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Returning genomic research results to family members raises complex questions. Genomic research on life-limiting conditions such as cancer, and research involving storage and reanalysis of data and specimens long into the future, makes these questions pressing. This author group, funded by an NIH grant, published consensus recommendations presenting a framework. This follow-up paper offers concrete guidance and tools for implementation. The group collected and analyzed relevant documents and guidance, including tools from the Clinical Sequencing Exploratory Research (CSER) Consortium. The authors then negotiated a consensus toolkit of processes and documents. That toolkit offers sample consent and notification documents plus decision flow-charts to address return of results to family of living and deceased participants, in adult and pediatric research. Core concerns are eliciting participant preferences on sharing results with family and on choice of a representative to make decisions about sharing after participant death.
Although medical care delivery by one's personal physician is the paradigmatic American healthcare arrangement, in the workplace setting, many Americans undergo medical evaluations to assess their fitness for duty or degree of impairment. This Article explores the complex and evolving legal status of occupational medical evaluations. Beginning with the legal and ethical frameworks of occupational medical practice, the Article then examines the effects of increasingly detailed legal regulation under the Americans with Disabilities Act and the Genetic Information Nondiscrimination Act on employees, employers, and physicians.
The debate about how to manage individual research results and incidental findings in genetic and genomic research has focused primarily on what information, if any, to offer back to research participants. However, increasing controversy surrounds the question of whether researchers have any responsibility to offer a participant’s results (defined here to include both individual research results and incidental findings) to the participant’s relatives, including after the participant’s death. This question arises in multiple contexts, including when researchers discover a result with potentially important health implications for genetic relatives, when a participant’s relatives ask a researcher whether any research results about the participant have implications for their own health or reproductive planning, when a participant’s relative asks whether any of the participant’s results have implications for a child’s health, and when the participant is deceased and the participant’s relatives seek information about the participant’s genetic results in order to address their own health or reproductive concerns.
Superhydrophobic surfaces have been shown to produce significant drag reduction for both laminar and turbulent flows of water through large- and small-scale channels. In this paper, a series of experiments were performed which investigated the effect of superhydrophobic-induced slip on the flow past a circular cylinder. In these experiments, circular cylinders were coated with a series of superhydrophobic surfaces fabricated from polydimethylsiloxane with well-defined micron-sized patterns of surface roughness. The presence of the superhydrophobic surface was found to have a significant effect on the vortex shedding dynamics in the wake of the circular cylinder. When compared to a smooth, no-slip cylinder, cylinders coated with superhydrophobic surfaces were found to delay the onset of vortex shedding and increase the length of the recirculation region in the wake of the cylinder. For superhydrophobic surfaces with ridges aligned in the flow direction, the separation point was found to move further upstream towards the front stagnation point of the cylinder and the vortex shedding frequency was found to increase. For superhydrophobic surfaces with ridges running normal to the flow direction, the separation point and shedding frequency trends were reversed. Thus, in this paper we demonstrate that vortex shedding dynamics is very sensitive to changes of feature spacing, size and orientation along superhydrophobic surfaces.
Odessa has played a significant role in Russian and Yiddish folklore and popular culture. Although the city has changed with the times, the Odessa variant of the Russian language and the Russian and Yiddish songs created in and about Odessa are the lasting product of a unique brand of multiculturalism. The Russian of Odessa shows die influence of Yiddish and Ukrainian in grammar, lexicon, and phraseology, and Odessa folk humor reflects Jewish sensibilities. Odessa Yiddish is permeated with Russianisms. The repertoire of Russian and Yiddish songs about Odessa reveals the mixed character of die respective languages. The songs portray a unique city: one tfiat is more impressive than Vienna or Paris; one that embodies progress and the carefree life but is also dangerous. These songs deal with various aspects of the Jewish experience but also with the life of the underworld, employing the stylistic conventions of the so-called blatnaia pesnia.
Consensual knowledge can produce widely varying levels of impact on different international negotiations. In the case of negotiations over UNCTAD's Integrated Program for Commodities, consensual knowledge developed among the experts involved. This consensus tended to support the position taken by the developed countries, thus pointing in a direction already taken for other reasons. Consensus in this case facilitated an agreement, but empirical and theoretical analysis both suggest it may prove to be an incorrect or unstable agreement. The outcome of the commodity negotiations implies that the interaction of key variables, such as uncertainty and the degree of acceptance of the knowledge, might yield different results in other cases. Various specific means might be used more effectively to diffuse expert knowledge among policy makers.
A recent collection of Soviet song texts differs from its many predecessors in one interesting respect. It contains Pavel German’s “Pesnia o kirpichnom zavode,“ better known as “Kirpichiki,” one of the most popular songs of the late 1920s, and a song that for decades symbolized the survival of petit-bourgeois tastes and poshlosf after the Revolution. This quiet rehabilitation can serve as the occasion to examine an aspect of Soviet cultural history that is rarely discussed outside the USSR, namely, the beginnings of Soviet popular music.
A functioning balance-of-power system, comparable to the one which existed throughout the first half of the nineteenth century, limits the ability of Small Powers to achieve their own goals. However, in compensation it provides more real security for them—in terms of the maintenance of independence—than other historical systems, all of which offered the Small Power some elements of maneuverability but to the detriment of long-range security. At first glance the contemporary political system appears to contradict this generalization: Surely, one would presume, the new status of Small Powers reflects a system in which the weaker units of international politics have finally achieved both security and influence. Nevertheless, a closer examination of actual patterns of interaction substantially qualifies this presumption: The original generalization, that is, remains basically sound.
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