The interaction of helminth infections with type 2 diabetes (T2D) has been a major area of research in the past few years. This paper, therefore, focuses on the systematic review of the effects of helminthic infections on metabolism and immune regulation related to T2D, with mechanisms through which both direct and indirect effects are mediated. Specifically, the possible therapeutic role of helminths in T2D management, probably mediated through the modulation of host metabolic pathways and immune responses, is of special interest. This paper discusses the current possibilities for translating helminth therapy from basic laboratory research to clinical application, as well as existing and future challenges. Although preliminary studies suggest the potential for helminth therapy for T2D patients, their safety and efficacy still need to be confirmed by larger-scale clinical studies.

In this paper, a brand-new adaptive fault-tolerant non-affine integrated guidance and control method based on reinforcement learning is proposed for a class of skid-to-turn (STT) missile. Firstly, considering the non-affine characteristics of the missile, a new non-affine integrated guidance and control (NAIGC) design model is constructed. For the NAIGC system, an adaptive expansion integral system is introduced to address the issue of challenging control brought on by the non-affine form of the control signal. Subsequently, the hyperbolic tangent function and adaptive boundary estimation are utilised to lessen the jitter due to disturbances in the control system and the deviation caused by actuator failures while taking into account the uncertainty in the NAIGC system. Importantly, actor-critic is introduced into the control framework, where the actor network aims to deal with the multiple uncertainties of the subsystem and generate the control input based on the critic results. Eventually, not only is the stability of the NAIGC closed-loop system demonstrated using Lyapunov theory, but also the validity and superiority of the method are verified by numerical simulations.

Aircraft ground taxiing contributes significantly to carbon emissions and engine wear. The electric towing tractor (ETT) addresses these issues by towing the aircraft to the runway end, thereby minimising ground taxiing. As the complexity of ETT towing operations increases, both the towing distance and time increase significantly, and the original method for estimating the number of ETTs is no longer applicable. Due to the substantial acquisition cost of ETT and the need to reduce waste while ensuring operational efficiency, this paper introduces for the first time an ETT quantity estimation model that combines simulation and vehicle scheduling models. The simulation model simulates the impact of ETT on apron operations, taxiing on taxiways and takeoffs and landings on runways. Key timing points for ETT usage by each aircraft are identified through simulation, forming the basis for determining the minimum number of vehicles required for airport operations using a hard-time window vehicle scheduling model. To ensure the validity of the model, simulation model verification is conducted. Furthermore, the study explores the influence of vehicle speed and airport scale on the required number of ETTs. The results demonstrate the effective representation of real-airport operations by the simulation model. ETT speed, airport runway and taxiway configurations, takeoff and landing frequencies and imbalances during peak periods all impact the required quantity of ETTs. A comprehensive approach considering these factors is necessary to determine the optimal number of ETTs.

In this paper, an adaptive neural output-constrained control algorithm is proposed for a class of non-affine kinetic kill vehicle (KKV) systems. The key point is that the non-affine control law can be designed and the output of the KKV system conform to the output limit with the aid of the proposed method. Due to the aerodynamic moments, the actual control torque is non-affine, which can be addressed by introducing an integral process to the design of the controller. Besides, in order to improve the control precision, a nonlinear mapping is put forward so that the output constraint can be transformed to the constraint of the introduced dynamic signal that can be simply achieved. From the simulation results it can be concluded that the states of the KKV system can track the desired trajectories in spite of different working conditions and the control precision is higher compared with other control methods.

The target backsheath field acceleration mechanism is one of the main mechanisms of laser-driven proton acceleration (LDPA) and strongly depends on the comprehensive performance of the ultrashort ultra-intense lasers used as the driving sources. The successful use of the SG-II Peta-watt (SG-II PW) laser facility for LDPA and its applications in radiographic diagnoses have been manifested by the good performance of the SG-II PW facility. Recently, the SG-II PW laser facility has undergone extensive maintenance and a comprehensive technical upgrade in terms of the seed source, laser contrast and terminal focus. LDPA experiments were performed using the maintained SG-II PW laser beam, and the highest cutoff energy of the proton beam was obviously increased. Accordingly, a double-film target structure was used, and the maximum cutoff energy of the proton beam was up to 70 MeV. These results demonstrate that the comprehensive performance of the SG-II PW laser facility was improved significantly.

Collaborative planning for multiple hypersonic vehicles can effectively improve operational effectiveness. Time coordination is one of the main forms of cooperation among multi-hypersonic glide vehicles, and time cooperation trajectory optimisation is a key technology that can significantly increase the success rate of flight missions. However, it is difficult to obtain satisfactory time as a constraint condition during trajectory optimisation. To solve this problem, a multilayer Perceptrona is trained and adopted in a time-decision module, whose input is a four-dimensional vector selected according to the trajectory characteristics. Additionally, the MLP will be capable of determining the optimal initial heading angle of each aircraft to reduce unnecessary manoeuvering performance consumption in the flight mission. Subsequently, to improve the cooperative flight performance of hypersonic glide vehicles, the speed-dependent angle-of-attack and bank command were designed and optimised using the Artificial Bee Colony algorithm. The final simulation results show that the novel strategy proposed in this study can satisfy terminal space constraints and collaborative time constraints simultaneously. Meanwhile, each aircraft saves an average of 13.08% flight range, and the terminal speed is increased by 315.6m/s compared to the optimisation results of general purpose optimal control software (GPOPS) tools.

The great demographic pressure brings tremendous volume of beef demand. The key to solve this problem is the growth and development of Chinese cattle. In order to find molecular markers conducive to the growth and development of Chinese cattle, sequencing was used to determine the position of copy number variations (CNVs), bioinformatics analysis was used to predict the function of ZNF146 gene, real-time fluorescent quantitative polymerase chain reaction (qPCR) was used for CNV genotyping and one-way analysis of variance was used for association analysis. The results showed that there exists CNV in Chr 18: 47225201-47229600 (5.0.1 version) of ZNF146 gene through the early sequencing results in the laboratory and predicted ZNF146 gene was expressed in liver, skeletal muscle and breast cells, and was amplified or overexpressed in pancreatic cancer, which promoted the development of tumour through bioinformatics. Therefore, it is predicted that ZNF146 gene affects the proliferation of muscle cells, and then affects the growth and development of cattle. Furthermore, CNV genotyping of ZNF146 gene was three types (deletion type, normal type and duplication type) by Real-time fluorescent quantitative PCR (qPCR). The association analysis results showed that ZNF146-CNV was significantly correlated with rump length of Qinchuan cattle, hucklebone width of Jiaxian red cattle and heart girth of Yunling cattle. From the above results, ZNF146-CNV had a significant effect on growth traits, which provided an important candidate molecular marker for growth and development of Chinese cattle.

We report the experimental results of the commissioning phase in the 10 PW laser beamline of the Shanghai Superintense Ultrafast Laser Facility (SULF). The peak power reaches 2.4 PW on target without the last amplifying during the experiment. The laser energy of 72 ± 9 J is directed to a focal spot of approximately 6 μm diameter (full width at half maximum) in 30 fs pulse duration, yielding a focused peak intensity around 2.0 × 1021 W/cm2. The first laser-proton acceleration experiment is performed using plain copper and plastic targets. High-energy proton beams with maximum cut-off energy up to 62.5 MeV are achieved using copper foils at the optimum target thickness of 4 μm via target normal sheath acceleration. For plastic targets of tens of nanometers thick, the proton cut-off energy is approximately 20 MeV, showing ring-like or filamented density distributions. These experimental results reflect the capabilities of the SULF-10 PW beamline, for example, both ultrahigh intensity and relatively good beam contrast. Further optimization for these key parameters is underway, where peak laser intensities of 1022–1023 W/cm2 are anticipated to support various experiments on extreme field physics.

The performance of hypersonic vehicles in the take-off stage considerably influences their capability of accomplishing the flight tasks. This study is aimed at enhancing the take-off performance of a cruise aircraft using the improved chimp optimisation algorithm. The proposed algorithm, which uses the Sobol sequence for initial population generation and a function of the weight factors, can effectively overcome the problems of premature convergence and low accuracy of the original algorithm. In particular, the Sobol sequence aims to obtain a better fitness value in the first iteration, and the weight factor aims to accelerate the convergence speed and avoid the local optimal solution. The take-off mass model of the hypersonic vehicle is constructed considering the flight data obtained using the pseudo-spectral method in the climb phase. Simulations are performed to evaluate the algorithm performance, and the results show that the algorithm can rapidly and stably optimise the benchmark function. Compared to the original algorithm, the proposed algorithm requires 28.89% less optimisation time and yields an optimised take-off mass that is 1.72kg smaller.

Background: Despite a higher prevalence of traumatic spinal cord injury (TSCI) amongst Canadian Indigenous peoples, there is a paucity of studies focused on Indigenous TSCI. We present the first Canada-wide study comparing TSCI amongst Canadian Indigenous and non-Indigenous peoples. Methods: This study is a retrospective analysis of prospectively-collected TSCI data from the Rick Hansen Spinal Cord Injury Registry (RHSCIR) from 2004-2019. We divided participants into Indigenous and non-Indigenous cohorts and compared them with respect to demographics, injury mechanism, level, severity, and outcomes. Results: Compared with non-Indigenous patients, Indigenous patients were younger, more female, less likely to have higher education, and less likely to be employed. The mechanism of injury was more likely due to assault or transportation-related trauma in the Indigenous group. The length of stay for Indigenous patients was longer. Indigenous patients were more likely to be discharged to a rural setting, less likely to be discharged home, and more likely to be unemployed following injury. Conclusions: Our results suggest that more resources need to be dedicated for transitioning Indigenous patients sustaining a TSCI to community living and for supporting these patients in their home communities. A focus on resources and infrastructure for Indigenous patients by engagement with Indigenous communities is needed.

A smart morphing winglet driven by piezoelectric Macro Fiber Composite (MFC) is designed to adjust cant angle autonomously for various flight conditions. The smart morphing winglet is composed of the MFC actuator, DC-DC converter, power supply, winglet part and wing part. A hinge is designed to transfer the bending deformation of intelligent MFC bending actuator to rotation of the winglet structure so as to achieve the adaptive cant angle. Experimental and numerical work are conducted to evaluate the performance of smart morphing winglet. It is demonstrated that the proposed intelligent MFC bending actuator has an excellent bending performance and load resistance. This smart morphing winglet exhibits the excellent characteristic of flexibility on large deformation and lightweight. Moreover, a series of wind tunnel tests are performed, which demonstrate that the winglet driven by intelligent MFC bending actuator produces sufficient deformation in various wind speed. At high wind speed, the cant angle of the winglet can reach 16 degrees, which is still considered to be very useful for improving the aerodynamic performance of the aircraft. The aerodynamic characteristics are investigated by wind tunnel tests with various attack angles. As a result, when the morphing winglet is actuated, the lift-to-drag ratio could vary up to 11.9% and 6.4%, respectively, under wind speeds of 5.4 and 8.5m/s. Meanwhile, different flight phases such as take-off, cruise and landing are considered to improve aerodynamic performance by adjusting the cant angle of winglet. The smart morphing winglet varies the aerofoil autonomously by controlling the low winglet device input voltage to remain optimal aerodynamic performance during the flight process. It demonstrates the feasibility of piezoelectric composites driving intelligent aircraft.

The early identification and prediction of hand-foot-and-mouth disease (HFMD) play an important role in the disease prevention and control. However, suitable models are different in regions due to the differences in geography, social economy factors. We collected data associated with daily reported HFMD cases and weather factors of Zibo city in 2010~2019 and used the generalised additive model (GAM) to evaluate the effects of weather factors on HFMD cases. Then, GAM, support vectors regression (SVR) and random forest regression (RFR) models are used to compare predictive results. The annual average incidence was 129.72/100 000 from 2010 to 2019. Its distribution showed a unimodal trend, with incidence increasing from March, peaking from May to September. Our study revealed the nonlinear relationship between temperature, rainfall and relative humidity and HFMD cases and based on the predictive result, the performances of three models constructed ranked in descending order are: SVR > GAM> RFR, and SVR has the smallest prediction errors. These findings provide quantitative evidence for the prediction of HFMD for special high-risk regions and can help public health agencies implement prevention and control measures in advance.

To investigate the influences of dietary riboflavin (RF) addition on nutrient digestion and rumen fermentation, eight rumen cannulated Holstein bulls were randomly allocated into four treatments in a repeated 4 × 4 Latin square design. Daily addition level of RF for each bull in control, low RF, medium RF and high RF was 0, 300, 600 and 900 mg, respectively. Increasing the addition level of RF, DM intake was not affected, average daily gain tended to be increased linearly and feed conversion ratio decreased linearly. Total tract digestibilities of DM, organic matter, crude protein (CP) and neutral-detergent fibre (NDF) increased linearly. Rumen pH decreased quadratically, and total volatile fatty acids (VFA) increased quadratically. Acetate molar percentage and acetate:propionate ratio increased linearly, but propionate molar percentage and ammonia-N content decreased linearly. Rumen effective degradability of DM increased linearly, NDF increased quadratically but CP was unaltered. Activity of cellulase and populations of total bacteria, protozoa, fungi, dominant cellulolytic bacteria, Prevotella ruminicola and Ruminobacter amylophilus increased linearly. Linear increase was observed for urinary total purine derivatives excretion. The data suggested that dietary RF addition was essential for rumen microbial growth, and no further increase in performance and rumen total VFA concentration was observed when increasing RF level from 600 to 900 mg/d in dairy bulls.

The aim of this study was to explore the frequency and distribution of gene mutations that are related to isoniazid (INH) and rifampin (RIF)-resistance in the strains of the multidrug-resistant tuberculosis (MDR-TB) Mycobacterium tuberculosis (M.tb) in Beijing, China. In this retrospective study, the genotypes of 173 MDR-TB strains were analysed by spoligotyping. The katG, inhA genes and the promoter region of inhA, in which genetic mutations confer INH resistance; and the rpoB gene, in which genetic mutations confer RIF resistance, were sequenced. The percentage of resistance-associated nucleotide alterations among the strains of different genotypes was also analysed. In total, 90.8% (157/173) of the MDR strains belonged to the Beijing genotype. Population characteristics were not significantly different among the strains of different genotypes. In total, 50.3% (87/173) strains had mutations at codon S315T of katG; 16.8% (29/173) of strains had mutations in the inhA promoter region; of them, 5.5% (15/173) had point mutations at −15 base (C→T) of the inhA promoter region. In total, 86.7% (150/173) strains had mutations at rpoB gene; of them, 40% (69/173) strains had mutations at codon S531L of rpoB. The frequency of mutations was not significantly higher in Beijing genotypic MDR strains than in non-Beijing genotypes. Beijing genotypic MDR-TB strains were spreading in Beijing and present a major challenge to TB control in this region. A high prevalence of katG Ser315Thr, inhA promoter region (−15C→T) and rpoB (S531L) mutations was observed. Molecular diagnostics based on gene mutations was a useful method for rapid detection of MDR-TB in Beijing, China.