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This chapter addresses the role of verbal working memory (WM) in language production and comprehension, focusing on data from brain-damaged individuals, while also drawing on related findings from healthy adults. The perspective on WM is the domain-specific model which includes WM buffers that are specific to phonological and semantic information and separate from long-term knowledge in these domains (Marti et al., 2020). Thus, the focus is on the separable contributions of these two buffers to language processes
Many individuals seeking treatment for social anxiety disorder (SAD) also meet criteria for a comorbid depressive disorder. Little is known, however, about how a comorbid depressive disorder affects social anxiety treatment. This study examined 61 participants with SAD and 72 with SAD and a comorbid depressive disorder (SAD+D) before and after 12 weeks of cognitive behavioural group therapy (CBGT) for social anxiety. Although patients with SAD+D reported more severe symptoms of social anxiety and depression at pretreatment, treatment was similarly effective for individuals with SAD and SAD+D. However, individuals with SAD+D continued to report higher symptom severity at post-treatment. Interestingly, CBGT for social anxiety also led to improvements in depressive symptoms despite the fact that depression was not targeted during treatment. Improvement in social anxiety symptoms predicted 26.8% of the variance in improvement in depressive symptoms. Results suggest that depressive symptoms need not be in remission for individuals to benefit from CBGT for social anxiety. However, more than 12 sessions of CBGT may be beneficial for individuals with comorbid depression.
Background: Post event processing (PEP) in social anxiety disorder involves rumination about social events after the fact, and is thought to be a crucial feature of the maintenance of the disorder. Aims: The current experiment aimed to manipulate the use of PEP in individuals with social anxiety disorder. Method: Forty-one individuals with social anxiety disorder completed a videotaped speech. Anxiety ratings and degree of PEP were measured after the task as well as the day following the experiment. Results: Individuals in the distract group reported a greater decrease in anxiety from baseline to post-experimental task than those asked to focus. Individuals in the distract group also reported higher PEP about the task than those instructed to complete a focus task, which appeared to be partially accounted for by baseline differences in symptom severity and state anxiety. Degree of PEP was positively correlated with anxiety ratings, both after the experimental task as well as 24 hours later. Conclusions: These findings suggest that naturalistic PEP is problematic for individuals with social anxiety disorder, especially for those with more severe symptoms. A distraction task, even with breakthrough PEP, appears to have useful short-term effects on anxiety reduction as compared to focus instructions.
A multicenter survey of 11 cancer centers was performed to determine the rate of hospital-onset Clostridium difficile infection (HO-CDI) and surveillance practices. Pooled rates of HO-CDI in patients with cancer were twice the rates reported for all US patients (15.8 vs 7.4 per 10,000 patient-days). Rates were elevated regardless of diagnostic test used.
Academic. Not leading to a decision; unpractical; theoretical, formal, or conventional.
Active. Opposed to contemplative or speculative: Given to outward action rather than inward contemplation or speculation; practical; esp. with “life.”
—Oxford English Dictionary
Tendentious as these definitions are, they refer to the colliding conceptions from which academic activism issues. The often reductive contrast between theory and practice, thinking and doing, has been used to regulate what is admissible as campus politics as if it were apparent in advance which actions were insufficiently imbued with reflection and which worldly commitments compromised disciplinary or institutional loyalty. Suffice it to say that drawing the boundary between activity appropriately inside and outside the academy has always been anxiously freighted. The pursuit of practically engaged knowledge has been constituted in a taut exchange with the very powers it has been called on to serve—persistently but not exclusively those of the state, of industry, and of professional associations (Newfield, Ivy; Readings; Chomsky; Starr). In the lineage of the Western university, degrees of critical separation from these authorities were hard-won and were conceived of as autonomy or academic freedom (Kant). The emergent disciplinary formations of the late nineteenth century made activist claims for equality in a self-designated professional cohort under the rubric of peer review. This compact, advanced by the American Association of University Professors, ceded institutional control to administrators in exchange for noninterference with the pursuit of specialized knowledge (even if manifest as political speech), which was apportioned to those elevated to the peerage through conferral of tenure (O'Neil; Thelin).
C, a newborn infant, develops persistent vomiting on the second day of life. X-rays show midgut volvulus, a condition in which the intestines have twisted around their blood supply. Surgical exploration reveals necrosis of all but 15 cm of his small bowel. The necrotic bowel is removed and total parenteral nutrition (TPN) is initiated. At one year of age, he is taking half of his nutritional needs through his intestinal tract; the other half is given intravenously. Blood chemistry tests show that he is starting to develop significant liver damage from the TPN. C's remaining small bowel has become dilated and dysfunctional. You have recently read about a new operation called the serial tapering enteroplasty (STEP), an innovative technique, which may be able to lengthen the remaining intestine and permit it to function more effectively. A surgical stapler in common use is deployed to segment the dilated bowel into a tapered, lengthened tube more closely resembling the shape of the small intestine (Kim et al., 2003). This operation, first developed in dogs, has been undertaken in a small number of infants with short bowel syndrome. It is considered a non-validated innovation by most pediatric surgeons and is not yet accepted as part of standard surgical practice. You would like to offer the procedure to your patient, but you do not think that there is time to go through the full Research Ethics Board approval process at your hospital. Your intention is to try to help, and perhaps other patients like him.[…]
As we move we change. How could it be otherwise? The direction and consequence of change is far from assured. Dance inscribes movement in the world as a practical accomplishment. It legibly affirms, even if ephemerally, fleetingly, that some immediate difference has been made when the outcome of movement in life might still be in doubt. As a means for registering what movement can be, dance shows us how we pass from one state to another. It does this literally, as bodies configure their realms of space and time, and allegorically, as a touchstone to what it means to be passing through this world. Dance reports on the art of passing, telling us how to dwell amongst so many departures and arrivals. It also instructs us in passing as self-representation, convincing us in performance that it is dancers we see. Such a lovely tale, this. Yet in a nation of immigrants, all are compelled to move, but not all get to pass. Those who lived by the land were evicted in the name of property. Those who were designated property were affixed to the land in bondage. Others worked off their debts of passage. Still more were promised mobility from migration.
The case study approach has a rich history in psychology as a method for observing the ways in which individuals may demonstrate abnormal thinking and behavior, for collecting evidence concerning the circumstances and consequences surrounding such disorders, and for providing data to generate and test models of human behavior (see Yin, 1998, for an overview). Nevertheless, the most typical methods for scientifically studying human cognition involve testing groups of healthy people – typically, college undergraduates. In their statistics and research methods courses, psychology students are trained to study the effects of manipulations that are significant across groups of participants despite considerable variation at the level of the individual. They are trained to be skeptical of reasoning from an individual case that goes against the general trend, and to be suspicious of the compelling anecdote that may be introduced to defend some position about how cognition or social interactions might work. Given this state of affairs, are the practitioners of the case study approach misguided, or can valid conclusions be drawn from findings with one patient? Can case reports that detail a client's symptoms and reactions to psychotherapy constitute scientific data? What about case studies that investigate how brain damage affects particular cognitive processes? The goal of this chapter is to demonstrate how single-case-study approaches in clinical psychology and cognitive neuropsychology have contributed to the advancement of theories and models of human cognition and to address the common concerns that researchers often have about case study methodology.
Dancers, dance theorists, and dance historians have long confronted a double marginality—a life in dance is fragile not simply because dance is ephemeral, but its professional opportunities are scarce. Within the academy, dance is notoriously treated as a minor literature, and dance studies seldom enjoy influence outside their specialized readerships. These predicaments for dance studies can attach to more general concerns about contemporary culture. A consumer society is oriented to mass media with little value for interpersonal encounter that live performance offers. The body has been eclipsed by the machine, and the drive for speed has rendered audiences intolerant of dance's gestural nuance and impatient with its kinesthetic detail. Accordingly, the persistence of dance would seem almost perverse, a nostalgic longing for lost innocence that winds up being self-marginalizing. Against this narrative, one that can be found among dance scholars who favor more restrictive aesthetic conceptions of dance art within Western concert conventions, Felicia McCarren offers a counter-Edenic tale, one that locates dance as central to modernism's own origins, that offers a rethinking of the one-dimensionally woeful account of mechanization, and ultimately provides a reason for those outside of dance to adopt its conceptual efficacy.
Although the working memory capacity involved in syntactic processing may be separate from the capacity involved in word list recall, other aspects of initial sentence interpretation appear to depend on some of the same capacities tapped by span tasks. Specifically, there appears to a capacity for lexical–semantic retention involved in both sentence comprehension and span measures.
We aimed to examine the hypotheses that major depression is aetiologically heterogeneous consisting of a mixture of ‘genetic’ and ‘non-genetic’ forms or, alternatively, a mixture of one form that is ‘pure’ depression and another that has a familial relationship with alcohol dependency or other disorders.
Method
One hundred and eleven twin pairs (44 monozygotic, 67 dizygotic) where the proband had received treatment for DSM–IV major depression were ascertained via a hospital register. Family history information on parents and siblings was obtained from the proband, co-twin or both. Diagnoses on parents and siblings were made blind to twin zygosity or concordance and compared in the relatives of concordant versus discordant twins.
Results
The lifetime prevalence and age-corrected risk of depression were no different in the relatives of concordant and discordant twin pairs. There was a marginally significant increase in the rate of alcohol abuse or dependence among the relatives of concordant twins but no difference between concordant and discordant pairs in respect of other axis I diagnosis among family members.
Conclusions
The results argue against genetic heterogeneity and suggest that major depression cannot usefully be divided into genetic and non-genetic forms or into ‘pure’ depression and depression associated with other disorders such as alcohol dependency.
Coatings of genetically engineered protein polymers based on the crystalline segment of B. Mori silk fibroinand cell binding domains from extracellular matrix proteins (ProNectin™ by Protein Polymer Technologies, Inc.) were applied to bare silicon wafers used to mimic microcircuit devices. These silicon devices have applications in the stimulation and monitoring of central nervous system activity but need bioactive coatings for integration into nervous tissue. Gel point coating technology was developed by preparing solutions at the onset of phase separation in protein polymer/formic acid/ ethanol systems. Dipping silicon wafer substrates into such solutions produced homogeneous thin protein polymer coatings. Quench coating techniques that create rough surfaces in a controlled manner were explored by driving protein polymer solutions through different regions of the protein polymer/formic acid/methanol system before drying. Atomic force microscopy was used to characterize the protein films.