle, so as to restore septal integrity. The paediatric cardiologist should provide the necessary information. Communication will be enhanced if the same words are used to account for the structures in question. Currently, however, the same term, namely “ventricular septal defect,” is used to account for markedly different areas within the heart. Closure of perimembranous defects found in hearts with concordant or discordant ventriculo-arterial connections restores the integrity of the ventricular septum, at the same time separating the systemic and pulmonary blood streams. When both arterial trunks arise from the right ventricle, in contrast, the surgeon when placing a baffle so as to separate the blood streams, does not close the channel most frequently described as the “ventricular septal defect.” In this review, we show that the perimembranous lesions as found in hearts with concordant or discordant ventriculo-arterial connections are the right ventricular entrances to the areas subtended beneath the hinges of the leaflets of the aortic or pulmonary valves. When both arterial trunks arise from the right ventricle, and the channel between the ventricles is directly subaortic, then the channel termed the “ventricular septal defect” is the left ventricular entrance to the comparable space subtended beneath the aortic root. We argue that recognition of these fundamental anatomical differences enhances the appreciation of the underlying morphology of the various lesions that reflect transfer, during cardiac development, of the aortic root from the morphologically right to the morphologically left ventricle.
Studies about brain structure in bipolar disorder have reported conflicting findings. These findings may be explained by the high degree of heterogeneity within bipolar disorder, especially if structural differences are mapped to single brain regions rather than networks.
Aims
We aim to complete a systematic review and meta-analysis to identify brain networks underlying structural abnormalities observed on T1-weighted magnetic resonance imaging scans in bipolar disorder across the lifespan. We also aim to explore how these brain networks are affected by sociodemographic and clinical heterogeneity in bipolar disorder.
Method
We will include case–control studies that focus on whole-brain analyses of structural differences between participants of any age with a standardised diagnosis of bipolar disorder and controls. The electronic databases Medline, PsycINFO and Web of Science will be searched. We will complete an activation likelihood estimation analysis and a novel coordinate-based network mapping approach to identify specific brain regions and brain circuits affected in bipolar disorder or relevant subgroups. Meta-regressions will examine the effect of sociodemographic and clinical variables on identified brain circuits.
Conclusions
Findings from this systematic review and meta-analysis will enhance understanding of the pathophysiology of bipolar disorder. The results will identify brain circuitry implicated in bipolar disorder, and how they may relate to relevant sociodemographic and clinical variables across the lifespan.
The recent achievement of fusion ignition with laser-driven technologies at the National Ignition Facility sets a historic accomplishment in fusion energy research. This accomplishment paves the way for using laser inertial fusion as a viable approach for future energy production. Europe has a unique opportunity to empower research in this field internationally, and the scientific community is eager to engage in this journey. We propose establishing a European programme on inertial-fusion energy with the mission to demonstrate laser-driven ignition in the direct-drive scheme and to develop pathway technologies for the commercial fusion reactor. The proposed roadmap is based on four complementary axes: (i) the physics of laser–plasma interaction and burning plasmas; (ii) high-energy high repetition rate laser technology; (iii) fusion reactor technology and materials; and (iv) reinforcement of the laser fusion community by international education and training programmes. We foresee collaboration with universities, research centres and industry and establishing joint activities with the private sector involved in laser fusion. This project aims to stimulate a broad range of high-profile industrial developments in laser, plasma and radiation technologies along with the expected high-level socio-economic impact.
Dentists prescribe 10% of all outpatient antibiotics in the United States and are the top specialty prescriber. Data on current antibiotic prescribing trends are scarce. Therefore, we evaluated trends in antibiotic prescribing rates by dentists, and we further assessed whether these trends differed by agent, specialty, and by patient characteristics.
Design:
Retrospective study of dental antibiotic prescribing included data from the IQVIA Longitudinal Prescription Data set from January 1, 2012 to December 31, 2019.
Methods:
The change in the dentist prescribing rate and mean days’ supply were evaluated using linear regression models.
Results:
Dentists wrote >216 million antibiotic prescriptions between 2012 and 2019. The annual dental antibiotic prescribing rate remained steady over time (P = .5915). However, the dental prescribing rate (antibiotic prescriptions per 1,000 dentists) increased in the Northeast (by 1,313 antibiotics per 1,000 dentists per year), among oral and maxillofacial surgeons (n = 13,054), prosthodontists (n = 2,381), endodontists (n = 2,255), periodontists (n = 1,961), and for amoxicillin (n = 2,562; P < .04 for all). The mean days’ supply significantly decreased over the study period by 0.023 days per 1,000 dentists per year (P < .001).
Conclusions:
From 2012 to 2019, dental prescribing rates for antibiotics remained unchanged, despite decreases in antibiotic prescribing nationally and changes in guidelines during the study period. However, mean days’ supply decreased over time. Dental specialties, such as oral and maxillofacial surgeons, had the highest prescribing rate with increases over time. Antibiotic stewardship efforts to improve unnecessary prescribing by dentists and targeting dental specialists may decrease overall antibiotic prescribing rates by dentists.
Scotland has low number of Gaelic speakers and as a consequence the addition of new speakers to the total mix of interlocutors is far more significant. However, the Gaelic language figures far less prominently as an element of both Scottish identity and public investment. Accordingly, with far fewer agencies and actors involved it may be easier to discern the role which the new speaker concept plays in policy discourse and resultant interventions. One complicating factor is the lack of a shared perspective on which elements should be prioritised in Gaelic language promotion and policy. On the one hand there are proponents who argue that as the Gaelic communities are in crisis all efforts should be prioritised into stabilising and sustaining language transmission within these atrophying communities. Others acknowledge the perilous state of traditional communities but argue that support is needed wherever Gaelic is present and elements such as Gaelic-medium education, the media and opportunities for new speakers to flourish also deserve attention. Both perspectives are reflective of what may be called the beleaguered self and contain a fair number of non-cognitive emotional predispositions which colour the rational debate on what is to be done. Consequently tension, disagreement, anger, grief and recrimination can come to shape the various discourses surrounding language policy. In a large-scale language community such fears can be absorbed as part of the general cut and thrust and may not presage any lack of mutual respect and constructive dialogue. But in a small, marginal context such tensions can lead to institutional polarisation between contending agencies and render the central thrust of language promotion less effective.
Chapter 7 investigates the reception of, and approach to, new speakers in Catalonia and Galicia. There is considerable evidence of a buy-in to the need to integrate new speakers and thus not only boost the profile of the respective language but also add to social cohesion in an increasingly multicultural and multilingual context. Particular attention is paid to the role of the Voluntariat per la Llengua programme in Catalonia.This pairs indigenous speakers with Catalan learners, several of whom migrated to Catalonia from Africa and Asia. Not only are the linguistic skills of the migrants improved by the programme but so also is the level of social cohesion and integration into the host community. Neofalantes in Galicia offer a quite distinct version of the new speaker phenomenon involving dual or mixed identities, ideological tension and challenges to official policies as to how best to represent the needs and demands of this small but very active section of society.
Chapter 8 is concerned with the policy community and in making recommendations at international, state, regional and local levels. The first task is to refine the results of the study, the second is to determine a set of generic observations and the third is to present country-specific recommendations. Defining a recommendation and distinguishing it from mere wish fulfilment are by no means simple tasks and some recommendations available in the literature are so general that it is difficult to interpret their meaning with any degree of precision. That is why the recommendations should be realisable. The chapters offers a suite of generic recommendations suitable for consideration in many jurisdictions before moving on to suggest very specific recommendations for each of the eight case study jurisdictions investigated. A certain reticence in acknowledging the salience of these recommendations is particularly characteristic of international migrants, refugees and what are sometime called translational workers as national and local authorities will determine that their obligation is to provide instruction in each state”s dominant language so as to enable the residents to function within the “normal” parameters of the educational, health and social services. Accordingly, while the focus of the investigation is on the reception and adoption of the new speaker concept as an element in policy formulation, the narrative also seeks to strengthen the interpretation by providing additional information on the various contexts within which the investigation was undertaken.