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Lifestyle modifications for those with mild cognitive impairment (MCI) may promote functional stability, lesson disease severity, and improve well-being outcomes such as quality of life. The current analysis of our larger comparative effectiveness study evaluated which specific combinations of lifestyle modifications offered as part of the Mayo Clinic Healthy Action to Benefit Independence in Thinking (HABIT) program contributed to the least functional decline in people with MCI (pwMCI) over 18 months.
Methods:
We undertook to compare evidence-based interventions with one another rather than to a no-treatment control group. The interventions were five behavioral treatments: computerized cognitive training (CCT), yoga, Memory Support System (MSS) training, peer support group (SG), and wellness education (WE), each delivered to both pwMCI and care partners, in a group-based program. To compare interventions, we randomly withheld one of the five HABIT® interventions in each of the group sessions. We conducted 24 group sessions with between 8 and 20 pwMCI–partner dyads in a session.
Results:
Withholding yoga led to the greatest declines in functional ability as measured by the Functional Activities Questionnaire and Clinical Dementia Rating. In addition, memory compensation (calendar) training and cognitive exercise appeared to have associations (moderate effect sizes) with better functional outcomes. Withholding SG or WE appeared to have little effect on functioning at 18 months.
Conclusions:
Overall, these results add to the growing literature that physical exercise can play a significant and lasting role in modifying outcomes in a host of medical conditions, including neurodegenerative diseases.
The objective of this study was to determine the effect of fertilizer placement on the growth of eclipta [Eclipta prostrata (L.) L.] and evaluate its interference with container-grown ornamental plants, including Japanese boxwood (Buxus microphylla Siebold & Zucc.) and ligustrum (Ligustrum lucidum W.T. Aiton). Results indicated that subdressing reduced E. prostrata shoot weight by 28%, 42%, and 46% at depths of 2.5, 5.0, and 7.5 cm, respectively, in comparison with a topdressed fertilizer treatment (a standard industry practice). Presence of E. prostrata reduced the growth of both ornamental species. Ligustrum shoot weight decreased as subdressing depth increased, while boxwood growth was most notably reduced at the 7.5-cm depth in comparison with topdressed containers. Overall, results indicated that subdressing may be an effective weed management strategy, but subdressing depth needs to be based on initial liner size to prevent possibly delays in production time.
Descartes thought he could suppose he was the victim of massive deception in regard to the external world. In fact he undertakes the supposing of it.
I will … suppose that … a certain evil spirit, not less clever and deceitful than powerful, has bent all his efforts to deceiving me. I will think that the sky, the air, the earth, colors, shapes, sounds, and all other external things are nothing but illusions and dreams that he has used to trick my credulity. I will regard myself as having no hands, no eyes, no flesh, no blood, nor any senses, but believing falsely that I have all these things.
Seated comfortably by his fire, Descartes imagines a remote possibility. Perhaps he is just a mind in the clutches of a deceiving demon. If Descartes is this man lounging here in his dressing gown, he is not vastly deceived; but if he is that mind, he is deceived indeed. The two possibilities are taken to be experientially indiscernible; and Descartes is assuming that the contents of his beliefs and the senses of his claims remain the same in either case. Thus, for example, whether he is this man or that mind, he believes he has two hands. But, and this is crucial, his belief is false if he is that mind, and true if he is this man. We begin to see what is required of cartesian semantics, and cartesian theories of the content of belief.
Weed management in container crops is primarily accomplished through frequent PRE herbicide applications and supplemental hand weeding. However, many ornamental species are sensitive to herbicides, and a significant number of tropical plants, ornamental grasses, and foliage crops have not been screened for herbicide tolerance. As nursery crops are produced in inert substrates that are largely composed of bark or peat, strategic fertilizer placement has the potential to significantly reduce weed growth in container-grown ornamentals. Growth and reproduction of three common container nursery weed species, eclipta [Eclipta prostrata (L.) L.], large crabgrass [Digitaria sanguinalis (L.) Scop.], and spotted spurge (Euphorbia maculata L.), were evaluated following fertilization via alternative methods, including subdressing or dibbling in comparison with industry standard practices of topdressing or incorporating a controlled-release fertilizer (17-5-11 [8 to 9 mo.]) to each 3.8-L container at 36.5 g per container. Fertilizer placement had little to no effect on germination of Eclipta prostrata or D. sanguinalis, but incorporation increased E. maculata germination by 77% to 183% compared with other placements or a nonfertilized control. Subdressing reduced seed production by 94%, 63%, and 92% for Eclipta prostrata, D. sanguinalis, and E. maculata, respectively, compared with the average number of seeds produced in the conventional placement methods (average of incorporation and topdressing). Dibbling fertilizer resulted in similar decreases in the case of D. sanguinalis and E. maculata, while Eclipta prostrata produced no seeds when fertilizer was dibbled. Similar to reductions observed in reproduction, subdressing fertilizer resulted in biomass decreases of 90%, 81%, and 85% compared with the average biomass of the incorporation and topdressed placements. Results suggest alternative fertilizer placements could be implemented as part of an integrated weed management program in container production to reduce weed growth.
Skunk-vine (Paederia foetida L.) is an invasive vine native to eastern and southern Asia and is widely distributed in Florida, Hawaii, and other southeastern U.S. states; however, little research has focused on herbicide control. Greenhouse and field experiments were conducted to determine efficacy of aminocyclopyrachlor, aminopyralid, fluroxypyr, glyphosate, imazapic, triclopyr amine, and triclopyr ester at low and high labeled rates when foliar applied to P. foetida at various growth stages in greenhouse experiments. Longer-term control was evaluated in field experiments in central Florida using the same herbicides. PRE herbicides labeled for use in landscape plantings, including dimethenamid-P, flumioxazin, indaziflam, isoxaben, and prodiamine, were also evaluated in greenhouse trials by seeding containers with P. foetida seed. In greenhouse experiments, POST herbicides, including aminocyclopyrachlor, aminopyralid, glyphosate, both triclopyr formulations, and the high rate of fluroxypyr (0.24 kg ae ha−1), provided >90% control across all growth stages at 4 mo after treatment with no regrowth observed. Imazapic provided 49% to 89% control, with efficacy decreasing with P. foetida size, and generally provided less control than other treatments. Field experiments confirmed results from greenhouse studies. In PRE trials, flumioxazin and prodiamine provided better control than all other PRE herbicides evaluated, reducing shoot weights by 99% and 84%, respectively, compared with nontreated controls. Our data suggest all herbicides evaluated POST could potentially be used to manage P. foetida, although less control was achieved with imazapic compared with other herbicides. Further research is needed to determine herbicide efficacy on more mature plants and to develop application methods that would be less injurious to non-target vegetation. In landscapes, flumioxazin or prodiamine could be used for PRE control, but POST options that are labeled for landscape use should be identified in future research.
Artilleryweed is an annual or short-lived perennial weed that is becoming increasingly problematic in nurseries and landscapes in tropical and subtropical environments. Currently, no herbicide recommendations exist for management of artilleryweed. Objectives of this trial were to evaluate PRE and POST herbicides for efficacy on artilleryweed. All studies were conducted in Apopka, FL in a shaded greenhouse. Herbicides evaluated for POST control included diquat, dimethenamid-P, flumioxazin, glufosinate, glyphosate, indaziflam, oxadiazon, pelargonic acid, sulfentrazone and sulfosulfuron applied at their highest labelled rates to mature (10 to 12 cm height) artilleryweed. For PRE experiments, pots were overseeded with artilleryweed seed and treated with dimethenamid-P, indaziflam, isoxaben, oxadiazon, oxyfluorfen+prodiamine, oxyfluorfen+pendimethalin, pendimethalin, pendimethalin+dimethenamid-P, prodiamine, prodiamine+isoxaben, S-metolachlor, or trifluralin+isoxaben. When assessing both initial fresh weight and regrowth, flumioxazin and glufosinate provided the most consistent POST control when applied at the highest labelled rate, although regrowth did occur following application with glufosinate. All PRE herbicides evaluated provided over 90% control of artilleryweed with the exception of isoxaben and trifluralin+isoxaben. Results indicate that several effective options exist for artilleryweed management, but more effective control will likely be achieved when herbicides are applied PRE.
Field studies were conducted in 1996 and 1997 at three locations throughout southern Ontario with the objective of developing dose-response curves of RPA 201772 for weed control and crop tolerance in corn. The biologically effective doses required to control redroot pigweed, velvetleaf, and wild mustard were 100, 90, and 80 g/ha, respectively. Yellow foxtail was controlled with 100 to 120 g/ha, while rates for common lambsquarters varied from 60 to 130 g/ha, depending on the year and location. Wild buckwheat control was poor (> 30%) at all of the doses tested. RPA 201772 did not reduce corn grain yield; however, temporary crop injury was evident on coarse sandy soils.
Field experiments were conducted in 1996 and 1997 at five locations in southwestern Ontario to develop dose-response curves for SAN 1269H (SAN 835H plus dicamba) for weed control and crop tolerance in corn. SAN 1269H controlled wild buckwheat (Polygonum convolvulus L.), common ragweed (Ambrosia artemisiifolia L.), common lambsquarters (Chenopodium album L.), pigweeds (Amaranthus retroflexus L. and A. powellii S. Wats.), barnyardgrass [Echinochloa crus-galli (L.) Beauv.], and yellow foxtail [Setaria glauca (L.) Beauv.]. Biologically effective doses of SAN 1269H (BAS 662H) were 440, 430, 180, and 40 g/ha for yellow foxtail, barnyard grass, wild buckwheat, and common ragweed, respectively. The biologically effective dose (that which provides 90% reduction in weed dry matter) for common lambsquarters was 560 g/ha when SAN 1269H was applied preemergence (PRE) and 110 g/ha when applied postemergence (POST). When applied PRE at a rate of 420 g/ha, pigweed was controlled, whereas only 85 g/ha was required when applied POST. Grain yield increased with dose of SAN 1269H and did not differ with time of application. Temporary crop injury was observed when SAN 1269H was applied at the four- to six-leaf growth stage. Optimum corn yields were achieved with doses of 100 to 250 g/ha.
Studies were conducted on the campuses of Texas A&M University in College Station, TX, and New Mexico State in Las Cruces, NM, to determine the spray droplet size spectra produced by quinclorac and 2,4-D as the liquid, dry, and emulsion formulations during application with various nozzle sizes using a laser spectrometer. Quinclorac and 2,4-D formulations were also sprayed through three different nozzle sizes in a drift chamber and allowed to settle on glass slides placed downwind. The amounts of each herbicide deposited on the slides were quantified using high-performance liquid chromatography/photodiode array (HPLC/PDA) analysis to assess spray deposition of each formulation at different wind velocities. Data from the laser spectrometer suggested that formulations of 2,4-D affected droplet size, particularly when the 380 ml/min flat-fan nozzle was used. Quinclorac droplet sizes were similar to water regardless of nozzle size. Liquid and dry-formulated 2,4-D tended to be deposited downwind in greater quantities than the emulsion formulation when using the 380 and 760 ml/min spray nozzles with wind velocity of 15 km/h.
Alligatorweed is a perennial, invasive weed in southern United States rice production, but knowledge on effective management of this weed is limited, especially in conventional (non-imidazolinone-resistant) rice fields. Field studies were conducted in multiple environments in southeastern Texas to evaluate different herbicide options involving penoxsulam, propanil, triclopyr, halosulfuron, bispyribac-sodium, bensulfuron, and quinclorac for alligatorweed control in conventional drill-seeded rice when applied at early POST (EPOST), late POST (LPOST), or both. Among the herbicide options evaluated, penoxsulam alone (up to 83%), penoxsulam plus triclopyr (up to 87%), or bispyribac-sodium plus triclopyr (92%) provided superior alligatorweed control. Plots treated with penoxsulam plus triclopyr EPOST produced the highest yields (9,550 kg ha−1), which were comparable to plots receiving penoxsulam plus triclopyr LPOST (9,320 kg ha−1), penoxsulam alone EPOST (9,280 kg ha−1), and penoxsulam plus halosulfuron LPOST (9,180 kg ha−1). Considering both weed control and rice grain yields, penoxsulam plus triclopyr applied EPOST was found to be the best option among the treatments tested. The treatments bensulfuron alone, bensulfuron plus propanil, penoxsulam plus propanil, triclopyr plus propanil, and bispyribac-sodium plus propanil provided poor (≤ 65%) alligatorweed control. Results also suggest the likelihood for antagonistic interactions when tank-mix combinations tested in this study included propanil.
Studies were conducted in 2003 and 2004 over seven environments evaluating rice root growth inhibition (RGI) and foliar injury from penoxsulam at 30 and 60 g ai/ha and bispyribac-sodium at 30 g ai/ha applied to four- to five-leaf rice at three flood timings, 1, 7, and 14 d after herbicide treatment (DAT), for five rice cultivars, ‘Bengal’, ‘Cypress’, ‘Wells’, ‘Cocodrie’, and ‘XP712’. Flooding at 1 and 7 DAT resulted in greater RGI compared with flood at 14 DAT when evaluated 1 wk after flood (WAF). By 2 WAF, RGI was greater with flooding at 1 DAT compared with flooding at 7 DAT for cultivars Bengal, Cypress, and Wells. Analyzing flood timing 1 DAT, bispyribac-sodium reduced root growth of Bengal and Cypress compared with penoxsulam at 30 g/ha at 1 week after treatment (WAT). At 2 WAT, RGI for Cocodrie was higher following penoxsulam at 60 g/ha when compared with bispyribac-sodium. By 3 WAT, RGI was higher following penoxsulam at 60 g/ha when compared with penoxsulam at 30 g/ha for Cocodrie and greater than bispyribac-sodium and penoxsulam at 30 g/ha for Cypress. Foliar injury following penoxsulam at both rates was less than injury following bispyribac-sodium for all cultivars except XP712 at 1 WAT. XP712 resulted in < 5% RGI and < 6% foliar injury at each evaluation. Rice grain yield was not affected by herbicide treatment for any cultivar compared with the standard treatment of propanil plus quinclorac.
Although primarily used as an effective PRE herbicide, indaziflam has been shown to provide early POST control of some weeds commonly found in nursery production. Previous investigation on the early POST efficacy of indaziflam focused on the liquid formulation, and the ability of the granular formulation to provide early POST weed control is unknown. Nursery trials were conducted to evaluate early POST control of oxalis using two formulations of indaziflam. Oxalis seeds were surface sown to nursery containers at two separate dates and grown until they reached the two- to four-leaf stage (2-4L) and six- to eight-leaf stage. Both growth stages were treated with indaziflam at 12.6, 25.1, 50.2, and 100.4 g ai ha−1 using either a granular (G) or liquid (SC) formulation. A chemical control treatment (glyphosate) and a nontreated control were also included for comparison. The SC formulation provided > 90% control of both oxalis growth stages at all four rates and was similar to glyphosate. The G formulation at 12.6 and 25.1 g ha−1 only provided marginal control, but overall performed similarly to the SC formulation at the 50.2 and 100.4 g ha−1 rate in most experiments. In contrast to the SC formulation, the G formulation is labeled for use over the top of container-grown nursery crops. Results of this research indicate that in areas where oxalis is the primary weed of concern, the G formulation of indaziflam could be applied to control small oxalis up to the 2-4L stage at the currently labeled rate (50.2 g ha−1).
Volatility and drift are problems commonly associated with auxin-like herbicides. Field and greenhouse studies were conducted at Texas A & M University to develop a method of quantifying volatility and subsequent off-target movement of 2,4-D, dicamba, and triclopyr. Rate–response curves were established by applying reduced rates ranging from 4 × 10−1 to 1 × 10−5 times the normal use rates of the herbicides to cotton and soybean and recording injury for 14 d after treatment (DAT) using a rating scale designed to quantify auxin-like herbicide injury. Injury from herbicide volatility was then produced on additional cotton and soybean plants through exposure to vapors of the dimethylamine salt of 2,4-D, diglycolamine salt of dicamba, and butoxyethyl ester of triclopyr using air chambers inside a greenhouse and volatility plots in the field. Injury resulting from this exposure was evaluated for 14 d using the same injury-evaluation scale that was used to produce the rate–response curves. Volatility-injury data were then applied to the rate–response curves so that herbicide rates corresponding with observed injury could be calculated. Using this method, herbicide volatility rates estimated from greenhouse-cotton injury were determined to be 3.0 × 10−3, 1.0 × 10−3, and 4.9 × 10−2 times the use rates of 2,4-D, dicamba, and triclopyr, respectively. Greenhouse-grown soybean developed injury consistent with 1.4 × 10−2, 1.0 × 10−3, and 2.5 × 10−2 times the normal use rate of 2,4-D, dicamba, and triclopyr, respectively. Under field conditions, cotton developed injury symptoms that were consistent with 4.0 × 10−3, 2.0 × 10−3, and 1.25 × 10−1 times the recommended use rates of 2,4-D, dicamba, and triclopyr, respectively. Field soybean displayed injury symptomology concordant with 1.6 × 10−1, 1.0 × 10−2, and 1.1 × 10−1 times the normal use rates of 2,4-D, dicamba, and triclopyr, respectively. This procedure provided herbicide volatility rate estimates that were consistent with rates and injury from the rate–response injury curves. Additional research is needed to ascertain its usefulness in determining long-term effects of drift injury on crop variables such as yield.
The development of glufosinate-resistant corn represents a new weed management system for corn growers. Field experiments were conducted from 1995 to 1997 at four locations in southwestern Ontario. The objective of this study was to determine the effect of timing of weed control relative to the growth stage of corn with glufosinate applied alone or in combination with residual herbicides. Control of all species tested improved with the addition of atrazine plus dicamba to glufosinate, applied from the two- to eight-leaf stage of corn growth. Based on a 90% weed dry matter reduction, glufosinate with atrazine plus dicamba controlled common ragweed, common lambsquarters, and pigweed species at the three-leaf stage of corn and yellow foxtail, barnyardgrass, and large crabgrass at the two-, four-, and eight-leaf stage of corn, respectively. Weed control with glufosinate alone was improved when applied at the later growth stages of corn. Glufosinate applied alone at the four-leaf stage of corn controlled common ragweed and common lambsquarters, whereas pigweed species were controlled effectively at the eight-leaf stage of corn growth. Corn grain yield was consistently higher when glufosinate was applied in combination with residual herbicides, compared to glufosinate alone. Glufosinate in combination with residual herbicides applied to corn at the three- to five-leaf stage may represent the best timing for weed control. Our data suggested that a tank mixture of glufosinate with other postemergence residual herbicides or a split application of glufosinate in combination with cultivation may be required for weed control in glufosinate-resistant corn.
Crop injury caused by drift of auxin-like herbicides has been a concern since their development. Research was conducted to describe a method of quantifying injury from auxin-like herbicides as a first step in determining crop damage. Reduced rates of 2,4-D, dicamba, and triclopyr were applied to cotton and soybean plants in the three- to six-leaf stage in field and greenhouse studies. Injury to leaves and stems were evaluated separately, and the values were combined so that one injury estimate was obtained for each individual plant rated. Injury symptoms were typical for auxin-type herbicides and ranged from slight bending of stems or petioles and wrinkled leaves to necrosis. Specific descriptions of leaf and stem injury levels were used to describe plant injury consistently. These descriptions were very detailed for the lower injury levels, but the characterizations became more general as the injury increased because of the prominence of factors such as necrosis. The injury evaluation method provided repeatable results for each herbicide and herbicide rate used. This injury evaluation method has many possible uses in auxin-like herbicide research and lays the foundation for forecasting the impact of early-season injury to cotton and soybean yield.
This paper provides an overview of interpolation of Banach and Hilbert spaces, with a focus on establishing when equivalence of norms is in fact equality of norms in the key results of the theory. (In brief, our conclusion for the Hilbert space case is that, with the right normalizations, all the key results hold with equality of norms.) In the final section we apply the Hilbert space results to the Sobolev spaces $H^{s}({\rm\Omega})$ and $\widetilde{H}^{s}({\rm\Omega})$, for $s\in \mathbb{R}$ and an open ${\rm\Omega}\subset \mathbb{R}^{n}$. We exhibit examples in one and two dimensions of sets ${\rm\Omega}$ for which these scales of Sobolev spaces are not interpolation scales. In the cases where they are interpolation scales (in particular, if ${\rm\Omega}$ is Lipschitz) we exhibit examples that show that, in general, the interpolation norm does not coincide with the intrinsic Sobolev norm and, in fact, the ratio of these two norms can be arbitrarily large.
For over a decade, the structure of the inner “hole” in the transition disk around TW Hydrae has been a subject of debate. To probe the innermost regions of the protoplanetary disk, observations at the highest possible spatial resolution are required. We present new interferometric data of TW Hya from near-infrared to millimeter wavelengths. We confront existing models of the disk structure with the complete data set and develop a new, detailed radiative-transfer model. This model is characterized by: 1) a spatial separation of the largest grains from the small disk grains; and 2) a smooth inner rim structure, rather than a sharp disk edge.
The genus Saltisedes Kubota, 1944 (Coleoptera: Staphylinidae: Pselaphinae: Tmesiphorini) is redefined and three new species are described and illustrated: S. hainanensis Yin and Nomura, new species (China), S. kojimai Nomura and Yin, new species (Japan), and S. yahiroi Nomura and Yin, new species (Malaysia). Saltisedes brunneus Kubota, 1944 (Japan), the only previously known species is redescribed. Stethotaphrus Newton and Chandler is placed as a junior synonym of Saltisedes, the placement results in the following new combinations: Saltisedes clavatus (Raffray, 1882), new combination, Saltisedes hamotoides (Schaufuss, 1882), new combination, Saltisedes javanicus (Raffray, 1882), new combination, Saltisedes longispina (Raffray, 1903), new combination, and Saltisedes weiri (Chandler, 2001), new combination. A list of known Saltisedes species is included and a key to the species from continental Asia and Japan is presented.
Children's assignment of novel words to nameless objects, over objects whose names they know (mutual exclusivity; ME) has been described as a driving force for vocabulary acquisition. Despite their ability to use ME to fast-map words (Preissler & Carey, 2005), children with autism show impaired language acquisition. We aimed to address this puzzle by building on studies showing that correct referent selection using ME does not lead to word learning unless ostensive feedback is provided on the child's object choice (Horst & Samuelson, 2008). We found that although toddlers aged 2;0 at risk for autism can use ME to choose the correct referent of a word, they do not benefit from feedback for long-term retention of the word–object mapping. Further, their difficulty using feedback is associated with their smaller receptive vocabularies. We propose that difficulties learning from social feedback, not lexical principles, limits vocabulary building during development in children at risk for autism.
In the treatment of children and adolescents with leukemia, nursing care complements and extends the efforts of other members of the healthcare team. The focus of nursing care is on the long-term as well as immediate needs of patients and their families and, therefore, includes strategies to prevent or manage complications and sequelae of the disease and its treatment. Another integral aspect of nursing care is assisting individual patients and families in achieving their developmental goals during treatment and follow-up.
This chapter, in addition to describing some of the challenges of nursing care of the child or adolescent with leukemia and providing practice recommendations specific to selected aspects of their care, offers a framework within which these aspects can be addressed and applies this framework to several practice examples. The supportive care framework includes six categories of needs and nine possible treatment phases in the spectrum of the cancer experience, as well as influencing factors that should be taken into consideration for each individual patient and family. The relationships between nursing strategies and both the identified supportive care needs and the phase of care are illustrated in examples of several major concerns that can arise in the treatment of childhood leukemia. For convenience, the examples are based primarily on the treatment of childhood acute lymphoblastic leukemia (ALL), but the same principles apply to acute myeloid leukemia (AML) and other leukemias in children. Whenever possible, the focus is on evidence-based practice.