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We suggest that as people move to construe robots as social agents, interact with them, and treat them as capable of social ties, they might develop (close) relationships with them. We then ask what kind of relationships can people form with bots, what functions can bots fulfill, and what are the societal and moral implications of such relationships.
The growth in wirelessly enabled sensor network technologies has enabled the low cost deployment of sensor platforms with applications in a range of sectors and communities. In the agricultural domain such sensors have been the foundation for the creation of decision support tools that enhance farm operational efficiency. This Research Reflection illustrates how these advances are assisting dairy farmers to optimise performance and illustrates where emerging sensor technology can offer additional benefits. One of the early applications for sensor technology at an individual animal level was the accurate identification of cattle entering into heat (oestrus) to increase the rate of successful pregnancies and thus optimise milk yield per animal. This was achieved through the use of activity monitoring collars and leg tags. Additional information relating to the behaviour of the cattle, namely the time spent eating and ruminating, was subsequently derived from collars giving further insights of economic value into the wellbeing of the animal, thus an enhanced range of welfare related services have been provisioned. The integration of the information from neck-mounted collars with the compositional analysis data of milk measured at a robotic milking station facilitates the early diagnosis of specific illnesses such as mastitis. The combination of different data streams also serves to eliminate the generation of false alarms, improving the decision making capability. The principle of integrating more data streams from deployed on-farm systems, for example, with feed composition data measured at the point of delivery using instrumented feeding wagons, supports the optimisation of feeding strategies and identification of the most productive animals. Optimised feeding strategies reduce operational costs and minimise waste whilst ensuring high welfare standards. These IoT-inspired solutions, made possible through Internet-enabled cloud data exchange, have the potential to make a major impact within farming practices. This paper gives illustrative examples and considers where new sensor technology from the automotive industry may also have a role.
Transplantation is a growing therapeutic option for patients with end-stage organ failure. The first successful human kidney transplant took place in 1954.However, it was not until the 1960s that immunosuppression became available, and not until the 1980s, with the introduction of cyclosporine, that consistently acceptable graft and patient survival was achieved. With restoration of organ function, patients experience an overall improvement in their health, increased libido, and return of fertility.
Imaging biomarkers for Alzheimer's disease include medial temporal lobe atrophy (MTLA) depicted on computed tomography (CT) or magnetic resonance imaging (MRI) and patterns of reduced metabolism on fluorodeoxyglucose positron emission tomography (FDG-PET).
Aims
To investigate whether MTLA on head CT predicts the diagnostic usefulness of an additional FDG-PET scan.
Method
Participants had a clinical diagnosis of Alzheimer's disease(n = 37) or dementia with Lewy bodies (DLB;n = 30) or were similarly aged controls(n = 30). We visually rated MTLA on coronally reconstructed CT scans and, separately and blind to CT ratings, abnormal appearances on FDG-PET scans.
Results
Using a pre-defined cut-off of MTLA ⩾5 on the Scheltens (0–8) scale, 0/30 controls, 6/30 DLB and 23/30 Alzheimer's disease had marked MTLA. FDG-PET performed well for diagnosing Alzheimer's disease v. DLB in the low-MTLA group (sensitivity/specificity of 71%/79%), but in the high-MTLA group diagnostic performance of FDG-PET was not better than chance.
Conclusions
In the presence of a high degree of MTLA, the most likely diagnosis is Alzheimer's disease, and an FDG-PET scan will probably not provide significant diagnostic information. However, in cases without MTLA, if the diagnosis is unclear, an FDG-PET scan may provide additional clinically useful diagnostic information.
We present the results of two 2.3 μm near-infrared (NIR) radial velocity (RV) surveys to detect exoplanets around 36 nearby and young M dwarfs. We use the CSHELL spectrograph (R ~ 46,000) at the NASA InfraRed Telescope Facility (IRTF), combined with an isotopic methane absorption gas cell for common optical path relative wavelength calibration. We have developed a sophisticated RV forward modeling code that accounts for fringing and other instrumental artifacts present in the spectra. With a spectral grasp of only 5 nm, we are able to reach long-term radial velocity dispersions of ~20–30 m s−1 on our survey targets.
Positron emission tomography (PET) and single photon emission computed tomography (SPECT) brain imaging are widely used as diagnostic tools for suspected dementia but no studies have directly compared participant views of the two procedures. We used a range of methods to explore preferences for PET and SPECT.
Methods:
Patients and controls (and accompanying carers) completed questionnaires immediately after undergoing PET and SPECT brain scans. Pulse rate data were collected during each scan. Scan attributes were prioritized using a card sorting exercise; carers and controls additionally answered willingness to pay (WTP) questions.
Results:
Few differences were found either between the scans or groups of participants, although carers marginally preferred SPECT. Diagnostic accuracy was prioritized over other scan characteristics. Mean heart rate during both scans was lower than baseline heart rate measured at home (p < 0.001).
Conclusion:
Most participants viewed PET and SPECT scans as roughly equivalent and did not have a preference for either scan. Carer preference for SPECT is likely to reflect their desire to be with the patient (routine practice for SPECT but not for PET), suggesting that they should be able to accompany vulnerable patients throughout imaging procedures wherever possible. Pulse rate data indicated that brain imaging was no more stressful than a home visit (HV) from a researcher. The data do not support the anecdotal view that PET is a more burdensome procedure and the use of PET or SPECT scans in dementia should be based on diagnostic accuracy of the technique.
Knowing what information, and from which sensory cues, is available to an animal regarding its position and direction of movement is vital for unravelling the mechanisms underlying animal navigation. Although considerable progress has been made with traditional field and laboratory techniques, these approaches generally do not provide direct control over the animal's motivation to display its sensory abilities. In contrast, psychologists have for many decades used conditioning as a reliable tool to study sensory perception as well as the mechanisms underlying learning. There has been growing interest in the use of conditioning techniques to investigate responses to stimuli that might be used in guiding movement over long distances. This review seeks to facilitate that development by providing a general introduction to conditioning and the considerations involved in designing robust conditioning experiments together with a perspective for its future use in studying sensory systems in migratory and homing species.
Maternal nutrition during pregnancy has a significant influence in establishing patterns of metabolism and postnatal behaviours in offspring, and therefore shapes their risk of developing disorders in later life. Although it is well established that a mismatch between food consumption and energy expenditure leads to obesity and metabolic dysregulation, little research has investigated the biological origin of such behaviour. We conducted the present experiments to investigate effects of early-life nutrition on preference between wheel running and lever pressing for food during adult life. To address this issue we employed a well-established experimental approach in the rat which has shown that offspring of mothers undernourished during pregnancy develop obesity and metabolic disorders when kept under standard laboratory conditions. Using this experimental approach, two studies were conducted where offspring of ad libitum-fed dams and dams undernourished throughout pregnancy were given the choice between wheel running and pressing a response lever for food. Across subsequent conditions, the rate at which the response lever provided food was varied from 0·22 to 6·0 (study 1) and 0·19 to 3·0 (study 2) pellets per min. Compared with the control group, offspring from dams undernourished during pregnancy showed a consistently greater preference for running over lever pressing for food throughout both experiments of the study. The results of the present study provide experimental evidence that a mother's nutrition during pregnancy can result in a long-term shift in her offspring's lifestyle choices that are relevant to obesity prevention. Such a shift, if endorsed, will have substantial and wide-ranging health consequences throughout the lifespan.
The concept of the developmental origins of adult disease was initially based on epidemiological observations relating evidence of a constrained fetal environment to a greater risk of metabolic and cardiovascular disorders in adult life. It was later recognised that those at greatest risk also have an increased propensity to developing obesity in childhood and during adult life (Barker and Osmond 1988, Hales and Barker 1992, Gluckman and Hanson 2004). The interest in the later effects of early environmental events has since been generalised to include possible prenatal effects on offspring behaviour and cognition. In this chapter, we review the existing human and animal literature on the early-life influences on offspring cognitive function and behaviour.
Human studies
Recently, interest has grown in the possibility of a relation between birthweight and subsequent cognitive function. Early research focused on comparisons between individuals of low birthweight (LBW) or small for gestational age (SGA) and those with normal birthweights (e.g., Ounsted et al. 1983, Pharoah et al. 1994, Strauss 2000). These studies showed that LBW and SGA individuals had an increased incidence of neurological deficits and/or poorer cognitive skills throughout childhood. Subsequent research has examined whether this relationship persists across the normal range of birthweights (e.g. Sorenson et al. 1997, Matte et al. 2001, Richards et al. 2001, 2002, Shenkin et al. 2001, Jefferis et al. 2002). The consensus from this research is that the relationship does hold across the range of normal birthweights, but that the effect is small.
To provide a composite view of the impact of indefinite detention under the Anti-Terrorism Crime and Security Act 2001. Until recently, a number of detainees had been detained under this legislation since December 2001. The impact of this on eight detainees and three of their spouses is examined through qualitative analysis of 48 reports and documents compiled by 11 psychiatrists and 1 psychologist.
Results
Detention has had a severe adverse impact on the mental health of all detainees and the spouses interviewed. All were clinically depressed and a number had post-traumatic stress disorder. The indefinite nature of detention was a major factor in their deterioration.
Clinical Implications
The use of indefinite detention without trial has severe adverse consequences that may pose insurmountable problems for the prison healthcare system.
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