We used a strand-specific RT-qPCR to evaluate viral replication as a surrogate for infectiousness among 242 asymptomatic inpatients with a positive severe acute respiratory coronavirus virus 2 (SARS-CoV-2) admission test. Only 21 patients (9%) had detectable SARS-CoV-2 minus-strand RNA. Because most patients were found to be noninfectious, our findings support the suspension of asymptomatic admission testing.

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) real-time reverse-transcription polymerase chain reaction (rRT-PCR) strand-specific assay can be used to identify active SARS-CoV-2 viral replication. We describe the characteristics of 337 hospitalized patients with at least 1 minus-strand SARS-CoV-2 assay performed >20 days after illness onset. This test is a novel tool to identify high-risk hospitalized patients with prolonged SARS-CoV-2 replication.

The goal of this study was to perform in situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in peripheral nerves to create a soft, precisely located injectable conductive polymer electrode for bi-directional communication. Intraneural PEDOT polymerization was performed to target both outer and inner fascicles via custom fabricated 3D printed cuff electrodes and monomer injection strategies using a combination electrode-cannula system. Electrochemistry, histology, and laser light sheet microscopy revealed the presence of PEDOT at specified locations inside of peripheral nerve. This work demonstrates the potential for using in situ PEDOT electrodeposition as an injectable electrode for recording and stimulation of peripheral nerves.

The ability to interface electronic materials with the peripheral nervous system is required for stimulation and monitoring of neural signals. Thus, the design and engineering of robust neural interfaces that maintain material-tissue contact in the presence of material or tissue micromotion offer the potential to conduct novel measurements and develop future therapies that require chronic interface with the peripheral nervous system. However, such remains an open challenge given the constraints of existing materials sets and manufacturing approaches for design and fabrication of neural interfaces. Here, we investigated the potential to leverage a rapid prototyping approach for the design and fabrication of nerve cuffs that contain supporting features to mechanically stabilize the interaction between cuff electrodes and peripheral nerve. A hybrid 3D printing and robotic-embedding (i.e., pick-and-place) system was used to design and fabricate silicone nerve cuffs (800 µm diameter) containing conforming platinum (Pt) electrodes. We demonstrate that the electrical impedance of the cuff electrodes can be reduced by deposition of the conducting polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) on cuff electrodes via a post-processing electropolymerization technique. The computer-aided design and manufacturing approach was also used to design and integrate supporting features to the cuff that mechanically stabilize the interface between the cuff electrodes and the peripheral nerve. Both ‘self-locking’ and suture-assisted locking mechanisms are demonstrated based on the principle of making geometric alterations to the cuff opening via 3D printing. Ultimately, this work shows 3D printing offers considerable opportunity to integrate supporting features, and potentially even novel electronic materials, into nerve cuffs that can support the design and engineering of next generation neural interfaces.

This paper presents the numerical simulations of flowfield over a typical Crew Module at Mach 4 for different angles-of-attack ranging from 0 to –25°. Detailed flow features such as contour of density gradient over the model, numerical oil flow and near wake vortex structures are captured very well in the present simulations. The location of the sonic line and its behaviour due to angles-of-attack is also captured in the simulations. The CP distribution on the windward and leeward side shows excellent match with the experimental results. Also, the prediction of aerodynamic coefficients shows very good agreement with the experimental results. The numerical simulation predicts CMcg, CN and CA within 8%, 4% and 3·5% respectively with respect to experimental values.

We describe a 38-year-old woman who developed symptoms of hallucinogen persisting perception disorder (HPPD) after using lysergic acid diethylamide (LSD) once and continued to have symptoms of HPPD for nearly 17 years, although she did not use LSD after her first use. The symptoms of HPPD were temporally related to her first LSD use and she responded well to risperidone within a few weeks of commencing on the same. Although different medications have been tried in the management of HPPD including risperidone, olanzapine, clonidine, fluoxetine, sertraline, benzodiazepines and anti-epileptic medications, none have been proven to be the definitive medication of choice in the treatment of HPPD. Furthermore, there have been case reports suggesting worsening of symptoms with risperidone; however, the response to risperidone in our patient suggests the possibility of its effectiveness in the management of HPPD symptoms in some patients.

This paper presents the powder X-ray diffraction data of BaFI recorded using a Guinier diffractometer and Mo Kα1 radiation. BaFI stabilizes at standard temperature of 25 °C and standard-atmospheric pressure (STP) in the tetragonal structure (space group P4/nmm; No. 129) with lattice parameters a=4.660(1) Å and c=7.960(5) Å. Our observed pattern is different from the existing observed powder diffraction data reported in the PDF files 34-716 (Beck, 1976) and 31-139 (), but matches almost perfectly with the pattern calculated by us from the reported single crystal data ( and with the calculated data available in PDF file 70-0481. Further, our data provide a number of new Bragg peaks extending beyond the range of d values available in the existing PDF files.

An incident beam X-ray collimator for Mao-Bell type diamond anvil cell (DAC) has been developed. Alignment of the collimator is carried out in situ while viewing the image of the collimated X-ray spot formed on a thin layer of fluorescent material spread on the diamond anvil culets with the help of a microscope. Special precaution has been taken to meet the radiation safety requirements during alignment and routine use. This collimator is of immense help for laboratory based high pressure X-ray diffraction experiments.

Using the method of matched asymptotic expansions, an expansion of the velocity potential for steady incompressible flow has been obtained to order ε4 for slender bodies of revolution at an angle of attack by representing the potential due to the body as a superposition of potentials of sources and doublets distributed along a segment of the axis inside the body excluding an interval near each end of the body. Also, expansions of the coefficients of longitudinal virtual mass and lateral virtual mass have been found. The pressure distributions over an ellipsoid of revolution of thickness ratio ε = 0·3 at zero angle of attack and at an angle of attack of 3° obtained by the present method are compared with results obtained from the exact theory and that of Van Dyke. The virtual-mass coefficients are also compared with those obtained from the exact theory and are found to be in good agreement up to ε = 0·3.

We present a new way of making macroporous materials using colloidal suspensions of ceramic nanoparticles. We start from a mondisperse emulsion of 0.5 to 3.0 μm diameter oil droplets suspended in an aqueous colloidal dispersion of 80–100 nm silica particles. Upon evaporation of the water, the silica particles form a particulate gel around the emulsion droplets. Removal of the emulsion droplets by dissolution in alcohol and subsequent drying produces a monolithic solid macroporous body. Bulk gels with volume greater than 1 cm3 could be easily produced with this method. Uniform films with thickness of approximately 10 μm have also been made by dip coating of the emulsion-silica colloid mixture. One can also use polystyrene particles as templates in place of the emulsion droplets. Using this approach, we were able to produce highly ordered macroporous titania and silica ceramics with pore sizes around 500 nm and typical dimensions of 3.0 × 2.0 × 0.5 mm3. These dimensions are much larger than those produced using alkoxides. Lower shrinkage associated with particulate gels reduces cracking and increases the structural integrity of the macroporous body.

Nanoindentation testing was used to obtain mechanical properties on realistic Sn-Ag solder joints made with (i) eutectic Sn-3.5Ag solder and (ii) in-situ Cu6Sn5 particle reinforced, eutectic Sn-Ag matrix composite solder. The composite solder joint contained ˜20 volume percent of intentionally-added Cu6Sn5 intermnetallic particles which were ∼5 microns in size. The Cu6Sn5 particles were dispersed in-situ in eutectic Sn-3.5Ag matrix alloy as a reinforcement phase to stabilize the microstructure by acting as a non-coarsening microconstituent phase. Mechanical properties characterization and deformation behavior were assessed on the bulk microstructure and on microconstituents in the actual solder joints. Mechanical property data obtained on constituents included hardness, elastic modulus, strain rate, and creep behavior. The pushing and rotation of the reinforcement particles that often occurred when contacted by the indenter provided a means for evaluating the interfacial shear strength of reinforcement particles in the solder matrix.

We present the results of experiments studying the effect of carrier depletion and interfacial stress on time to breakdown of'thin oxide films during constant current stressing High energy electrons resulting from carrier depletion conditions increase damage to oxides during tunneling. Carrier depletion conditions cause a dramatic decrease in time to breakdown and increase the number of early failures substantially. Mechanical interfacial stress results in a degradation in oxide reliability. Anode interfacial stress has been uniquely isolated from other phenomena such as cathode surface roughness, and has been shown to result in accelerated breakdown. These results have implications on oxide reliability and on test methodologies to obtain a measure of the same

The 1 Miz dielectric constants of a variety of synthetic aluminate garnets: Y3Al5O12, Ho3A15O12, Y2.93Nd.07Sc2Al3O12 and Gd2.95Nd.05Sc1 98Cr .02A13O12 and several silicates: CaB2Si2O8 (danburite), Ca3Al2Si3O12 (grossular) and Mg2Al4Si5O18(cordierite) were determined using the two-terminal method with edge corrections. These data and polarizabilities derived from the published single crystal dielectric constants of simple oxides were used to compare compound polarizabilities obtained from the Clausius-Mosotti equation and the oxide additivity rule.

Experimental studies on deformation behavior of Cu-10Ni-6Sn spinodal alloy specimens subjected to different aging treatments were carried out at various temperatures ranging from 77°K to 353°K, using a micro-tensile device. It was found that the total elongation was independent of aging time as long as the modulated structure was coherent. Observed slip distribution and activation energy obtained in these investigations are presented. Transmission electron microscopy of deformed specimens showed straight dislocations in as-quenched samples; they were curved and wavy in aged samples. Burgers vector analysis of the dislocations present in the deformed aged samples indicated that they were of mixed character. Preliminary theoretical results on the role of wave-squaring of the internal stress field on CRSS are also presented.

The quasi-static thermocapillary migration of a bubble located inside a drop in free fall is considered for arbitrary axisymmetric temperature fields prescribed on the drop surface. Some results are presented, and an approximation based on the superposition of simpler solutions is discussed.