Pubertal timing matters for psychological development. Early maturation in girls is linked to risk for depression and externalizing problems in adolescence and possibly adulthood, and early and late maturation in boys are linked to depression. It is unclear whether pubertal timing uniquely predicts problems; it might instead mediate the continuity of behavior problems from childhood to adolescence or create psychological risk specifically in youth with existing problems, thus moderating the link. We investigated these issues in 534 girls and 550 boys, measuring pubertal timing by a logistic model fit to annual self-report measures of development and, in girls, age at menarche. Prepuberty internalizing and externalizing behavior problems were reported by parents. Adolescent behavior problems were reported by parents and youth. As expected, behavior problems were moderately stable. Pubertal timing was not predicted by childhood problems, so it did not mediate the continuity of behavior problems from childhood to adolescence. Pubertal timing did not moderate links between early and later problems for girls. For boys, early maturation accentuated the link between childhood problems and adolescent substance use. Overall, the replicated links between puberty and behavior problems appear to reflect the unique effects of puberty and child behavior problems on the development of adolescent behavior problems.

OBJECTIVES/SPECIFIC AIMS: To build capacity for community engaged, translational research in faculty across the university. METHODS/STUDY POPULATION: Each year, the Community Engagement Research Core (CERC) of the Penn State CTSI invites applications for one to two Community Engagement Faculty Fellowships. Applicant teams are comprised of a junior or mid-level investigator seeking to expand their work into the CEnR arena under the mentorship of a senior investigator with expertise in community engaged scholarship. The fellow must develop a plan for the mentoring year, including a timeline, activities to be undertaken together, knowledge to be acquired, deliverables, and a budget. The funding supports two course releases or the clinical equivalent for the fellow, and a small budget to support the mentor’s research program. Proposals are evaluated using NIH scientific merit criteria. RESULTS/ANTICIPATED RESULTS: We are in our second year of the fellowship program. Two highly qualified fellows are currently working with established community-based mentors. The 2017-2018 fellowship team showcases how an effective mentor-fellow partnership can help move a fellow’s work along the translational spectrum. By working with her mentor, our first fellow’s research has expanded from basic discovery science in a university hospital to development of a neonatal intensive care unit intervention to be employed with parents in the community. The 2018-2019 scholar, who utilized the community engagement research core (CERC) of the PSU CTSI in preparation of a PCORI grant, has since received the PCORI award and is working with her mentor to bring her innovative mental health screenings to the public schools. We are currently evaluating applications for the third year of the program, and please to have engaged applicants from across several Penn State campuses and disciplines. DISCUSSION/SIGNIFICANCE OF IMPACT: The fellowship is enjoying early success in terms of fellow productivity, expanding translational research expertise, and fueling interest across the Penn State campuses in community engagement research. Future work will focus on sustainability planning for this type of program, metrics for tracking success, and plans for integrating fellows into a growing community of engaged scholars at the university.

The Insch granite-diorite complex of Aberdeenshire consists of acid and intermediate igneous rocks that are quite distinct from, and younger than, the differentiates of the Insch basic mass.

The main components of the complex include two types of uniform granite (one pink, one grey), and a variety of inhomogeneous dioritic rocks (diorite xenoliths in grey granite matrix, granodiorite with residual mafic inclusions, and more uniform diorite). Full chemical analyses for major and trace elements are presented for sixteen rocks representative of all types, together with initial 87Sr/86Sr ratios and rare-earth-element distribution patterns for a selection of samples. The pink granite is not chemically related to the remaining members of the complex. Comparison with chemical data for a range of basic igneous rocks of the Insch and Boganclogh basic masses discredits the hypothesis that the diorite rocks were produced by assimilation of any of these in the grey granite magma. A primary diorite magma is recognized as essential to the petrogenesis of the complex.

The deep subsurface of other planetary bodies is of special interest for robotic and human exploration. The subsurface provides access to planetary interior processes, thus yielding insights into planetary formation and evolution. On Mars, the subsurface might harbour the most habitable conditions. In the context of human exploration, the subsurface can provide refugia for habitation from extreme surface conditions. We describe the fifth Mine Analogue Research (MINAR 5) programme at 1 km depth in the Boulby Mine, UK in collaboration with Spaceward Bound NASA and the Kalam Centre, India, to test instruments and methods for the robotic and human exploration of deep environments on the Moon and Mars. The geological context in Permian evaporites provides an analogue to evaporitic materials on other planetary bodies such as Mars. A wide range of sample acquisition instruments (NASA drills, Small Planetary Impulse Tool (SPLIT) robotic hammer, universal sampling bags), analytical instruments (Raman spectroscopy, Close-Up Imager, Minion DNA sequencing technology, methane stable isotope analysis, biomolecule and metabolic life detection instruments) and environmental monitoring equipment (passive air particle sampler, particle detectors and environmental monitoring equipment) was deployed in an integrated campaign. Investigations included studying the geochemical signatures of chloride and sulphate evaporitic minerals, testing methods for life detection and planetary protection around human-tended operations, and investigations on the radiation environment of the deep subsurface. The MINAR analogue activity occurs in an active mine, showing how the development of space exploration technology can be used to contribute to addressing immediate Earth-based challenges. During the campaign, in collaboration with European Space Agency (ESA), MINAR was used for astronaut familiarization with future exploration tools and techniques. The campaign was used to develop primary and secondary school and primary to secondary transition curriculum materials on-site during the campaign which was focused on a classroom extra vehicular activity simulation.

Although cross-sectional twin studies have assessed the genetic and environmental etiologies of substance use during adolescence and early adulthood, comparisons of results across different samples, measures, and cohorts are problematic. While several longitudinal twin studies have investigated these issues, few corroborating adoption studies have been conducted. The current study is the first to estimate the magnitude of genetic, shared environmental, and non-shared environmental influences on substance use (cigarettes, alcohol, and marijuana) from ages 14 to 18 years, using a prospective longitudinal adoption design. Adoptive and control sibling correlations provided substantial evidence for early genetic effects on cigarette, alcohol, and marijuana use/no use. Shared environmental effects were relatively modest, except for alcohol use, which showed increases in late adolescence (age 17 to 18 years). Sibling similarity for quantity/frequency of use also support additive genetic influences across adolescence, with some shared environmental influences for all three substances. To test the stability of these influences across time, a series of independent pathway models were run to explore common and age-specific influences. For all substances, there were minimal age-specific additive genetic and shared environmental influences on quantity/frequency of use. Further, there was a trend toward increasing genetic influences on cigarette and alcohol use across ages. Genetic influences on marijuana were important early, but did not contribute substantially at age 17 and 18 years. Overall, the findings indicate that genetic influences make important contributions to the frequency/quantity of substance use in adolescence, and suggest that new genetic influences may emerge in late adolescence for cigarette and alcohol use.

An investigation was carried out to determine whether there were significant changes in the intake of dietary fibre (NSP) and phytate of adult men and women in the UK from 1982 (aged 36 years) to 1999 (aged 53 years). The 1253 subjects studied were members of the Medical Research Council National Survey of Health and Development; a longitudinal study of a nationally representative cohort of births in 1946. Food intake was recorded in a 5 d diary at age 36 years in 1982, 43 years in 1989 and 53 years in 1999. The food composition database was amended with revised values for phytate. Outcome measures were mean intakes of total NSP and phytate by year, sex and food source. There were significant changes in total NSP and phytate intake over the three time points. Intakes of NSP rose significantly between 1982 and 1999 for men and women but phytate intakes rose significantly only between 1989 and 1999. Cereal foods were the most important source of both NSP and phytate. Between 1989 and 1999 there was a significant increase in the contribution from pasta, rice and other grains. The present study shows that an increase in dietary fibre that is in accordance with dietary guidelines would almost inevitably be accompanied by a rise in phytate. The increased dietary phytate is discussed in relation to its recognised inhibition of mineral absorption and its merits with regard to protection against some cancers and other diseases of an ageing population.

In looking at the map of the Great Lake region, you have all noticed the backward bending thumb of Michigan projecting into the icy waters of Lake Superior; yet but few of you, perhaps, have realized that extending along that thumb there runs a band or ring of native copper. It does not, like most gold or silver bands, extend around the finger, but along it—from the base of the hand to the end of the thumb—this central band lies embedded in the flesh binding all together. Shall we now dissect it, laying bare its flesh, muscle, and bone, and try to explain its marvellous organization ?

Syenite.—Much of the eastern coast of Essex County, Massachusetts, extending from Salem to a point beyond West Manchester, has been found by the writer to be occupied by a typical syenite of a reddish and greyish colour, which in its macroscopic characters appears to be identical with that from Planen'schen Grund, Saxony. The syenite in places contains much biotite, and also, near West Manchester, quartz grains (segregations ?). This syenite is often cut by dykes of a fine-grained greyish syenite, which holds the same relation to the syenite proper as the micro-granite dykes do to the granite of the region, and hence, for convenience of description, the rock of the syenite dykes may be styled micro-syenite

The Comores Archipelago comprises four principal islands, lying in a WNW–ESE line at the northern end of the Mozambique Channel. The Islands are almost entirely volcanic and show a simple age progression from Grande Comore, with its active shield volcano Kharthala (2650m), east-south-eastwards through Mohéli and Anjouan, which are quite deeply dissected, to Mayotte, which is in an advanced stage of erosion and subsidence, and is encircled by a barrier reef. There is also evidence of minor volcanic rejuvenation in relatively recent times in Mayotte, and perhaps Anjouan and Mohéli. The lavas of Kharthala, and the neighbouring extinct shield volcano (Massif de la Grille) on Grande Comore are all basaltic, ranging from oceanitic and ankaramitic to aphyric types. Numerous tuff cones occur, especially on the flanks of Massif de la Grille. Basaltic lavas, similar to those of Grande Comore, form the bulk of the dissected volcanic shields of Mohéli and Anjouan, but there is also evidence of differentiation towards alkalic under-saturated end products, both as lavas and as intrusive bodies. Lherzolitic and gabbroic nodules are locally abundant on each of the islands, while xenoliths of sandstone and quartzite have been found on the three westernmost islands. Petrochemical data are presented for a considerable variety of Comores rocks, and the volcanic activity is discussed in terms of the major structural features of the Madagascar-Mozambique region.