NASA’s all-sky survey mission, the Transiting Exoplanet Survey Satellite (TESS), is specifically engineered to detect exoplanets that transit bright stars. Thus far, TESS has successfully identified approximately 400 transiting exoplanets, in addition to roughly 6 000 candidate exoplanets pending confirmation. In this study, we present the results of our ongoing project, the Validation of Transiting Exoplanets using Statistical Tools (VaTEST). Our dedicated effort is focused on the confirmation and characterisation of new exoplanets through the application of statistical validation tools. Through a combination of ground-based telescope data, high-resolution imaging, and the utilisation of the statistical validation tool known as TRICERATOPS, we have successfully discovered eight potential super-Earths. These planets bear the designations: TOI-238b (1.61$^{+0.09} _{-0.10}$ R$_\oplus$), TOI-771b (1.42$^{+0.11} _{-0.09}$ R$_\oplus$), TOI-871b (1.66$^{+0.11} _{-0.11}$ R$_\oplus$), TOI-1467b (1.83$^{+0.16} _{-0.15}$ R$_\oplus$), TOI-1739b (1.69$^{+0.10} _{-0.08}$ R$_\oplus$), TOI-2068b (1.82$^{+0.16} _{-0.15}$ R$_\oplus$), TOI-4559b (1.42$^{+0.13} _{-0.11}$ R$_\oplus$), and TOI-5799b (1.62$^{+0.19} _{-0.13}$ R$_\oplus$). Among all these planets, six of them fall within the region known as ‘keystone planets’, which makes them particularly interesting for study. Based on the location of TOI-771b and TOI-4559b below the radius valley we characterised them as likely super-Earths, though radial velocity mass measurements for these planets will provide more details about their characterisation. It is noteworthy that planets within the size range investigated herein are absent from our own solar system, making their study crucial for gaining insights into the evolutionary stages between Earth and Neptune.

In this paper we investigate the vortex structure and dynamics formed in the near field of a turbulent axisymmetric jet subjected to transverse acoustic forcing. Full three-dimensional phase-averaged velocity measurements were obtained to elucidate the coherent structures formed when the jet is positioned at the pressure node of a plane standing wave oriented transversely to the streamwise flow direction, which creates a plane symmetry about the nodal line dissecting the jet exit. Due to the change in phase that occurs across the nodal line, it was found that axisymmetry is broken and the jet undergoes a periodic transverse flapping motion consistent with a sinuous mode. This was accompanied by a periodic train of interconnected vortex structures, resembling inverted hairpin (or horseshoe) vortices, formed as the shear layers rolled up in anti-phase either side of the jet, and propagated a few diameters downstream before breaking up. An inviscid vortex model employing inverted hairpin line vortices is shown to capture both the dynamics of the vortex structures and the fluctuating velocity fields. Overall, the jet response and resulting vortex dynamics observed represent a significant departure from the axisymmetric flow structures observed with conventional longitudinal forcing and more closely resemble the phenomenon of bifurcating jets.

In this paper we investigate the continuous, local exchange of fluid elements as they are entrained and detrained across the turbulent/non-turbulent interface (TNTI) in a high Reynolds number axisymmetric jet. To elucidate characteristic kinematic features of local entrainment and detrainment processes, simultaneous high-speed particle image velocimetry and planar laser-induced fluorescence measurements were undertaken. Using an interface-tracking technique, we evaluate and analyse the conditional dependence of local entrainment velocity in a frame of reference moving with the TNTI in terms of the interface geometry and the local flow field. We find that the local entrainment velocity is intermittent with a characteristic length scale of the order of the Taylor micro-scale and that the contribution to the net entrainment rate arises from the imbalance between local entrainment and detrainment rates that occurs with a ratio of two parts of entrainment to one part detrainment. On average, an increase in local entrainment is correlated with excursions of the TNTI towards jet centreline into regions of higher streamwise momentum, convex surface curvature facing the turbulent side of the jet and along the leading edges of the interface. In contrast, detrainment is correlated with excursions of the TNTI away from the jet centreline into regions of lower streamwise momentum, concave surface curvature and along the trailing edge. We find that strong entrainment is characterised by a local counterflow velocity field in the frame of reference moving with the TNTI which enhances the transport of rotational and irrotational fluid elements. On the other hand, detrainment is characterised by locally uniform flow fields with the local fluid velocity on either side of the TNTI advecting in the same direction. These local flow patterns and the strength of entrainment or detrainment rates are also observed to be strongly influenced by the presence and relative strength of vortical structures which are of the order of the Taylor micro-scale that populate the turbulent region along the jet boundary.

A characteristic feature of axisymmetric jets, and turbulent shear flows in general, is the entrainment of mass across the turbulent/non-turbulent interface (TNTI). The multi-scale nature of the TNTI surface area was recently observed to exhibit power-law scaling with a fractal dimension, $D_{f}$ , between $D_{f}=2.3{-}2.4$ , inferred from two-dimensional data, in both high Reynolds number boundary layers and the far field of axisymmetric jets. In this paper, we show that the fractal scaling previously observed in the far field of an axisymmetric jet is established at the end of the potential core. Simultaneous measurements of the velocity and scalar fields were obtained and coarse grain filtering was applied over two decades of scale separation, showing that $D_{f}$ evolves to ${\approx}2.35$ at $x/d=4.6$ , which is similar to $D_{f}$ found in the far field between $x/d=40{-}60$ . This is evidence that scale separation becomes sufficiently developed to achieve scale invariance of the TNTI surface area in the near field of the jet well before self-similarity is established. We also observe that the onset of this geometric scale invariance coincides with the onset of radial homogeneity shown by two-point velocity correlations. Finally, we present a simple theoretical basis for these results using an exact fractal construction based on the Koch curve and applying a coarse-grain filtering analysis.

We consider the scaling of the mass flux and entrainment velocity across the turbulent/non-turbulent interface (TNTI) in the far field of an axisymmetric jet at high Reynolds number. Time-resolved, simultaneous multi-scale particle image velocimetry (PIV) and planar laser-induced fluorescence (PLIF) are used to identify and track the TNTI, and directly measure the local entrainment velocity along it. Application of box-counting and spatial-filtering methods, with filter sizes $\unicode[STIX]{x1D6E5}$ spanning over two decades in length, show that the mean length of the TNTI exhibits a power-law behaviour with a fractal dimension $D\approx 0.31{-}0.33$ . More importantly, we invoke a multi-scale methodology to confirm that the mean mass flux, which is equal to the product of the entrainment velocity and the surface area, remains constant across the range of filter sizes. The results, within experimental uncertainty, also show that the entrainment velocity along the TNTI exhibits a power-law behaviour with $\unicode[STIX]{x1D6E5}$ , such that the entrainment velocity increases with increasing $\unicode[STIX]{x1D6E5}$ . In fact, the mean entrainment velocity scales at a rate that balances the scaling of the TNTI length such that the mass flux remains independent of the coarse-grain filter size, as first suggested by Meneveau & Sreenivasan (Phys. Rev. A, vol. 41, no. 4, 1990, pp. 2246–2248). Hence, at the smallest scales the entrainment velocity is small but is balanced by the presence of a very large surface area, whilst at the largest scales the entrainment velocity is large but is balanced by a smaller (smoother) surface area.

Research efforts at Bombardier Aerospace have investigated design constraints that need to be addressed when considering the design of a future unconventional fuselage concept. Using a composite design platform integrated with structural health monitoring (SHM) technologies, the design space is broadened and there are many more unknowns to investigate from our current knowledge of the subject to date. The principal idea is to identify structural zones and quantify stress levels in areas of concern, referred to as ‘hot-spots’, by integrating an SHM system at a conceptual design level. This new concept would require an assessment of benefits and detriments in order to evaluate the certification processes, impact on maintenance, operation, and ownership costs.

The integration of an SHM system using onboard sensors introduces many challenges, such as the requirement for multiple sensors in the structure and additional systems weight. The investigation shows how the aircraft structural design would be impacted and how design, stress, supply-chain, manufacturing, and the systems departments need to be harmonised in order to design a feasible and integrated SHM-structural fuselage concept.

In this paper we examine the invariants $p$ and $q$ of the reduced $2\times 2$ velocity gradient tensor (VGT) formed from a two-dimensional (2D) slice of an incompressible three-dimensional (3D) flow. Using data from both 2D particle image velocimetry (PIV) measurements and 3D direct numerical simulations of various turbulent flows, we show that the joint probability density functions (p.d.f.s) of $p$ and $q$ exhibit a common characteristic asymmetric shape consistent with $\langle pq\rangle \lt 0$ . An explanation for this inequality is proposed. Assuming local homogeneity we derive $\langle p\rangle = 0$ and $\langle q\rangle = 0$ . With the addition of local isotropy the sign of $\langle pq\rangle $ is proved to be the same as that of the skewness of $\partial {u}_{1} / \partial {x}_{1} $ , hence negative. This suggests that the observed asymmetry in the joint p.d.f.s of $p{{\ndash}}q$ stems from the universal predominance of vortex stretching at the smallest scales. Some advantages of this joint p.d.f. compared with that of $Q{{\ndash}}R$ obtained from the full $3\times 3$ VGT are discussed. Analysing the eigenvalues of the reduced strain-rate matrix associated with the reduced VGT, we prove that in some cases the 2D data can unambiguously discriminate between the bi-axial (sheet-forming) and axial (tube-forming) strain-rate configurations of the full $3\times 3$ strain-rate tensor.

Urinary incontinence is a common symptom in women, more so in older people, with a significant impact on physical health and wellbeing. About 1 in 5 people have impaired continence. Symptom categorization at initial assessment is the key to guiding further therapy. Non-pharmacological options (bladder training for 6 weeks with guidance from a trained physiotherapist) are preferred and can be supported with biofeedback. If unsuccessful, anticholinergics are added and, rarely, surgical options need consideration.

Anticholinergics are the mainstay of pharmacological management of urge incontinence. The National Institute of Health and Clinical Excellence (NICE) recommends immediate release oxybutynin as the first-line agent, with recourse to others if there are adverse effects. The pharmacology, efficacy and adverse effect profile of the various anticholinergic drugs is reviewed, allowing the reader to make an informed choice of appropriate anticholinergics for urge incontinence.

Intracellular vitamin C acts to protect cells against oxidative stress by intercepting reactive oxygen species (ROS) and minimising DNA damage. However, rapid increases in intracellular vitamin C may induce ROS with subsequent DNA damage priming DNA repair processes. Herein, we examine the potential of vitamin C and the derivative ascorbate-2-phosphate (2-AP) to induce a nucleotide excision repair (NER) response to DNA damage in a model of peripheral blood mononuclear cells. Exposure of cells to elevated levels of vitamin C induced ROS activity, resulting in increased levels of deoxycytidine glyoxal (gdC) and 8-oxo-2′-deoxyguanosine (8-oxodG) adducts in DNA; a stress response was also induced by 2-AP, but was delayed in comparison to vitamin C. Evidence of gdC repair was also apparent. Measurement of cyclobutane thymine–thymine dimers (T < >T) in DNA and culture supernatant were included as a positive marker for NER activity; this was evidenced by a reduction in DNA and increases in culture supernatant levels of T < >T for vitamin C-treated cells. Genomics analysis fully supported these findings confirming that 2-AP, in particular, induced genes associated with stress response, cell cycle arrest, DNA repair and apoptosis, and additionally provided evidence for the involvement of vitamin C in the mobilisation of intracellular catalytic Fe.