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The 2007 adoption of the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) marked a critical juncture in the area of Indigenous rights. As a nonbinding agreement, its adoption is at the discretion of each state, resulting in significant state-level variation. Importantly, within-state variations remain underexplored. These differences are potentially significant in federal, decentralized countries such as Canada. This article examines why some provinces and territories lead in implementing the key principles embedded in UNDRIP, whereas others have dragged their feet. We collected 230 Canadian regulations introduced at the subnational level between 2007 and 2023, and assessed the impact of three key variables (i.e. political ideology, resource politics and issue voting). We found that none of these variables explained within-state variations on their own. To further explore the role of these variables, we subsequently compared two provinces at different stages of the UNDRIP implementation spectrum (Québec and British Columbia).
Yeats was an important – if sometimes ambivalent – early supporter of O’Casey. As co-director of the Abbey, Yeats played an important part in first getting O’Casey’s Dublin writing to the stage and in defending that work from critics. Yet, although the Abbey had fostered O’Casey’s talents, W. B. Yeats led his fellow directions in rejecting O’Casey’s 1928 work The Silver Tassie in a way that had a major impact both upon O’Casey’s career and upon the Abbey Theatre’s own history. This chapter interrogates the relationship between O’Casey and Yeats, which is inextricably bound to central tensions at the heart of the early years of the Abbey Theatre.
The implications contained in Richardson's article on item analysis in March 1936 issue of Psychometrika are examined in the light of multiple factor theory. It is shown that item analysis is a necessary, but not a sufficient condition for the construction of a test which shall measure a single trait. The intercorrelations of certain items selected by a method of item analysis are examined, found to contain many zero and some negative correlations. Multiple factor analysis showed that eight traits were measured by the items which had been asserted to measure only one.
A rigorous and an approximate solution are found for the problem: Given a primary trait matrix for n tests and r1 traits, and a matrix for the same n tests and r2 reference axes, to discover the transformation which will transform the second matrix into the first, or primary trait matrix. Formulas for determining the limits of the effect of using the approximate solution are presented. The method is applied to a set of twenty hypothetical tests, defined by their loadings on four orthogonal primary traits. After factoring the inter-correlations of these variables by Thurstone's centroid method, approximating the diagonals, the original hypothetical matrix is reproduced with a root mean square discrepancy of .014 by assuming as known the primary trait loadings of only the first eight tests. The method is applied to the results of factoring two batteries of 14 tests, having 8 tests in common, to give the factor loadings of the two batteries on the same reference axes. The method provides a means of comparing directly and quantitatively the results of two different factor studies, provided they have tests in common, and of testing the stability of simple structure under changes in the battery. The relations of the method here developed to certain problems in multiple correlation are shown.
A modification of the method of successive intervals is presented which yields scale values correlating .995 with those from Thurstone's method described by Saffir. Values yielded by the present method can be obtained in 25 per cent of the time required by the older method and are shown to be, on a priori grounds, more reliable as well.
Correlation coefficients derived from an hypothetical simple structure for twenty tests and four factors were “loaded” with chance error components. Centroid analyses and rotations to give least square determinations of the hypothetical simple structure were made for several conditions. It is concluded that the experimental situation of inaccurate coefficients and estimated communalities permits accurate determination of primary trait loadings provided that the rank of the centroid matrix is equal to or greater than that of the underlying primary trait matrix. Of several criteria for the completeness of factorization which were tested, none was wholly satisfactory.
It is shown that by making the assumption that the knowledge of the test-item and the knowledge of the entire test are both distributed normally, the correlation coefficient between any item and the entire test can be expressed as a function solely of two proportions — the percentage of a high-scoring group passing the item and the percentage of a low-scoring group passing the item. This function is expressed graphically as a family of curves for each of two conditions — where the high-scoring and low-scoring groups are samples of the highest and the lowest quarters respectively, and where they are samples from the upper and lower halves. It is shown, moreover, that two other common measures of item validity, the upper-lower difference and the critical ratio of the upper-lower difference, may be drawn on the same coordinate axes.
In an attempt to investigate the concept of neurotic tendency thirty-nine of the forty-two most discriminative items in the Thurstone Neurotic Inventory were administered as a questionnaire to a group of five hundred male college students. An analysis of the table of intercorrelations by Thurstone's centroid method showed that eight factors were sufficient to account for the observed intercorrelations with negligible residuals. The eight centroid factors were then transformed into a simple structure. It is concluded that a single trait of neurotic tendency cannot be postulated and tentative hypotheses are formed as to the nature of the primary traits revealed by the analysis.
Readministering the same test to the same students a week later showed a high consistency of response both on the test as a whole, and on the individual items.
A general formula for the reliability of a weighted composite has been derived by which that reliability can be estimated from a knowledge of the weights whatever their source, reliabilities, dispersions, and intercorrelations of the components. The Spearman-Brown formula has been shown to be a special case of the general statement. The effect of the internal consistency or intercorrelation of the components has been investigated and the conditions defining the set of weights yielding maximum reliability shown to be that the weight of a component is proportional to the sum of its intercorrelations with the remaining components and inversely proportional to its error variance.
School-based interventions encouraging children to replace sugar-sweetened beverages with water show promise for reducing child overweight. However, students with child food insecurity (CFI) may not respond to nutrition interventions like children who are food-secure.
Design:
The Water First cluster-randomised trial found that school water access and promotion prevented child overweight and increased water intake. This secondary analysis used mixed-effects regression to evaluate the interaction between the Water First intervention and food insecurity, measured using the Child Food Security Assessment, on child weight status (anthropometric measurements) and dietary intake (student 24-h recalls, beverage intake surveys).
Setting:
Eighteen elementary schools (serving ≥ 50 % children from low-income households), in which drinking water had not been previously promoted, in the San Francisco Bay Area.
Participants:
Students in fourth-grade classes (n 1056).
Results:
Food insecurity interacted with the intervention. Among students with no CFI, the intervention group had a lower prevalence of obesity from baseline to 7 months (–0·04, CI –0·08, 0·01) compared with no CFI controls (0·01, CI –0·01, 0·04) (P = 0·04). Among students with high CFI, the intervention group had a pronounced increase in the volume of water consumed between baseline and 7 months (86·2 %, CI 21·7, 185·0 %) compared with high CFI controls (–13·6 %, CI –45·3, 36·6 %) (P = 0·02).
Conclusions:
Addressing food insecurity in the design of water promotion interventions may enhance the benefit to children, reducing the prevalence of obesity.
OBJECTIVES/GOALS: Clinical and translational science needs to address roadblocks to translational processes. We conducted a survey at two institutions, a private medical school and a large public university, to understand the frequency and distribution of barriers and roadblocks to research. METHODS/STUDY POPULATION: We reviewed the literature to compile a pool of barriers and roadblocks and convened a panel of relevant stakeholders to develop a 20-item questionnaire. Survey respondents were asked to select and prioritize the five leading clinical and translational roadblocks, provide information regarding their academic degrees and rank/position, complete open-ended items regarding their areas of research, and optionally add additional remarks in a comment box. The survey was disseminated in August 2022 via REDCap to faculty and staff with active research protocols at Baylor College of Medicine and the University of Houston. RESULTS/ANTICIPATED RESULTS: In total, 227 respondents completed the survey. Their disciplines were basic science (29.5%), translational research (52.9%), clinical research (55.5%), community-engaged research (9.7%), and educational research (9.7%). Respondents identified 1) lack of access to trained research coordinators, 2) lack of understanding about different resources that facilitate research, 3) complex regulatory environment and delays, 4) fragmented infrastructure for administrative and fiscal processes, and 5) inadequate funding for pilot projects to foster new research. Other roadblocks included lack of established community stakeholder partnerships, inadequate access to medical record data, and limited biostatistical support. In the comments, several respondents noted that all items included were important. DISCUSSION/SIGNIFICANCE: Research workforce recruitment/training was the highest priority followed by lack of access to information and administrative bottlenecks. We are building an online portal to increase awareness and simplify access to competency-based training and research services. Initiatives are underway to address other roadblocks.
Employing a developmental psychopathology framework, we tested the utility of the hormesis model in examining the strengthening of children and youth through limited levels of adversity in relation to internalizing and externalizing outcomes within a brain-by-development context.
Methods:
Analyzing data from the Adolescent Brain and Cognitive Development study (N = 11,878), we formed latent factors of threat, deprivation, and unpredictability. We examined linear and nonlinear associations between adversity dimensions and youth psychopathology symptoms and how change of resting-state functional connectivity (rsFC) in the default mode network (DMN) from Time 1 to Time 5 moderates these associations.
Results:
A cubic association was found between threat and youth internalizing problems; low-to-moderate family conflict levels reduced these problems. Deprivation also displayed a cubic relation with youth externalizing problems, with moderate deprivation levels associated with fewer problems. Unpredictability linearly increased both problem types. Change in DMN rsFC significantly moderated the cubic link between threat levels and internalizing problems, with declining DMN rsFC levels from Time 1 to Time 5 facilitating hormesis. Hormetic effects peaked earlier, emphasizing the importance of sensitive periods and developmental timing of outcomes related to earlier experiences.
Conclusions:
Strengthening through limited environmental adversity is crucial for developing human resilience. Understanding this process requires considering both linear and nonlinear adversity-psychopathology associations. Testing individual differences by brain and developmental context will inform preventive intervention programming.
To test vitamin D3 and omega-3s for late-life depression prevention under the National Academy of Medicine framework for indicated (targeting subthreshold depression) and selective (targeting presence of high-risk factors) prevention.
Methods:
VITamin D and OmegA-3 TriaL (VITAL) is a 2x2 factorial trial of vitamin D3 (2000 IU/day) and/or omega-3s (1 g/day) for cardiovascular and cancer prevention (enrollment: November 2011-March 2014; end date: December 31, 2017). In this targeted prevention study, we included 720 VITAL clinical sub-cohort participants who completed neurobehavioral assessments at baseline and 2 years (91.9% retention). High-risk factors were: subthreshold or clinical anxiety, impaired activities of daily living, physical/functional limitation, medical comorbidity, cognitive impairment, caregiving burden, problem drinking, and low psychosocial support. Co-primary outcomes were: incident major depression (MDD), adjudicated using DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th edition); change in mood (Patient Health Questionnaire-9 [PHQ-9]). We used exact tests to determine treatment effects on MDD incidence and repeated measures models to determine treatment effects on PHQ-9.
Results:
11.1% had subthreshold depression, 60.8% had ≥1 high-risk factors, MDD incidence=4.7% (5.0% among completers), and mean PHQ-9 change=0.02 points. Among those with subthreshold depression, the MDD risk ratio (95% confidence intervals)=0.36 (0.06 to 1.28) for vitamin D3 and 0.85 (0.25 to 2.92) for omega-3s, compared to placebos; results were also null among those with ≥1 high-risk factors [vitamin D3 vs. placebo: 0.63 (0.25 to 1.53); omega-3s vs. placebo: 1.08 (0.46 to 2.71)]. There were no significant differences in PHQ-9 change comparing either supplement with placebo.
Conclusion:
Neither vitamin D3 nor omega-3s showed benefits for indicated and selective prevention of late-life depression; statistical power was limited.